Polygenic control of Caenorhabditis elegans fat storage

Nature Genetics

Volumn 38, Issue 3, 2006, Pages 363-368

  Mak, Ho Yi ^a,b   Nelson, Laura S ^c   Basson, Michael ^c,d   Johnson, Carl D ^c,e   Ruvkun, Gary ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Axys Pharmaceuticals Inc   (United States)

^d Nature Medicine   (United States)

^e Hereditary Disease Foundation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A ACYLTRANSFERASE; CARRIER PROTEIN; CYCLIC NUCLEOTIDE; FATTY ACID;

ALLELE; ARTICLE; CAENORHABDITIS ELEGANS; FATTY ACID OXIDATION; GENETIC SCREENING; INTESTINE; LIPID STORAGE; MULTIFACTORIAL INHERITANCE; MUTANT; NERVE CELL; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; UPREGULATION;

ACETYL-COA C-ACYLTRANSFERASE; ADIPOSE TISSUE; ANIMALS; CAENORHABDITIS ELEGANS; CILIA; MUTATION; NEURONS;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 33644616841     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1739     Document Type: Article

References (30)

1. Ikeda, A., Nishina, P.M. & Naggert, J.K. The tubby-like proteins, a family with roles in neuronal development and function. J. Cell Sci. 115, 9-14 (2002).
2. Katsanis, N., Lupski, J.R. & Beales, P.L. Exploring the molecular basis of Bardet-Biedl syndrome. Hum. Mol. Genet. 10, 2293-2299 (2001).
3. Sahly, I. et al. Prominent neuronal-specific tub gene expression in cellular targets of tubby mice mutation. Hum. Mol. Genet. 7, 1437-1447 (1998).
4. Stubdal, H. et al. Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss-of-function mutation. Mol. Cell. Biol. 20, 878-882 (2000).
5. Kleyn, P.W. et al. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell 85, 281-290 (1996).
6. Noben-Trauth, K., Naggert, J.K., North, M.A. & Nishina, P.M. A candidate gene for the mouse mutation tubby. Nature 380, 534-538 (1996).
7. Ashrafi, K. et al. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421, 268-272 (2003).
8. Mathieu, M. et al. The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism. J. Mol. Biol. 273, 714-728 (1997).
9. Fujiwara, M., Sengupta, P. & McIntire, S.L. Regulation of body size and behavioral state of C. elegans by sensory perception and the EGL-4 cGMP-dependent protein kinase. Neuron 36, 1091-1102 (2002).
10. Ansley, S.J. et al. Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature 425, 628-633 (2003).
11. Qin, H., Rosenbaum, J.L. & Barr, M.M. An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons. Curr. Biol. 11, 457-461 (2001).
12. Haycraft, C.J., Swoboda, P., Taulman, P.D., Thomas, J.H. & Yoder, B.K. The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms. Development 128, 1493-1505 (2001).
13. Fujiwara, M., Ishihara, T. & Katsura, I. A novel WD40 protein, CHE-2, acts cell-autonomously in the formation of C. elegans sensory cilia. Development 126, 4839-4848 (1999).
14. Perens, E.A. & Shaham, S. C. elegans daf-6 encodes a patched-related protein required for lumen formation. Dev. Cell 8, 893-906 (2005).
15. Komatsu, H., Mori, I., Rhee, J.S., Akaike, N. & Ohshima, Y. Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans. Neuron 17, 707-718 (1996).
16. Coates, J.C. & de Bono, M. Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans. Nature 419, 925-929 (2002).
17. Kim, J.C. et al. The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat. Genet. 36, 462-470 (2004).
18. White, J.G., Southgate, E., Thomson, J.N. & Brenner, S. The structure of the nervous system of the nematode Caenorhabditis elegans. Phil. Trans. R. Soc. Lond. B 314, 1-340 (1986).
19. Bargmann, C.I. & Horvitz, H.R. Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans. Neuron 7, 729-742 (1991).
20. Troemel, E.R., Chou, J.H., Dwyer, N.D., Colbert, H.A. & Bargmann, C.I. Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans. Cell 83, 207-218 (1995).
21. Li, C., Nelson, L.S., Kim, K., Nathoo, A. & Hart, A.C. Neuropeptide gene families in the nematode Caenorhabditis elegans. Ann. NY Acad. Sci. 897, 239-252 (1999).
22. Li, W., Kennedy, S.G. & Ruvkun, G. daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev. 17, 844-858 (2003).
23. Pierce, S.B. et al. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 15, 672-686 (2001).
24. Ren, P. et al. Control of C. elegans larval development by neuronal expression of a TGF-beta homolog. Science 274, 1389-1391 (1996).
25. Schackwitz, W.S., Inoue, T. & Thomas, J.H. Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Neuron 17, 719-728 (1996).
26. de Bono, M., Tobin, D.M., Davis, M.W., Avery, L. & Bargmann, C.I. Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. Nature 419, 899-903 (2002).
27. Bargmann, C.I. & Horvitz, H.R. Control of larval development by chemosensory neurons in Caenorhabditis elegans. Science 251, 1243-1246 (1991).
28. Apfeld, J. & Kenyon, C. Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-809 (1999).
29. Kimura, K.D., Tissenbaum, H.A., Liu, Y. & Ruvkun, G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-946 (1997).
30. Wicks, S.R., Yeh, R.T., Gish, W.R., Waterston, R.H. & Plasterk, R.H. Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map. Nat. Genet. 28, 160-164 (2001).