메뉴 건너뛰기




Volumn 10, Issue 6, 2014, Pages

Loss of a Neural AMP-Activated Kinase Mimics the Effects of Elevated Serotonin on Fat, Movement, and Hormonal Secretions

Author keywords

[No Author keywords available]

Indexed keywords

FAT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; SEROTONIN; TRANSFORMING GROWTH FACTOR BETA; AAK-2 PROTEIN, C ELEGANS; CAENORHABDITIS ELEGANS PROTEIN; DAF-28 PROTEIN, C. ELEGANS; DAF-7 PROTEIN, C ELEGANS; INSULIN RECEPTOR; LIPID; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; TRYPTOPHAN HYDROXYLASE;

EID: 84903482476     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004394     Document Type: Article
Times cited : (35)

References (65)
  • 1
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
    • doi:10.1038/nrm2249
    • Hardie DG, (2007) AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nature Publishing Group 8: 774-785 doi:10.1038/nrm2249.
    • (2007) Nature Publishing Group , vol.8 , pp. 774-785
    • Hardie, D.G.1
  • 2
    • 75749104187 scopus 로고    scopus 로고
    • AMPK as a mediator of hormonal signalling
    • doi:10.1677/JME-09-0063
    • Lim CT, Kola B, Korbonits M, (2010) AMPK as a mediator of hormonal signalling. J Mol Endocrinol 44: 87-97 doi:10.1677/JME-09-0063.
    • (2010) J Mol Endocrinol , vol.44 , pp. 87-97
    • Lim, C.T.1    Kola, B.2    Korbonits, M.3
  • 3
    • 1842484296 scopus 로고    scopus 로고
    • AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    • doi:10.1038/nature02440
    • Minokoshi Y, Alquier T, Furukawa N, Kim Y-B, Lee A, et al. (2004) AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428: 569-574 doi:10.1038/nature02440.
    • (2004) Nature , vol.428 , pp. 569-574
    • Minokoshi, Y.1    Alquier, T.2    Furukawa, N.3    Kim, Y.-B.4    Lee, A.5
  • 4
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
    • doi:10.1016/j.cmet.2004.12.003
    • Kahn BB, Alquier T, Carling D, Hardie DG, (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metabolism 1: 15-25 doi:10.1016/j.cmet.2004.12.003.
    • (2005) Cell Metabolism , vol.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 5
    • 28244466264 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase
    • doi:10.1074/jbc.M507443200
    • Rattan R, Giri S, Singh AK, Singh I, (2005) 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem 280: 39582-39593 doi:10.1074/jbc.M507443200.
    • (2005) J Biol Chem , vol.280 , pp. 39582-39593
    • Rattan, R.1    Giri, S.2    Singh, A.K.3    Singh, I.4
  • 6
    • 10644282295 scopus 로고    scopus 로고
    • The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
    • doi:10.1101/gad.1255404
    • Apfeld J, O'Connor G, McDonagh T, DiStefano PS, Curtis R, (2004) The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes & Development 18: 3004-3009 doi:10.1101/gad.1255404.
    • (2004) Genes & Development , vol.18 , pp. 3004-3009
    • Apfeld, J.1    O'Connor, G.2    McDonagh, T.3    DiStefano, P.S.4    Curtis, R.5
  • 7
    • 84863516398 scopus 로고    scopus 로고
    • AMP-Activated Kinase Links Serotonergic Signaling to Glutamate Release for Regulation of Feeding Behavior in C. elegans
    • doi:10.1016/j.cmet.2012.05.014
    • Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, et al. (2012) AMP-Activated Kinase Links Serotonergic Signaling to Glutamate Release for Regulation of Feeding Behavior in C. elegans. Cell Metabolism 16: 113-121 doi:10.1016/j.cmet.2012.05.014.
    • (2012) Cell Metabolism , vol.16 , pp. 113-121
    • Cunningham, K.A.1    Hua, Z.2    Srinivasan, S.3    Liu, J.4    Lee, B.H.5
  • 8
    • 34748850786 scopus 로고    scopus 로고
    • Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress
    • doi:10.1016/j.cmet.2007.08.011
    • Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, et al. (2007) Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress. Cell Metabolism 6: 280-293 doi:10.1016/j.cmet.2007.08.011.
    • (2007) Cell Metabolism , vol.6 , pp. 280-293
    • Schulz, T.J.1    Zarse, K.2    Voigt, A.3    Urban, N.4    Birringer, M.5
  • 9
    • 58149339613 scopus 로고    scopus 로고
    • Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival
    • doi:10.1038/nature07536
    • Narbonne P, Roy R, (2009) Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Nature 457: 210-214 doi:10.1038/nature07536.
    • (2009) Nature , vol.457 , pp. 210-214
    • Narbonne, P.1    Roy, R.2
  • 10
    • 84964892932 scopus 로고    scopus 로고
    • C. elegans AMPKs promote survival and arrest germline development during nutrient stress
    • Fukuyama M, Sakuma K, Park R, Kasuga H, Nagaya R, et al. (2012) C. elegans AMPKs promote survival and arrest germline development during nutrient stress. Biology Open 1: 929-936.
    • (2012) Biology Open , vol.1 , pp. 929-936
    • Fukuyama, M.1    Sakuma, K.2    Park, R.3    Kasuga, H.4    Nagaya, R.5
  • 11
    • 84865798000 scopus 로고    scopus 로고
    • Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae
    • doi:10.1016/j.cmet.2012.07.016
    • Xie M, Roy R, (2012) Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae. Cell Metabolism 16: 322-335 doi:10.1016/j.cmet.2012.07.016.
    • (2012) Cell Metabolism , vol.16 , pp. 322-335
    • Xie, M.1    Roy, R.2
  • 12
    • 33645090940 scopus 로고    scopus 로고
    • Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling
    • doi:10.1242/dev.02232
    • Narbonne P, Roy R, (2006) Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling. Development 13: 611-619 doi:10.1242/dev.02232.
    • (2006) Development , vol.13 , pp. 611-619
    • Narbonne, P.1    Roy, R.2
  • 13
    • 34848850156 scopus 로고    scopus 로고
    • An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans
    • doi:10.1016/j.cub.2007.08.047
    • Greer EL, Dowlatshahi D, Banko MR, Villen J, Hoang K, (2007) An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans. Current Biology 17: 1646-1656 doi:10.1016/j.cub.2007.08.047.
    • (2007) Current Biology , vol.17 , pp. 1646-1656
    • Greer, E.L.1    Dowlatshahi, D.2    Banko, M.R.3    Villen, J.4    Hoang, K.5
  • 14
    • 79951787452 scopus 로고    scopus 로고
    • Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
    • doi:10.1038/nature09706
    • Mair W, Morantte I, Rodrigues APC, Manning G, Montminy M, et al. (2011) Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature 470: 404-408 doi:10.1038/nature09706.
    • (2011) Nature , vol.470 , pp. 404-408
    • Mair, W.1    Morantte, I.2    Rodrigues, A.P.C.3    Manning, G.4    Montminy, M.5
  • 15
    • 0342680006 scopus 로고    scopus 로고
    • Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
    • doi:10.1038/35000609
    • Sze JY, Victor M, Loer C, Shi Y, Ruvkun G, (2000) Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature 403: 560-564 doi:10.1038/35000609.
    • (2000) Nature , vol.403 , pp. 560-564
    • Sze, J.Y.1    Victor, M.2    Loer, C.3    Shi, Y.4    Ruvkun, G.5
  • 16
    • 33751434331 scopus 로고    scopus 로고
    • Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses
    • doi:10.1016/j.cmet.2006.11.004
    • Liang B, Moussaif M, Kuan C-J, Gargus JJ, Sze JY, (2006) Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses. Cell Metabolism 4: 429-440 doi:10.1016/j.cmet.2006.11.004.
    • (2006) Cell Metabolism , vol.4 , pp. 429-440
    • Liang, B.1    Moussaif, M.2    Kuan, C.-J.3    Gargus, J.J.4    Sze, J.Y.5
  • 17
    • 0033714116 scopus 로고    scopus 로고
    • C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway
    • Sawin ER, Ranganathan R, Horvitz HR, (2000) C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron 26: 619-631.
    • (2000) Neuron , vol.26 , pp. 619-631
    • Sawin, E.R.1    Ranganathan, R.2    Horvitz, H.R.3
  • 18
    • 0025063432 scopus 로고
    • Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans
    • doi:10.1002/jez.1402530305
    • Avery L, Horvitz HR, (1990) Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans. J Exp Zool 253: 263-270 doi:10.1002/jez.1402530305.
    • (1990) J Exp Zool , vol.253 , pp. 263-270
    • Avery, L.1    Horvitz, H.R.2
  • 19
    • 44349100977 scopus 로고    scopus 로고
    • Serotonin Regulates C. elegans Fat and Feeding through Independent Molecular Mechanisms
    • doi:10.1016/j.cmet.2008.04.012
    • Srinivasan S, Sadegh L, Elle IC, Christensen AGL, Faergeman NJ, et al. (2008) Serotonin Regulates C. elegans Fat and Feeding through Independent Molecular Mechanisms. Cell Metabolism 7: 533-544 doi:10.1016/j.cmet.2008.04.012.
    • (2008) Cell Metabolism , vol.7 , pp. 533-544
    • Srinivasan, S.1    Sadegh, L.2    Elle, I.C.3    Christensen, A.G.L.4    Faergeman, N.J.5
  • 20
    • 0019977293 scopus 로고
    • Serotonin and octopamine in the nematode Caenorhabditis elegans
    • doi:10.1126/science.6805073
    • Horvitz HR, Chalfie M, Trent C, Sulston JE, Evans PD, (1982) Serotonin and octopamine in the nematode Caenorhabditis elegans. Science 216: 1012-1014 doi:10.1126/science.6805073.
    • (1982) Science , vol.216 , pp. 1012-1014
    • Horvitz, H.R.1    Chalfie, M.2    Trent, C.3    Sulston, J.E.4    Evans, P.D.5
  • 21
    • 31544457058 scopus 로고    scopus 로고
    • Dietary choice behavior in Caenorhabditis elegans
    • doi:10.1242/jeb.01955
    • Shtonda BB, Avery L, (2006) Dietary choice behavior in Caenorhabditis elegans. Journal of Experimental Biology 209: 89-102 doi:10.1242/jeb.01955.
    • (2006) Journal of Experimental Biology , vol.209 , pp. 89-102
    • Shtonda, B.B.1    Avery, L.2
  • 22
    • 27744466522 scopus 로고    scopus 로고
    • Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans
    • doi:10.1038/nature04216
    • Zhang Y, Lu H, Bargmann CI, (2005) Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans. Nature 438: 179-184 doi:10.1038/nature04216.
    • (2005) Nature , vol.438 , pp. 179-184
    • Zhang, Y.1    Lu, H.2    Bargmann, C.I.3
  • 23
    • 84859765702 scopus 로고    scopus 로고
    • Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses
    • doi:10.1016/j.cell.2012.02.050
    • Melo JA, Ruvkun G, (2012) Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. Cell 149: 452-466 doi:10.1016/j.cell.2012.02.050.
    • (2012) Cell , vol.149 , pp. 452-466
    • Melo, J.A.1    Ruvkun, G.2
  • 24
    • 33645569464 scopus 로고    scopus 로고
    • Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx
    • doi:10.1016/j.cmet.2006.02.012
    • You Y-J, Kim J, Cobb M, Avery L, (2006) Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx. Cell Metabolism 3: 237-245 doi:10.1016/j.cmet.2006.02.012.
    • (2006) Cell Metabolism , vol.3 , pp. 237-245
    • You, Y.-J.1    Kim, J.2    Cobb, M.3    Avery, L.4
  • 25
    • 0016800415 scopus 로고
    • Analgesic effect of fluoxetine hydrochloride (Lilly 110140), a specific inhibitor of serotonin uptake
    • RB M.L P.LA F.LD L
    • RB M, L P, LA F, LD L, (1975) Analgesic effect of fluoxetine hydrochloride (Lilly 110140), a specific inhibitor of serotonin uptake. Psychopharmacol Commun 1: 511-521.
    • (1975) Psychopharmacol Commun , vol.1 , pp. 511-521
  • 26
    • 0035882491 scopus 로고    scopus 로고
    • Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine
    • Ranganathan R, Sawin ER, Trent C, Horvitz HR, (2001) Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and-independent activities of fluoxetine. Journal of Neuroscience 21: 5871-5884.
    • (2001) Journal of Neuroscience , vol.21 , pp. 5871-5884
    • Ranganathan, R.1    Sawin, E.R.2    Trent, C.3    Horvitz, H.R.4
  • 27
    • 0026002375 scopus 로고
    • Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans
    • Bargmann CI, Horvitz HR, (1991) Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans. Neuron 7: 729-742.
    • (1991) Neuron , vol.7 , pp. 729-742
    • Bargmann, C.I.1    Horvitz, H.R.2
  • 28
    • 47249157348 scopus 로고    scopus 로고
    • The Caenorhabditis elegans AMP-activated Protein Kinase AAK-2 Is Phosphorylated by LKB1 and Is Required for Resistance to Oxidative Stress and for Normal Motility and Foraging Behavior
    • doi:10.1074/jbc.M709115200
    • Lee H, Cho JS, Lambacher N, Lee J, Lee SJ, et al. (2008) The Caenorhabditis elegans AMP-activated Protein Kinase AAK-2 Is Phosphorylated by LKB1 and Is Required for Resistance to Oxidative Stress and for Normal Motility and Foraging Behavior. Journal of Biological Chemistry 283: 14988-14993 doi:10.1074/jbc.M709115200.
    • (2008) Journal of Biological Chemistry , vol.283 , pp. 14988-14993
    • Lee, H.1    Cho, J.S.2    Lambacher, N.3    Lee, J.4    Lee, S.J.5
  • 29
    • 17444408824 scopus 로고    scopus 로고
    • Serotonin (5HT), fluoxetine, imipramine and dopamine target distinct 5HT receptor signaling to modulate Caenorhabditis elegans egg-laying behavior
    • doi:10.1534/genetics.104.032540
    • Dempsey CM, Mackenzie SM, Gargus A, Blanco G, (2005) Serotonin (5HT), fluoxetine, imipramine and dopamine target distinct 5HT receptor signaling to modulate Caenorhabditis elegans egg-laying behavior. Genetics 169: 1425-1436 doi:10.1534/genetics.104.032540.
    • (2005) Genetics , vol.169 , pp. 1425-1436
    • Dempsey, C.M.1    Mackenzie, S.M.2    Gargus, A.3    Blanco, G.4
  • 30
    • 33644764020 scopus 로고    scopus 로고
    • SER-7, a Caenorhabditis elegans 5-HT7-like receptor, is essential for the 5-HT stimulation of pharyngeal pumping and egg laying
    • doi:10.1534/genetics.105.044495
    • Hobson RJ, Hapiak VM, Xiao H, Buehrer KL, (2006) SER-7, a Caenorhabditis elegans 5-HT7-like receptor, is essential for the 5-HT stimulation of pharyngeal pumping and egg laying. Genetics 172: 159-169 doi:10.1534/genetics.105.044495.
    • (2006) Genetics , vol.172 , pp. 159-169
    • Hobson, R.J.1    Hapiak, V.M.2    Xiao, H.3    Buehrer, K.L.4
  • 31
    • 84887449305 scopus 로고    scopus 로고
    • An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat
    • doi:10.1016/j.cmet.2013.09.007
    • Noble T, Stieglitz J, Srinivasan S, (2013) An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat. Cell Metabolism 18: 672-684 doi:10.1016/j.cmet.2013.09.007.
    • (2013) Cell Metabolism , vol.18 , pp. 672-684
    • Noble, T.1    Stieglitz, J.2    Srinivasan, S.3
  • 32
    • 59449097532 scopus 로고    scopus 로고
    • Biological Engineering Division Massachusetts Institute of Technology Barry R. Masters Visiting Scientist, Peter So Professor of Mechanical and Biological Engineering Massachusetts Institute of Technology, Oxford University Press
    • Biological Engineering Division Massachusetts Institute of Technology Barry R. Masters Visiting Scientist, Peter So Professor of Mechanical and Biological Engineering Massachusetts Institute of Technology (2008) Handbook of Biomedical Nonlinear Optical Microscopy. Oxford University Press. 1 pp.
    • (2008) Handbook of Biomedical Nonlinear Optical Microscopy , pp. 1
  • 33
    • 79551553753 scopus 로고    scopus 로고
    • RNAi screening for fat regulatory genes with SRS microscopy
    • doi:10.1038/NMETH.1556
    • Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS, (2011) RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods 8: 135-U152 doi:10.1038/NMETH.1556.
    • (2011) Nat Methods , vol.8 , pp. 135-152
    • Wang, M.C.1    Min, W.2    Freudiger, C.W.3    Ruvkun, G.4    Xie, X.S.5
  • 34
    • 35548956009 scopus 로고    scopus 로고
    • Monitoring of lipid storage in Caenorhabditis elegans using coherent anti-Stokes Raman scattering (CARS) microscopy
    • doi:10.1073/pnas.0703594104
    • Hellerer T, Axaeng C, Brackmann C, Hillertz P, Pilon M, et al. (2007) Monitoring of lipid storage in Caenorhabditis elegans using coherent anti-Stokes Raman scattering (CARS) microscopy. Proc Natl Acad Sci USA 104: 14658-14663 doi:10.1073/pnas.0703594104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14658-14663
    • Hellerer, T.1    Axaeng, C.2    Brackmann, C.3    Hillertz, P.4    Pilon, M.5
  • 35
    • 15744386624 scopus 로고    scopus 로고
    • Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans
    • doi:10.1371/journal.pbio.0030053
    • Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto KR, (2005) Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol 3: e53 doi:10.1371/journal.pbio.0030053.
    • (2005) PLoS Biol , vol.3
    • Van Gilst, M.R.1    Hadjivassiliou, H.2    Jolly, A.3    Yamamoto, K.R.4
  • 36
    • 33745178477 scopus 로고    scopus 로고
    • A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans
    • doi:10.1101/gad.1395406
    • Taubert S, Van Gilst MR, Hansen M, Yamamoto KR, (2006) A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and-independent pathways in C. elegans. Genes & Development 20: 1137-1149 doi:10.1101/gad.1395406.
    • (2006) Genes & Development , vol.20 , pp. 1137-1149
    • Taubert, S.1    Van Gilst, M.R.2    Hansen, M.3    Yamamoto, K.R.4
  • 38
    • 0030813398 scopus 로고    scopus 로고
    • daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G, (1997) daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942-946.
    • (1997) Science , vol.277 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 40
    • 0016766716 scopus 로고
    • The dauerlarva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans
    • doi:10.1016/0012-1606(75)90109-8
    • Cassada RC, Russell RL, (1975) The dauerlarva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans. Dev Biol 46: 326-342 doi:10.1016/0012-1606(75)90109-8.
    • (1975) Dev Biol , vol.46 , pp. 326-342
    • Cassada, R.C.1    Russell, R.L.2
  • 41
    • 84855179325 scopus 로고    scopus 로고
    • Hyperactive Neuroendocrine Secretion Causes Size, Feeding, and Metabolic Defects of C. elegans Bardet-Biedl Syndrome Mutants
    • doi:10.1371/journal.pbio.1001219.g007
    • Lee BH, Liu J, Wong D, Srinivasan S, Ashrafi K, (2011) Hyperactive Neuroendocrine Secretion Causes Size, Feeding, and Metabolic Defects of C. elegans Bardet-Biedl Syndrome Mutants. PLoS Biol 9: e1001219 doi:10.1371/journal.pbio.1001219.g007.
    • (2011) PLoS Biol , vol.9
    • Lee, B.H.1    Liu, J.2    Wong, D.3    Srinivasan, S.4    Ashrafi, K.5
  • 42
    • 34248143947 scopus 로고    scopus 로고
    • Neuropeptidergic signaling in the nematode Caenorhabditis elegans
    • doi:10.1016/j.pneurobio.2007.01.006
    • Husson SJ, Mertens I, Janssen T, Lindemans M, Schoofs L, (2007) Neuropeptidergic signaling in the nematode Caenorhabditis elegans. Progress in Neurobiology 82: 33-55 doi:10.1016/j.pneurobio.2007.01.006.
    • (2007) Progress in Neurobiology , vol.82 , pp. 33-55
    • Husson, S.J.1    Mertens, I.2    Janssen, T.3    Lindemans, M.4    Schoofs, L.5
  • 43
    • 10544256181 scopus 로고    scopus 로고
    • Control of C. elegans larval development by neuronal expression of a TGF-beta homolog
    • Ren P, Lim CS, Johnsen R, Albert PS, Pilgrim D, et al. (1996) Control of C. elegans larval development by neuronal expression of a TGF-beta homolog. Science 274: 1389-1391.
    • (1996) Science , vol.274 , pp. 1389-1391
    • Ren, P.1    Lim, C.S.2    Johnsen, R.3    Albert, P.S.4    Pilgrim, D.5
  • 44
    • 0030272986 scopus 로고    scopus 로고
    • Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans
    • Schackwitz WS, Inoue T, Thomas JH, (1996) Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Neuron 17: 719-728.
    • (1996) Neuron , vol.17 , pp. 719-728
    • Schackwitz, W.S.1    Inoue, T.2    Thomas, J.H.3
  • 45
    • 33846675810 scopus 로고    scopus 로고
    • ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells
    • doi:10.1016/j.cell.2006.12.031
    • Kao G, Nordenson C, Still M, Rönnlund A, Tuck S, et al. (2007) ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells. Cell 128: 577-587 doi:10.1016/j.cell.2006.12.031.
    • (2007) Cell , vol.128 , pp. 577-587
    • Kao, G.1    Nordenson, C.2    Still, M.3    Rönnlund, A.4    Tuck, S.5
  • 46
    • 33845881679 scopus 로고    scopus 로고
    • PKC-1 regulates secretion of neuropeptides
    • doi:10.1038/nn1810
    • Sieburth D, Madison JM, Kaplan JM, (2006) PKC-1 regulates secretion of neuropeptides. Nat Neurosci 10: 49-57 doi:10.1038/nn1810.
    • (2006) Nat Neurosci , vol.10 , pp. 49-57
    • Sieburth, D.1    Madison, J.M.2    Kaplan, J.M.3
  • 47
    • 55449120240 scopus 로고    scopus 로고
    • A TRPV Channel Modulates C. elegans Neurosecretion, Larval Starvation Survival, and Adult Lifespan
    • doi:10.1371/journal.pgen.1000213
    • Lee BH, Ashrafi K, (2008) A TRPV Channel Modulates C. elegans Neurosecretion, Larval Starvation Survival, and Adult Lifespan. PLoS Genet 4: e1000213 doi:10.1371/journal.pgen.1000213.
    • (2008) PLoS Genet , vol.4
    • Lee, B.H.1    Ashrafi, K.2
  • 48
    • 0030611081 scopus 로고    scopus 로고
    • Novel Ca2+-binding Protein (CAPS) Related to UNC-31 Required for Ca2+-activated Exocytosis
    • doi:10.1074/jbc.272.32.19637
    • Ann K, (1997) Novel Ca2+-binding Protein (CAPS) Related to UNC-31 Required for Ca2+-activated Exocytosis. Journal of Biological Chemistry 272: 19637-19640 doi:10.1074/jbc.272.32.19637.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 19637-19640
    • Ann, K.1
  • 49
    • 15544390526 scopus 로고    scopus 로고
    • Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network
    • doi:10.1534/genetics.104.032334
    • Schade MA, Reynolds NK, Dollins CM, Miller KG, (2005) Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network. Genetics 169: 631-649 doi:10.1534/genetics.104.032334.
    • (2005) Genetics , vol.169 , pp. 631-649
    • Schade, M.A.1    Reynolds, N.K.2    Dollins, C.M.3    Miller, K.G.4
  • 50
    • 59649125326 scopus 로고    scopus 로고
    • Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in Caenorhabditis elegans
    • doi:10.1523/JNEUROSCI.4585-08.2009
    • Harris GP, Hapiak VM, Wragg RT, Miller SB, Hughes LJ, et al. (2009) Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in Caenorhabditis elegans. Journal of Neuroscience 29: 1446-1456 doi:10.1523/JNEUROSCI.4585-08.2009.
    • (2009) Journal of Neuroscience , vol.29 , pp. 1446-1456
    • Harris, G.P.1    Hapiak, V.M.2    Wragg, R.T.3    Miller, S.B.4    Hughes, L.J.5
  • 51
    • 8844226709 scopus 로고    scopus 로고
    • Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    • doi:10.1126/science.1100747
    • Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, et al. (2004) Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306: 1383-1386 doi:10.1126/science.1100747.
    • (2004) Science , vol.306 , pp. 1383-1386
    • Zimmermann, R.1    Strauss, J.G.2    Haemmerle, G.3    Schoiswohl, G.4    Birner-Gruenberger, R.5
  • 52
    • 48149109399 scopus 로고    scopus 로고
    • Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding
    • doi:10.1016/j.cmet.2008.06.005
    • Greer ER, Perez CL, Van Gilst MR, Lee BH, Ashrafi K, (2008) Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metabolism 8: 118-131 doi:10.1016/j.cmet.2008.06.005.
    • (2008) Cell Metabolism , vol.8 , pp. 118-131
    • Greer, E.R.1    Perez, C.L.2    Van Gilst, M.R.3    Lee, B.H.4    Ashrafi, K.5
  • 53
    • 70350365111 scopus 로고    scopus 로고
    • C. elegans major fats are stored in vesicles distinct from lysosome-related organelles
    • doi:10.1016/j.cmet.2009.10.002
    • O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G, (2009) C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metabolism 10: 430-435 doi:10.1016/j.cmet.2009.10.002.
    • (2009) Cell Metabolism , vol.10 , pp. 430-435
    • O'Rourke, E.J.1    Soukas, A.A.2    Carr, C.E.3    Ruvkun, G.4
  • 54
    • 70449560405 scopus 로고    scopus 로고
    • The Influence of Bacterial Diet on Fat Storage in C. elegans
    • doi:10.1371/journal.pone.0007545
    • Brooks KK, Liang B, Watts JL, (2009) The Influence of Bacterial Diet on Fat Storage in C. elegans. PLoS ONE 4: e7545 doi:10.1371/journal.pone.0007545.
    • (2009) PLoS ONE , vol.4
    • Brooks, K.K.1    Liang, B.2    Watts, J.L.3
  • 55
    • 79952971308 scopus 로고    scopus 로고
    • A whole-organism screen identifies new regulators of fat storage
    • doi:10.1038/nchembio.534
    • Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, et al. (2011) A whole-organism screen identifies new regulators of fat storage. Nat Chem Biol 7: 206-213 doi:10.1038/nchembio.534.
    • (2011) Nat Chem Biol , vol.7 , pp. 206-213
    • Lemieux, G.A.1    Liu, J.2    Mayer, N.3    Bainton, R.J.4    Ashrafi, K.5
  • 56
    • 84900800420 scopus 로고    scopus 로고
    • AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels
    • doi:10.1152/physiol.00050.2013
    • Hardie DG, Ashford MLJ, (2014) AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels. Physiology (Bethesda) 29: 99-107 doi:10.1152/physiol.00050.2013.
    • (2014) Physiology (Bethesda) , vol.29 , pp. 99-107
    • Hardie, D.G.1    Ashford, M.L.J.2
  • 57
    • 33745204479 scopus 로고    scopus 로고
    • AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
    • doi:10.1113/jphysiol.2006.113217
    • Xue B, Kahn BB, (2006) AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol (Lond) 574: 73-83 doi:10.1113/jphysiol.2006.113217.
    • (2006) J Physiol (Lond) , vol.574 , pp. 73-83
    • Xue, B.1    Kahn, B.B.2
  • 58
    • 77956431307 scopus 로고    scopus 로고
    • Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
    • doi:10.1038/nm.2207
    • López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, et al. (2010) Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med 16: 1001-1008 doi:10.1038/nm.2207.
    • (2010) Nat Med , vol.16 , pp. 1001-1008
    • López, M.1    Varela, L.2    Vázquez, M.J.3    Rodríguez-Cuenca, S.4    González, C.R.5
  • 59
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • doi:10.1038/415339a
    • Minokoshi Y, Kim Y-B, Peroni OD, Fryer LGD, Müller C, et al. (2002) Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415: 339-343 doi:10.1038/415339a.
    • (2002) Nature , vol.415 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.-B.2    Peroni, O.D.3    Fryer, L.G.D.4    Müller, C.5
  • 60
    • 33847609962 scopus 로고    scopus 로고
    • Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes
    • doi:10.1017/S1462399407000245
    • Daniel D Lam LKH, (2007) Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes. Expert Rev Mol Med 9: 1-24 doi:10.1017/S1462399407000245.
    • (2007) Expert Rev Mol Med , vol.9 , pp. 1-24
    • Daniel D Lam, L.K.H.1
  • 61
    • 0022511742 scopus 로고
    • Metabolic mechanism of the anorectic and leptogenic effects of the serotonin agonist fenfluramine
    • Even P, Nicolaidis S, (1986) Metabolic mechanism of the anorectic and leptogenic effects of the serotonin agonist fenfluramine. Appetite 7Suppl: 141-163.
    • (1986) Appetite , vol.7
    • Even, P.1    Nicolaidis, S.2
  • 62
    • 0023191789 scopus 로고
    • Effect of diet and fenfluramine on thermogenesis in the rat: possible involvement of serotonergic mechanisms
    • Rothwell NJ, Stock MJ, (1987) Effect of diet and fenfluramine on thermogenesis in the rat: possible involvement of serotonergic mechanisms. Int J Obes 11: 319-324.
    • (1987) Int J Obes , vol.11 , pp. 319-324
    • Rothwell, N.J.1    Stock, M.J.2
  • 63
    • 0025773552 scopus 로고
    • Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds
    • doi:10.1016/0006-8993(91)90348-Y
    • Le Feuvre RA, Aisenthal L, Rothwell NJ (1991) Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds. Brain Res: 245-250. doi:10.1016/0006-8993(91)90348-Y.
    • (1991) Brain Res , pp. 245-250
    • Le Feuvre, R.A.1    Aisenthal, L.2    Rothwell, N.J.3
  • 64
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner S, (1974) The genetics of Caenorhabditis elegans. Genetics 77: 71-94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 65
    • 84855465409 scopus 로고    scopus 로고
    • Analyses of C. elegans fat metabolic pathways
    • doi:10.1016/B978-0-12-394620-1.00013-8
    • Barros AG de A, Liu J, Lemieux GA, Mullaney BC, Ashrafi K, (2012) Analyses of C. elegans fat metabolic pathways. Methods Cell Biol 107: 383-407 doi:10.1016/B978-0-12-394620-1.00013-8.
    • (2012) Methods Cell Biol , vol.107 , pp. 383-407
    • Barros, A.G.A.1    Liu, J.2    Lemieux, G.A.3    Mullaney, B.C.4    Ashrafi, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.