The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegans dauer pathway

Genes and Development

Volumn 11, Issue 20, 1997, Pages 2679-2690

  Patterson, Garth I ^a   Koweek, Allison ^a   Wong, Arthur ^a   Liu, Yanxia ^a   Ruvkun, Gary ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Diapause; Neuroendocrine; TGF signaling

Indexed keywords

HYBRID PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CELL NUCLEUS; CONTROLLED STUDY; DEVELOPMENT; GENE MAPPING; GENE MUTATION; METABOLISM; NEUROENDOCRINOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN LOCALIZATION; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL;

ANIMALIA; CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 0030776478     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.20.2679     Document Type: Article

References (49)

1. Attisano, L., J.L. Wrana, E. Montalvo, and J. Massague. 1994. TGF-β receptors and actions. Biochim. Biophys. Acta 1222: 71-80.
2. Baker, J.C. and R.M. Harland. 1996. A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes & Dev. 10: 1880-1889.
3. Bargmann, C.I. and H.R. Horvitz 1991. Control of larval development by chemosensory neurons in Caenorhabditis elegans. Science 251: 1243-1246.
4. Chalfie, M., Y. Tu, G. Euskirchen, W.W. Ward, and D.C. Prasher. 1994. Green fluorescent protein as a marker for gene expression. Science 263: 802-805.
5. Chen, X., M. Rubrock, and M. Whitman. 1996. A transcriptional partner for MAD proteins in TGF-β signaling. Nature 383 :691-696.
6. Chen, X., E. Weisberg, V. Fridmacher, M. Watanabe, G. Naco, and M. Whitman. 1997. Role of Smad4 and FAST-1 in the assembly of activin responsive factor. Nature (in press).
7. Chen, Y., J. Lebrun, and W. Vale. 1996. Regulation of transforming growth factor-β and activin-induced transcription by mammalian Mad proteins. Proc. Nad. Acad. Sci. 93: 12992-12997.
8. Estevez, M., L. Attisano, J.L. Wrana, P.S. Albert, J. Massague, and D.L. Riddle. 1993. The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature 365: 644-649.
9. Finney, M. and G.B. Ruvkun. 1990. The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell 63: 895-905.
10. Genetics Computer Group. 1994. Program manual for the Wisconsin package, version 8. Madison, WI.
11. Georgi, L.L., P.S. Albert, and D.L. Riddle. 1990. daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase. Cell 61: 635-645.
12. Golden, J.W. and D.L. Riddle. 1984. The Caenorhabditis elegans dauer larva: Developmental effects of pheromone, food, and temperature. Dev. Biol. 102:368-378.
13. Graff, J.M., A. Bansal, and D.A. Melton. 1996. Xenopus mad proteins transduce distinct subsets of signals for the TGF-β superfamily. Cell 85: 479-485.
14. Hahn, S.A., M. Schutte, A.T.M. Shamsul Hoque, C.A. Moskaluk, L.T. da Costa, E. Rosenblum, C.L. Weinstein, A. Fischer, C.J. Yeo, R.H. Hruban, and S.E. Kern. 1996. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271:350-353.
15. Hayashi, H., S. Abdollah, Y. Qiu, J. Cai, Y. Xu, B.W. Grinnell, M.A. Richardson, J.N. Topper, M.A. Gimbrone, J.L. Wrana, and D. Falb. 1997. The MAD related protein Srnad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell 89: 1165-1173.
16. Hobert, O., I. Mori, Y. Yamashita, H. Honda, Y. Ohshima, Y. Liu, and G. Ruvkun. 1997. Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron 19: 345-357.
17. Hoodless, P.A., T. Haerry, S. Abdollah, M. Stapleton, M.B. O'Conner, L. Attisano, and J.L. Wrana. 1996. MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85: 489-500.
18. Kim, J., K. Johnson, H.J. Chen, S. Carroll, and A. Laughon. 1997. Mad binds to DNA and directly mediates activation of vestigial by DPP. Nature 388: 304-308.
19. Kimble, J. 1981. Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans. Dev. Biol. 87: 286-300.
20. Kimble, J. and J.G. White. 1981. On the control of germ cell development in Caenorhabditis elegans. Dev. Biol. 81: 208-219.
21. Kimura, K.D., H.A. Tissenbaum, Y. Liu, and G. Ruvkun. 1997. daf-2, an insulin-receptor-like gene that regulates longevity and diapause in C. elegans. Science 277: 942-946.
22. Kretzschmar, M., F. Liu, A. Hata, J. Doody, and J. Massague. 1997. The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes & Dev. 11: 984-995.
23. Lagna, G., A. Hata, A. Hemmati-Brivanlou, and J. Massague. 1996. Partnership between DPC4 and SMAD proteins in TGF-β signaling pathways. Nature 383: 832-836.
24. Liu, F., A. Hata, J.C. Baker, J. Doody, J. Carcamo, R.M. Harland, and J. Massague. 1996. A human mad protein acting as a BMP-regulated transcriptional activator. Nature 381: 620-623.
25. Macias-Silva, M., S. Abdollah, P.A. Hoodless, R. Pirone, L. Attisano, and J.L. Wrana. 1996. MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87: 1215-1224.
26. Massague, J. 1996. TGF-β signaling: Receptors, transducers and mad proteins. Cell 85: 947-950.
27. Mello, C.C., J.M. Kramer, D. Stinchcomb, and V. Ambros. 1991. Efficient gene transfer in C. elegans: Extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10: 3959-3970.
28. Miyazano, K., P. ten Dijke, H. Ichijo, and C.-H. Heldin. 1994. Receptors for transforming-growth-factor-β. Adv. Immunol. 55: 181-220.
29. Morris, J.Z., H.A. Tissenbaum, and G. Ruvkun. 1996. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382: 536-539.
30. Newfeld, S.J., A. Mehra, M.A. Singer, J.L. Wrana, L. Attisano, and W.M. Gelbart. 1997. Mothers against dpp participates in a DPP/TGF-β responsive serine-threonine kinase signal transduction cascade. Development 124: 3167-3176.
31. Raftery, L.A., V. Twombly, K. Wharton, and W.M. Gelbart. 1995. Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139: 241-254.
32. Ren, P., C. Lim, R. Johnsen, P.S. Albert, D. Pilgrim, and D.L. Riddle. 1996. Control of C. elegans larval development by neuronal expression of a TGF-β homolog. Science 274: 1389-1391.
33. Riddle, D.L. and P.S. Albert. 1997. Genetic and environmental regulation of dauer larva development. In C. elegans II (ed. D.L. Riddle, T. Blumenthal, B.J. Meyer, and J.R. Priess), pp. 739-768. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
34. Riddle, D.L., M.M. Swanson, and P.S. Albert. 1981. Interacting genes in dauer larva formation. Nature 290: 668-671.
35. Savage, C., P. Das, A.L. Finelli, S.R. Townsend, C. Sun, S.E.Baird, and R.W. Padgett. 1996. Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor-β pathway components. Proc. Natl. Acad. Sci. 93: 490-794.
36. Schackwitz, W.S., T. Inoue, and J.H. Thomas. 1996. Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Neuron 17: 719-728.
37. Sekelsky, J.J., S.J. Newfeld, L.A. Raftery, E.H. Chartoff, and W.M. Gelbart. 1995. Genetic characterization and cloning of Mothers against Dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139: 1347-1358.
38. Sulston, J.E., E. Schierenberg, J.G. White, and J.N. Thomson. 1983. The embryonic cell lineage of the nematode Caenorhabditis elegans. 100: 64-119.
39. Swanson, M.M. and D.L. Riddle. 1981. Critical periods in the development of the Caenorhabditis elegans dauer larva. Dev. Biol 84: 27-40.
40. Thomas, J.T., D.A. Birnby, and J.J. Vowels. 1993. Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans. Genetics 134: 1105-1117.
41. Trent, C., N. Tsung, and H.R. Horvitz. 1983. Egg laying defective mutants of the nematode Caenorhabditis elegans. Genetics 104: 619-647.
42. Topper, J.N., J. Cai, Y. Qui, K.R. Anderson, Y. Xu, J. Deeds, R. Feeley, B. Wolf, C. Gimeno, B.A. Sampson, et al. 1997. Vascular MADs: Two novel MAD related genes selectively inducible by flow in human vascular endothelium. Proc. Natl. Acad. Sci. 94: 9314-9319.
43. Vale, W., A. Hsueh, C. Rivier, and J. Yu. 1990. The inhibin/activin family of hormones and growth factors. In Peptide growth factors and their receptors (ed. M.B. Sporn and A.B. Roberts), pp. 211-248. Springer-Verlag, Heidelberg, Germany.
44. Vowels, J.J. and J.H. Thomas. 1992. Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130: 105-123.
45. Weiser, R., I.L. Wrana, and J. Massague. 1995. GS domain mutations that constitutively activate TβR-1, the downstream signaling component in the TGF-β receptor complex. EMBO J. 14:2199-2208.
46. Wrana, J.L. and L. Attisano. 1996. MAD-related proteins in TGF-β signaling. Trends Genet. 12: 493-496.
47. Wu, R.-Y., Y. Zhang, X.-H. Feng, and R. Derynck. 1997. Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol Cell. Biol. 17: 2521-2528.
48. Zhang, Y., X. Feng, R. Wu, and R. Derynck. 1996. Receptor-associated Mad homologs synergize as effectors of the TGF-β response. Nature 383: 168-172.
49. Zhang, Y., T. Musci, and R. Derynck. 1997. The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function. Curr. Biol. 7: 270-276.