메뉴 건너뛰기




Volumn 43, Issue , 2015, Pages 3-10

Oncogenes strike a balance between cellular growth and homeostasis

Author keywords

AMPK; Autophagy; Cancer metabolism; ER stress; Hypoxia inducible factors; Stress response

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; HIF1A PROTEIN, HUMAN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; MYC PROTEIN; MYC PROTEIN, HUMAN; PROTEIN P21; TARGET OF RAPAMYCIN KINASE;

EID: 84948085766     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2015.08.005     Document Type: Review
Times cited : (35)

References (82)
  • 2
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
    • Ward P.S., Thompson C.B. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012, 21:297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 3
    • 57749187631 scopus 로고    scopus 로고
    • Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency
    • Barna M., Pusic A., Zollo O., Costa M., Kondrashov N., Rego E., et al. Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature 2008, 456:971-975.
    • (2008) Nature , vol.456 , pp. 971-975
    • Barna, M.1    Pusic, A.2    Zollo, O.3    Costa, M.4    Kondrashov, N.5    Rego, E.6
  • 4
    • 84925491509 scopus 로고    scopus 로고
    • MTORC1-mediated translational elongation limits intestinal tumour initiation and growth
    • Faller W.J., Jackson T.J., Knight J.R., Ridgway R.A., Jamieson T., Karim S.A., et al. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature 2015, 517:497-500.
    • (2015) Nature , vol.517 , pp. 497-500
    • Faller, W.J.1    Jackson, T.J.2    Knight, J.R.3    Ridgway, R.A.4    Jamieson, T.5    Karim, S.A.6
  • 5
    • 84908213474 scopus 로고    scopus 로고
    • Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?
    • Sabharwal S.S., Schumacker P.T. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?. Nat. Rev. Cancer 2014, 14:709-721.
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 709-721
    • Sabharwal, S.S.1    Schumacker, P.T.2
  • 6
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante M., Sabatini D.M. mTOR signaling in growth control and disease. Cell 2012, 149:274-293.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 7
    • 84874995247 scopus 로고    scopus 로고
    • Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1
    • Ben-Sahra I., Howell J.J., Asara J.M., Manning B.D. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science 2013, 339:1323-1328.
    • (2013) Science , vol.339 , pp. 1323-1328
    • Ben-Sahra, I.1    Howell, J.J.2    Asara, J.M.3    Manning, B.D.4
  • 8
    • 84874961313 scopus 로고    scopus 로고
    • Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis
    • Robitaille A.M., Christen S., Shimobayashi M., Cornu M., Fava L.L., Moes S., et al. Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 2013, 339:1320-1323.
    • (2013) Science , vol.339 , pp. 1320-1323
    • Robitaille, A.M.1    Christen, S.2    Shimobayashi, M.3    Cornu, M.4    Fava, L.L.5    Moes, S.6
  • 9
    • 84925873653 scopus 로고    scopus 로고
    • Nutrient-sensing mechanisms across evolution
    • Chantranupong L., Wolfson R.L., Sabatini D.M. Nutrient-sensing mechanisms across evolution. Cell 2015, 161:67-83.
    • (2015) Cell , vol.161 , pp. 67-83
    • Chantranupong, L.1    Wolfson, R.L.2    Sabatini, D.M.3
  • 10
    • 0037108750 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    • Tee A.R., Fingar D.C., Manning B.D., Kwiatkowski D.J., Cantley L.C., Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:13571-13576.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 13571-13576
    • Tee, A.R.1    Fingar, D.C.2    Manning, B.D.3    Kwiatkowski, D.J.4    Cantley, L.C.5    Blenis, J.6
  • 12
    • 84920415711 scopus 로고    scopus 로고
    • The role for autophagy in cancer
    • White E. The role for autophagy in cancer. J. Clin. Investig. 2015, 125:42-46.
    • (2015) J. Clin. Investig. , vol.125 , pp. 42-46
    • White, E.1
  • 13
    • 84918827750 scopus 로고    scopus 로고
    • Cellular and metabolic functions for autophagy in cancer cells
    • Kenific C.M., Debnath J. Cellular and metabolic functions for autophagy in cancer cells. Trends Cell Biol. 2015, 25:37-45.
    • (2015) Trends Cell Biol. , vol.25 , pp. 37-45
    • Kenific, C.M.1    Debnath, J.2
  • 14
    • 40649104735 scopus 로고    scopus 로고
    • Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis
    • Ozcan U., Ozcan L., Yilmaz E., Duvel K., Sahin M., Manning B.D., et al. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol. Cell 2008, 29:541-551.
    • (2008) Mol. Cell , vol.29 , pp. 541-551
    • Ozcan, U.1    Ozcan, L.2    Yilmaz, E.3    Duvel, K.4    Sahin, M.5    Manning, B.D.6
  • 16
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: from stress pathway to homeostatic regulation
    • Walter P., Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 2011, 334:1081-1086.
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 17
    • 33744539521 scopus 로고    scopus 로고
    • Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
    • Obeng E.A., Carlson L.M., Gutman D.M., Harrington W.J., Lee K.P., Boise L.H. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 2006, 107:4907-4916.
    • (2006) Blood , vol.107 , pp. 4907-4916
    • Obeng, E.A.1    Carlson, L.M.2    Gutman, D.M.3    Harrington, W.J.4    Lee, K.P.5    Boise, L.H.6
  • 18
    • 45849137877 scopus 로고    scopus 로고
    • Regulation of hepatic lipogenesis by the transcription factor XBP1
    • Lee A.H., Scapa E.F., Cohen D.E., Glimcher L.H. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 2008, 320:1492-1496.
    • (2008) Science , vol.320 , pp. 1492-1496
    • Lee, A.H.1    Scapa, E.F.2    Cohen, D.E.3    Glimcher, L.H.4
  • 19
    • 79957605136 scopus 로고    scopus 로고
    • Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
    • Fu S., Yang L., Li P., Hofmann O., Dicker L., Hide W., et al. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 2011, 473:528-531.
    • (2011) Nature , vol.473 , pp. 528-531
    • Fu, S.1    Yang, L.2    Li, P.3    Hofmann, O.4    Dicker, L.5    Hide, W.6
  • 20
    • 77955483125 scopus 로고    scopus 로고
    • Activation of a metabolic gene regulatory network downstream of mTOR complex 1
    • Duvel K., Yecies J.L., Menon S., Raman P., Lipovsky A.I., Souza A.L., et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol. Cell 2010, 39:171-183.
    • (2010) Mol. Cell , vol.39 , pp. 171-183
    • Duvel, K.1    Yecies, J.L.2    Menon, S.3    Raman, P.4    Lipovsky, A.I.5    Souza, A.L.6
  • 21
    • 50049116472 scopus 로고    scopus 로고
    • SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
    • Porstmann T., Santos C.R., Griffiths B., Cully M., Wu M., Leevers S., et al. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab. 2008, 8:224-236.
    • (2008) Cell Metab. , vol.8 , pp. 224-236
    • Porstmann, T.1    Santos, C.R.2    Griffiths, B.3    Cully, M.4    Wu, M.5    Leevers, S.6
  • 23
    • 84877984661 scopus 로고    scopus 로고
    • Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
    • Young R.M., Ackerman D., Quinn Z.L., Mancuso A., Gruber M., Liu L., et al. Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes Dev. 2013, 27:1115-1131.
    • (2013) Genes Dev. , vol.27 , pp. 1115-1131
    • Young, R.M.1    Ackerman, D.2    Quinn, Z.L.3    Mancuso, A.4    Gruber, M.5    Liu, L.6
  • 24
    • 84877961669 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
    • Griffiths B., Lewis C.A., Bensaad K., Ros S., Zhang Q., Ferber E.C., et al. Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth. Cancer Metab. 2013, 1:3.
    • (2013) Cancer Metab. , vol.1 , pp. 3
    • Griffiths, B.1    Lewis, C.A.2    Bensaad, K.3    Ros, S.4    Zhang, Q.5    Ferber, E.C.6
  • 25
    • 84921824443 scopus 로고    scopus 로고
    • Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shift
    • Medvetz D., Priolo C., Henske E.P. Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shift. Mol. Cancer Res. 2015, 13:3-8.
    • (2015) Mol. Cancer Res. , vol.13 , pp. 3-8
    • Medvetz, D.1    Priolo, C.2    Henske, E.P.3
  • 26
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang C.V. MYC on the path to cancer. Cell 2012, 149:22-35.
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 27
    • 84870546460 scopus 로고    scopus 로고
    • ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth
    • Hart L.S., Cunningham J.T., Datta T., Dey S., Tameire F., Lehman S.L., et al. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J. Clin. Investig. 2012, 122:4621-4634.
    • (2012) J. Clin. Investig. , vol.122 , pp. 4621-4634
    • Hart, L.S.1    Cunningham, J.T.2    Datta, T.3    Dey, S.4    Tameire, F.5    Lehman, S.L.6
  • 28
    • 84887613799 scopus 로고    scopus 로고
    • SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease
    • Shin J., He M., Liu Y., Paredes S., Villanova L., Brown K., et al. SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep. 2013, 5:654-665.
    • (2013) Cell Rep. , vol.5 , pp. 654-665
    • Shin, J.1    He, M.2    Liu, Y.3    Paredes, S.4    Villanova, L.5    Brown, K.6
  • 29
    • 84922784813 scopus 로고    scopus 로고
    • Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis
    • Carroll P.A., Diolaiti D., McFerrin L., Gu H., Djukovic D., Du J., et al. Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis. Cancer Cell 2015, 27:271-285.
    • (2015) Cancer Cell , vol.27 , pp. 271-285
    • Carroll, P.A.1    Diolaiti, D.2    McFerrin, L.3    Gu, H.4    Djukovic, D.5    Du, J.6
  • 30
    • 64749116346 scopus 로고    scopus 로고
    • C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
    • Gao P., Tchernyshyov I., Chang T.C., Lee Y.S., Kita K., Ochi T., et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009, 458:762-765.
    • (2009) Nature , vol.458 , pp. 762-765
    • Gao, P.1    Tchernyshyov, I.2    Chang, T.C.3    Lee, Y.S.4    Kita, K.5    Ochi, T.6
  • 31
    • 70350728803 scopus 로고    scopus 로고
    • MYC-induced cancer cell energy metabolism and therapeutic opportunities
    • Dang C.V., Le A., Gao P. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin. Cancer Res. 2009, 15:6479-6483.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 6479-6483
    • Dang, C.V.1    Le, A.2    Gao, P.3
  • 32
    • 21744442902 scopus 로고    scopus 로고
    • Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis
    • Li F., Wang Y., Zeller K.I., Potter J.J., Wonsey D.R., O'Donnell K.A., et al. Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol. Cell. Biol. 2005, 25:6225-6234.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 6225-6234
    • Li, F.1    Wang, Y.2    Zeller, K.I.3    Potter, J.J.4    Wonsey, D.R.5    O'Donnell, K.A.6
  • 33
    • 1542373685 scopus 로고    scopus 로고
    • Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
    • Kelly D.P., Scarpulla R.C. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 2004, 18:357-368.
    • (2004) Genes Dev. , vol.18 , pp. 357-368
    • Kelly, D.P.1    Scarpulla, R.C.2
  • 34
    • 84859167179 scopus 로고    scopus 로고
    • Deregulated MYC expression induces dependence upon AMPK-related kinase 5
    • Liu L., Ulbrich J., Muller J., Wustefeld T., Aeberhard L., Kress T.R., et al. Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature 2012, 483:608-612.
    • (2012) Nature , vol.483 , pp. 608-612
    • Liu, L.1    Ulbrich, J.2    Muller, J.3    Wustefeld, T.4    Aeberhard, L.5    Kress, T.R.6
  • 37
    • 79960286223 scopus 로고    scopus 로고
    • Signal transduction by reactive oxygen species
    • Finkel T. Signal transduction by reactive oxygen species. J. Cell Biol. 2011, 194:7-15.
    • (2011) J. Cell Biol. , vol.194 , pp. 7-15
    • Finkel, T.1
  • 39
    • 84860321700 scopus 로고    scopus 로고
    • Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
    • Ying H., Kimmelman A.C., Lyssiotis C.A., Hua S., Chu G.C., Fletcher-Sananikone E., et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 2012, 149:656-670.
    • (2012) Cell , vol.149 , pp. 656-670
    • Ying, H.1    Kimmelman, A.C.2    Lyssiotis, C.A.3    Hua, S.4    Chu, G.C.5    Fletcher-Sananikone, E.6
  • 40
    • 84873678601 scopus 로고    scopus 로고
    • Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
    • Jiang P., Du W., Mancuso A., Wellen K.E., Yang X. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature 2013, 493:689-693.
    • (2013) Nature , vol.493 , pp. 689-693
    • Jiang, P.1    Du, W.2    Mancuso, A.3    Wellen, K.E.4    Yang, X.5
  • 41
    • 84879777723 scopus 로고    scopus 로고
    • Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
    • Guo J.Y., Karsli-Uzunbas G., Mathew R., Aisner S.C., Kamphorst J.J., Strohecker A.M., et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev. 2013, 27:1447-1461.
    • (2013) Genes Dev. , vol.27 , pp. 1447-1461
    • Guo, J.Y.1    Karsli-Uzunbas, G.2    Mathew, R.3    Aisner, S.C.4    Kamphorst, J.J.5    Strohecker, A.M.6
  • 42
  • 43
    • 79952228407 scopus 로고    scopus 로고
    • Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
    • Guo J.Y., Chen H.Y., Mathew R., Fan J., Strohecker A.M., Karsli-Uzunbas G., et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 2011, 25:460-470.
    • (2011) Genes Dev. , vol.25 , pp. 460-470
    • Guo, J.Y.1    Chen, H.Y.2    Mathew, R.3    Fan, J.4    Strohecker, A.M.5    Karsli-Uzunbas, G.6
  • 45
    • 84878464291 scopus 로고    scopus 로고
    • Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
    • Kamphorst J.J., Cross J.R., Fan J., de Stanchina E., Mathew R., White E.P., et al. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:8882-8887.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 8882-8887
    • Kamphorst, J.J.1    Cross, J.R.2    Fan, J.3    de Stanchina, E.4    Mathew, R.5    White, E.P.6
  • 46
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and the response to hypoxic stress
    • Majmundar A.J., Wong W.J., Simon M.C. Hypoxia-inducible factors and the response to hypoxic stress. Mol. Cell 2010, 40:294-309.
    • (2010) Mol. Cell , vol.40 , pp. 294-309
    • Majmundar, A.J.1    Wong, W.J.2    Simon, M.C.3
  • 47
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza G.L. Hypoxia-inducible factors in physiology and medicine. Cell 2012, 148:399-408.
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 48
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
    • Kaelin W.G., Ratcliffe P.J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 2008, 30:393-402.
    • (2008) Mol. Cell , vol.30 , pp. 393-402
    • Kaelin, W.G.1    Ratcliffe, P.J.2
  • 49
    • 84655161946 scopus 로고    scopus 로고
    • HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression
    • Keith B., Johnson R.S., Simon M.C. HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Nat. Rev. Cancer 2012, 12:9-22.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 50
    • 58049216350 scopus 로고    scopus 로고
    • Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2
    • Toschi A., Lee E., Gadir N., Ohh M., Foster D.A. Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. J. Biol. Chem. 2008, 283:34495-34499.
    • (2008) J. Biol. Chem. , vol.283 , pp. 34495-34499
    • Toschi, A.1    Lee, E.2    Gadir, N.3    Ohh, M.4    Foster, D.A.5
  • 51
    • 13444283313 scopus 로고    scopus 로고
    • Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death
    • Blum R., Jacob-Hirsch J., Amariglio N., Rechavi G., Kloog Y. Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. Cancer Res. 2005, 65:999-1006.
    • (2005) Cancer Res. , vol.65 , pp. 999-1006
    • Blum, R.1    Jacob-Hirsch, J.2    Amariglio, N.3    Rechavi, G.4    Kloog, Y.5
  • 52
    • 0035937715 scopus 로고    scopus 로고
    • Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
    • Chen C., Pore N., Behrooz A., Ismail-Beigi F., Maity A. Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J. Biol. Chem. 2001, 276:9519-9525.
    • (2001) J. Biol. Chem. , vol.276 , pp. 9519-9525
    • Chen, C.1    Pore, N.2    Behrooz, A.3    Ismail-Beigi, F.4    Maity, A.5
  • 53
    • 34548257176 scopus 로고    scopus 로고
    • HIF-dependent antitumorigenic effect of antioxidants in vivo
    • Gao P., Zhang H., Dinavahi R., Li F., Xiang Y., Raman V., et al. HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell 2007, 12:230-238.
    • (2007) Cancer Cell , vol.12 , pp. 230-238
    • Gao, P.1    Zhang, H.2    Dinavahi, R.3    Li, F.4    Xiang, Y.5    Raman, V.6
  • 55
    • 84893465244 scopus 로고    scopus 로고
    • Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth
    • Sun R.C., Denko N.C. Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth. Cell Metab. 2014, 19:285-292.
    • (2014) Cell Metab. , vol.19 , pp. 285-292
    • Sun, R.C.1    Denko, N.C.2
  • 56
    • 84856014884 scopus 로고    scopus 로고
    • Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
    • Metallo C.M., Gameiro P.A., Bell E.L., Mattaini K.R., Yang J., Hiller K., et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 2012, 481:380-384.
    • (2012) Nature , vol.481 , pp. 380-384
    • Metallo, C.M.1    Gameiro, P.A.2    Bell, E.L.3    Mattaini, K.R.4    Yang, J.5    Hiller, K.6
  • 57
    • 84875354450 scopus 로고    scopus 로고
    • In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation
    • Gameiro P.A., Yang J., Metelo A.M., Perez-Carro R., Baker R., Wang Z., et al. In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. Cell Metab. 2013, 17:372-385.
    • (2013) Cell Metab. , vol.17 , pp. 372-385
    • Gameiro, P.A.1    Yang, J.2    Metelo, A.M.3    Perez-Carro, R.4    Baker, R.5    Wang, Z.6
  • 60
    • 84980050613 scopus 로고    scopus 로고
    • HIF-2alpha dependent lipid storage promotes endoplasmic reticulum homeostasis in clear cell renal cell carcinoma
    • Qiu B., Ackerman D., Sanchez D.J., Li B., Ochocki J.D., Grazioli A., et al. HIF-2alpha dependent lipid storage promotes endoplasmic reticulum homeostasis in clear cell renal cell carcinoma. Cancer Discov. 2015, 5(6):652-667.
    • (2015) Cancer Discov. , vol.5 , Issue.6 , pp. 652-667
    • Qiu, B.1    Ackerman, D.2    Sanchez, D.J.3    Li, B.4    Ochocki, J.D.5    Grazioli, A.6
  • 61
    • 80054771537 scopus 로고    scopus 로고
    • Genetic and functional studies implicate HIF1alpha as a 14q kidney cancer suppressor gene
    • Shen C., Beroukhim R., Schumacher S.E., Zhou J., Chang M., Signoretti S., et al. Genetic and functional studies implicate HIF1alpha as a 14q kidney cancer suppressor gene. Cancer Discov. 2011, 1:222-235.
    • (2011) Cancer Discov. , vol.1 , pp. 222-235
    • Shen, C.1    Beroukhim, R.2    Schumacher, S.E.3    Zhou, J.4    Chang, M.5    Signoretti, S.6
  • 62
    • 20744445650 scopus 로고    scopus 로고
    • Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
    • Raval R.R., Lau K.W., Tran M.G., Sowter H.M., Mandriota S.J., Li J.L., et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol. Cell. Biol. 2005, 25:5675-5686.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 5675-5686
    • Raval, R.R.1    Lau, K.W.2    Tran, M.G.3    Sowter, H.M.4    Mandriota, S.J.5    Li, J.L.6
  • 63
    • 0036527785 scopus 로고    scopus 로고
    • The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma
    • Maranchie J.K., Vasselli J.R., Riss J., Bonifacino J.S., Linehan W.M., Klausner R.D. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 2002, 1:247-255.
    • (2002) Cancer Cell , vol.1 , pp. 247-255
    • Maranchie, J.K.1    Vasselli, J.R.2    Riss, J.3    Bonifacino, J.S.4    Linehan, W.M.5    Klausner, R.D.6
  • 64
    • 2342597973 scopus 로고    scopus 로고
    • Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth
    • Kondo K., Kim W.Y., Lechpammer M., Kaelin W.G. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol. 2003, 1:E83.
    • (2003) PLoS Biol. , vol.1 , pp. E83
    • Kondo, K.1    Kim, W.Y.2    Lechpammer, M.3    Kaelin, W.G.4
  • 65
    • 84862777063 scopus 로고    scopus 로고
    • Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
    • S1-2
    • Schodel J., Bardella C., Sciesielski L.K., Brown J.M., Pugh C.W., Buckle V., et al. Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression. Nat. Genet. 2012, 44:420-425. S1-2.
    • (2012) Nat. Genet. , vol.44 , pp. 420-425
    • Schodel, J.1    Bardella, C.2    Sciesielski, L.K.3    Brown, J.M.4    Pugh, C.W.5    Buckle, V.6
  • 67
    • 0242581718 scopus 로고    scopus 로고
    • Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells
    • Gunaratnam L., Morley M., Franovic A., de Paulsen N., Mekhail K., Parolin D.A., et al. Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells. J. Biol. Chem. 2003, 278:44966-44974.
    • (2003) J. Biol. Chem. , vol.278 , pp. 44966-44974
    • Gunaratnam, L.1    Morley, M.2    Franovic, A.3    de Paulsen, N.4    Mekhail, K.5    Parolin, D.A.6
  • 68
    • 84861913952 scopus 로고    scopus 로고
    • Lipid droplets and cellular lipid metabolism
    • Walther T.C., Farese R.V. Lipid droplets and cellular lipid metabolism. Annu. Rev. Biochem. 2012, 81:687-714.
    • (2012) Annu. Rev. Biochem. , vol.81 , pp. 687-714
    • Walther, T.C.1    Farese, R.V.2
  • 69
    • 84875326507 scopus 로고    scopus 로고
    • Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets
    • Wilfling F., Wang H., Haas J.T., Krahmer N., Gould T.J., Uchida A., et al. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev. Cell 2013, 24:384-399.
    • (2013) Dev. Cell , vol.24 , pp. 384-399
    • Wilfling, F.1    Wang, H.2    Haas, J.T.3    Krahmer, N.4    Gould, T.J.5    Uchida, A.6
  • 70
    • 84918821005 scopus 로고    scopus 로고
    • Validation of mammalian target of rapamycin biomarker panel in patients with clear cell renal cell carcinoma
    • Haddad A.Q., Kapur P., Singla N., Raman J.D., Then M.T., Nuhn P., et al. Validation of mammalian target of rapamycin biomarker panel in patients with clear cell renal cell carcinoma. Cancer 2014, 121(1):43-50.
    • (2014) Cancer , vol.121 , Issue.1 , pp. 43-50
    • Haddad, A.Q.1    Kapur, P.2    Singla, N.3    Raman, J.D.4    Then, M.T.5    Nuhn, P.6
  • 71
    • 84920112762 scopus 로고    scopus 로고
    • The AMP-activated protein kinase (AMPK) and cancer: many faces of a metabolic regulator
    • Faubert B., Vincent E.E., Poffenberger M.C., Jones R.G. The AMP-activated protein kinase (AMPK) and cancer: many faces of a metabolic regulator. Cancer Lett. 2015, 356:165-170.
    • (2015) Cancer Lett. , vol.356 , pp. 165-170
    • Faubert, B.1    Vincent, E.E.2    Poffenberger, M.C.3    Jones, R.G.4
  • 72
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: a nutrient and energy sensor that maintains energy homeostasis
    • Hardie D.G., Ross F.A., Hawley S.A. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 2012, 13:251-262.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 73
    • 84866425291 scopus 로고    scopus 로고
    • Translational control in cancer etiology
    • Ruggero D. Translational control in cancer etiology. Cold Spring Harb. Perspect. Biol. 2013, 5(2):5.
    • (2013) Cold Spring Harb. Perspect. Biol. , vol.5 , Issue.2 , pp. 5
    • Ruggero, D.1
  • 74
    • 1642328617 scopus 로고    scopus 로고
    • Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398
    • Browne G.J., Finn S.G., Proud C.G. Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. J. Biol. Chem. 2004, 279:12220-12231.
    • (2004) J. Biol. Chem. , vol.279 , pp. 12220-12231
    • Browne, G.J.1    Finn, S.G.2    Proud, C.G.3
  • 75
    • 0037143449 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis
    • Horman S., Browne G., Krause U., Patel J., Vertommen D., Bertrand L., et al. Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr. Biol. 2002, 12:1419-1423.
    • (2002) Curr. Biol. , vol.12 , pp. 1419-1423
    • Horman, S.1    Browne, G.2    Krause, U.3    Patel, J.4    Vertommen, D.5    Bertrand, L.6
  • 76
    • 84878271546 scopus 로고    scopus 로고
    • The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation
    • Leprivier G., Remke M., Rotblat B., Dubuc A., Mateo A.R., Kool M., et al. The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell 2013, 153:1064-1079.
    • (2013) Cell , vol.153 , pp. 1064-1079
    • Leprivier, G.1    Remke, M.2    Rotblat, B.3    Dubuc, A.4    Mateo, A.R.5    Kool, M.6
  • 77
    • 85027952132 scopus 로고    scopus 로고
    • Androgens regulate prostate cancer cell growth via an AMPK-PGC-1alpha-mediated metabolic switch
    • Tennakoon J.B., Shi Y., Han J.J., Tsouko E., White M.A., Burns A.R., et al. Androgens regulate prostate cancer cell growth via an AMPK-PGC-1alpha-mediated metabolic switch. Oncogene 2014, 33:5251-5261.
    • (2014) Oncogene , vol.33 , pp. 5251-5261
    • Tennakoon, J.B.1    Shi, Y.2    Han, J.J.3    Tsouko, E.4    White, M.A.5    Burns, A.R.6
  • 78
    • 84902201289 scopus 로고    scopus 로고
    • The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation
    • Yan M., Gingras M.C., Dunlop E.A., Nouet Y., Dupuy F., Jalali Z., et al. The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. J. Clin. Investig. 2014, 124:2640-2650.
    • (2014) J. Clin. Investig. , vol.124 , pp. 2640-2650
    • Yan, M.1    Gingras, M.C.2    Dunlop, E.A.3    Nouet, Y.4    Dupuy, F.5    Jalali, Z.6
  • 79
    • 84857789085 scopus 로고    scopus 로고
    • The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
    • Masson N., Singleton R.S., Sekirnik R., Trudgian D.C., Ambrose L.J., Miranda M.X., et al. The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity. EMBO Rep. 2012, 13:251-257.
    • (2012) EMBO Rep. , vol.13 , pp. 251-257
    • Masson, N.1    Singleton, R.S.2    Sekirnik, R.3    Trudgian, D.C.4    Ambrose, L.J.5    Miranda, M.X.6
  • 80
    • 84872159532 scopus 로고    scopus 로고
    • AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo
    • Faubert B., Boily G., Izreig S., Griss T., Samborska B., Dong Z., et al. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab. 2013, 17:113-124.
    • (2013) Cell Metab. , vol.17 , pp. 113-124
    • Faubert, B.1    Boily, G.2    Izreig, S.3    Griss, T.4    Samborska, B.5    Dong, Z.6
  • 81
    • 84875235453 scopus 로고    scopus 로고
    • Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity
    • Atkins C., Liu Q., Minthorn E., Zhang S.Y., Figueroa D.J., Moss K., et al. Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2013, 73:1993-2002.
    • (2013) Cancer Res. , vol.73 , pp. 1993-2002
    • Atkins, C.1    Liu, Q.2    Minthorn, E.3    Zhang, S.Y.4    Figueroa, D.J.5    Moss, K.6
  • 82
    • 84871878351 scopus 로고    scopus 로고
    • PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis
    • Gao Y., Sartori D.J., Li C., Yu Q.C., Kushner J.A., Simon M.C., et al. PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis. Mol. Cell. Biol. 2012, 32:5129-5139.
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 5129-5139
    • Gao, Y.1    Sartori, D.J.2    Li, C.3    Yu, Q.C.4    Kushner, J.A.5    Simon, M.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.