Coordinated regulation of protein synthesis and degradation by mTORC1

Nature

Volumn 513, Issue 7518, 2014, Pages 440-443

  Zhang, Yinan ^a   Nicholatos, Justin ^a   Dreier, John R ^b   Ricoult, Stéphane J H ^a   Widenmaier, Scott B ^a   Hotamisligil, Gökhan S ^a   Kwiatkowski, David J ^b   Manning, Brendan D ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 AMINO 1 ISOPROPYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 3 YL) 1H INDOL 5 OL; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEASOME; RAPAMYCIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2; TUBERIN; AMINO ACID; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NUCLEAR RESPIRATORY FACTOR 1; PROTEIN; TARGET OF RAPAMYCIN KINASE;

AMINO ACID; CATABOLISM; DEGRADATION; EUKARYOTE; GENE EXPRESSION; HOMEOSTASIS; PROTEIN; PROTEOMICS; QUALITY CONTROL; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; ANIMAL; C57BL MOUSE; CHEMISTRY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; SIGNAL TRANSDUCTION;

EUKARYOTA;

AMINO ACIDS; ANIMALS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; NUCLEAR RESPIRATORY FACTOR 1; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BIOSYNTHESIS; PROTEINS; PROTEOLYSIS; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TOR SERINE-THREONINE KINASES; TRANSCRIPTION, GENETIC;

EID: 84906898355     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13492     Document Type: Article

References (17)

1. Dibble, C. C. & Manning, B. D. Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nature Cell Biol. 15, 555-564 (2013).
2. Cornu, M., Albert, V. & Hall, M. N. mTOR in aging, metabolism, and cancer. Curr. Opin. Genet. Dev. 23, 53-62 (2013).
3. Suraweera, A., Munch, C., Hanssum, A. & Bertolotti, A. Failure of amino acid homeostasis causes cell death following proteasome inhibition. Mol. Cell 48, 242-253 (2012).
4. Fonseca, R., Vabulas, R. M., Hartl, F. U., Bonhoeffer, T. & Nagerl, U. V. A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP. Neuron 52, 239-245 (2006).
5. Singh, R. & Cuervo, A. M. Autophagy in the cellular energetic balance. Cell Metab. 13, 495-504 (2011).
6. Ebato, C. et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab. 8, 325-332 (2008).
7. Radhakrishnan, S. K. et al. Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. Mol. Cell 38, 17-28 (2010).
8. Steffen, J., Seeger, M., Koch, A. & Kruger, E. Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop. Mol. Cell 40, 147-158 (2010).
9. Düvel, K. et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol. Cell 39, 171-183 (2010).
10. Radhakrishnan, S. K., den Besten, W. & Deshaies, R. J. p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition. eLife 3, e01856 (2014).
11. Ozcan, U. et al. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol. Cell 29, 541-551 (2008).
12. Schröder, M. & Kaufman, R. J. The mammalian unfolded protein response. Annu. Rev. Biochem. 74, 739-789 (2005).
13. Rome, S. et al. Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle. Physiol. Genomics 34, 327-337 (2008).
14. Reed, B. D., Charos, A. E., Szekely, A. M., Weissman, S. M. & Snyder, M. Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes. PLoS Genet. 4, e1000133 (2008).
15. Yuan, E. et al. Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features. Hum. Mol. Genet. 21, 4286-4300 (2012).
16. Lee, C. S., Ho, D. V. & Chan, J. Y. Nuclear factor-erythroid2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice. FEBS J. 280, 3609-3620 (2013).
17. Yecies, J. L. et al. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab. 14, 21-32 (2011).