Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition

Cell

Volumn 158, Issue 5, 2014, Pages 1094-1109

  Shaul, Yoav D ^a,b   Freinkman, Elizaveta ^a   Comb, William C ^a   Cantor, Jason R ^a   Tam, Wai Leong ^a,f   Thiru, Prathapan ^a   Kim, Dohoon ^a   Kanarek, Naama ^a   Pacold, Michael E ^a,d   Chen, Walter W ^a   Bierie, Brian ^a   Possemato, Richard ^a   Reinhardt, Ferenc ^a   Weinberg, Robert A ^a,b   Yaffe, Michael B ^b,c   Sabatini, David M ^a,b,e  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f GENOME INSTITUTE OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; PYRIMIDINE; PYRIMIDINE DERIVATIVE; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GRADING; CARCINOGENESIS; CATALYSIS; CELL PROLIFERATION; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; METABOLISM; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; CARCINOMA; CYTOLOGY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENETICS; MESODERM; TUMOR CELL LINE;

ANIMALS; CARCINOMA; CELL LINE, TUMOR; DIHYDROURACIL DEHYDROGENASE (NADP); EPITHELIAL-MESENCHYMAL TRANSITION; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMANS; MESODERM; MICE; PYRIMIDINES; RNA, SMALL INTERFERING;

EID: 84907302546     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2014.07.032     Document Type: Article

References (56)

1. M. Al-Hajj, M.S. Wicha, A. Benito-Hernandez, S.J. Morrison, and M.F. Clarke Prospective identification of tumorigenic breast cancer cells Proc. Natl. Acad. Sci. USA 100 2003 3983 3988
2. U. Amstutz, T.K. Froehlich, and C.R. Largiadèr Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity Pharmacogenomics 12 2011 1321 1336
3. M.G.K. Benesch, X. Tang, T. Maeda, A. Ohhata, Y.Y. Zhao, B.P.C. Kok, J. Dewald, M. Hitt, J.M. Curtis, T.P.W. McMullen, and D.N. Brindley Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice FASEB J. 28 2014 2655 2666
4. T. Brabletz To differentiate or not - routes towards metastasis Nat. Rev. Cancer 12 2012 425 436
5. B. Büchel, P. Rhyn, S. Schürch, C. Bühr, U. Amstutz, and C.R. Largiadèr LC-MS/MS method for simultaneous analysis of uracil, 5,6-dihydrouracil, 5-fluorouracil and 5-fluoro-5,6-dihydrouracil in human plasma for therapeutic drug monitoring and toxicity prediction in cancer patients Biomed. Chromatogr. 27 2013 7 16
6. J.R. Cantor, and D.M. Sabatini Cancer cell metabolism: one hallmark, many faces Cancer Discov. 2 2012 881 898
7. L. Carey, E. Winer, G. Viale, D. Cameron, and L. Gianni Triple-negative breast cancer: disease entity or title of convenience? Nat. Rev. Clin. Oncol. 7 2010 683 692
8. C.L. Chaffer, N.D. Marjanovic, T. Lee, G. Bell, C.G. Kleer, F. Reinhardt, A.C. D'Alessio, R.A. Young, and R.A. Weinberg Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity Cell 154 2013 61 74
9. B. Chaneton, P. Hillmann, L. Zheng, A.C.L. Martin, O.D.K. Maddocks, A. Chokkathukalam, J.E. Coyle, A. Jankevics, F.P. Holding, and K.H. Vousden et al. Serine is a natural ligand and allosteric activator of pyruvate kinase M2 Nature 491 2012 458 462
10. L. Dang, D.W. White, S. Gross, B.D. Bennett, M.A. Bittinger, E.M. Driggers, V.R. Fantin, H.G. Jang, S. Jin, and M.C. Keenan et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature 462 2009 739 744
11. N.G. Dolinnaya, E.A. Kubareva, E.A. Romanova, R.M. Trikin, and T.S. Oretskaya Thymidine glycol: the effect on DNA molecular structure and enzymatic processing Biochimie 95 2013 134 147
12. S.C. Elbein, H. Zheng, Y. Jia, W. Chu, J.J. Cooper, T. Hale, and Z. Zhang Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy Mol. Genet. Metab. 82 2004 321 328
13. E. Gottlieb, and I.P.M. Tomlinson Mitochondrial tumour suppressors: a genetic and biochemical update Nat. Rev. Cancer 5 2005 857 866
14. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
15. W. He, F.J.P. Miao, D.C.H. Lin, R.T. Schwandner, Z. Wang, J. Gao, J.-L. Chen, H. Tian, and L. Ling Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors Nature 429 2004 188 193
16. P.P. Hsu, and D.M. Sabatini Cancer cell metabolism: Warburg and beyond Cell 134 2008 703 707
17. J. Hu, J.W. Locasale, J.H. Bielas, J. O'Sullivan, K. Sheahan, L.C. Cantley, M.G. Vander Heiden, and D. Vitkup Heterogeneity of tumor-induced gene expression changes in the human metabolic network Nat. Biotechnol. 31 2013 522 529
18. H. Ide, and S.S. Wallace Dihydrothymidine and thymidine glycol triphosphates as substrates for DNA polymerases: differential recognition of thymine C5-C6 bond saturation and sequence specificity of incorporation Nucleic Acids Res. 16 1988 11339 11354
19. H. Ide, R.J. Melamede, and S.S. Wallace Synthesis of dihydrothymidine and thymidine glycol 5′-triphosphates and their ability to serve as substrates for Escherichia coli DNA polymerase I Biochemistry 26 1987 964 969
20. A. Jaggupilli, and E. Elkord Significance of CD44 and CD24 as cancer stem cell markers: an enduring ambiguity Clin. Dev. Immunol. 2012 2012 708036
21. J. Kao, K. Salari, M. Bocanegra, Y.-L. Choi, L. Girard, J. Gandhi, K.A. Kwei, T. Hernandez-Boussard, P. Wang, and A.F. Gazdar et al. Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery PLoS ONE 4 2009 e6146
22. S. Li, C. Mo, Q. Peng, X. Kang, C. Sun, K. Jiang, L. Huang, Y. Lu, J. Sui, X. Qin, and Y. Liu Cell surface glycan alterations in epithelial mesenchymal transition process of Huh7 hepatocellular carcinoma cell PLoS ONE 8 2013 e71273
23. J.W. Locasale, A.R. Grassian, T. Melman, C.A. Lyssiotis, K.R. Mattaini, A.J. Bass, G. Heffron, C.M. Metallo, T. Muranen, and H. Sharfi et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis Nat. Genet. 43 2011 869 874
24. B. Lohkamp, N. Voevodskaya, Y. Lindqvist, and D. Dobritzsch Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination. Biochim. Biophys. Acta 1804 2010 2198 2206
25. Z. Ma, and K. Vosseller O-GlcNAc in cancer biology Amino Acids 45 2013 719 733
26. S.A. Mani, W. Guo, M.-J. Liao, E.N. Eaton, A. Ayyanan, A.Y. Zhou, M. Brooks, F. Reinhard, C.C. Zhang, and M. Shipitsin et al. The epithelial-mesenchymal transition generates cells with properties of stem cells Cell 133 2008 704 715
27. M.A. Nieto, and A. Cano The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity Semin. Cancer Biol. 22 2012 361 368
28. D.K. Nomura, J.Z. Long, S. Niessen, H.S. Hoover, S.-W. Ng, and B.F. Cravatt Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis Cell 140 2010 49 61
29. S.M. Offer, N.J. Wegner, C. Fossum, K. Wang, and R.B. Diasio Phenotypic profiling of DPYD variations relevant to 5-fluorouracil sensitivity using real-time cellular analysis and in vitro measurement of enzyme activity Cancer Res. 73 2013 1958 1968
30. P.U. Onganer, M.J. Seckl, and M.B.A. Djamgoz Neuronal characteristics of small-cell lung cancer Br. J. Cancer 93 2005 1197 1201
31. D.M. Parham Neuroectodermal and neuroendocrine tumors principally seen in children Am. J. Clin. Pathol. 115 Suppl 2001 S113 S128
32. J.G. Park, J.H. Lee, M.S. Kang, K.J. Park, Y.M. Jeon, H.J. Lee, H.S. Kwon, H.S. Park, K.S. Yeo, and K.U. Lee et al. Characterization of cell lines established from human hepatocellular carcinoma Int. J. Cancer 62 1995 276 282
33. S.Y. Park, H.S. Kim, N.H. Kim, S. Ji, S.Y. Cha, J.G. Kang, I. Ota, K. Shimada, N. Konishi, and H.W. Nam et al. Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition EMBO J. 29 2010 3787 3796
34. R. Possemato, K.M. Marks, Y.D. Shaul, M.E. Pacold, D. Kim, K. Birsoy, S. Sethumadhavan, H.-K. Woo, H.G. Jang, and A.K. Jha et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer Nature 476 2011 346 350
35. C. Scheel, and R.A. Weinberg Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int. J. Cancer 129 2011 2310 2314
36. A. Schulze, and A.L. Harris How cancer metabolism is tuned for proliferation and vulnerable to disruption Nature 491 2012 364 373
37. A. Singh, and J. Settleman EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer Oncogene 29 2010 4741 4751
38. J. Stagg, U. Divisekera, N. McLaughlin, J. Sharkey, S. Pommey, D. Denoyer, K.M. Dwyer, and M.J. Smyth Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis Proc. Natl. Acad. Sci. USA 107 2010 1547 1552
39. A. Subramanian, P. Tamayo, V.K. Mootha, S. Mukherjee, B.L. Ebert, M.A. Gillette, A. Paulovich, S.L. Pomeroy, T.R. Golub, and E.S. Lander et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles Proc. Natl. Acad. Sci. USA 102 2005 15545 15550
40. W.L. Tam, and R.A. Weinberg The epigenetics of epithelial-mesenchymal plasticity in cancer Nat. Med. 19 2013 1438 1449
41. W.L. Tam, H. Lu, J. Buikhuisen, B.S. Soh, E. Lim, F. Reinhardt, Z.J. Wu, J.A. Krall, B. Bierie, and W. Guo et al. Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells Cancer Cell 24 2013 347 364
42. J.H. Taube, J.I. Herschkowitz, K. Komurov, A.Y. Zhou, S. Gupta, J. Yang, K. Hartwell, T.T. Onder, P.B. Gupta, and K.W. Evans et al. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes Proc. Natl. Acad. Sci. USA 107 2010 15449 15454
43. D.A. Tennant, R.V. Durán, and E. Gottlieb Targeting metabolic transformation for cancer therapy Nat. Rev. Cancer 10 2010 267 277
44. J.H. Tsai, J.L. Donaher, D.A. Murphy, S. Chau, and J. Yang Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis Cancer Cell 22 2012 725 736
45. O.A. Ulanovskaya, A.M. Zuhl, and B.F. Cravatt NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink Nat. Chem. Biol. 9 2013 300 306
46. A.B.P. van Kuilenburg, R. Meinsma, E. Beke, B. Assmann, A. Ribes, I. Lorente, R. Busch, E. Mayatepek, N.G.G.M. Abeling, and A. van Cruchten et al. beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities Hum. Mol. Genet. 13 2004 2793 2801
47. A.B.P. van Kuilenburg, D. Dobritzsch, J. Meijer, R. Meinsma, J.-F. Benoist, B. Assmann, S. Schubert, G.F. Hoffmann, M. Duran, and M.C. de Vries et al. Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients Biochim. Biophys. Acta 1802 2010 639 648
48. R.G.W. Verhaak, K.A. Hoadley, E. Purdom, V. Wang, Y. Qi, M.D. Wilkerson, C.R. Miller, L. Ding, T. Golub, J.P. Mesirov Cancer Genome Atlas Research Network Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 Cancer Cell 17 2010 98 110
49. P.S. Ward, and C.B. Thompson Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate Cancer Cell 21 2012 297 308
50. H. Zhang, Y. Jia, J.J. Cooper, T. Hale, Z. Zhang, and S.C. Elbein Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels J. Clin. Endocrinol. Metab. 89 2004 748 755
51. W.C. Zhang, N. Shyh-Chang, H. Yang, A. Rai, S. Umashankar, S. Ma, B.S. Soh, L.L. Sun, B.C. Tai, and M.E. Nga et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis Cell 148 2012 259 272
52. J. Barretina, G. Caponigro, N. Stransky, K. Venkatesan, A.A. Margolin, S. Kim, C.J. Wilson, J. Lehár, G.V. Kryukov, and D. Sonkin et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity Nature 483 2012 603 607
53. T. Barrett, D.B. Troup, S.E. Wilhite, P. Ledoux, D. Rudnev, C. Evangelista, I.F. Kim, A. Soboleva, M. Tomashevsky, and R. Edgar NCBI GEO: mining tens of millions of expression profiles - database and tools update Nucleic Acids Res. 35 2007 D760 D765
54. M. Dai, P. Wang, A.D. Boyd, G. Kostov, B. Athey, E.G. Jones, W.E. Bunney, R.M. Myers, T.P. Speed, and H. Akil et al. Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data Nucleic Acids Res. 33 2005 e175
55. B. Elenbaas, L. Spirio, F. Koerner, M.D. Fleming, D.B. Zimonjic, J.L. Donaher, N.C. Popescu, W.C. Hahn, and R.A. Weinberg Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells Genes Dev. 15 2001 50 65
56. O.D.K. Maddocks, C.R. Berkers, S.M. Mason, L. Zheng, K. Blyth, E. Gottlieb, and K.H. Vousden Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells Nature 493 2012 542 546