Erratum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells (Nature (2015) 520 (192-197) DOI:10.1038/nature14362);Fatty acid carbon is essential for dNTP synthesis in endothelial cells

Nature

Volumn 520, Issue 7546, 2015, Pages 192-197

  Schoors, Sandra ^a,b   Bruning, Ulrike ^a,b   Missiaen, Rindert ^a,b   Queiroz, Karla C S ^a,b   Borgers, Gitte ^a,b   Elia, Ilaria ^a,b   Zecchin, Annalisa ^a,b   Cantelmo, Anna Rita ^a,b   Christen, Stefan ^a,b   Goveia, Jermaine ^a,b   Heggermont, Ward ^c,f   Goddé, Lucica ^a,b   Vinckier, Stefan ^a,b   Van Veldhoven, Paul P ^a   Eelen, Guy ^a,b   Schoonjans, Luc ^a,b   Gerhardt, Holger ^a,b,d   Dewerchin, Mieke ^a,b   Baes, Myriam ^a   De Bock, Katrien ^a,b   Ghesquière, Bart ^a,b   Lunt, Sophia Y ^e   Fendt, Sarah Maria ^a,b   Carmeliet, Peter ^a,b   more..

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^e Michigan State University   (United States)

^f UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ASPARTIC ACID; CARBON; CPT1A ENZYME; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; DEOXYRIBONUCLEOTIDE; DNA; FATTY ACID; MEMBRANE ENZYME; NUCLEOTIDE; PYRIMIDINE NUCLEOSIDE; UNCLASSIFIED DRUG; URIDINE PHOSPHATE; ACETIC ACID; ADENOSINE TRIPHOSPHATE; CARNITINE PALMITOYLTRANSFERASE; GLUCOSE;

ACETATE; CARBON; CELL ORGANELLE; ENZYME ACTIVITY; FATTY ACID; HOMEOSTASIS; INHIBITION; REDOX POTENTIAL; RODENT;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL MIGRATION; CITRIC ACID CYCLE; CONTROLLED STUDY; DNA REPLICATION; ENDOTHELIUM CELL; ENERGY; FATTY ACID OXIDATION; GENE SILENCING; HOMEOSTASIS; HUMAN; HUMAN CELL; ISOTOPE LABELING; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; OXIDATION REDUCTION REACTION; PHENOTYPE; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BLOOD VESSEL; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; NEOVASCULARIZATION, PATHOLOGIC; PATHOLOGY; RETINOPATHY OF PREMATURITY; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL;

MURINAE; MUS;

ACETIC ACID; ADENOSINE TRIPHOSPHATE; ANIMALS; BLOOD VESSELS; CARBON; CARNITINE O-PALMITOYLTRANSFERASE; CELL LINE, TUMOR; CELL PROLIFERATION; CITRIC ACID CYCLE; DISEASE MODELS, ANIMAL; DNA; ENDOTHELIAL CELLS; FATTY ACIDS; GENE SILENCING; GLUCOSE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; NEOVASCULARIZATION, PATHOLOGIC; NUCLEOTIDES; OXIDATION-REDUCTION; RETINOPATHY OF PREMATURITY;

EID: 84927563455     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14624     Document Type: Erratum

References (35)

1. Potente, M., Gerhardt, H. & Carmeliet, P. Basic and therapeutic aspects of angiogenesis. Cell 146, 873-887 (2011).
2. Ausprunk, D. H. & Folkman, J. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc. Res. 14, 53-65 (1977).
3. Welti, J., Loges, S., Dimmeler, S. & Carmeliet, P. Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer. J. Clin. Invest. 123, 3190-3200 (2013).
4. De Bock, K. et al. Role of PFKFB3-driven glycolysis in vessel sprouting. Cell 154, 651-663 (2013).
5. De Bock, K., Georgiadou, M. & Carmeliet, P. Role of endothelial cell metabolism in vessel sprouting. Cell Metab. 18, 634-647 (2013).
6. Colavitti, R. et al. Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR. J. Biol. Chem. 277, 3101-3108 (2002).
7. Fendt, S. M. et al. Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells. Nat. Commun. 4, 2236 (2013).
8. Vander Heiden, M. G. Exploiting tumor metabolism: challenges for clinical translation. J. Clin. Invest. 123, 3648-3651 (2013).
9. Thompson, C. B. Wnt meets Warburg: another piece in the puzzle? EMBO J. 33, 1420-1422 (2014).
10. Carracedo, A., Cantley, L. C. & Pandolfi, P. P. Cancer metabolism: fatty acid oxidation in the limelight. Nature Rev. Cancer 13, 227-232 (2013).
11. Henry, T. D., Satran, D. & Jolicoeur, E. M. Treatment of refractory angina in patients not suitable for revascularization. Nature Rev. Cardiol. 11, 78-95 (2014).
12. Morris, G. W., Iams, T. A., Slepchenko, K. G. & McKee, E. E. Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3′-azido-3′-deoxythymidine-dependent cardiotoxicity. Biochem. J. 422, 513-520 (2009).
13. Fairbanks, L. D., Bofill, M., Ruckemann, K. & Simmonds, H. A. Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors. J. Biol. Chem. 270, 29682-29689 (1995).
14. Lunt, S. Y. et al. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Mol. Cell 57, 95-107 (2015).
15. Cheung, E. C. et al. TIGAR is required for efficient intestinal regeneration and tumorigenesis. Dev. Cell 25, 463-477 (2013).
16. Jaffe, E. A., Nachman, R. L., Becker, C. G. & Minick, C. R. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 52, 2745-2756 (1973).
17. Michieli, P. et al. Targeting the tumor and its microenvironment by a dual-function decoy Met receptor. Cancer Cell 6, 61-73 (2004).
18. Carlotti, F. et al. Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes. Mol. Ther. 9, 209-217 (2004).
19. Geudens, I. et al. Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arterioscler. Thromb. Vasc. Biol. 30, 1695-1702 (2010).
20. Korff, T., Krauss, T. & Augustin, H. G. Three-dimensional spheroidal culture of cytotrophoblast cells mimics the phenotype and differentiation of cytotrophoblasts from normal and preeclamptic pregnancies. Exp. Cell Res. 297, 415-423 (2004).
21. Schoors, S. et al. Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 19, 37-48 (2014).
22. Carmeliet, P. et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nature Med. 7, 575-583 (2001).
23. Dagher, Z., Ruderman, N., Tornheim, K. & Ido, Y. Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. Circ. Res. 88, 1276-1282 (2001).
24. Wang, R. et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871-882 (2011).
25. Aragonës, J. et al. Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nature Genet. 40, 170-180 (2008).
26. Fendt, S. M. et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Res. 73, 4429-4438 (2013).
27. Antoniewicz, M. R., Kelleher, J. K. & Stephanopoulos, G. Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions. Metab. Eng. 9, 68-86 (2007).
28. C mass isotopomer distributions for natural stable isotope abundance. J. Mass Spectrom. 31, 255-262 (1996).
29. 13C-experiments and gas chromatography-mass spectrometry data: protocol and principles. Methods Mol. Biol. 358, 177-197 (2007).
30. Wilson, P. M. et al. A novel fluorescence-based assay for the rapid detection and quantification of cellular deoxyribonucleoside triphosphates. Nucleic Acids Res. 39, e112 (2011).
31. Sakaue-Sawano, A. et al. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 132, 487-498 (2008).
32. Millard, P., Letisse, F., Sokol, S. & Portais, J. C. IsoCor: correcting MS data in isotope labeling experiments. Bioinformatics 28, 1294-1296 (2012).
33. Büscher, J. M., Czernik, D., Ewald, J. C., Sauer, U. & Zamboni, N. Cross-platform comparison of methods for quantitative metabolomics of primary metabolism. Anal. Chem. 81, 2135-2143 (2009).
34. Benedito, R. et al. The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell 137, 1124-1135 (2009).
35. Scott, A. & Fruttiger, M. Oxygen-induced retinopathy: a model for vascular pathology in the retina. Eye 24, 416-421 (2010).