Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling

Molecular Cell

Volumn 59, Issue 3, 2015, Pages 345-358

  Kang, Hee Bum ^a   Fan, Jun ^a   Lin, Ruiting ^a   Elf, Shannon ^a   Ji, Quanjiang ^b   Zhao, Liang ^a   Jin, Lingtao ^a   Seo, Jae Ho ^a   Shan, Changliang ^a   Arbiser, Jack L ^a,c   Cohen, Cynthia ^a   Brat, Daniel ^a   Miziorko, Henry M ^d   Kim, Eunhee ^e   Abdel Wahab, Omar ^e   Merghoub, Taha ^e   Fröhling, Stefan ^f   Scholl, Claudia ^g   Tamayo, Pablo ^h   Barbie, David A ^h   Zhou, Lu ⁱ   Pollack, Brian P ^a,c   Fisher, Kevin ^a   Kudchadkar, Ragini R ^a   Lawson, David H ^a   Sica, Gabriel ^a   Rossi, Michael ^a   Lonial, Sagar ^a   Khoury, Hanna J ^a   Khuri, Fadlo R ^a   Lee, Benjamin H ^j   Boggon, Titus J ^k   He, Chuan ^b   Kang, Sumin ^a   Chen, Jing ^a   more..

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c ATLANTA VA MEDICAL CENTER   (United States)

^d UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^f UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^g GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^h BROAD INSTITUTE OF MIT AND HARVARD   (United States)

ⁱ FUDAN UNIVERSITY   (China)

^j NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^k YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACETOACETIC ACID; B RAF KINASE; HYDROXYMETHYLGLUTARYL COENZYME A LYASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; OCTAMER TRANSCRIPTION FACTOR 1; SHORT HAIRPIN RNA; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A LYASE; ACETOACETIC ACID DERIVATIVE; BRAF PROTEIN, HUMAN; LYASE; MAP2K1 PROTEIN, HUMAN; POU2F1 PROTEIN, HUMAN;

A375 CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HAIRY CELL LEUKEMIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KETOGENESIS; LEUKEMIA CELL; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR XENOGRAFT; UPREGULATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; TUMOR CELL LINE;

ACETOACETATES; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKEMIA, HAIRY CELL; MAP KINASE KINASE 1; MELANOMA; MUTATION; OCTAMER TRANSCRIPTION FACTOR-1; OXO-ACID-LYASES; PROTO-ONCOGENE PROTEINS B-RAF; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84938588282     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.05.037     Document Type: Article

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