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Volumn 41, Issue 12, 2002, Pages 913-958

Clinical significance of the cytochrome P450 2C19 genetic polymorphism

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIINFECTIVE AGENT; ARTEMISIN; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CARISOPRODOL; CIMETIDINE; CITALOPRAM; CYANOCOBALAMIN; CYCLOGUANIL; CYTOCHROME P450 2C19; DIAZEPAM; FELBAMATE; FLUNITRAZEPAM; HEXOBARBITAL; LANSOPRAZOLE; MEPHENYTOIN; METHYLPHENOBARBITAL; NELFINAVIR; OMEPRAZOLE; PANTOPRAZOLE; PHENOBARBITAL; PHENYTOIN; PROGUANIL; PROPRANOLOL DERIVATIVE; PROTON PUMP INHIBITOR; RIFAMPICIN; TOLBUTAMIDE; UNINDEXED DRUG;

EID: 0036394942     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-200241120-00002     Document Type: Review
Times cited : (803)

References (356)
  • 1
    • 0010934844 scopus 로고
    • Family study of a genetically determined deficiency of mephenytoin hydroxylation in man
    • Kupfer A, Desmond PV, Schenker S, et al. Family study of a genetically determined deficiency of mephenytoin hydroxylation in man [letter]. Pharmacologist 1979; 21: 173
    • (1979) Pharmacologist , vol.21 , pp. 173
    • Kupfer, A.1    Desmond, P.V.2    Schenker, S.3
  • 2
    • 0028260641 scopus 로고
    • The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
    • de Morais SM, Wilkinson GR, Blaisdell J, et al. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem 1994; 269: 15419-22
    • (1994) J Biol Chem , vol.269 , pp. 15419-15422
    • De Morais, S.M.1    Wilkinson, G.R.2    Blaisdell, J.3
  • 3
    • 0028590127 scopus 로고
    • Biochemistry and molecular biology of the human CYP2C subfamily
    • Goldstein JA, de Morais SM. Biochemistry and molecular biology of the human CYP2C subfamily. Pharmacogenetics 1994; 4: 285-99
    • (1994) Pharmacogenetics , vol.4 , pp. 285-299
    • Goldstein, J.A.1    De Morais, S.M.2
  • 4
    • 0027445449 scopus 로고
    • Isolation and characterization of human liver cytochrome P450 2C19: Correlation between 2C19 and S-mephenytoin 4′-hydroxylation
    • Wrighton SA, Stevens JC, Becker GW, et al. Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4′-hydroxylation. Arch Biochem Biophys 1993; 306: 240-5
    • (1993) Arch Biochem Biophys , vol.306 , pp. 240-245
    • Wrighton, S.A.1    Stevens, J.C.2    Becker, G.W.3
  • 5
    • 0028279041 scopus 로고
    • Evidence that CYP2C19 is the major (S)-mephenytoin 4-hydroxylase in humans
    • Goldstein JA, Faletto MB, Romkes-Sparks M, et al. Evidence that CYP2C19 is the major (S)-mephenytoin 4-hydroxylase in humans. Biochemistry 1994; 33: 1743-52
    • (1994) Biochemistry , vol.33 , pp. 1743-1752
    • Goldstein, J.A.1    Faletto, M.B.2    Romkes-Sparks, M.3
  • 6
    • 0018407241 scopus 로고
    • Stereoselectivity of differential routes of drug metabolism: The fate of the enantiomers of [14C]-mephenytoin in the dog
    • Kupfer A, Bircher J. Stereoselectivity of differential routes of drug metabolism: the fate of the enantiomers of [14C]-mephenytoin in the dog. J Pharmacol Exp Ther 1979; 209: 190-5
    • (1979) J Pharmacol Exp Ther , vol.209 , pp. 190-195
    • Kupfer, A.1    Bircher, J.2
  • 7
  • 8
    • 0021326423 scopus 로고
    • Mephenytoin hydroxylation deficiency: Kinetics after repeated doses
    • Kupfer A, Desmond PV, Patwardhan R, et al. Mephenytoin hydroxylation deficiency: kinetics after repeated doses. Clin Pharmacol Ther 1984; 35: 33-9
    • (1984) Clin Pharmacol Ther , vol.35 , pp. 33-39
    • Kupfer, A.1    Desmond, P.V.2    Patwardhan, R.3
  • 9
    • 0021237993 scopus 로고
    • Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man
    • Kupfer A, Preisig R. Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man. Eur J Clin Pharmacol 1984; 26: 753-9
    • (1984) Eur J Clin Pharmacol , vol.26 , pp. 753-759
    • Kupfer, A.1    Preisig, R.2
  • 10
    • 0019954836 scopus 로고
    • Stereoselective metabolism and disposition of the enantiomers of mephenytoin during chronic oral administration of the racemic drug in man
    • Kupfer A, Desmond PV, Schenker S, et al. Stereoselective metabolism and disposition of the enantiomers of mephenytoin during chronic oral administration of the racemic drug in man. J Pharmacol Exp Ther 1982; 221: 590-7
    • (1982) J Pharmacol Exp Ther , vol.221 , pp. 590-597
    • Kupfer, A.1    Desmond, P.V.2    Schenker, S.3
  • 11
    • 0022503196 scopus 로고
    • Family studies of mephenytoin hydroxylation deficiency
    • Inaba T, Jurima M, Kalow W. Family studies of mephenytoin hydroxylation deficiency. Am J Hum Genet 1986; 38: 768-72
    • (1986) Am J Hum Genet , vol.38 , pp. 768-772
    • Inaba, T.1    Jurima, M.2    Kalow, W.3
  • 13
    • 0029783939 scopus 로고    scopus 로고
    • Genetic polymorphism of S-mephenytoin 4′-hydroxylation
    • Daniel HI, Edeki TI. Genetic polymorphism of S-mephenytoin 4′-hydroxylation. Psychopharmacol Bull 1996; 32: 219-30
    • (1996) Psychopharmacol Bull , vol.32 , pp. 219-230
    • Daniel, H.I.1    Edeki, T.I.2
  • 14
    • 0032821754 scopus 로고    scopus 로고
    • Genetic polymorphism of (S)-mephenytoin 4′-hydroxylation in populations of African descent
    • Xie HG, Kim RB, Stein CM, et al. Genetic polymorphism of (S)-mephenytoin 4′-hydroxylation in populations of African descent. Br J Clin Pharmacol 1999; 48: 402-8
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 402-408
    • Xie, H.G.1    Kim, R.B.2    Stein, C.M.3
  • 15
    • 0032716358 scopus 로고    scopus 로고
    • Allelic, genotypic and phenotypic distributions of S-mephenytoin 4′-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world
    • Xie HG, Stein CM, Kim RB, et al. Allelic, genotypic and phenotypic distributions of S-mephenytoin 4′-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world. Pharmacogenetics 1999; 9: 539-49
    • (1999) Pharmacogenetics , vol.9 , pp. 539-549
    • Xie, H.G.1    Stein, C.M.2    Kim, R.B.3
  • 16
    • 0022454027 scopus 로고
    • The genetic defect of mephenytoin hydroxylation
    • Kalow W. The genetic defect of mephenytoin hydroxylation. Xenobiotica 1986; 16: 379-89
    • (1986) Xenobiotica , vol.16 , pp. 379-389
    • Kalow, W.1
  • 17
    • 0029028932 scopus 로고
    • Geographical/interracial differences in polymorphic drug oxidation
    • Bertilsson L. Geographical/interracial differences in polymorphic drug oxidation. Clin Pharmacokinet 1995; 29: 192-209
    • (1995) Clin Pharmacokinet , vol.29 , pp. 192-209
    • Bertilsson, L.1
  • 18
    • 0030995879 scopus 로고    scopus 로고
    • Molecular mechanisms of genetic polymorphisms of drug metabolism
    • Meyer UA, Zanger UM. Molecular mechanisms of genetic polymorphisms of drug metabolism. Annu Rev Pharmacol Toxicol 1997; 37: 269-96
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 269-296
    • Meyer, U.A.1    Zanger, U.M.2
  • 19
    • 0033828454 scopus 로고    scopus 로고
    • The CYP2C19 enzyme polymorphism
    • Wedlund PJ. The CYP2C19 enzyme polymorphism. Pharmacology 2000; 61: 174-83
    • (2000) Pharmacology , vol.61 , pp. 174-183
    • Wedlund, P.J.1
  • 20
    • 0025763625 scopus 로고
    • Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily
    • Romkes M, Faletto MB, Blaisdell J, et al. Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. Biochemistry 1991; 30: 3247-55
    • (1991) Biochemistry , vol.30 , pp. 3247-3255
    • Romkes, M.1    Faletto, M.B.2    Blaisdell, J.3
  • 21
    • 0033168090 scopus 로고    scopus 로고
    • RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver
    • Zaphiropoulos PG. RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver. Nucleic Acids Res 1999; 27: 2585-90
    • (1999) Nucleic Acids Res , vol.27 , pp. 2585-2590
    • Zaphiropoulos, P.G.1
  • 22
    • 0035118551 scopus 로고    scopus 로고
    • Metabolic characterization of the major human small intestinal cytochrome p450s
    • Obach RS, Zhang QY, Dunbar D, et al. Metabolic characterization of the major human small intestinal cytochrome p450s. Drug Metab Dispos 2001; 29: 347-52
    • (2001) Drug Metab Dispos , vol.29 , pp. 347-352
    • Obach, R.S.1    Zhang, Q.Y.2    Dunbar, D.3
  • 23
    • 0028044085 scopus 로고
    • Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese
    • de Morais SM, Wilkinson GR, Blaisdell J, et al. Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol 1994; 46: 594-8
    • (1994) Mol Pharmacol , vol.46 , pp. 594-598
    • De Morais, S.M.1    Wilkinson, G.R.2    Blaisdell, J.3
  • 24
    • 0035028479 scopus 로고    scopus 로고
    • Molecular basis of ethnic differences in drug disposition and response
    • Xie HG, Kim RB, Wood AJ, et al. Molecular basis of ethnic differences in drug disposition and response. Annu Rev Pharmacol Toxicol 2001; 41: 815-50
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 815-850
    • Xie, H.G.1    Kim, R.B.2    Wood, A.J.3
  • 25
    • 0030904031 scopus 로고    scopus 로고
    • Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor olizer phenotype in various Oriental, Caucasian, Saudi Arabian and American Black populations
    • Goldstein JA, Ishizaki T, Chiba K, et al. Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor olizer phenotype in various Oriental, Caucasian, Saudi Arabian and American Black populations. Pharmacogenetics 1997; 7: 59-64
    • (1997) Pharmacogenetics , vol.7 , pp. 59-64
    • Goldstein, J.A.1    Ishizaki, T.2    Chiba, K.3
  • 26
    • 0028846823 scopus 로고
    • A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli
    • Richardson TH, Jung F, Griffin KJ, et al. A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli. Arch Biochem Biophys 1995; 323: 87-96
    • (1995) Arch Biochem Biophys , vol.323 , pp. 87-96
    • Richardson, T.H.1    Jung, F.2    Griffin, K.J.3
  • 27
    • 0032159423 scopus 로고    scopus 로고
    • Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin
    • Ibeanu GC, Goldstein JA, Meyer UA, et al. Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin. J Pharmacol Exp Ther 1998; 286: 1490-5
    • (1998) J Pharmacol Exp Ther , vol.286 , pp. 1490-1495
    • Ibeanu, G.C.1    Goldstein, J.A.2    Meyer, U.A.3
  • 28
    • 0028860954 scopus 로고
    • Genetic analysis of the S-mephenytoin polymorphism in a Chinese population
    • de Morais SMF, Goldstein JA, Xie HG, et al. Genetic analysis of the S-mephenytoin polymorphism in a Chinese population. Clin Pharmacol Ther 1995; 58: 404-12
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 404-412
    • De Morais, S.M.F.1    Goldstein, J.A.2    Xie, H.G.3
  • 29
    • 15444340367 scopus 로고    scopus 로고
    • A new genetic defect in human CYP2C19: Mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin
    • Ferguson RJ, de Morais SM, Benhamou S, et al. A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin. J Pharmacol Exp Ther 1998; 284: 356-61
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 356-361
    • Ferguson, R.J.1    De Morais, S.M.2    Benhamou, S.3
  • 30
    • 15644372745 scopus 로고    scopus 로고
    • An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians
    • Ibeanu GC, Blaisdell J, Ghanayem BI, et al. An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians. Pharmacogenetics 1998; 8: 129-35
    • (1998) Pharmacogenetics , vol.8 , pp. 129-135
    • Ibeanu, G.C.1    Blaisdell, J.2    Ghanayem, B.I.3
  • 31
    • 8244249473 scopus 로고    scopus 로고
    • Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele
    • Xiao ZS, Goldstein JA, Xie HG, et al. Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele. J Pharmacol Exp Ther 1997; 281: 604-9
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 604-609
    • Xiao, Z.S.1    Goldstein, J.A.2    Xie, H.G.3
  • 32
    • 0032797302 scopus 로고    scopus 로고
    • A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin
    • Ibeanu GC, Blaisdell J, Ferguson RJ, et al. A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. J Pharmacol Exp Ther 1999; 290: 635-40
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 635-640
    • Ibeanu, G.C.1    Blaisdell, J.2    Ferguson, R.J.3
  • 33
    • 0030432585 scopus 로고    scopus 로고
    • Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
    • Aklillu E, Persson I, Bertilsson L, et al. Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther 1996; 278: 441-6
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 441-446
    • Aklillu, E.1    Persson, I.2    Bertilsson, L.3
  • 34
    • 0029018767 scopus 로고
    • The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: A population study
    • Balian JD, Sukhova N, Harris JW, et al. The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study. Clin Pharmacol Ther 1995; 57: 662-9
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 662-669
    • Balian, J.D.1    Sukhova, N.2    Harris, J.W.3
  • 35
    • 0022178173 scopus 로고
    • Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations
    • Nakamura K, Goto F, Ray WA, et al. Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations. Clin Pharmacol Ther 1985; 38: 402-8
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 402-408
    • Nakamura, K.1    Goto, F.2    Ray, W.A.3
  • 36
    • 0022220338 scopus 로고
    • Genetic polymorphism of mephenytoin p(4′)-hydroxylation: Difference between Orientals and Caucasians
    • Jurima M, Inaba T, Kadar D, et al. Genetic polymorphism of mephenytoin p(4′)-hydroxylation: difference between Orientals and Caucasians. Br J Clin Pharmacol 1985; 19: 483-7
    • (1985) Br J Clin Pharmacol , vol.19 , pp. 483-487
    • Jurima, M.1    Inaba, T.2    Kadar, D.3
  • 37
    • 0026506140 scopus 로고
    • Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin
    • Bertilsson L, Lou YQ, Du YL, et al. Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin. Clin Pharmacol Ther 1992; 51: 388-97
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 388-397
    • Bertilsson, L.1    Lou, Y.Q.2    Du, Y.L.3
  • 38
    • 0026705708 scopus 로고
    • Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics
    • Sohn DR, Kusaka M, Ishizaki T, et al. Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics. Clin Pharmacol Ther 1992; 52: 160-9
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 160-169
    • Sohn, D.R.1    Kusaka, M.2    Ishizaki, T.3
  • 39
    • 0029775045 scopus 로고    scopus 로고
    • Genetic polymorphism of S-mephenytoin 4′-hydroxylation in African-Americans
    • Edeki TI, Goldstein JA, de Morais SM, et al. Genetic polymorphism of S-mephenytoin 4′-hydroxylation in African-Americans. Pharmacogenetics 1996; 6: 357-60
    • (1996) Pharmacogenetics , vol.6 , pp. 357-360
    • Edeki, T.I.1    Goldstein, J.A.2    De Morais, S.M.3
  • 40
    • 0023919439 scopus 로고
    • Mephenytoin hydroxylation in the Cuna Amerindians of Panama
    • Inaba T, Jorge LF, Arias TD. Mephenytoin hydroxylation in the Cuna Amerindians of Panama. Br J Clin Pharmacol 1988; 25: 75-9
    • (1988) Br J Clin Pharmacol , vol.25 , pp. 75-79
    • Inaba, T.1    Jorge, L.F.2    Arias, T.D.3
  • 41
    • 0030975288 scopus 로고    scopus 로고
    • High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu
    • Kaneko A, Laneko O, Taleo G, et al. High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu. Lancet 1997; 349: 921-2
    • (1997) Lancet , vol.349 , pp. 921-922
    • Kaneko, A.1    Laneko, O.2    Taleo, G.3
  • 42
    • 0030444707 scopus 로고    scopus 로고
    • Genotyping of S-mephenytoin 4′-hydroxylation in an extended Japanese population
    • Kubota T, Chiba K, Ishizaki T. Genotyping of S-mephenytoin 4′-hydroxylation in an extended Japanese population. Clin Pharmacol Ther 1996; 60: 661-6
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 661-666
    • Kubota, T.1    Chiba, K.2    Ishizaki, T.3
  • 43
    • 0024442372 scopus 로고
    • Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus Mainland Chinese
    • Horai Y, Nakano M, Ishizaki T, et al. Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus Mainland Chinese. Clin Pharmacol Ther 1989; 46: 198-207
    • (1989) Clin Pharmacol Ther , vol.46 , pp. 198-207
    • Horai, Y.1    Nakano, M.2    Ishizaki, T.3
  • 44
    • 0024818411 scopus 로고
    • Polymorphic drug metabolism
    • Relling MV. Polymorphic drug metabolism. Clin Pharm 1989; 8: 852-63
    • (1989) Clin Pharm , vol.8 , pp. 852-863
    • Relling, M.V.1
  • 45
    • 0030473384 scopus 로고    scopus 로고
    • Cyp2c19 genotype and phenotype determined by omeprazole in a Korean population
    • Roh HK, Dahl ML, Tybring G, et al. Cyp2c19 genotype and phenotype determined by omeprazole in a Korean population. Pharmacogenetics 1996; 6: 547-51
    • (1996) Pharmacogenetics , vol.6 , pp. 547-551
    • Roh, H.K.1    Dahl, M.L.2    Tybring, G.3
  • 46
    • 0028028050 scopus 로고
    • Debrisoquine and mephenytoin oxidation in Sinhalese: A population study
    • Weerasuriya K, Jayakody RL, Smith CA, et al. Debrisoquine and mephenytoin oxidation in Sinhalese: a population study. Br J Clin Pharmacol 1994; 34: 466-70
    • (1994) Br J Clin Pharmacol , vol.34 , pp. 466-470
    • Weerasuriya, K.1    Jayakody, R.L.2    Smith, C.A.3
  • 47
    • 0031949327 scopus 로고    scopus 로고
    • Genetic polymorphism of the hepatic cytochrome P4502C19 in North Indian subjects
    • Lamba JK, Dhiman RK, Kohli KK. Genetic polymorphism of the hepatic cytochrome P4502C19 in north Indian subjects. Clin Pharmacol Ther 1998; 63: 422-7
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 422-427
    • Lamba, J.K.1    Dhiman, R.K.2    Kohli, K.K.3
  • 48
    • 0025086218 scopus 로고
    • Frequency of impaired mephenytoin 4′-hydroxylation in an Indian population
    • Doshi BS, Kulkarni RD, Chauhan BL, et al. Frequency of impaired mephenytoin 4′-hydroxylation in an Indian population [letter]. Br J Clin Pharmacol 1990; 30: 779-80
    • (1990) Br J Clin Pharmacol , vol.30 , pp. 779-780
    • Doshi, B.S.1    Kulkarni, R.D.2    Chauhan, B.L.3
  • 49
    • 0028030327 scopus 로고
    • Dapsone N-acetylation, metoprolol alpha-hydroxylation, and S-mephenytoin 4-hydroxylation polymorphisms in an Indonesian population: A cocktail and extended phenotyping assessment trial
    • Setiabudy R, Kusaka M, Chiba K, et al. Dapsone N-acetylation, metoprolol alpha-hydroxylation, and S-mephenytoin 4-hydroxylation polymorphisms in an Indonesian population: a cocktail and extended phenotyping assessment trial. Clin Pharmacol Ther 1994; 56: 142-53
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 142-153
    • Setiabudy, R.1    Kusaka, M.2    Chiba, K.3
  • 50
    • 0027272518 scopus 로고
    • Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark
    • Brosen K, Skjelbo E, Flachs H. Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark. Br J Clin Pharmacol 1993; 36: 105-8
    • (1993) Br J Clin Pharmacol , vol.36 , pp. 105-108
    • Brosen, K.1    Skjelbo, E.2    Flachs, H.3
  • 51
    • 0031875471 scopus 로고    scopus 로고
    • Genetic polymorphism of debrisoquine (CYP2D6) and proguanil (CYP2C19) in South Pacific Polynesian population
    • Wanwimolruk S, Bhawan S, Coville PF, et al. Genetic polymorphism of debrisoquine (CYP2D6) and proguanil (CYP2C19) in South Pacific Polynesian population. Eur J Clin Pharmacol 1998; 54: 431-5
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 431-435
    • Wanwimolruk, S.1    Bhawan, S.2    Coville, P.F.3
  • 52
    • 0025809648 scopus 로고
    • Sparteine and mephenytoin oxidation: Genetic polymorphisms in East and West Greenland
    • Clasen K, Madsen L, Brosen K, et al. Sparteine and mephenytoin oxidation: genetic polymorphisms in east and west Greenland. Clin Pharmacol Ther 1991; 49: 624-31
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 624-631
    • Clasen, K.1    Madsen, L.2    Brosen, K.3
  • 53
    • 0028114838 scopus 로고
    • S-Mephenytoin, sparteine and debrisoquine oxidation: Genetic polymorphisms in a Turkish population
    • Basci NE, Brosen K, Bozkurt A, et al. S-Mephenytoin, sparteine and debrisoquine oxidation: genetic polymorphisms in a Turkish population. Br J Clin Pharmacol 1994; 38: 463-5
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 463-465
    • Basci, N.E.1    Brosen, K.2    Bozkurt, A.3
  • 54
    • 0028892079 scopus 로고
    • S-Mephenytoin hydroxylation phenotypes in a Jordanian population
    • Hadidi HF, Irshaid YM, Woosley RL, et al. S-Mephenytoin hydroxylation phenotypes in a Jordanian population. Clin Pharmacol Ther 1995; 58: 542-7
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 542-547
    • Hadidi, H.F.1    Irshaid, Y.M.2    Woosley, R.L.3
  • 55
    • 2042431033 scopus 로고    scopus 로고
    • Phenotypic-genotypic analysis of CYP2C19 in the Jewish Israeli population
    • Sviri S, Shpizen S, Leitersdorf E, et al. Phenotypic-genotypic analysis of CYP2C19 in the Jewish Israeli population. Clin Pharmacol Ther 1999; 65: 275-82
    • (1999) Clin Pharmacol Ther , vol.65 , pp. 275-282
    • Sviri, S.1    Shpizen, S.2    Leitersdorf, E.3
  • 56
    • 13144258722 scopus 로고    scopus 로고
    • Bantu Tanzanians have a decreased capacity to metabolize omeprazole and mephenytoin in relation to their CYP2C19 genotype
    • Herrlin K, Massele AY, Jande M, et al. Bantu Tanzanians have a decreased capacity to metabolize omeprazole and mephenytoin in relation to their CYP2C19 genotype. Clin Pharmacol Ther 1998; 64: 391-401
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 391-401
    • Herrlin, K.1    Massele, A.Y.2    Jande, M.3
  • 57
    • 0029960882 scopus 로고    scopus 로고
    • Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians
    • Skjelbo E, Mutabingwa TK, Bygbjerg LB, et al. Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians. Clin Pharmacol Ther 1996; 59: 304-11
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 304-311
    • Skjelbo, E.1    Mutabingwa, T.K.2    Bygbjerg, L.B.3
  • 58
    • 0029055448 scopus 로고
    • Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe
    • Masimirembwa C, Bertilsson L, Johansson I, et al. Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe. Clin Pharmacol Ther 1995; 57: 656-61
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 656-661
    • Masimirembwa, C.1    Bertilsson, L.2    Johansson, I.3
  • 59
    • 0030462277 scopus 로고    scopus 로고
    • S-Mephenytoin hydroxylation phenotype and cyp2c19 genotype among Ethiopians
    • Persson I, Aklillu E, Rodrigues F, et al. S-Mephenytoin hydroxylation phenotype and cyp2c19 genotype among Ethiopians. Pharmacogenetics 1996; 6: 521-6
    • (1996) Pharmacogenetics , vol.6 , pp. 521-526
    • Persson, I.1    Aklillu, E.2    Rodrigues, F.3
  • 60
    • 0031682185 scopus 로고    scopus 로고
    • CYP2D6 and CYP2C19 genotypes in an elderly Swedish population
    • Yamada H, Dahl ML, Lannfelt L, et al. CYP2D6 and CYP2C19 genotypes in an elderly Swedish population. Eur J Clin Pharmacol 1998; 54: 479-81
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 479-481
    • Yamada, H.1    Dahl, M.L.2    Lannfelt, L.3
  • 61
    • 0024336503 scopus 로고
    • S-Mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin
    • Sanz EJ, Villen T, Alm C, et al. S-Mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin. Clin Pharmacol Ther 1989; 45: 495-9
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 495-499
    • Sanz, E.J.1    Villen, T.2    Alm, C.3
  • 62
    • 0023762605 scopus 로고
    • Phenotyping polymorphic drug metabolism in the French Caucasian population
    • Jacqz E, Dulac H, Mathieu H. Phenotyping polymorphic drug metabolism in the French Caucasian population. Eur J Clin Pharmacol 1988; 35: 167-71
    • (1988) Eur J Clin Pharmacol , vol.35 , pp. 167-171
    • Jacqz, E.1    Dulac, H.2    Mathieu, H.3
  • 63
    • 0024319297 scopus 로고
    • Mephenytoin and sparteine oxidation: Genetic polymorphisms in Denmark
    • Drohse A, Bathum L, Brosen K, et al. Mephenytoin and sparteine oxidation: genetic polymorphisms in Denmark. Br J Clin Pharmacol 1989; 27: 620-5
    • (1989) Br J Clin Pharmacol , vol.27 , pp. 620-625
    • Drohse, A.1    Bathum, L.2    Brosen, K.3
  • 64
    • 0031858351 scopus 로고    scopus 로고
    • Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevity: Role of CYP2D6 and CYP2C19 in longevity
    • Bathum L, Andersen-Ranberg K, Boldsen J, et al. Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevity: role of CYP2D6 and CYP2C19 in longevity. Eur J Clin Pharmacol 1998; 54: 427-30
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 427-430
    • Bathum, L.1    Andersen-Ranberg, K.2    Boldsen, J.3
  • 65
    • 0012887670 scopus 로고    scopus 로고
    • Allele frequency of cyp2c19 in a Portuguese population
    • Ruas JL, Lechner MC. Allele frequency of cyp2c19 in a Portuguese population. Pharmacogenetics 1997; 7: 333-5
    • (1997) Pharmacogenetics , vol.7 , pp. 333-335
    • Ruas, J.L.1    Lechner, M.C.2
  • 66
    • 0027253112 scopus 로고
    • Frequency of S-mephenytoin hydroxylation deficiency in 373 Spanish subjects compared to other Caucasian populations
    • Reviriego J, Bertilsson L, Carrillo JA, et al. Frequency of S-mephenytoin hydroxylation deficiency in 373 Spanish subjects compared to other Caucasian populations. Eur J Clin Pharmacol 1993; 44: 593-5
    • (1993) Eur J Clin Pharmacol , vol.44 , pp. 593-595
    • Reviriego, J.1    Bertilsson, L.2    Carrillo, J.A.3
  • 67
    • 0031445496 scopus 로고    scopus 로고
    • Debrisoquine and S-mephenytoin hydroxylation polymorphisms in a Russian population living in Estonia
    • Marandi T, Dahl ML, Rago L, et al. Debrisoquine and S-mephenytoin hydroxylation polymorphisms in a Russian population living in Estonia. Eur J Clin Pharmacol 1997; 53: 257-60
    • (1997) Eur J Clin Pharmacol , vol.53 , pp. 257-260
    • Marandi, T.1    Dahl, M.L.2    Rago, L.3
  • 68
    • 0029895951 scopus 로고    scopus 로고
    • Debrisoquin and S-mephenytoin hydroxylation phenotypes and CYP2D6 genotypes in an Estonian population
    • Marandi T, Dahl ML, Kiivet RA, et al. Debrisoquin and S-mephenytoin hydroxylation phenotypes and CYP2D6 genotypes in an Estonian population. Pharmacol Toxicol 1996; 78: 303-7
    • (1996) Pharmacol Toxicol , vol.78 , pp. 303-307
    • Marandi, T.1    Dahl, M.L.2    Kiivet, R.A.3
  • 69
    • 0031787036 scopus 로고    scopus 로고
    • Relationship between proguanil metabolic ratio and CYP2C19 genotype in a Caucasian population
    • Hoskins JM, Shenfield GM, Gross AS. Relationship between proguanil metabolic ratio and CYP2C19 genotype in a Caucasian population. Br J Clin Pharmacol 1998; 46: 499-504
    • (1998) Br J Clin Pharmacol , vol.46 , pp. 499-504
    • Hoskins, J.M.1    Shenfield, G.M.2    Gross, A.S.3
  • 70
    • 0029912595 scopus 로고    scopus 로고
    • Determination of CYP2C19 phenotype in black Americans: Correlation with genotype
    • Marinac J, Balian JD, Foxworth JW, et al. Determination of CYP2C19 phenotype in black Americans: correlation with genotype. Clin Pharmacol Ther 1996; 60: 138-44
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 138-144
    • Marinac, J.1    Balian, J.D.2    Foxworth, J.W.3
  • 71
    • 0002656419 scopus 로고    scopus 로고
    • Analysis of CYP2D6 and CYP2C19 genotypes in large African-American (AA) and Caucasian (C) population
    • Martin DE, Flockhart DA, Jorkasky DK. Analysis of CYP2D6 and CYP2C19 genotypes in large African-American (AA) and Caucasian (C) population [abstract]. Clin Pharmacol Ther 1998; 63: 206
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 206
    • Martin, D.E.1    Flockhart, D.A.2    Jorkasky, D.K.3
  • 72
    • 0021684926 scopus 로고
    • Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism
    • Wedlund PJ, Aslanian WS, McAllister CB, et al. Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism. Clin Pharmacol Ther 1984; 36: 773-80
    • (1984) Clin Pharmacol Ther , vol.36 , pp. 773-780
    • Wedlund, P.J.1    Aslanian, W.S.2    McAllister, C.B.3
  • 73
    • 0021690577 scopus 로고
    • Mephenytoin and sparteine pharmacogenetics in Canadian Caucasians
    • Inaba T, Jurima M, Nakano M, et al. Mephenytoin and sparteine pharmacogenetics in Canadian Caucasians. Clin Pharmacol Ther 1984; 36: 670-6
    • (1984) Clin Pharmacol Ther , vol.36 , pp. 670-676
    • Inaba, T.1    Jurima, M.2    Nakano, M.3
  • 74
    • 0031714780 scopus 로고    scopus 로고
    • Canadian Native Indians exhibit unique CYP2A6 and CYP2C19 mutant allele frequencies
    • Nowak MP, Sellers EM, Tyndale RF. Canadian Native Indians exhibit unique CYP2A6 and CYP2C19 mutant allele frequencies. Clin Pharmacol Ther 1998; 64: 378-83
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 378-383
    • Nowak, M.P.1    Sellers, E.M.2    Tyndale, R.F.3
  • 75
    • 0029760287 scopus 로고    scopus 로고
    • CYP2C19 genotyping and associated mephenytoin hydroxylation polymorphism in a Canadian Inuit population
    • Jurima-Romet M, Goldstein JA, Le Belle M, et al. CYP2C19 genotyping and associated mephenytoin hydroxylation polymorphism in a Canadian Inuit population. Pharmacogenetics 1996; 6: 329-39
    • (1996) Pharmacogenetics , vol.6 , pp. 329-339
    • Jurima-Romet, M.1    Goldstein, J.A.2    Le Belle, M.3
  • 76
    • 0035133641 scopus 로고    scopus 로고
    • Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in aborigines from Western Australia
    • Griese EU, Ilett KF, Kitteringham NR, et al. Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in aborigines from western Australia. Pharmacogenetics 2001; 11: 69-76
    • (2001) Pharmacogenetics , vol.11 , pp. 69-76
    • Griese, E.U.1    Ilett, K.F.2    Kitteringham, N.R.3
  • 77
    • 0025223056 scopus 로고
    • Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: Interethnic differences in comparison with white subjects
    • Zhang YA, Reviriego J, Lou YQ, et al. Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: interethnic differences in comparison with white subjects. Clin Pharmacol Ther 1990; 48: 496-502
    • (1990) Clin Pharmacol Ther , vol.48 , pp. 496-502
    • Zhang, Y.A.1    Reviriego, J.2    Lou, Y.Q.3
  • 78
    • 0028211993 scopus 로고
    • Interethnic differences in omeprazole metabolism in the two S-mephenytoin hydroxylation phenotypes studied in Caucasians and Orientals
    • Ishizaki T, Sohn DR, Kobayashi K, et al. Interethnic differences in omeprazole metabolism in the two S-mephenytoin hydroxylation phenotypes studied in Caucasians and Orientals. Ther Drug Monit 1994; 16: 214-5
    • (1994) Ther Drug Monit , vol.16 , pp. 214-215
    • Ishizaki, T.1    Sohn, D.R.2    Kobayashi, K.3
  • 79
    • 0034892729 scopus 로고    scopus 로고
    • Genetic polymorphisms and functional characterization of the 5′-flanking region of the human CYP2C9 gene: In vitro and in vivo studies
    • Shintani M, Ieiri I, Inoue K, et al. Genetic polymorphisms and functional characterization of the 5′-flanking region of the human CYP2C9 gene: in vitro and in vivo studies. Clin Pharmacol Ther 2001; 70: 175-82
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 175-182
    • Shintani, M.1    Ieiri, I.2    Inoue, K.3
  • 81
    • 0032868321 scopus 로고    scopus 로고
    • Phenotypes and genotypes for CYP2D6 and CYP2C19 in a black Tanzanian population
    • Bathum L, Skjelbo E, Mutabingwa TK, et al. Phenotypes and genotypes for CYP2D6 and CYP2C19 in a black Tanzanian population. Br J Clin Pharmacol 1999; 48: 395-401
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 395-401
    • Bathum, L.1    Skjelbo, E.2    Mutabingwa, T.K.3
  • 82
    • 0029953919 scopus 로고    scopus 로고
    • Effects of omeprazole and cimetidine on the urinary metabolic ratio of proguanil in healthy volunteers
    • Somogyi AA, Reinhard HA, Bochner F. Effects of omeprazole and cimetidine on the urinary metabolic ratio of proguanil in healthy volunteers. Eur J Clin Pharmacol 1996; 50: 417-9
    • (1996) Eur J Clin Pharmacol , vol.50 , pp. 417-419
    • Somogyi, A.A.1    Reinhard, H.A.2    Bochner, F.3
  • 83
    • 0025326803 scopus 로고
    • Effect of omeprazole and cimetidine on plasma diazepam levels
    • Andersson T, Andren K, Cederberg C, et al. Effect of omeprazole and cimetidine on plasma diazepam levels. Eur J Clin Pharmacol 1990; 39: 51-4
    • (1990) Eur J Clin Pharmacol , vol.39 , pp. 51-54
    • Andersson, T.1    Andren, K.2    Cederberg, C.3
  • 84
    • 0030748999 scopus 로고    scopus 로고
    • Pharmacokinetic interactions with felbamate: In vitro-in vivo correlation
    • Glue P, Banfield CR, Perhach JL, et al. Pharmacokinetic interactions with felbamate: in vitro-in vivo correlation. Clin Pharmacokinet 1997; 33: 214-24
    • (1997) Clin Pharmacokinet , vol.33 , pp. 214-224
    • Glue, P.1    Banfield, C.R.2    Perhach, J.L.3
  • 85
    • 0029738965 scopus 로고    scopus 로고
    • Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine
    • Jeppesen U, Gram LF, Vistisen K, et al. Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. Eur J Clin Pharmacol 1996; 51: 73-8
    • (1996) Eur J Clin Pharmacol , vol.51 , pp. 73-78
    • Jeppesen, U.1    Gram, L.F.2    Vistisen, K.3
  • 86
    • 0028842707 scopus 로고
    • The effects of selective serotonin reuptake inhibitors and their metabolites on S-mephenytoin 4′-hydroxylase activity in human liver microsomes
    • Kobayashi K, Yamamoto T, Chiba K, et al. The effects of selective serotonin reuptake inhibitors and their metabolites on S-mephenytoin 4′-hydroxylase activity in human liver microsomes. Br J Clin Pharmacol 1995; 40: 481-5
    • (1995) Br J Clin Pharmacol , vol.40 , pp. 481-485
    • Kobayashi, K.1    Yamamoto, T.2    Chiba, K.3
  • 87
    • 0035103586 scopus 로고    scopus 로고
    • Fluoxetine pharmacokinetics and effect on CYP2C19 in young and elderly volunteers
    • Harvey AT, Preskorn SH. Fluoxetine pharmacokinetics and effect on CYP2C19 in young and elderly volunteers. J Clin Psychopharmacol 2001; 21: 161-6
    • (2001) J Clin Psychopharmacol , vol.21 , pp. 161-166
    • Harvey, A.T.1    Preskorn, S.H.2
  • 88
    • 0030864218 scopus 로고    scopus 로고
    • Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: Effects of contents of these two forms in individual human samples
    • Yamazaki H, Inoue K, Shaw PM, et al. Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples. J Pharmacol Exp Ther 1997; 283: 434-42
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 434-442
    • Yamazaki, H.1    Inoue, K.2    Shaw, P.M.3
  • 89
    • 0008789270 scopus 로고    scopus 로고
    • Fluvoxamine inhibits the CYP2C19-catalysed metabolism of proguanil in vitro
    • Rasmussen BB, Nielsen TL, Brosen K. Fluvoxamine inhibits the CYP2C19-catalysed metabolism of proguanil in vitro. Eur J Clin Pharmacol 1998; 54: 735-40
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 735-740
    • Rasmussen, B.B.1    Nielsen, T.L.2    Brosen, K.3
  • 90
    • 12644276395 scopus 로고    scopus 로고
    • Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide
    • Jeppesen U, Rasmussen BB, Brosen K. Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide. Clin Pharmacol Ther 1997; 62: 279-86
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 279-286
    • Jeppesen, U.1    Rasmussen, B.B.2    Brosen, K.3
  • 91
    • 0035144768 scopus 로고    scopus 로고
    • Inhibition of Cytochrome P450 (CYP450) isoforms by isoniazid: Potent inhibition of CYP2C19 and CYP3A
    • Desta Z, Soukhova NV, Flockhart DA. Inhibition of Cytochrome P450 (CYP450) isoforms by isoniazid: potent inhibition of CYP2C19 and CYP3A. Antimicrob Agents Chemother 2001; 45: 382-92
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 382-392
    • Desta, Z.1    Soukhova, N.V.2    Flockhart, D.A.3
  • 92
    • 0023136337 scopus 로고
    • Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes
    • Hall SD, Guengerich FP, Branch RA, et al. Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes. J Pharmacol Exp Ther 1987; 240: 216-22
    • (1987) J Pharmacol Exp Ther , vol.240 , pp. 216-222
    • Hall, S.D.1    Guengerich, F.P.2    Branch, R.A.3
  • 93
    • 0024335072 scopus 로고
    • Effects of ketoconazole on the polymorphic 4-hydroxylations of S-mephenytoin and debrisoquine
    • Atiba JO, Blaschke TF, Wilkinson GR. Effects of ketoconazole on the polymorphic 4-hydroxylations of S-mephenytoin and debrisoquine. Br J Clin Pharmacol 1989; 28: 161-5
    • (1989) Br J Clin Pharmacol , vol.28 , pp. 161-165
    • Atiba, J.O.1    Blaschke, T.F.2    Wilkinson, G.R.3
  • 94
    • 0030811096 scopus 로고    scopus 로고
    • Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms
    • Ko JW, Sukhova N, Thacker D, et al. Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms. Drug Metab Dispos 1997; 25: 853-62
    • (1997) Drug Metab Dispos , vol.25 , pp. 853-862
    • Ko, J.W.1    Sukhova, N.2    Thacker, D.3
  • 95
    • 0029114726 scopus 로고
    • Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4′-hydroxylation
    • Ishizaki T, Chiba K, Manabe K, et al. Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4′-hydroxylation. Clin Pharmacol Ther 1995; 58: 155-64
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 155-164
    • Ishizaki, T.1    Chiba, K.2    Manabe, K.3
  • 96
    • 0029127629 scopus 로고
    • Interethnic difference in omeprazole's inhibition of diazepam metabolism
    • Caraco Y, Tateishi T, Wood AJ. Interethnic difference in omeprazole's inhibition of diazepam metabolism. Clin Pharmacol Ther 1995; 58: 62-72
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 62-72
    • Caraco, Y.1    Tateishi, T.2    Wood, A.J.3
  • 97
    • 0029859728 scopus 로고    scopus 로고
    • Differences between white subjects and Chinese subjects in the in vivo inhibition of cytochrome P450s, 2C19, 2D6, and 3A by omeprazole
    • Caraco Y, Wilkinson GR, Wood AJ. Differences between white subjects and Chinese subjects in the in vivo inhibition of cytochrome P450s, 2C19, 2D6, and 3A by omeprazole. Clin Pharmacol Ther 1996; 60: 396-404
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 396-404
    • Caraco, Y.1    Wilkinson, G.R.2    Wood, A.J.3
  • 98
    • 0030899603 scopus 로고    scopus 로고
    • Inhibition by omeprazole of proguanil metabolism: Mechanism of the interaction in vitro and prediction of in vivo results from the in vitro experiments
    • Funck-Brentano C, Becquemont L, Leneveu A, et al. Inhibition by omeprazole of proguanil metabolism: mechanism of the interaction in vitro and prediction of in vivo results from the in vitro experiments. J Pharmacol Exp Ther 1997; 280: 730-8
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 730-738
    • Funck-Brentano, C.1    Becquemont, L.2    Leneveu, A.3
  • 99
    • 0034904673 scopus 로고    scopus 로고
    • Drug interaction studies with esomeprazole, the (S)-isomer of omeprazole
    • Andersson T, Hassan-Alin M, Hasselgren G, et al. Drug interaction studies with esomeprazole, the (S)-isomer of omeprazole. Clin Pharmacokinet 2001; 40: 523-37
    • (2001) Clin Pharmacokinet , vol.40 , pp. 523-537
    • Andersson, T.1    Hassan-Alin, M.2    Hasselgren, G.3
  • 100
    • 0029016328 scopus 로고
    • Moclobemide, a substrate of CYP2C19, and an inhibitor of CYP2C9, CYP2D6, and CYP1A2: A panel study
    • Gram LF, Guentert TW, Grange S, et al. Moclobemide, a substrate of CYP2C19, and an inhibitor of CYP2C9, CYP2D6, and CYP1A2: a panel study. Clin Pharmacol Ther 1995; 57: 670-7
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 670-677
    • Gram, L.F.1    Guentert, T.W.2    Grange, S.3
  • 101
    • 0033837621 scopus 로고    scopus 로고
    • No sex-related differences but significant inhibition by oral contraceptives of CYP2C19 activity as measured by the probe drugs mephenytoin and omeprazole in healthy Swedish white subjects
    • Laine K, Tybring G, Bertilsson L. No sex-related differences but significant inhibition by oral contraceptives of CYP2C19 activity as measured by the probe drugs mephenytoin and omeprazole in healthy Swedish white subjects. Clin Pharmacol Ther 2000; 68: 151-9
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 151-159
    • Laine, K.1    Tybring, G.2    Bertilsson, L.3
  • 102
    • 0034876431 scopus 로고    scopus 로고
    • In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes
    • Barecki ME, Casciano CN, Johnson WW, et al. In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes. Drug Metab Dispos 2001; 29: 1173-5
    • (2001) Drug Metab Dispos , vol.29 , pp. 1173-1175
    • Barecki, M.E.1    Casciano, C.N.2    Johnson, W.W.3
  • 103
    • 0010808013 scopus 로고    scopus 로고
    • Mechanism-based inactivation of CYP2C19 and CYP2D6 by tamoxifen (TAM) and its metabolite N-desmethyltamoxifen (NDTAM)
    • Desta Z, Park J, Soukhova N, et al. Mechanism-based inactivation of CYP2C19 and CYP2D6 by tamoxifen (TAM) and its metabolite N-desmethyltamoxifen (NDTAM) [abstract]. Clin Pharmacol Ther 2001; 69: 9
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 9
    • Desta, Z.1    Park, J.2    Soukhova, N.3
  • 104
    • 0035834052 scopus 로고    scopus 로고
    • Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19
    • Ha-Duong NT, Dijols S, Macherey AC, et al. Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19. Biochemistry 2001; 40: 12112-22
    • (2001) Biochemistry , vol.40 , pp. 12112-12122
    • Ha-Duong, N.T.1    Dijols, S.2    Macherey, A.C.3
  • 105
    • 0032945411 scopus 로고    scopus 로고
    • Ticlopidine decreases the in vivo activity of CYP2C19 as measured by omeprazole metabolism
    • Tateishi T, Kumai T, Watanabe M, et al. Ticlopidine decreases the in vivo activity of CYP2C19 as measured by omeprazole metabolism. Br J Clin Pharmacol 1999; 47: 454-7
    • (1999) Br J Clin Pharmacol , vol.47 , pp. 454-457
    • Tateishi, T.1    Kumai, T.2    Watanabe, M.3
  • 106
    • 0032841888 scopus 로고    scopus 로고
    • The tole of CYP2C19 in the metabolism of (±)-bufuralol, the prototypic substrate of CYP2D6
    • Mankowski DC. The tole of CYP2C19 in the metabolism of (±)-bufuralol, the prototypic substrate of CYP2D6. Drug Metab Dispos 1999; 27: 1024-8
    • (1999) Drug Metab Dispos , vol.27 , pp. 1024-1028
    • Mankowski, D.C.1
  • 107
    • 0034128040 scopus 로고    scopus 로고
    • In vitro inhibition of the cytochrome P450 (CYP) system by the antiplatelet drug ticlopidine: Potent effect on CYP2C19 and CYP2D6
    • Ko JW, Desta Z, Soukhova N, et al. In vitro inhibition of the cytochrome P450 (CYP) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. Br J Clin Pharmacol 2000; 49: 343-51
    • (2000) Br J Clin Pharmacol , vol.49 , pp. 343-351
    • Ko, J.W.1    Desta, Z.2    Soukhova, N.3
  • 108
    • 0028787051 scopus 로고
    • Cytochrome P450 isoenzymes and antiepileptic drug interactions
    • Levy RH. Cytochrome P450 isoenzymes and antiepileptic drug interactions. Epilepsia 1995; 36 Suppl. 5: S8-13
    • (1995) Epilepsia , vol.36 , pp. S8-S13
    • Levy, R.H.1
  • 109
    • 0022390883 scopus 로고
    • In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase
    • Inaba T, Jurima M, Mahon WA, et al. In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase. Drug Metab Dispos 1985; 13: 443-8
    • (1985) Drug Metab Dispos , vol.13 , pp. 443-448
    • Inaba, T.1    Jurima, M.2    Mahon, W.A.3
  • 110
    • 0001254804 scopus 로고    scopus 로고
    • Prediction of zonisamide interactions based on metabolic isozymes
    • Mather GG, Carlson S, Trager WF, et al. Prediction of zonisamide interactions based on metabolic isozymes [abstract]. Epilepsia 1997; 38 Suppl. 8: 108
    • (1997) Epilepsia , vol.38 , pp. 108
    • Mather, G.G.1    Carlson, S.2    Trager, W.F.3
  • 111
    • 0031931510 scopus 로고    scopus 로고
    • The induction effect of rifampicin on activity of mephenytoin 4′-hydroxylase related to M1 mutation of CYP2C19 and gene dose
    • Feng HJ, Huang SL, Wang W, et al. The induction effect of rifampicin on activity of mephenytoin 4′-hydroxylase related to M1 mutation of CYP2C19 and gene dose. Br J Clin Pharmacol 1998; 45: 27-9
    • (1998) Br J Clin Pharmacol , vol.45 , pp. 27-29
    • Feng, H.J.1    Huang, S.L.2    Wang, W.3
  • 112
    • 0025005022 scopus 로고
    • Induction of polymorphic 4′-hydroxylation of S-mephenytoin by rifampicin
    • Zhou HH, Anthony LB, Wood AJ, et al. Induction of polymorphic 4′-hydroxylation of S-mephenytoin by rifampicin. Br J Clin Pharmacol 1990; 30: 471-5
    • (1990) Br J Clin Pharmacol , vol.30 , pp. 471-475
    • Zhou, H.H.1    Anthony, L.B.2    Wood, A.J.3
  • 113
    • 0016758480 scopus 로고
    • Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance
    • Zilly W, Breimer DD, Richter E. Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance. Eur J Clin Pharmacol 1975; 9: 219-27
    • (1975) Eur J Clin Pharmacol , vol.9 , pp. 219-227
    • Zilly, W.1    Breimer, D.D.2    Richter, E.3
  • 114
    • 0025786589 scopus 로고
    • Age-dependent stereoselective increase in the oral clearance of hexobarbitone isomers caused by rifampicin
    • Smith DA, Chandler MH, Shedlofsky SI, et al. Age-dependent stereoselective increase in the oral clearance of hexobarbitone isomers caused by rifampicin. Br J Clin Pharmacol 1991; 32: 735-9
    • (1991) Br J Clin Pharmacol , vol.32 , pp. 735-739
    • Smith, D.A.1    Chandler, M.H.2    Shedlofsky, S.I.3
  • 115
    • 0033427677 scopus 로고    scopus 로고
    • Stereospecific analysis of omeprazole supports artemisinin as a potent inducer of CYP2C19
    • Mihara K, Svensson US, Tybring G, et al. Stereospecific analysis of omeprazole supports artemisinin as a potent inducer of CYP2C19. Fundam Clin Pharmacol 1999; 13: 671-5
    • (1999) Fundam Clin Pharmacol , vol.13 , pp. 671-675
    • Mihara, K.1    Svensson, U.S.2    Tybring, G.3
  • 116
    • 13144307057 scopus 로고    scopus 로고
    • Artemisinin induces omeprazole metabolism in human beings
    • Svensson US, Ashton M, Trinh NH, et al. Artemisinin induces omeprazole metabolism in human beings. Clin Pharmacol Ther 1998; 64: 160-7
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 160-167
    • Svensson, U.S.1    Ashton, M.2    Trinh, N.H.3
  • 117
    • 0025064349 scopus 로고
    • Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole
    • Andersson T, Cederberg C, Evardsson G, et al. Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole. Clin Pharmacol Ther 1990; 47: 79-85
    • (1990) Clin Pharmacol Ther , vol.47 , pp. 79-85
    • Andersson, T.1    Cederberg, C.2    Evardsson, G.3
  • 118
    • 0033942763 scopus 로고    scopus 로고
    • Selective and potent inhibition of human CYP2C19 activity by a conformationally targeted antipeptide antibody
    • Schulz-Utermoehl T, Mountfield RJ, Madsen K, et al. Selective and potent inhibition of human CYP2C19 activity by a conformationally targeted antipeptide antibody. Drug Metab Dispos 2000; 28: 715-7
    • (2000) Drug Metab Dispos , vol.28 , pp. 715-717
    • Schulz-Utermoehl, T.1    Mountfield, R.J.2    Madsen, K.3
  • 119
    • 0033199499 scopus 로고    scopus 로고
    • P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
    • Waxman DJ. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch Biochem Biophys 1999; 369: 11-23
    • (1999) Arch Biochem Biophys , vol.369 , pp. 11-23
    • Waxman, D.J.1
  • 120
    • 0034042711 scopus 로고    scopus 로고
    • Induction of drug metabolizing enzymes: Pharmacokinetic and toxicological consequences in humans
    • Fuhr U. Induction of drug metabolizing enzymes: pharmacokinetic and toxicological consequences in humans. Clin Pharmacokinet 2000; 38: 493-504
    • (2000) Clin Pharmacokinet , vol.38 , pp. 493-504
    • Fuhr, U.1
  • 121
    • 0023928098 scopus 로고
    • Oxidative metabolism of hexobarbital in human liver: Relationship to polymorphic S-mephenytoin 4-hydroxylation
    • Knodell RG, Dubey RK, Wilkinson GR, et al. Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation. J Pharmacol Exp Ther 1988; 245: 845-9
    • (1988) J Pharmacol Exp Ther , vol.245 , pp. 845-849
    • Knodell, R.G.1    Dubey, R.K.2    Wilkinson, G.R.3
  • 122
    • 0028207548 scopus 로고
    • Stereoselective disposition of hexobarbital and its metabolites: Relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects
    • Adedoyin A, Prakash C, O'Shea D, et al. Stereoselective disposition of hexobarbital and its metabolites: relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects. Pharmacogenetics 1994; 4: 27-38
    • (1994) Pharmacogenetics , vol.4 , pp. 27-38
    • Adedoyin, A.1    Prakash, C.2    O'Shea, D.3
  • 123
    • 0018134916 scopus 로고
    • Influence of corticosteroid on hexobarbital and tolbutamide disposition
    • Breimer DD, Zilly W, Richter E. Influence of corticosteroid on hexobarbital and tolbutamide disposition. Clin Pharmacol Ther 1978; 24: 208-12
    • (1978) Clin Pharmacol Ther , vol.24 , pp. 208-212
    • Breimer, D.D.1    Zilly, W.2    Richter, E.3
  • 124
    • 0033736113 scopus 로고    scopus 로고
    • In vivo modulation of CYP enzymes by quinidine and rifampin
    • Branch RA, Adedoyin A, Frye RF, et al. In vivo modulation of CYP enzymes by quinidine and rifampin. Clin Pharmacol Ther 2000; 68: 401-11
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 401-411
    • Branch, R.A.1    Adedoyin, A.2    Frye, R.F.3
  • 125
    • 0021960864 scopus 로고
    • Extent of urinary excretion of p-hydroxyphenytoin in healthy subjects given phenytoin
    • Dickinson RG, Hooper WD, Patterson M, et al. Extent of urinary excretion of p-hydroxyphenytoin in healthy subjects given phenytoin. Ther Drug Monit 1985; 7: 283-9
    • (1985) Ther Drug Monit , vol.7 , pp. 283-289
    • Dickinson, R.G.1    Hooper, W.D.2    Patterson, M.3
  • 126
    • 0023219332 scopus 로고
    • Stereochemistry of aromatic phenytoin hydroxylation in various drug hydroxylation phenotypes in humans
    • Fritz S, Lindner W, Roots I, et al. Stereochemistry of aromatic phenytoin hydroxylation in various drug hydroxylation phenotypes in humans. J Pharmacol Exp Ther 1987; 241: 615-22
    • (1987) J Pharmacol Exp Ther , vol.241 , pp. 615-622
    • Fritz, S.1    Lindner, W.2    Roots, I.3
  • 127
    • 8244261385 scopus 로고    scopus 로고
    • Stereoselective 4′-hydroxylation of phenytoin: Relationship to (S)-mephenytoin polymorphism in Japanese
    • Ieiri I, Mamiya K, Urae A, et al. Stereoselective 4′-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese. Br J Clin Pharmacol 1997; 43: 441-5
    • (1997) Br J Clin Pharmacol , vol.43 , pp. 441-445
    • Ieiri, I.1    Mamiya, K.2    Urae, A.3
  • 128
    • 0030792284 scopus 로고    scopus 로고
    • Carbamazepine treatment induces the CYP3A catalyzed sulfoxidation of omeprazole, but has no or less effect on hydroxylation via CYP2C19
    • Bertilsson L, Tybring G, Widen J, et al. Carbamazepine treatment induces the CYP3A catalyzed sulfoxidation of omeprazole, but has no or less effect on hydroxylation via CYP2C19. Br J Clin Pharmacol 1997; 44: 186-9
    • (1997) Br J Clin Pharmacol , vol.44 , pp. 186-189
    • Bertilsson, L.1    Tybring, G.2    Widen, J.3
  • 129
    • 0035081487 scopus 로고    scopus 로고
    • P-hydroxylation of phenobarbital: Relationship to (S)-mephenytoin hydroxylation (CYP2C19) polymorphism
    • Hadama A, Ieiri I, Morita T, et al. P-hydroxylation of phenobarbital: relationship to (S)-mephenytoin hydroxylation (CYP2C19) polymorphism. Ther Drug Monit 2001; 23: 115-8
    • (2001) Ther Drug Monit , vol.23 , pp. 115-118
    • Hadama, A.1    Ieiri, I.2    Morita, T.3
  • 130
    • 4243511541 scopus 로고    scopus 로고
    • Cloning and sequencing of 5′-regulatory region of CYP2C19
    • Zhao X, Rae J, Flockhart DA. Cloning and sequencing of 5′-regulatory region of CYP2C19 [abstract]. Clin Pharmacol Ther 2001; 69 (2): P72
    • (2001) Clin Pharmacol Ther , vol.69 , Issue.2 , pp. P72
    • Zhao, X.1    Rae, J.2    Flockhart, D.A.3
  • 131
    • 0031847721 scopus 로고    scopus 로고
    • Selective effect of liver disease on the activities of specific metabolizing enzymes: Investigation of cytochromes P450 2C19 and 2D6
    • Adedoyin A, Arns PA, Richards WO, et al. Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6. Clin Pharmacol Ther 1998; 64: 8-17
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 8-17
    • Adedoyin, A.1    Arns, P.A.2    Richards, W.O.3
  • 132
    • 0027339295 scopus 로고
    • Pharmacokinetics of [14C]omeprazole in patients with liver cirrhosis
    • Andersson T, Olsson R, Regardh CG, et al. Pharmacokinetics of [14C]omeprazole in patients with liver cirrhosis. Clin Pharmacokinet 1993; 24: 71-8
    • (1993) Clin Pharmacokinet , vol.24 , pp. 71-78
    • Andersson, T.1    Olsson, R.2    Regardh, C.G.3
  • 133
    • 0029088251 scopus 로고
    • Phenocopies of poor metabolizers of omeprazole caused by liver disease and drug treatment
    • Rost KL, Brockmoller J, Esdorn F, et al. Phenocopies of poor metabolizers of omeprazole caused by liver disease and drug treatment. J Hepatol 1995; 23: 268-77
    • (1995) J Hepatol , vol.23 , pp. 268-277
    • Rost, K.L.1    Brockmoller, J.2    Esdorn, F.3
  • 134
    • 0033866253 scopus 로고    scopus 로고
    • Single and multiple dose pharmacokinetics of nelfinavir and CYP2C19 activity in human immunodeficiency virus-infected patients with chronic liver disease
    • Khaliq Y, Gallicano K, Seguin I, et al. Single and multiple dose pharmacokinetics of nelfinavir and CYP2C19 activity in human immunodeficiency virus-infected patients with chronic liver disease. Br J Clin Pharmacol 2000; 50: 108-15
    • (2000) Br J Clin Pharmacol , vol.50 , pp. 108-115
    • Khaliq, Y.1    Gallicano, K.2    Seguin, I.3
  • 135
    • 0031412782 scopus 로고    scopus 로고
    • Mephenytoin disposition and serum bile acids as indices of hepatic function in chronic viral hepatitis
    • Arns PA, Adedoyin A, DiBisceglie AM, et al. Mephenytoin disposition and serum bile acids as indices of hepatic function in chronic viral hepatitis. Clin Pharmacol Ther 1997; 62: 527-37
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 527-537
    • Arns, P.A.1    Adedoyin, A.2    DiBisceglie, A.M.3
  • 136
    • 0008615560 scopus 로고    scopus 로고
    • A discordance of the cytochrome P450 2C19 genotype and phenotype in patients with advanced cancer
    • Williams ML, Bhargava P, Cherrouk I, et al. A discordance of the cytochrome P450 2C19 genotype and phenotype in patients with advanced cancer. Br J Clin Pharmacol 2000; 49: 485-8
    • (2000) Br J Clin Pharmacol , vol.49 , pp. 485-488
    • Williams, M.L.1    Bhargava, P.2    Cherrouk, I.3
  • 137
    • 0028091801 scopus 로고
    • Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome
    • Flockhart DA, Clauw DJ, Sale EB, et al. Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome. Clin Pharmacol Ther 1994; 56: 398-405
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 398-405
    • Flockhart, D.A.1    Clauw, D.J.2    Sale, E.B.3
  • 139
    • 0035103616 scopus 로고    scopus 로고
    • Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers
    • Hagg S, Spigset O, Dahlqvist R. Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers. Br J Clin Pharmacol 2001; 51: 169-73
    • (2001) Br J Clin Pharmacol , vol.51 , pp. 169-173
    • Hagg, S.1    Spigset, O.2    Dahlqvist, R.3
  • 140
    • 0030909951 scopus 로고    scopus 로고
    • Evidence for the effect of gender on activity of (S)-mephenytoin 4′-hydroxylase (CYP2C19) in a Chinese population
    • Xie HG, Huang ZH, Xiao ZS, et al. Evidence for the effect of gender on activity of (S)-mephenytoin 4′-hydroxylase (CYP2C19) in a Chinese population. Pharmacogenetics 1997; 7: 115-9
    • (1997) Pharmacogenetics , vol.7 , pp. 115-119
    • Xie, H.G.1    Huang, Z.H.2    Xiao, Z.S.3
  • 141
    • 0031934315 scopus 로고    scopus 로고
    • Molecular modeling of human 2C subfamily enzymes CYP2C9 and CYP2C19: Rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily
    • Lewis DF, Dickins M, Weaver RJ, et al. Molecular modeling of human 2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily. Xenobiotica 1998; 28: 235-68
    • (1998) Xenobiotica , vol.28 , pp. 235-268
    • Lewis, D.F.1    Dickins, M.2    Weaver, R.J.3
  • 142
    • 0024580554 scopus 로고
    • Importance of genetic factor in the regulation of diazepam metabolism: Relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype
    • Bertilsson L, Henthorn TK, Sanz EJ, et al. Importance of genetic factor in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype. Clin Pharmacol Ther 1989; 45: 348-55
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 348-355
    • Bertilsson, L.1    Henthorn, T.K.2    Sanz, E.J.3
  • 143
    • 0029842851 scopus 로고    scopus 로고
    • The elimination of diazepam in Chinese subjects is dependent on the mephenytoin oxidation phenotype
    • Wan J, Xia H, He N, et al. The elimination of diazepam in Chinese subjects is dependent on the mephenytoin oxidation phenotype. Br J Clin Pharmacol 1996; 42: 471-4
    • (1996) Br J Clin Pharmacol , vol.42 , pp. 471-474
    • Wan, J.1    Xia, H.2    He, N.3
  • 144
    • 0025038681 scopus 로고
    • The pharmacokinetics and activation of proguanil in man: Consequences of variability in drug metabolism
    • Helsby NA, Ward SA, Edwards G, et al. The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism. Br J Clin Pharmacol 1990; 30: 593-8
    • (1990) Br J Clin Pharmacol , vol.30 , pp. 593-598
    • Helsby, N.A.1    Ward, S.A.2    Edwards, G.3
  • 145
    • 0002161215 scopus 로고    scopus 로고
    • The role of CYP2C19 in the formation of nelfinavir hydroxy-t-butylamide (M8): In vitro/in vivo correlation
    • Lillibridge JH, Lee CA, Pithavala YK, et al. The role of CYP2C19 in the formation of nelfinavir hydroxy-t-butylamide (M8): in vitro/in vivo correlation [abstract]. ISSX Proceedings 1998; 13: 119
    • (1998) ISSX Proceedings , vol.13 , pp. 119
    • Lillibridge, J.H.1    Lee, C.A.2    Pithavala, Y.K.3
  • 146
    • 0031260323 scopus 로고    scopus 로고
    • Progesterone and testosterone hydroxylation by cytochromes p450 2c19, 2c9, and 3a4 in human liver microsomes
    • Yamazaki H, Shimada T. Progesterone and testosterone hydroxylation by cytochromes p450 2c19, 2c9, and 3a4 in human liver microsomes. Arch Biochem Biophys 1997; 346: 161-9
    • (1997) Arch Biochem Biophys , vol.346 , pp. 161-169
    • Yamazaki, H.1    Shimada, T.2
  • 147
    • 0031657035 scopus 로고    scopus 로고
    • Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen: Role of CYP2C19 and CYP1A2 in O-demethylation
    • Stresser DM, Kupfer D. Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen: role of CYP2C19 and CYP1A2 in O-demethylation. Drug Metab Dispos 1998; 26: 868-74
    • (1998) Drug Metab Dispos , vol.26 , pp. 868-874
    • Stresser, D.M.1    Kupfer, D.2
  • 148
    • 0035059510 scopus 로고    scopus 로고
    • Flunitrazepam metabolism by cytochrome P450s 2C19 and 3A4
    • Kilicarslan T, Haining RL, Rettie AE, et al. Flunitrazepam metabolism by cytochrome P450s 2C19 and 3A4. Drug Metab Dispos 2001; 29: 460-5
    • (2001) Drug Metab Dispos , vol.29 , pp. 460-465
    • Kilicarslan, T.1    Haining, R.L.2    Rettie, A.E.3
  • 149
    • 0034818768 scopus 로고    scopus 로고
    • Effect of the CYP2C19 oxidation polymorphism on fluoxetine metabolism in Chinese healthy subjects
    • Liu ZQ, Cheng ZN, Huang SL, et al. Effect of the CYP2C19 oxidation polymorphism on fluoxetine metabolism in Chinese healthy subjects. Br J Clin Pharmacol 2001; 52: 96-9
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 96-99
    • Liu, Z.Q.1    Cheng, Z.N.2    Huang, S.L.3
  • 150
    • 0034923234 scopus 로고    scopus 로고
    • Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19
    • Wang JH, Liu ZQ, Wang W, et al. Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19. Clin Pharmacol Ther 2001; 70: 42-7
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 42-47
    • Wang, J.H.1    Liu, Z.Q.2    Wang, W.3
  • 151
    • 0023472854 scopus 로고
    • Biliary excretion of intravenous [14C]omeprazole in humans
    • Lind T, Andersson T, Skanberg I, et al. Biliary excretion of intravenous [14C]omeprazole in humans. Clin Pharmacol Ther 1987; 42: 504-8
    • (1987) Clin Pharmacol Ther , vol.42 , pp. 504-508
    • Lind, T.1    Andersson, T.2    Skanberg, I.3
  • 152
    • 0027366623 scopus 로고
    • Oxidative metabolism of omeprazole in human liver microsomes: Consegregation with S-mephenytoin 4′-hydroxylation
    • Chiba K, Kobayashi K, Manabe K, et al. Oxidative metabolism of omeprazole in human liver microsomes: consegregation with S-mephenytoin 4′-hydroxylation. J Pharmacol Exp Ther 1993; 266: 52-9
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 52-59
    • Chiba, K.1    Kobayashi, K.2    Manabe, K.3
  • 153
    • 0028923801 scopus 로고
    • Oxidative metabolism of lansoprazole by human liver cytochromes P450
    • Pichard L, Curi-Pedrosa R, Bonfils C, et al. Oxidative metabolism of lansoprazole by human liver cytochromes P450. Mol Pharmacol 1995; 47: 410-8
    • (1995) Mol Pharmacol , vol.47 , pp. 410-418
    • Pichard, L.1    Curi-Pedrosa, R.2    Bonfils, C.3
  • 154
    • 0030938161 scopus 로고    scopus 로고
    • Metabolic disposition of lansoprazole in relation to the S-mephenytoin 4′-hydroxylation phenotype status
    • Sohn DR, Kwon JT, Kim HK, et al. Metabolic disposition of lansoprazole in relation to the S-mephenytoin 4′-hydroxylation phenotype status. Clin Pharmacol Ther 1997; 61: 574-82
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 574-582
    • Sohn, D.R.1    Kwon, J.T.2    Kim, H.K.3
  • 155
    • 0029977698 scopus 로고    scopus 로고
    • Pharmacokinetics, metabolism and interactions of acid pump inhibitors: Focus on omeprazole, lansoprazole and pantoprazole
    • Andersson T. Pharmacokinetics, metabolism and interactions of acid pump inhibitors: focus on omeprazole, lansoprazole and pantoprazole. Clin Pharmacokinet 1996; 31: 9-28
    • (1996) Clin Pharmacokinet , vol.31 , pp. 9-28
    • Andersson, T.1
  • 156
    • 0029083823 scopus 로고
    • Comparison of the kinetic disposition and metabolism of E3810, a new proton pump inhibitor, and omeprazole in relation to S-mephenytoin 4′-hydroxylation status
    • Yasuda SU, Horai Y, Tomono Y, et al. Comparison of the kinetic disposition and metabolism of E3810, a new proton pump inhibitor, and omeprazole in relation to S-mephenytoin 4′-hydroxylation status. Clin Pharmacol Ther 1995: 58: 143-54
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 143-154
    • Yasuda, S.U.1    Horai, Y.2    Tomono, Y.3
  • 157
    • 0029872402 scopus 로고    scopus 로고
    • Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor
    • VandenBranden M, Ring BJ, Binkley SN, et al. Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor. Pharmacogenetics 1996; 6: 81-91
    • (1996) Pharmacogenetics , vol.6 , pp. 81-91
    • VandenBranden, M.1    Ring, B.J.2    Binkley, S.N.3
  • 158
    • 0033787393 scopus 로고    scopus 로고
    • Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: Roles of cytochromes P450, 2C9, 2C19, and 3A4
    • Komatsu T, Yamazaki H, Asahi S, et al. Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450, 2C9, 2C19, and 3A4. Drug Metab Dispos 2000; 28 (11): 1361-8
    • (2000) Drug Metab Dispos , vol.28 , Issue.11 , pp. 1361-1368
    • Komatsu, T.1    Yamazaki, H.2    Asahi, S.3
  • 159
    • 0021125904 scopus 로고
    • Stereoselective metabolism and pharmacogenetic control of 5-phenyl-5-ethyl-hydantoin (nirvanol) in humans
    • Kupfer A, Patwardhan R, Ward SA, et al. Stereoselective metabolism and pharmacogenetic control of 5-phenyl-5-ethyl-hydantoin (nirvanol) in humans. J Pharmacol Exp Ther 1984; 230: 28-33
    • (1984) J Pharmacol Exp Ther , vol.230 , pp. 28-33
    • Kupfer, A.1    Patwardhan, R.2    Ward, S.A.3
  • 160
    • 0025358273 scopus 로고
    • Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects
    • Schellens JH, van der Wart JH, Breimer DD. Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects. Br J Clin Pharmacol 1990; 29: 665-71
    • (1990) Br J Clin Pharmacol , vol.29 , pp. 665-671
    • Schellens, J.H.1    Van der Wart, J.H.2    Breimer, D.D.3
  • 161
    • 0027935778 scopus 로고
    • Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms
    • Andersson T, Miners JO, Veronese ME, et al. Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms. Br J Clin Pharmacol 1994; 38: 131-7
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 131-137
    • Andersson, T.1    Miners, J.O.2    Veronese, M.E.3
  • 162
    • 0027744044 scopus 로고
    • Cytochrome P450 medicated metabolism of diazepam in human and rat: Involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner
    • Yasumori T, Nagata K, Yang SK, et al. Cytochrome P450 medicated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner. Pharmacogenetics 1993; 3: 291-301
    • (1993) Pharmacogenetics , vol.3 , pp. 291-301
    • Yasumori, T.1    Nagata, K.2    Yang, S.K.3
  • 163
    • 0032700187 scopus 로고    scopus 로고
    • Flunitrazepam oxidative metabolism in human liver microsomes: Involvement of CYP2C19 and CYP3A4
    • Coller JK, Somogyi AA, Bochner F. Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4. Xenobiotica 1999; 29: 973-86
    • (1999) Xenobiotica , vol.29 , pp. 973-986
    • Coller, J.K.1    Somogyi, A.A.2    Bochner, F.3
  • 164
    • 0034037772 scopus 로고    scopus 로고
    • CYP2C19 polymorphism effect on phenobarbitone: Pharmacokinetics in Japanese patients with epilepsy: Analysis by population pharmacokinetics
    • Mamiya K, Hadama A, Yukawa E, et al. CYP2C19 polymorphism effect on phenobarbitone: pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics. Eur J Clin Pharmacol 2000; 55: 821-5
    • (2000) Eur J Clin Pharmacol , vol.55 , pp. 821-825
    • Mamiya, K.1    Hadama, A.2    Yukawa, E.3
  • 165
    • 0025253095 scopus 로고
    • Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2
    • Yasumori T, Murayama N, Yamazoe Y, et al. Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2. Clin Pharmacol Ther 1990; 47: 313-22
    • (1990) Clin Pharmacol Ther , vol.47 , pp. 313-322
    • Yasumori, T.1    Murayama, N.2    Yamazoe, Y.3
  • 166
    • 0022212549 scopus 로고
    • Steroselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation
    • Kupfer A, Branch RA. Steroselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation. Clin Pharmacol Ther 1985; 38: 414-8
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 414-418
    • Kupfer, A.1    Branch, R.A.2
  • 167
    • 0035149429 scopus 로고    scopus 로고
    • Role of CYP2C19 in stereoselective hydroxylation of mephobarbital by human liver microsomes
    • Kobayashi K, Kogo M, Tani M, et al. Role of CYP2C19 in stereoselective hydroxylation of mephobarbital by human liver microsomes. Drug Metab Dispos 2001; 29: 36-40
    • (2001) Drug Metab Dispos , vol.29 , pp. 36-40
    • Kobayashi, K.1    Kogo, M.2    Tani, M.3
  • 168
    • 0028214383 scopus 로고
    • Carisoprodol elimination in humans
    • Olsen H, Koppang E, Alvan G, et al. Carisoprodol elimination in humans. Ther Drug Monit 1994; 16: 337-40
    • (1994) Ther Drug Monit , vol.16 , pp. 337-340
    • Olsen, H.1    Koppang, E.2    Alvan, G.3
  • 169
    • 0029819847 scopus 로고    scopus 로고
    • Formation of meprobamate from carisoprodol is catalysed by CYP2C19
    • Dalen P, Alvan G, Wakelkamp M, et al. Formation of meprobamate from carisoprodol is catalysed by CYP2C19. Pharmacogenetics 1996; 6 (5): 387-94
    • (1996) Pharmacogenetics , vol.6 , Issue.5 , pp. 387-394
    • Dalen, P.1    Alvan, G.2    Wakelkamp, M.3
  • 170
    • 0028864296 scopus 로고
    • Comparison of chloroguanide and mephenytoin for the in vivo assessment of genetically determined CYP2C19 activity in humans
    • Partovian C, Jacqz-Aigrain E, Keundjian A, et al. Comparison of chloroguanide and mephenytoin for the in vivo assessment of genetically determined CYP2C19 activity in humans. Clin Pharmacol Ther 1995; 58: 257-63
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 257-263
    • Partovian, C.1    Jacqz-Aigrain, E.2    Keundjian, A.3
  • 171
    • 0025307263 scopus 로고
    • In vitro metabolism of the biguanide antimalarials in human liver microsomes: Evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme
    • Helsby NA, Ward SA, Howells RE, et al. In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme. Br J Clin Pharmacol 1990; 30: 287-91
    • (1990) Br J Clin Pharmacol , vol.30 , pp. 287-291
    • Helsby, N.A.1    Ward, S.A.2    Howells, R.E.3
  • 172
    • 0028228630 scopus 로고
    • In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase
    • Birkett DJ, Rees DL, Andersson T, et al. In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase. Br J Clin Pharmacol 1994; 37: 413-20
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 413-420
    • Birkett, D.J.1    Rees, D.L.2    Andersson, T.3
  • 173
    • 0028903810 scopus 로고
    • The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides
    • Wright JD, Helsby NA, Ward SA. The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides. Br J Clin Pharmacol 1995; 39: 441-4
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 441-444
    • Wright, J.D.1    Helsby, N.A.2    Ward, S.A.3
  • 174
    • 0027472058 scopus 로고
    • Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms
    • Sindrup SH, Brosen K, Hansen MG, et al. Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms. Ther Drug Monit 1993; 15: 11-7
    • (1993) Ther Drug Monit , vol.15 , pp. 11-17
    • Sindrup, S.H.1    Brosen, K.2    Hansen, M.G.3
  • 175
    • 0032587641 scopus 로고    scopus 로고
    • Effect of the CYP2D6*10 genotype on venlafaxine pharmacokinetics in healthy adult volunteers
    • Fukuda T, Yamamoto I, Nishida Y, et al. Effect of the CYP2D6*10 genotype on venlafaxine pharmacokinetics in healthy adult volunteers. Br J Clin Pharmacol 1999; 47: 450-3
    • (1999) Br J Clin Pharmacol , vol.47 , pp. 450-453
    • Fukuda, T.1    Yamamoto, I.2    Nishida, Y.3
  • 176
    • 0025964524 scopus 로고
    • The mephenytoin oxidation polymorphism is partially responsible for
    • Skjelbo E, Brosen K, Hallas J, et al. The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine. Clin Pharmacol Ther 1991; 49: 18-23
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 18-23
    • Skjelbo, E.1    Brosen, K.2    Hallas, J.3
  • 177
    • 0027389155 scopus 로고
    • The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R-ratio): A population study
    • Skjelbo E, Gram LF, Brosen K. The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R-ratio): a population study. Br J Clin Pharmacol 1993; 35: 331-4
    • (1993) Br J Clin Pharmacol , vol.35 , pp. 331-334
    • Skjelbo, E.1    Gram, L.F.2    Brosen, K.3
  • 178
    • 0027945112 scopus 로고
    • Metabolic disposition of imipramine in oriental subjects: Relation to metoprolol alpha-hydroxylation and S-mephenytoin 4′-hydroxylation phenotypes
    • Koyama E, Sohn DR, Shin SG, et al. Metabolic disposition of imipramine in oriental subjects: relation to metoprolol alpha-hydroxylation and S-mephenytoin 4′-hydroxylation phenotypes. J Pharmacol Exp Ther 1994; 271: 860-7
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 860-867
    • Koyama, E.1    Sohn, D.R.2    Shin, S.G.3
  • 179
    • 0028303496 scopus 로고
    • Single-dose kinetics of clomipramine: Relationship to the sparteine and S-mephenytoin oxidation polymorphisms
    • Nielsen KK, Brosen K, Hansen MG, et al. Single-dose kinetics of clomipramine: relationship to the sparteine and S-mephenytoin oxidation polymorphisms. Clin Pharmacol Ther 1994; 55: 518-27
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 518-527
    • Nielsen, K.K.1    Brosen, K.2    Hansen, M.G.3
  • 180
    • 0034072429 scopus 로고    scopus 로고
    • Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19- and CYP3A4/5-phenotyped patients
    • Eap CB, Bender S, Gastpar M, et al. Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19- and CYP3A4/5-phenotyped patients. Ther Drug Monit 2000; 22: 209-14
    • (2000) Ther Drug Monit , vol.22 , pp. 209-214
    • Eap, C.B.1    Bender, S.2    Gastpar, M.3
  • 181
    • 0026469799 scopus 로고
    • Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes
    • Breyer-Pfaff U, Pfandl B, Nill K, et al. Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes. Clin Pharmacol Ther 1992; 52: 350-8
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 350-358
    • Breyer-Pfaff, U.1    Pfandl, B.2    Nill, K.3
  • 182
    • 0030992855 scopus 로고    scopus 로고
    • Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes
    • Olesen OV, Linnet K. Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes. Drug Metab Dispos 1997; 25: 740-4
    • (1997) Drug Metab Dispos , vol.25 , pp. 740-744
    • Olesen, O.V.1    Linnet, K.2
  • 183
    • 0029897864 scopus 로고    scopus 로고
    • Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin
    • Eap CB, Guentert TW, Schaublin-Loidl M, et al. Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin. Clin Pharmacol Ther 1996; 59: 322-31
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 322-331
    • Eap, C.B.1    Guentert, T.W.2    Schaublin-Loidl, M.3
  • 184
    • 0024534047 scopus 로고
    • Propanolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities
    • Ward SA, Walle T, Walle UK, et al. Propanolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities. Clin Pharmacol Ther 1989; 45: 72-9
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 72-79
    • Ward, S.A.1    Walle, T.2    Walle, U.K.3
  • 185
    • 0031856787 scopus 로고    scopus 로고
    • Characterization of cyp2c19 and cyp2c9 from human liver: Respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations
    • Lasker JM, Wester MR, Aramsombatdee E, et al. Characterization of cyp2c19 and cyp2c9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. Arch Biochem Biophys 1998; 353: 16-28
    • (1998) Arch Biochem Biophys , vol.353 , pp. 16-28
    • Lasker, J.M.1    Wester, M.R.2    Aramsombatdee, E.3
  • 186
    • 0029867317 scopus 로고    scopus 로고
    • Formation of (R)-8-hydroxywarfarin in human liver microsomes: A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19
    • Wienkers LC, Wurden CJ, Storch E, et al. Formation of (R)-8-hydroxywarfarin in human liver microsomes: a new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19. Drug Metab Dispos 1996; 24: 610-4
    • (1996) Drug Metab Dispos , vol.24 , pp. 610-614
    • Wienkers, L.C.1    Wurden, C.J.2    Storch, E.3
  • 187
    • 0035134941 scopus 로고    scopus 로고
    • Role of cytochrome P450 in estradiol metabolism in vitro
    • Cheng ZN, Shu Y, Liu ZQ, et al. Role of cytochrome P450 in estradiol metabolism in vitro. Acta Pharmacol Sin 2001: 22: 148-54
    • (2001) Acta Pharmacol Sin , vol.22 , pp. 148-154
    • Cheng, Z.N.1    Shu, Y.2    Liu, Z.Q.3
  • 188
    • 0032239288 scopus 로고    scopus 로고
    • The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel
    • Gentile DM, Verhoeven CH, Shimada T, et al. The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel. J Pharmacol Exp Ther 1998; 287: 975-82
    • (1998) J Pharmacol Exp Ther , vol.287 , pp. 975-982
    • Gentile, D.M.1    Verhoeven, C.H.2    Shimada, T.3
  • 189
    • 0030758131 scopus 로고    scopus 로고
    • Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation
    • Chang TK, Yu L, Goldstein JA, et al. Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation. Pharmacogenetics 1997; 7: 211-21
    • (1997) Pharmacogenetics , vol.7 , pp. 211-221
    • Chang, T.K.1    Yu, L.2    Goldstein, J.A.3
  • 190
    • 0029582977 scopus 로고
    • The role of human cytochrome P450 enzymes in the metabolism of anticancer agents; implications for drug interactions
    • Kivisto KT, Kroemer HK, Eichelbaum M. The role of human cytochrome P450 enzymes in the metabolism of anticancer agents; implications for drug interactions. Br J Clin Pharmacol 1995; 40: 523-30
    • (1995) Br J Clin Pharmacol , vol.40 , pp. 523-530
    • Kivisto, K.T.1    Kroemer, H.K.2    Eichelbaum, M.3
  • 191
    • 0030434074 scopus 로고    scopus 로고
    • Proton pump inhibitory therapy: Then and now
    • Schepp W. Proton pump inhibitory therapy: then and now. Yale J Biol Med 1996; 69: 175-86
    • (1996) Yale J Biol Med , vol.69 , pp. 175-186
    • Schepp, W.1
  • 192
    • 0028926928 scopus 로고
    • The pharmacology of the gastric acid pump: The H+, K+ ATPase
    • Sachs G, Shin JM, Briving C, et al. The pharmacology of the gastric acid pump: the H+, K+ ATPase. Annu Rev Pharmacol Toxicol 1995; 35: 277-305
    • (1995) Annu Rev Pharmacol Toxicol , vol.35 , pp. 277-305
    • Sachs, G.1    Shin, J.M.2    Briving, C.3
  • 193
    • 0000136169 scopus 로고    scopus 로고
    • Are the orally administered proton pump inhibitors equivalent?: A comparison of lansoprazole, omeprazole, pantoprazole, and rabeprazole
    • Thomson AB. Are the orally administered proton pump inhibitors equivalent?: a comparison of lansoprazole, omeprazole, pantoprazole, and rabeprazole. Curr Gastroenterol Rep 2000; 2: 482-93
    • (2000) Curr Gastroenterol Rep , vol.2 , pp. 482-493
    • Thomson, A.B.1
  • 194
    • 0027145018 scopus 로고
    • Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism
    • Andersson T, Miners JO, Veronese ME, et al. Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism. Br J Clin Pharmacol 1993; 36: 521-30
    • (1993) Br J Clin Pharmacol , vol.36 , pp. 521-530
    • Andersson, T.1    Miners, J.O.2    Veronese, M.E.3
  • 195
    • 0033856082 scopus 로고    scopus 로고
    • Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes
    • Abelo A, Andersson TB, Antonsson M, et al. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metab Dispos 2000; 28: 966-72
    • (2000) Drug Metab Dispos , vol.28 , pp. 966-972
    • Abelo, A.1    Andersson, T.B.2    Antonsson, M.3
  • 196
    • 0030430339 scopus 로고    scopus 로고
    • Identification of the human P450 enzymes involved in lansoprazole metabolism
    • Pearce RE, Rodrigues AD, Goldstein JA, et al. Identification of the human P450 enzymes involved in lansoprazole metabolism. J Pharmacol Exp Ther 1996; 277: 805-16
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 805-816
    • Pearce, R.E.1    Rodrigues, A.D.2    Goldstein, J.A.3
  • 197
    • 0028276695 scopus 로고
    • Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism
    • Andersson T, Miners JO, Veronese ME, et al. Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism. Br J Clin Pharmacol 1994; 37: 597-604
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 597-604
    • Andersson, T.1    Miners, J.O.2    Veronese, M.E.3
  • 198
    • 0034061821 scopus 로고    scopus 로고
    • Pharmacokinetic considerations in the eradication of Helicobacter pylori
    • Klotz U. Pharmacokinetic considerations in the eradication of Helicobacter pylori. Clin Pharmacokinet 2000; 38: 243-70
    • (2000) Clin Pharmacokinet , vol.38 , pp. 243-270
    • Klotz, U.1
  • 199
    • 0034935013 scopus 로고    scopus 로고
    • Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole
    • Andersson T, Hassan-Alin M, Hasselgren G, et al. Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole. Clin Pharmacokinet 2001; 40: 411-26
    • (2001) Clin Pharmacokinet , vol.40 , pp. 411-426
    • Andersson, T.1    Hassan-Alin, M.2    Hasselgren, G.3
  • 200
    • 0030803665 scopus 로고    scopus 로고
    • Enantioselective hydroxylation of omeprazole catalyzed by CYP2C19 in Swedish white subjects
    • Tybring G, Bottiger Y, Widen J, et al. Enantioselective hydroxylation of omeprazole catalyzed by CYP2C19 in Swedish white subjects. Clin Pharmacol Ther 1997; 62: 129-37
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 129-137
    • Tybring, G.1    Bottiger, Y.2    Widen, J.3
  • 201
    • 0029944431 scopus 로고    scopus 로고
    • Determination of R(+)-and S(-)-lansoprazole using chiral stationary-phase liquid chromatography and their enantioselective pharmacokinetics in humans
    • Katsuki H, Yagi H, Arimori K, et al. Determination of R(+)-and S(-)-lansoprazole using chiral stationary-phase liquid chromatography and their enantioselective pharmacokinetics in humans. Pharm Res 1996; 13 (4): 611-5
    • (1996) Pharm Res , vol.13 , Issue.4 , pp. 611-615
    • Katsuki, H.1    Yagi, H.2    Arimori, K.3
  • 202
    • 0035103370 scopus 로고    scopus 로고
    • Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in extensive and poor metabolizers of S-mephenytoin
    • Tanaka M, Ohkubo T, Otani K, et al. Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in extensive and poor metabolizers of S-mephenytoin. Clin Pharmacol Ther 2001; 69: 108-13
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 108-113
    • Tanaka, M.1    Ohkubo, T.2    Otani, K.3
  • 203
    • 0025100774 scopus 로고
    • The pharmacokinetics of omeprazole in humans: A study of single intravenous and oral doses
    • Regardh CG, Andersson T, Lagerstrom PO, et al. The pharmacokinetics of omeprazole in humans: a study of single intravenous and oral doses. Ther Drug Monit 1990; 12: 163-72
    • (1990) Ther Drug Monit , vol.12 , pp. 163-172
    • Regardh, C.G.1    Andersson, T.2    Lagerstrom, P.O.3
  • 204
    • 0031910445 scopus 로고    scopus 로고
    • Pharmacokinetics and effect on caffeine metabolism of the proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole
    • Andersson T, Holmberg J, Rohss K, et al. Pharmacokinetics and effect on caffeine metabolism of the proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole. J Clin Pharmacol 1998; 45: 369-75
    • (1998) J Clin Pharmacol , vol.45 , pp. 369-375
    • Andersson, T.1    Holmberg, J.2    Rohss, K.3
  • 205
    • 0033003579 scopus 로고    scopus 로고
    • CYP2C19 genotypes and omeprazole metabolism after single and repeated dosing when combined with clarithromycin
    • Zhou Q, Yamamoto I, Fukuda T, et al. CYP2C19 genotypes and omeprazole metabolism after single and repeated dosing when combined with clarithromycin. Eur J Clin Pharmacol 1999; 55: 43-7
    • (1999) Eur J Clin Pharmacol , vol.55 , pp. 43-47
    • Zhou, Q.1    Yamamoto, I.2    Fukuda, T.3
  • 206
    • 0029043462 scopus 로고
    • Interphenotype differences in disposition and effect on gastrin levels of omeprazole- suitability of omeprazole as a probe for CYP2C19
    • Chang M, Tybring G, Dahl ML, et al. Interphenotype differences in disposition and effect on gastrin levels of omeprazole- suitability of omeprazole as a probe for CYP2C19. Br J Clin Pharmacol 1995; 39: 511-8
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 511-518
    • Chang, M.1    Tybring, G.2    Dahl, M.L.3
  • 207
    • 0032586730 scopus 로고    scopus 로고
    • CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans
    • Furuta T, Ohashi K, Kosuge K, et al. CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans. Clin Pharmacol Ther 1999; 65: 552-61
    • (1999) Clin Pharmacol Ther , vol.65 , pp. 552-561
    • Furuta, T.1    Ohashi, K.2    Kosuge, K.3
  • 208
    • 0033694865 scopus 로고    scopus 로고
    • Omeprazole and CYP2C19 polymorphism: Effects of long-term treatment on gastrin, pepsinogen I, and chromogranin A in patients with acid related disorders
    • Sagar M, Bertilsson L, Stridsberg M, et al. Omeprazole and CYP2C19 polymorphism: effects of long-term treatment on gastrin, pepsinogen I, and chromogranin A in patients with acid related disorders. Aliment Pharmacol Ther 2000; 14: 1495-502
    • (2000) Aliment Pharmacol Ther , vol.14 , pp. 1495-1502
    • Sagar, M.1    Bertilsson, L.2    Stridsberg, M.3
  • 209
    • 0000140377 scopus 로고    scopus 로고
    • Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer
    • Furuta T, Ohashi K, Kamata T, et al. Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med 1998; 129: 1027-30
    • (1998) Ann Intern Med , vol.129 , pp. 1027-1030
    • Furuta, T.1    Ohashi, K.2    Kamata, T.3
  • 210
    • 0033383967 scopus 로고    scopus 로고
    • Sufficient effect of 1-week omeprazole and amoxicillin dual treatment for Helicobacter pylori eradication in cytochrome P450 2C19 poor metabolizers
    • Aoyama N, Tanigawara Y, Kita T, et al. Sufficient effect of 1-week omeprazole and amoxicillin dual treatment for Helicobacter pylori eradication in cytochrome P450 2C19 poor metabolizers. J Gastroenterol 1999; 34 Suppl. 11: 80-3
    • (1999) J Gastroenterol , vol.34 , pp. 80-83
    • Aoyama, N.1    Tanigawara, Y.2    Kita, T.3
  • 211
    • 0000334112 scopus 로고    scopus 로고
    • CYP2C19 genotype-related efficacy of omeprazole for the treatment of infection caused by Helicobacter pylori
    • Tanigawara Y, Aoyama N, Kita T, et al. CYP2C19 genotype-related efficacy of omeprazole for the treatment of infection caused by Helicobacter pylori. Clin Pharmacol Ther 1999; 66: 528-34
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 528-534
    • Tanigawara, Y.1    Aoyama, N.2    Kita, T.3
  • 212
    • 0034047729 scopus 로고    scopus 로고
    • Cure of refractory duodenal ulcer and infection caused by Helicobacter pylori by high doses of omeprazole and amoxicillin in a homozygous CYP2C19 extensive metabolizer patient
    • Furuta T, Takashima M, Shirai N, et al. Cure of refractory duodenal ulcer and infection caused by Helicobacter pylori by high doses of omeprazole and amoxicillin in a homozygous CYP2C19 extensive metabolizer patient. Clin Pharmacol Ther 2000; 67: 684-9
    • (2000) Clin Pharmacol Ther , vol.67 , pp. 684-689
    • Furuta, T.1    Takashima, M.2    Shirai, N.3
  • 213
    • 0033793888 scopus 로고    scopus 로고
    • CYP2C19 genotype status and intragastric pH during dosing with lansoprazole or rabeprazole
    • Adachi K, Katsube T, Kawamura A, et al. CYP2C19 genotype status and intragastric pH during dosing with lansoprazole or rabeprazole. Aliment Pharmacol Ther 2000; 14: 1259-66
    • (2000) Aliment Pharmacol Ther , vol.14 , pp. 1259-1266
    • Adachi, K.1    Katsube, T.2    Kawamura, A.3
  • 214
    • 0034977147 scopus 로고    scopus 로고
    • Effects of genotypic differences in CYP2C19 status on cure rates for Helicobacter pylori infection by dual therapy with rabeprazole plus amoxicillin
    • Furuta T, Shirai N, Takashima M, et al. Effects of genotypic differences in CYP2C19 status on cure rates for Helicobacter pylori infection by dual therapy with rabeprazole plus amoxicillin. Pharmacogenetics 2001; 11: 341-8
    • (2001) Pharmacogenetics , vol.11 , pp. 341-348
    • Furuta, T.1    Shirai, N.2    Takashima, M.3
  • 215
    • 0034851652 scopus 로고    scopus 로고
    • Efficacy of triple therapy with rabeprazole for Helicobacter pylori infection and CYP2C19 genetic polymorphism
    • Hokari K, Sugiyama T, Kato M, et al. Efficacy of triple therapy with rabeprazole for Helicobacter pylori infection and CYP2C19 genetic polymorphism. Aliment Pharmacol Ther 2001; 15: 1479-84
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1479-1484
    • Hokari, K.1    Sugiyama, T.2    Kato, M.3
  • 216
    • 0032843591 scopus 로고    scopus 로고
    • Effects of clarithromycin on the metabolism of omeprazole in relation to CYP2C19 genotype status in humans
    • Furuta T, Ohashi K, Kobayashi K, et al. Effects of clarithromycin on the metabolism of omeprazole in relation to CYP2C19 genotype status in humans. Clin Pharmacol Ther 1999; 66: 265-74
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 265-274
    • Furuta, T.1    Ohashi, K.2    Kobayashi, K.3
  • 217
    • 0030662173 scopus 로고    scopus 로고
    • Inhibition of the sulfoxidation of omeprazole by ketoconazole in poor and extensive metabolizers of S-mephenytoin
    • Bottiger Y, Tybring G, Gotharson E, et al. Inhibition of the sulfoxidation of omeprazole by ketoconazole in poor and extensive metabolizers of S-mephenytoin. Clin Pharmacol Ther 1997; 62: 384-91
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 384-391
    • Bottiger, Y.1    Tybring, G.2    Gotharson, E.3
  • 218
    • 0034691064 scopus 로고    scopus 로고
    • St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
    • Moore LB, Goodwin B, Jones SA, et al. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proc Natl Acad Sci U S A 2000; 97: 7500-2
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7500-7502
    • Moore, L.B.1    Goodwin, B.2    Jones, S.A.3
  • 219
    • 0034676513 scopus 로고    scopus 로고
    • Use of the nuclear receptor PXR to predict drug interactions
    • Moore JT, Kliewer SA. Use of the nuclear receptor PXR to predict drug interactions. Toxicology 2000; 153: 1-10
    • (2000) Toxicology , vol.153 , pp. 1-10
    • Moore, J.T.1    Kliewer, S.A.2
  • 221
    • 0030016683 scopus 로고    scopus 로고
    • Diazepam-omeprazole inhibition interaction: An in vitro investigation using liver microsomes
    • Zomorodi K, Houston JB. Diazepam-omeprazole inhibition interaction: an in vitro investigation using liver microsomes. Br J Clin Pharmacol 1996; 42: 157-62
    • (1996) Br J Clin Pharmacol , vol.42 , pp. 157-162
    • Zomorodi, K.1    Houston, J.B.2
  • 222
    • 0022398138 scopus 로고
    • Omeprazole inhibits oxidative drug metabolism: Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro
    • Gugler R, Jensen JC. Omeprazole inhibits oxidative drug metabolism: studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro. Gastroenterology 1985; 89: 1235-41
    • (1985) Gastroenterology , vol.89 , pp. 1235-1241
    • Gugler, R.1    Jensen, J.C.2
  • 223
  • 224
    • 0033496008 scopus 로고    scopus 로고
    • Effect of omeprazole on the metabolism of cilostazol
    • Suri A, Bramer SL. Effect of omeprazole on the metabolism of cilostazol. Clin Pharmacokinet 1999; 37 Suppl. 2: 53-9
    • (1999) Clin Pharmacokinet , vol.37 , pp. 53-59
    • Suri, A.1    Bramer, S.L.2
  • 225
    • 0028051743 scopus 로고
    • Specific and dose-dependent enzyme induction by omeprazole in human beings
    • Rost KL, Brosicke H, Heinemeyer G, et al. Specific and dose-dependent enzyme induction by omeprazole in human beings. Hepatology 1994; 20: 1204-12
    • (1994) Hepatology , vol.20 , pp. 1204-1212
    • Rost, K.L.1    Brosicke, H.2    Heinemeyer, G.3
  • 226
    • 0034983922 scopus 로고    scopus 로고
    • Effect of omeprazole on the pharmacokinetics of sustained-release carbamazepine in healthy male volunteers
    • Dixit RK, Chawla AB, Kumar N, et al. Effect of omeprazole on the pharmacokinetics of sustained-release carbamazepine in healthy male volunteers. Methods Find Exp Clin Pharmacol 2001; 23: 37-9
    • (2001) Methods Find Exp Clin Pharmacol , vol.23 , pp. 37-39
    • Dixit, R.K.1    Chawla, A.B.2    Kumar, N.3
  • 227
    • 0025368026 scopus 로고
    • Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450
    • Diaz D, Fabre I, Daujat M, et al. Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450. Gastroenterology 1990; 99: 737-47
    • (1990) Gastroenterology , vol.99 , pp. 737-747
    • Diaz, D.1    Fabre, I.2    Daujat, M.3
  • 229
    • 0028336745 scopus 로고
    • Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva
    • Fuhr U, Rost KL. Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva. Pharmacogenetics 1994; 4: 109-16
    • (1994) Pharmacogenetics , vol.4 , pp. 109-116
    • Fuhr, U.1    Rost, K.L.2
  • 230
    • 0028240671 scopus 로고
    • Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolic ratios: Coincidence with plasma clearance and breath test
    • Rost KL, Roots I. Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolic ratios: coincidence with plasma clearance and breath test. Clin Pharmacol Ther 1994; 55: 402-11
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 402-411
    • Rost, K.L.1    Roots, I.2
  • 231
    • 0028197212 scopus 로고
    • Four-week treatment with omeprazole increases the metabolism of caffeine
    • Nousbaum JB, Berthou F, Carlhant D, et al. Four-week treatment with omeprazole increases the metabolism of caffeine. Am J Gastroenterol 1994; 89: 371-5
    • (1994) Am J Gastroenterol , vol.89 , pp. 371-375
    • Nousbaum, J.B.1    Berthou, F.2    Carlhant, D.3
  • 232
    • 0029931568 scopus 로고    scopus 로고
    • Lack of pantoprazole drug interactions in man: An updated review
    • Steinijans VW, Huber R, Hartmann M, et al. Lack of pantoprazole drug interactions in man: an updated review. Int J Clin Pharmacol Ther 1996; 34: 243-62
    • (1996) Int J Clin Pharmacol Ther , vol.34 , pp. 243-262
    • Steinijans, V.W.1    Huber, R.2    Hartmann, M.3
  • 233
    • 0036338758 scopus 로고    scopus 로고
    • Enantioselective disposition of lansoprazole in extensive and poor metabolizers of CYP2C19
    • Kim KA, Shon JH, Park JY, et al. Enantioselective disposition of lansoprazole in extensive and poor metabolizers of CYP2C19. Clin Pharmacol Ther 2000; 72: 90-9
    • (2000) Clin Pharmacol Ther , vol.72 , pp. 90-99
    • Kim, K.A.1    Shon, J.H.2    Park, J.Y.3
  • 234
    • 0032868028 scopus 로고    scopus 로고
    • Lack of drug interaction between omeprazole, lansoprazole, pantoprazole and theophylline
    • Dilger K, Zheng Z, Klotz U. Lack of drug interaction between omeprazole, lansoprazole, pantoprazole and theophylline. Br J Clin Pharmacol 1999; 48: 438-44
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 438-444
    • Dilger, K.1    Zheng, Z.2    Klotz, U.3
  • 235
    • 0026543515 scopus 로고
    • Theophylline steady state pharmacokinetics is not altered by omeprazole
    • Taubert AM, Geneve J, Bocquentin M, et al. Theophylline steady state pharmacokinetics is not altered by omeprazole. Eur J Clin Pharmacol 1992; 42: 343-5
    • (1992) Eur J Clin Pharmacol , vol.42 , pp. 343-345
    • Taubert, A.M.1    Geneve, J.2    Bocquentin, M.3
  • 236
    • 0032976824 scopus 로고    scopus 로고
    • Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers
    • Ko JW, Jang IJ, Shin JG, et al. Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers. Clin Pharmacol Ther 1999; 65: 606-14
    • (1999) Clin Pharmacol Ther , vol.65 , pp. 606-614
    • Ko, J.W.1    Jang, I.J.2    Shin, J.G.3
  • 237
    • 0033621625 scopus 로고    scopus 로고
    • Vitamin B12 levels during prolonged treatment with proton pump inhibitors
    • Howden CW. Vitamin B12 levels during prolonged treatment with proton pump inhibitors. J Clin Gastroenterol 2000; 30: 29-33
    • (2000) J Clin Gastroenterol , vol.30 , pp. 29-33
    • Howden, C.W.1
  • 238
    • 0032917214 scopus 로고    scopus 로고
    • Effect of CYP2C19 polymorphism on serum levels of vitamin B12 in patients on long-term omeprazole treatment
    • Sagar M, Janczewska I, Ljungdahl A, et al. Effect of CYP2C19 polymorphism on serum levels of vitamin B12 in patients on long-term omeprazole treatment. Aliment Pharmacol Ther 1999; 13: 453-8
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 453-458
    • Sagar, M.1    Janczewska, I.2    Ljungdahl, A.3
  • 239
    • 0029842475 scopus 로고    scopus 로고
    • Cobalamin deficiency with megaloblastic anemia in one patient under long-term omeprazole therapy
    • Bellou A, Aimone-Gastin I, De Korwin JD, et al. Cobalamin deficiency with megaloblastic anemia in one patient under long-term omeprazole therapy. J Intern Med 1996; 240: 161-4
    • (1996) J Intern Med , vol.240 , pp. 161-164
    • Bellou, A.1    Aimone-Gastin, I.2    De Korwin, J.D.3
  • 240
    • 10544248170 scopus 로고    scopus 로고
    • The cytochrome P450 2D6 (CYP2D6) enzyme polymorphism: Screening costs and influence on clinical outcomes in psychiatry
    • Chen S, Chou WH, Blouin RA, et al. The cytochrome P450 2D6 (CYP2D6) enzyme polymorphism: screening costs and influence on clinical outcomes in psychiatry. Clin Pharmacol Ther 1996; 60: 522-34
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 522-534
    • Chen, S.1    Chou, W.H.2    Blouin, R.A.3
  • 241
    • 0034255677 scopus 로고    scopus 로고
    • A SNPshot: Pharmacogenetics and the future of drug therapy
    • Pfost DR, Boyce-Jacino MT, Grant DM. A SNPshot: pharmacogenetics and the future of drug therapy. Trends Biotechnol 2000; 18: 334-8
    • (2000) Trends Biotechnol , vol.18 , pp. 334-338
    • Pfost, D.R.1    Boyce-Jacino, M.T.2    Grant, D.M.3
  • 242
    • 17344390256 scopus 로고    scopus 로고
    • Clinical pharmacology: Blue-chip technology
    • Flockhart DA, Webb DJ. Clinical pharmacology: blue-chip technology. Lancet 1998; 352 Suppl. 4: SIV2
    • (1998) Lancet , vol.352 , pp. SIV2
    • Flockhart, D.A.1    Webb, D.J.2
  • 243
    • 0010802276 scopus 로고    scopus 로고
    • Valley Forge (PA): Amerisource Corporation
    • Amerisource Corporation. Average wholesales prices of drugs. Valley Forge (PA): Amerisource Corporation, 2001
    • (2001) Average Wholesales Prices of Drugs
  • 246
    • 0031034344 scopus 로고    scopus 로고
    • Diazepam metabolism by cDNA-expressed human 2C P450s: Identification of P4502C18 and P4502C19 as low KM diazepam N-demethylases
    • Jung F, Richardson TH, Raucy JL, et al. Diazepam metabolism by cDNA-expressed human 2C P450s: identification of P4502C18 and P4502C19 as low KM diazepam N-demethylases. Drug Metab Dispos 1997; 25: 133-9
    • (1997) Drug Metab Dispos , vol.25 , pp. 133-139
    • Jung, F.1    Richardson, T.H.2    Raucy, J.L.3
  • 247
    • 0028589604 scopus 로고
    • Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4′-hydroxylation
    • Yasumori T, Li QH, Yamazoe Y, et al. Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4′-hydroxylation. Pharmacogenetics 1994; 4: 323-31
    • (1994) Pharmacogenetics , vol.4 , pp. 323-331
    • Yasumori, T.1    Li, Q.H.2    Yamazoe, Y.3
  • 248
    • 0028600597 scopus 로고
    • The importance of substrate concentration in determining cytochromes P450 therapeutically relevant in vivo
    • Kato R, Yamazoe Y. The importance of substrate concentration in determining cytochromes P450 therapeutically relevant in vivo. Pharmacogenetics 1994; 4: 359-62
    • (1994) Pharmacogenetics , vol.4 , pp. 359-362
    • Kato, R.1    Yamazoe, Y.2
  • 249
    • 0027208084 scopus 로고
    • Why are diazepam metabolism and polymorphic S-mephenytoin hydroxylation associated with each other in white and Korean populations but not in Chinese populations?
    • Bertilsson L, Kalow W. Why are diazepam metabolism and polymorphic S-mephenytoin hydroxylation associated with each other in white and Korean populations but not in Chinese populations? Clin Pharmacol Ther 1993; 53: 608-10
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 608-610
    • Bertilsson, L.1    Kalow, W.2
  • 250
    • 0033375477 scopus 로고    scopus 로고
    • Effect of the gene dosage of CYP2C19 on diazepam metabolism in Chinese subjects
    • Qin XP, Xie HG, Wang W, et al. Effect of the gene dosage of CYP2C19 on diazepam metabolism in Chinese subjects. Clin Pharmacol Ther 1999; 66: 642-6
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 642-646
    • Qin, X.P.1    Xie, H.G.2    Wang, W.3
  • 251
    • 0023113714 scopus 로고
    • Differences in diazepam pharmacokinetics in Chinese and white Caucasians: Relation to body lipid stores
    • Kumana CR, Lauder IJ, Chan M, et al. Differences in diazepam pharmacokinetics in Chinese and white Caucasians: relation to body lipid stores. Eur J Clin Pharmacol 1987; 32: 211-5
    • (1987) Eur J Clin Pharmacol , vol.32 , pp. 211-215
    • Kumana, C.R.1    Lauder, I.J.2    Chan, M.3
  • 252
    • 0021183443 scopus 로고
    • Clinical importance of the interaction of diazepam and cimetidine
    • Greenblatt DJ, Abernethy DR, Morse DS, et al. Clinical importance of the interaction of diazepam and cimetidine. N Engl J Med 1984; 310: 1639-43
    • (1984) N Engl J Med , vol.310 , pp. 1639-1643
    • Greenblatt, D.J.1    Abernethy, D.R.2    Morse, D.S.3
  • 253
    • 0023906457 scopus 로고    scopus 로고
    • The effect of fluoxetine on the pharmacokinetics and psychomotor responses of diazepam
    • Lemberger L, Rowe H, Bosomworth JC, et al. The effect of fluoxetine on the pharmacokinetics and psychomotor responses of diazepam. Clin Pharmacol Ther 1998; 63: 412-9
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 412-419
    • Lemberger, L.1    Rowe, H.2    Bosomworth, J.C.3
  • 254
    • 0031024040 scopus 로고    scopus 로고
    • Warfarin-fluoxetine and diazepam-fluoxetine interaction
    • Dent LA, Orrock MW. Warfarin-fluoxetine and diazepam-fluoxetine interaction. Pharmacotherapy 1997; 17: 170-2
    • (1997) Pharmacotherapy , vol.17 , pp. 170-172
    • Dent, L.A.1    Orrock, M.W.2
  • 256
    • 0019625012 scopus 로고
    • Elevation of steady-state diazepam levels by cimetidine
    • Klotz U, Reimann I. Elevation of steady-state diazepam levels by cimetidine. Clin Pharmacol Ther 1981; 30: 513-7
    • (1981) Clin Pharmacol Ther , vol.30 , pp. 513-517
    • Klotz, U.1    Reimann, I.2
  • 257
    • 0030016562 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction of pantoprazole with diazepam in man
    • Gugler R, Hartmann M, Rudi J, et al. Lack of pharmacokinetic interaction of pantoprazole with diazepam in man. Br J Clin Pharmacol 1996; 42: 249-52
    • (1996) Br J Clin Pharmacol , vol.42 , pp. 249-252
    • Gugler, R.1    Hartmann, M.2    Rudi, J.3
  • 258
    • 0031019242 scopus 로고    scopus 로고
    • Effect of sertraline on the pharmacokinetics and protein binding of diazepam in healthy volunteers
    • Gardner MJ, Baris BA, Wilner KD, et al. Effect of sertraline on the pharmacokinetics and protein binding of diazepam in healthy volunteers. Clin Pharmacokinet 1997; 32 Suppl. 1: 43-9
    • (1997) Clin Pharmacokinet , vol.32 , pp. 43-49
    • Gardner, M.J.1    Baris, B.A.2    Wilner, K.D.3
  • 259
    • 0023236446 scopus 로고
    • The effect of antipyrine and rifampin on the metabolism of diazepam
    • Ohnhaus EE, Brockmeyer N, Dylewicz P, et al. The effect of antipyrine and rifampin on the metabolism of diazepam. Clin Pharmacol Ther 1987; 42: 148-56
    • (1987) Clin Pharmacol Ther , vol.42 , pp. 148-156
    • Ohnhaus, E.E.1    Brockmeyer, N.2    Dylewicz, P.3
  • 260
    • 0024448282 scopus 로고
    • Diazepam treatment does not influence the debrisoquine or mephenytoin hydroxylation phenotyping tests
    • Spina E, Buemi AL, Sanz EJ, et al. Diazepam treatment does not influence the debrisoquine or mephenytoin hydroxylation phenotyping tests. Ther Drug Monit 1989; 11: 721-3
    • (1989) Ther Drug Monit , vol.11 , pp. 721-723
    • Spina, E.1    Buemi, A.L.2    Sanz, E.J.3
  • 261
    • 0023111189 scopus 로고
    • No interaction of diazepam on amitriptyline disposition in depressed patients
    • Otani K, Nordin C, Bertilsson L. No interaction of diazepam on amitriptyline disposition in depressed patients. Ther Drug Monit 1987; 9: 120-2
    • (1987) Ther Drug Monit , vol.9 , pp. 120-122
    • Otani, K.1    Nordin, C.2    Bertilsson, L.3
  • 262
    • 0030036673 scopus 로고    scopus 로고
    • Relationship of in vitro data on drug metabolism to in vivo pharmacokinetics and drug interactions: Implications for diazepam disposition in humans
    • Schmider J, Greenblatt DJ, von Moltke LL, et al. Relationship of in vitro data on drug metabolism to in vivo pharmacokinetics and drug interactions: implications for diazepam disposition in humans. J Clin Psychopharmacol 1996; 16: 267-72
    • (1996) J Clin Psychopharmacol , vol.16 , pp. 267-272
    • Schmider, J.1    Greenblatt, D.J.2    Von Moltke, L.L.3
  • 263
    • 0019840197 scopus 로고
    • Diazepam-cimetidine drug interaction: A clinically significant effect
    • Ruffalo RL, Thompson JF, Segal JL. Diazepam-cimetidine drug interaction: a clinically significant effect. South Med J 1981; 74: 1075-8
    • (1981) South Med J , vol.74 , pp. 1075-1078
    • Ruffalo, R.L.1    Thompson, J.F.2    Segal, J.L.3
  • 264
    • 0025064286 scopus 로고
    • Pharmacokinetic drug interactions with phenytoin (Part I)
    • Nation RL, Evans AM, Milne RW. Pharmacokinetic drug interactions with phenytoin (Part I). Clin Pharmacokinet 1990; 18: 37-60
    • (1990) Clin Pharmacokinet , vol.18 , pp. 37-60
    • Nation, R.L.1    Evans, A.M.2    Milne, R.W.3
  • 265
    • 0025348366 scopus 로고
    • Pharmacokinetic drug interactions with phenytoin (Part II)
    • Nation RL, Evans AM, Milne RW. Pharmacokinetic drug interactions with phenytoin (Part II). Clin Pharmacokinet 1990; 18: 131-50
    • (1990) Clin Pharmacokinet , vol.18 , pp. 131-150
    • Nation, R.L.1    Evans, A.M.2    Milne, R.W.3
  • 266
    • 0031841377 scopus 로고    scopus 로고
    • Cytochrome P4502C9: An enzyme of major importance in human drug metabolism
    • Miners JO, Birkett DJ. Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. Br J Clin Pharmacol 1998; 45: 525-38
    • (1998) Br J Clin Pharmacol , vol.45 , pp. 525-538
    • Miners, J.O.1    Birkett, D.J.2
  • 267
    • 0030454133 scopus 로고    scopus 로고
    • Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite
    • Bajpai M, Roskos LK, Shen DD, et al. Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite. Drug Metab Dispos 1996; 24: 1401-3
    • (1996) Drug Metab Dispos , vol.24 , pp. 1401-1403
    • Bajpai, M.1    Roskos, L.K.2    Shen, D.D.3
  • 268
    • 0033151546 scopus 로고    scopus 로고
    • Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: Difference in chiral preference of CYP2C9 and CYP2C19
    • Yasumori T, Chen LS, Li QH, et al. Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: difference in chiral preference of CYP2C9 and CYP2C19. Biochem Pharmacol 1999; 57: 1297-303
    • (1999) Biochem Pharmacol , vol.57 , pp. 1297-1303
    • Yasumori, T.1    Chen, L.S.2    Li, Q.H.3
  • 269
    • 0022574425 scopus 로고
    • Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism
    • Shiimada T, Misono KS, Guengerich FP. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. J Biol Chem 1985; 261: 909-21
    • (1985) J Biol Chem , vol.261 , pp. 909-921
    • Shiimada, T.1    Misono, K.S.2    Guengerich, F.P.3
  • 270
    • 0030858160 scopus 로고    scopus 로고
    • Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy
    • Odani A, Hashimoto Y, Otsuki Y, et al. Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy. Clin Pharmacol Ther 1997; 62: 287-92
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 287-292
    • Odani, A.1    Hashimoto, Y.2    Otsuki, Y.3
  • 271
    • 0032440352 scopus 로고    scopus 로고
    • The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: Studies in stereoselective hydroxylation and population pharmacokinetics
    • Mamiya K, Ieiri I, Shimamato J, et al. The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics. Epilepsia 1998; 39: 1317-23
    • (1998) Epilepsia , vol.39 , pp. 1317-1323
    • Mamiya, K.1    Ieiri, I.2    Shimamato, J.3
  • 272
    • 0031900131 scopus 로고    scopus 로고
    • The relationship between phenytoin pharmacokinetics and the cyp2c19 genotype in Japanese epileptic patients
    • Watanabe M, Iwahashi K, Kugoh T, et al. The relationship between phenytoin pharmacokinetics and the cyp2c19 genotype in Japanese epileptic patients. Clin Neuropharmacol 1998; 21: 122-6
    • (1998) Clin Neuropharmacol , vol.21 , pp. 122-126
    • Watanabe, M.1    Iwahashi, K.2    Kugoh, T.3
  • 273
    • 0029798278 scopus 로고    scopus 로고
    • Acute phenytoin toxicity followed by seizure breakthrough from a ticlopidine-phenytoin interaction
    • Privitera M, Welty TE, et al. Acute phenytoin toxicity followed by seizure breakthrough from a ticlopidine-phenytoin interaction. Arch Neurol 1996; 53: 1191-2
    • (1996) Arch Neurol , vol.53 , pp. 1191-1192
    • Privitera, M.1    Welty, T.E.2
  • 275
    • 0031430539 scopus 로고    scopus 로고
    • Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19
    • Donahue SR, Flockhart DA, Abernethy DR, et al. Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19. Clin Pharmacol Ther 1997; 62: 572-7
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 572-577
    • Donahue, S.R.1    Flockhart, D.A.2    Abernethy, D.R.3
  • 276
    • 0028829913 scopus 로고
    • Evaluation of a potential enantioselective interaction between ticlopidine and warfarin in chronically anticoagulated patients
    • Gidal BE, Sorkness CA, McGill KA, et al. Evaluation of a potential enantioselective interaction between ticlopidine and warfarin in chronically anticoagulated patients. Ther Drug Monit 1995; 17: 33-8
    • (1995) Ther Drug Monit , vol.17 , pp. 33-38
    • Gidal, B.E.1    Sorkness, C.A.2    McGill, K.A.3
  • 277
    • 0032874278 scopus 로고    scopus 로고
    • Heterologous expression and kinetic characterization of human cytochromes P-450: Validation of a pharmaceutical tool for drug metabolism research
    • Masimirembwa CM, Otter C, Berg M, et al. Heterologous expression and kinetic characterization of human cytochromes P-450: validation of a pharmaceutical tool for drug metabolism research. Drug Metab Dispos 1999; 27: 1117-22
    • (1999) Drug Metab Dispos , vol.27 , pp. 1117-1122
    • Masimirembwa, C.M.1    Otter, C.2    Berg, M.3
  • 279
    • 0002275260 scopus 로고
    • The steady-state (SS) pharmacokinetics (PK) of phenytoin (Dilantin) and topiramate (Topamax) in epileptic patients on monotherapy, and during combination therapy
    • Gisclon LG, Curtin CR, Kramer LD. The steady-state (SS) pharmacokinetics (PK) of phenytoin (Dilantin) and topiramate (Topamax) in epileptic patients on monotherapy, and during combination therapy [abstract]. Epilepsia 1994; 35 Suppl. 8: 54
    • (1994) Epilepsia , vol.35 , pp. 54
    • Gisclon, L.G.1    Curtin, C.R.2    Kramer, L.D.3
  • 280
    • 0025340059 scopus 로고
    • A study of the interaction between omeprazole and phenytoin in epileptic patients
    • Andersson T, Lagerstrom PO, Unge P. A study of the interaction between omeprazole and phenytoin in epileptic patients. Ther Drug Monit 1990; 12: 329-33
    • (1990) Ther Drug Monit , vol.12 , pp. 329-333
    • Andersson, T.1    Lagerstrom, P.O.2    Unge, P.3
  • 281
    • 0010866744 scopus 로고
    • The effect of felbamate on phenobarbital serum concentrations
    • Sachdeo R, Padela MF. The effect of felbamate on phenobarbital serum concentrations [abstract]. Epilepsia 1994; 35 Suppl. 8: 94
    • (1994) Epilepsia , vol.35 , pp. 94
    • Sachdeo, R.1    Padela, M.F.2
  • 282
    • 13244300645 scopus 로고    scopus 로고
    • Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: Analysis with a dose-dependent clearance model
    • Odani A, Hashimoto Y, Takayanagi K, et al. Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: analysis with a dose-dependent clearance model. Biol Pharm Bull 1996; 19: 444-8
    • (1996) Biol Pharm Bull , vol.19 , pp. 444-448
    • Odani, A.1    Hashimoto, Y.2    Takayanagi, K.3
  • 283
    • 0026499882 scopus 로고
    • Elevation of plasma phenytoin by viloxazine in epileptic patients: A clinically significant drug interaction
    • Pisani F, Fazio A, Artesi C, et al. Elevation of plasma phenytoin by viloxazine in epileptic patients: a clinically significant drug interaction. J Neurol Neurosurg Psychiatry 1992; 55: 126-7
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , pp. 126-127
    • Pisani, F.1    Fazio, A.2    Artesi, C.3
  • 284
    • 0032819729 scopus 로고    scopus 로고
    • Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin
    • Aynacioglu AS, Brockmoller J, Bauer S, et al. Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin. Br J Clin Pharmacol 1999; 48: 409-15
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 409-415
    • Aynacioglu, A.S.1    Brockmoller, J.2    Bauer, S.3
  • 285
    • 0029841727 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between antiepileptic drugs: Clinical considerations
    • Riva R, Albani F, Contin M, et al. Pharmacokinetic interactions between antiepileptic drugs: clinical considerations. Clin Pharmacokinet 1996; 31: 470-93
    • (1996) Clin Pharmacokinet , vol.31 , pp. 470-493
    • Riva, R.1    Albani, F.2    Contin, M.3
  • 286
    • 0031800865 scopus 로고    scopus 로고
    • A mechanistic approach to antiepileptic drug interactions
    • Anderson GD. A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother 1998; 32: 554-63
    • (1998) Ann Pharmacother , vol.32 , pp. 554-563
    • Anderson, G.D.1
  • 287
    • 0028328318 scopus 로고
    • Potential pharmacokinetic interaction between felbamate and phenobarbital
    • Gidal BE, Zupanc ML. Potential pharmacokinetic interaction between felbamate and phenobarbital. Ann Pharmacother 1994; 28: 455-8
    • (1994) Ann Pharmacother , vol.28 , pp. 455-458
    • Gidal, B.E.1    Zupanc, M.L.2
  • 288
    • 0028818418 scopus 로고
    • Effects of felbamate on the pharmacokinetics of phenobarbital
    • Reidenberg P, Glue P, Banfield CR, et al. Effects of felbamate on the pharmacokinetics of phenobarbital. Clin Pharmacol Ther 1995; 58: 279-87
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 279-287
    • Reidenberg, P.1    Glue, P.2    Banfield, C.R.3
  • 289
    • 0019160901 scopus 로고
    • Centrally acting oral skeletal muscle relaxants
    • Elenbaas JK. Centrally acting oral skeletal muscle relaxants. Am J Hosp Pharm 1980; 37: 1313-23
    • (1980) Am J Hosp Pharm , vol.37 , pp. 1313-1323
    • Elenbaas, J.K.1
  • 290
    • 0030976985 scopus 로고    scopus 로고
    • Reappraisal of human CYP450 isoforms involved in imipramine N-demethylation and 2-hydroxylation: A study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYP450s
    • Koyama E, Chiba K, Tani M, et al. Reappraisal of human CYP450 isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYP450s. J Pharmacol Exp Ther 1997; 281: 1199-210
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 1199-1210
    • Koyama, E.1    Chiba, K.2    Tani, M.3
  • 291
    • 0031908744 scopus 로고    scopus 로고
    • Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: Dominance of CYP 2C19 and 3A4
    • Venkatakrishnan K, Greenblatt DJ, von Moltke LL, et al. Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4. J Clin Pharmacol 1998; 38: 112-21
    • (1998) J Clin Pharmacol , vol.38 , pp. 112-121
    • Venkatakrishnan, K.1    Greenblatt, D.J.2    Von Moltke, L.L.3
  • 292
    • 0030425332 scopus 로고    scopus 로고
    • The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways
    • Nielsen KK, Flinois JP, Beaune PH, et al. The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways. J Pharmacol Exp Ther 1996; 277: 1659-64
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1659-1664
    • Nielsen, K.K.1    Flinois, J.P.2    Beaune, P.H.3
  • 293
    • 0031057666 scopus 로고    scopus 로고
    • Effect of ketoconazole on the pharmacokinetics of imipramine and desipramine in healthy subjects
    • Spina E, Avenoso A, Campo GM, et al. Effect of ketoconazole on the pharmacokinetics of imipramine and desipramine in healthy subjects. Br J Clin Pharmacol 1997; 43: 315-8
    • (1997) Br J Clin Pharmacol , vol.43 , pp. 315-318
    • Spina, E.1    Avenoso, A.2    Campo, G.M.3
  • 294
    • 0030957623 scopus 로고    scopus 로고
    • Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes
    • Rochat B, Amey M, Gillet M, et al. Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes. Pharmacogenetics 1997; 7: 1-10
    • (1997) Pharmacogenetics , vol.7 , pp. 1-10
    • Rochat, B.1    Amey, M.2    Gillet, M.3
  • 295
    • 14444282584 scopus 로고    scopus 로고
    • Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes
    • Kobayashi K, Chiba K, Yagi T, et al. Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes. J Pharmacol Exp Ther 1997; 280: 927-33
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 927-933
    • Kobayashi, K.1    Chiba, K.2    Yagi, T.3
  • 296
    • 0030898353 scopus 로고    scopus 로고
    • Imipramine demethylation in vivo: Impact of CYP1A2, CYP2C19, and CYP3A4
    • Madsen H, Rasmussen BB, Brosen K. Imipramine demethylation in vivo: impact of CYP1A2, CYP2C19, and CYP3A4. Clin Pharmacol Ther 1997; 61: 319-24
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 319-324
    • Madsen, H.1    Rasmussen, B.B.2    Brosen, K.3
  • 297
    • 0030481308 scopus 로고    scopus 로고
    • Imipramine metabolism in relation to the sparteine oxidation polymorphism: A family study
    • Madsen H, Hansen TS, Brosen K. Imipramine metabolism in relation to the sparteine oxidation polymorphism: a family study. Pharmacogenetics 1996; 6: 513-9
    • (1996) Pharmacogenetics , vol.6 , pp. 513-519
    • Madsen, H.1    Hansen, T.S.2    Brosen, K.3
  • 298
    • 0030055999 scopus 로고    scopus 로고
    • Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4′-hydroxylation status in Japanese depressive patients
    • Koyama E, Tanaka T, Chiba K, et al. Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4′-hydroxylation status in Japanese depressive patients. J Clin Psychopharmacol 1996; 16 (4): 286-93
    • (1996) J Clin Psychopharmacol , vol.16 , Issue.4 , pp. 286-293
    • Koyama, E.1    Tanaka, T.2    Chiba, K.3
  • 299
    • 0030872484 scopus 로고    scopus 로고
    • Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy
    • Morinobu S, Tanaka T, Kawakatsu S, et al. Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy. Psychiatry Clin Neurosci 1997; 51: 253-7
    • (1997) Psychiatry Clin Neurosci , vol.51 , pp. 253-257
    • Morinobu, S.1    Tanaka, T.2    Kawakatsu, S.3
  • 300
    • 0017364411 scopus 로고
    • Clinical implications of imipramine plasma levels for depressive illness
    • Glassman AH, Perel JM, Shostak M, et al. Clinical implications of imipramine plasma levels for depressive illness. Arch Gen Psychiatry 1977; 34: 197-204
    • (1977) Arch Gen Psychiatry , vol.34 , pp. 197-204
    • Glassman, A.H.1    Perel, J.M.2    Shostak, M.3
  • 301
    • 0018147521 scopus 로고
    • The cardiac effects of therapeutic plasma concentrations of imipramine
    • Kantor SJ, Glassman AH, Bigger JTJ, et al. The cardiac effects of therapeutic plasma concentrations of imipramine. Am J Psychiatry 1978; 135: 534-8
    • (1978) Am J Psychiatry , vol.135 , pp. 534-538
    • Kantor, S.J.1    Glassman, A.H.2    Bigger, J.T.J.3
  • 302
    • 0030659112 scopus 로고    scopus 로고
    • Seizures and myoclonus associated with antidepressant treatment: Assessment of potential risk factors, including CYP2D6 and CYP2C19 polymorphisms, and treatment with CYP2D6 inhibitors
    • Spigset O, Hedenmalm K, Dahl ML, et al. Seizures and myoclonus associated with antidepressant treatment: assessment of potential risk factors, including CYP2D6 and CYP2C19 polymorphisms, and treatment with CYP2D6 inhibitors. Acta Psychiatr Scand 1997; 96: 379-84
    • (1997) Acta Psychiatr Scand , vol.96 , pp. 379-384
    • Spigset, O.1    Hedenmalm, K.2    Dahl, M.L.3
  • 304
    • 0031979755 scopus 로고    scopus 로고
    • Metabolism of the newer antidepressants: An overview of the pharmacological and pharmacokinetic implications
    • Caccia S. Metabolism of the newer antidepressants: an overview of the pharmacological and pharmacokinetic implications. Clin Pharmacokinet 1998; 34: 281-302
    • (1998) Clin Pharmacokinet , vol.34 , pp. 281-302
    • Caccia, S.1
  • 305
    • 0032870729 scopus 로고    scopus 로고
    • Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP450) isoforms in vitro: Preferential inhibition of CYP2D6
    • Shin JG, Soukhova N, Flockhart DA. Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP450) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab Dispos 1999; 27: 1078-84
    • (1999) Drug Metab Dispos , vol.27 , pp. 1078-1084
    • Shin, J.G.1    Soukhova, N.2    Flockhart, D.A.3
  • 306
    • 9044221758 scopus 로고    scopus 로고
    • Antidepressants and drug-metabolizing enzymes: Expert group repon
    • Meyer UA, Amrein R, Balant LP, et al. Antidepressants and drug-metabolizing enzymes: expert group repon. Acta Psychiatr Scand 1996; 93: 71-9
    • (1996) Acta Psychiatr Scand , vol.93 , pp. 71-79
    • Meyer, U.A.1    Amrein, R.2    Balant, L.P.3
  • 307
    • 0025572192 scopus 로고
    • Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations
    • Alvan G, Bechtel P, Iselius L, et al. Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. Eur J Clin Pharmacol 1990; 39: 533-7
    • (1990) Eur J Clin Pharmacol , vol.39 , pp. 533-537
    • Alvan, G.1    Bechtel, P.2    Iselius, L.3
  • 308
    • 0027965620 scopus 로고
    • Genetic analysis of the Chinese chromosome P4502D locus: Characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
    • Johansson I, Oscarson M, Yue QY, et al. Genetic analysis of the Chinese chromosome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol Pharmacol 1994; 46: 452-9
    • (1994) Mol Pharmacol , vol.46 , pp. 452-459
    • Johansson, I.1    Oscarson, M.2    Yue, Q.Y.3
  • 309
    • 0035029870 scopus 로고    scopus 로고
    • Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19
    • Yu KS, Yim DS, Cho JY, et al. Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19. Clin Pharmacol Ther 2001; 69: 266-73
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 266-273
    • Yu, K.S.1    Yim, D.S.2    Cho, J.Y.3
  • 310
    • 0028245323 scopus 로고
    • Concurrent use of more than one major psychotropic drug (polypsychopharmacy) in outpatients: A prescription database study
    • Rosholm JU, Hallas J, Gram LF. Concurrent use of more than one major psychotropic drug (polypsychopharmacy) in outpatients: a prescription database study. Br J Clin Pharmacol 1994; 37: 533-8
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 533-538
    • Rosholm, J.U.1    Hallas, J.2    Gram, L.F.3
  • 312
    • 0017681464 scopus 로고
    • Interaction between phenytoin and imipramine
    • Perucca E, Richens A. Interaction between phenytoin and imipramine. Br J Clin Pharmacol 1977; 4: 485-6
    • (1977) Br J Clin Pharmacol , vol.4 , pp. 485-486
    • Perucca, E.1    Richens, A.2
  • 313
    • 0021364758 scopus 로고
    • Cimetidine-imipramine interaction: Case report and comments
    • Shapiro PA. Cimetidine-imipramine interaction: case report and comments [letter]. Am J Psychiatry 1984; 141: 152
    • (1984) Am J Psychiatry , vol.141 , pp. 152
    • Shapiro, P.A.1
  • 314
    • 0021345477 scopus 로고
    • Cimetidine interaction with imipramine and nortriptyline
    • Henauer SA, Hollister LE. Cimetidine interaction with imipramine and nortriptyline. Clin Pharmacol Ther 1984; 35: 183-7
    • (1984) Clin Pharmacol Ther , vol.35 , pp. 183-187
    • Henauer, S.A.1    Hollister, L.E.2
  • 316
    • 0025968525 scopus 로고
    • Cimetidine alters the disposition kinetics of the monoamine oxidase-A inhibitor moclobemide
    • Schoerlin MP, Mayersohn M, Hoevels B, et al. Cimetidine alters the disposition kinetics of the monoamine oxidase-A inhibitor moclobemide. Clin Pharmacol Ther 1991; 49: 32-8
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 32-38
    • Schoerlin, M.P.1    Mayersohn, M.2    Hoevels, B.3
  • 317
    • 0030010301 scopus 로고    scopus 로고
    • Pharmacokinetic fluvoxamine-clomipramine interaction with favorable therapeutic consequences in therapy-resistant depressive patient
    • Conus P, Bondolfi G, Eap CB, et al. Pharmacokinetic fluvoxamine-clomipramine interaction with favorable therapeutic consequences in therapy-resistant depressive patient. Pharmacopsychiatry 1996; 29: 108-10
    • (1996) Pharmacopsychiatry , vol.29 , pp. 108-110
    • Conus, P.1    Bondolfi, G.2    Eap, C.B.3
  • 318
    • 0029947678 scopus 로고    scopus 로고
    • Combination treatment with clomipramine and fluvoxamine: Drug monitoring, safety, and tolerability data
    • Szegedi A, Wetzel H, Leal M, et al. Combination treatment with clomipramine and fluvoxamine: drug monitoring, safety, and tolerability data. J Clin Psychiatry 1996; 57: 257-64
    • (1996) J Clin Psychiatry , vol.57 , pp. 257-264
    • Szegedi, A.1    Wetzel, H.2    Leal, M.3
  • 319
    • 0029903801 scopus 로고    scopus 로고
    • Non-response to citalopram in depressive patients: Pharmacokinetic and clinical consequences of a fluvoxamine augmentation
    • Bondolfi G, Chautems C, Rochat B, et al. Non-response to citalopram in depressive patients: pharmacokinetic and clinical consequences of a fluvoxamine augmentation. Psychopharmacology (Berl) 1996; 128: 421-5
    • (1996) Psychopharmacology (Berl) , vol.128 , pp. 421-425
    • Bondolfi, G.1    Chautems, C.2    Rochat, B.3
  • 320
    • 0029949026 scopus 로고    scopus 로고
    • Fluoxetine-imipramine interaction
    • Leroi I, Walentynowicz MA. Fluoxetine-imipramine interaction [letter]. Can J Psychiatry 1996; 41: 318-9
    • (1996) Can J Psychiatry , vol.41 , pp. 318-319
    • Leroi, I.1    Walentynowicz, M.A.2
  • 321
    • 0026552617 scopus 로고
    • Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction
    • Bergstrom RF, Peyton AL, Lemberger L. Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction. Clin Pharmacol Ther 1992; 51: 239-48
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 239-248
    • Bergstrom, R.F.1    Peyton, A.L.2    Lemberger, L.3
  • 322
    • 0031901578 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic interactions between fluoxetine and moclobemide in the investigation of development of the 'serotonin syndrome'
    • Dingemanse J, Wallnofer A, Gieschke R, et al. Pharmacokinetic and pharmacodynamic interactions between fluoxetine and moclobemide in the investigation of development of the 'serotonin syndrome'. Clin Pharmacol Ther 1998; 63: 403-13
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 403-413
    • Dingemanse, J.1    Wallnofer, A.2    Gieschke, R.3
  • 323
    • 0030921915 scopus 로고    scopus 로고
    • Fatality associated with combined fluoxetine-amitriptyline therapy
    • Preskorn SH, Baker B. Fatality associated with combined fluoxetine-amitriptyline therapy [letter]. JAMA 1997; 277: 1682
    • (1997) JAMA , vol.277 , pp. 1682
    • Preskorn, S.H.1    Baker, B.2
  • 324
    • 0017386702 scopus 로고
    • Induction of imipramine metabolism following barbiturate administration
    • Hewick DS, Sparks RG, Stevenson IH, et al. Induction of imipramine metabolism following barbiturate administration [abstract]. Br J Clin Pharmacol 1977; 4: 399P
    • (1977) Br J Clin Pharmacol , vol.4 , pp. 399P
    • Hewick, D.S.1    Sparks, R.G.2    Stevenson, I.H.3
  • 325
    • 0030843952 scopus 로고    scopus 로고
    • Possible interaction between imipramine and butalbital
    • Garey KW, Amsden GW, Johns CA. Possible interaction between imipramine and butalbital. Pharmacotherapy 1997; 17: 1041-2
    • (1997) Pharmacotherapy , vol.17 , pp. 1041-1042
    • Garey, K.W.1    Amsden, G.W.2    Johns, C.A.3
  • 326
    • 0029558898 scopus 로고
    • N-Demethylation of amitriptyline in vitro: Role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors
    • Schmider J, Greenblatt DJ, von Moltke LL, et al. N-Demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors. J Pharmacol Exp Ther 1995; 275: 592-7
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 592-597
    • Schmider, J.1    Greenblatt, D.J.2    Von Moltke, L.L.3
  • 327
    • 0029824886 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes: Interpretation of their interactions with selective serotonin reuptake inhibitors. Part II
    • Harvey AT, Preskorn SH. Cytochrome P450 enzymes: interpretation of their interactions with selective serotonin reuptake inhibitors. Part II. J Clin Psychopharmacol 1996; 16: 345-55
    • (1996) J Clin Psychopharmacol , vol.16 , pp. 345-355
    • Harvey, A.T.1    Preskorn, S.H.2
  • 328
    • 0029553002 scopus 로고
    • Selective serotonin reuptake inhibitors and tricyclic antidepressants in combination: Interactions and therapeutic uses
    • Taylor D. Selective serotonin reuptake inhibitors and tricyclic antidepressants in combination: interactions and therapeutic uses. Br J Psychiatry 1995; 167: 575-80
    • (1995) Br J Psychiatry , vol.167 , pp. 575-580
    • Taylor, D.1
  • 329
    • 0034894010 scopus 로고    scopus 로고
    • CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: A first step towards subpopulation-specific dosages
    • Kirchheiner J, Brosen K, Dahl ML, et al. CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages. Acta Psychiatr Scand 2001; 104: 173-92
    • (2001) Acta Psychiatr Scand , vol.104 , pp. 173-192
    • Kirchheiner, J.1    Brosen, K.2    Dahl, M.L.3
  • 330
    • 0025735576 scopus 로고
    • The activation of the biguanide antimalarial proguanil co-segregates with mephenytoin oxidation polymorphism: A panel study
    • Ward SA, Helsby NA, Skjelbo E, et al. The activation of the biguanide antimalarial proguanil co-segregates with mephenytoin oxidation polymorphism: a panel study. Br J Clin Pharmacol 1991; 31: 689-92
    • (1991) Br J Clin Pharmacol , vol.31 , pp. 689-692
    • Ward, S.A.1    Helsby, N.A.2    Skjelbo, E.3
  • 331
    • 0030432381 scopus 로고    scopus 로고
    • Pharmacogenetic determination of the effects of codeine and prediction of drug interactions
    • Caraco Y, Sheller J, Wood AJ. Pharmacogenetic determination of the effects of codeine and prediction of drug interactions. J Pharmacol Exp Ther 1996; 278: 1165-74
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 1165-1174
    • Caraco, Y.1    Sheller, J.2    Wood, A.J.3
  • 332
    • 0029815579 scopus 로고    scopus 로고
    • Proguanil polymorphism does not affect the antimalarial activity of proguanil combined with atovaquone in vitro
    • Edstein MD, Yeo AE, Kyle DE, et al. Proguanil polymorphism does not affect the antimalarial activity of proguanil combined with atovaquone in vitro. Trans R Soc Trop Med Hyg 1996; 90: 418-21
    • (1996) Trans R Soc Trop Med Hyg , vol.90 , pp. 418-421
    • Edstein, M.D.1    Yeo, A.E.2    Kyle, D.E.3
  • 333
    • 0032782389 scopus 로고    scopus 로고
    • Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations
    • Kaneko A, Bergqvist Y, Taleo G, et al. Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations. Pharmacogenetics 1999; 9: 317-26
    • (1999) Pharmacogenetics , vol.9 , pp. 317-326
    • Kaneko, A.1    Bergqvist, Y.2    Taleo, G.3
  • 334
    • 0031460883 scopus 로고    scopus 로고
    • The hydroxylation of omeprazole correlates with S-mephenytoin and proguanil metabolism
    • Kortunay S, Basci NE, Bozkurt A, et al. The hydroxylation of omeprazole correlates with S-mephenytoin and proguanil metabolism. Eur J Clin Pharmacol 1997; 53: 261-4
    • (1997) Eur J Clin Pharmacol , vol.53 , pp. 261-264
    • Kortunay, S.1    Basci, N.E.2    Bozkurt, A.3
  • 335
    • 0032926172 scopus 로고    scopus 로고
    • Intrinsic efficacy of proguanil against falciparum and vivax malaria independent of the metabolite cycloguanil
    • Kaneko A, Bergqvist Y, Takechi M, et al. Intrinsic efficacy of proguanil against falciparum and vivax malaria independent of the metabolite cycloguanil. J Infect Dis 1999; 179: 974-9
    • (1999) J Infect Dis , vol.179 , pp. 974-979
    • Kaneko, A.1    Bergqvist, Y.2    Takechi, M.3
  • 336
    • 0035086498 scopus 로고    scopus 로고
    • Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: Structural identification, levels in plasma, and antiviral activities
    • Zhang KE, Wu E, Patick AK, et al. Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities. Antimicrob Agents Chemother 2001; 45: 1086-93
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 1086-1093
    • Zhang, K.E.1    Wu, E.2    Patick, A.K.3
  • 337
    • 0035947339 scopus 로고    scopus 로고
    • Analysis of variation in plasma concentrations of nelfinavir and its active metabolite M8 in HIV-positive patients
    • Baede-van Dijk PA, Hugen PW, Verweij-van Wissen CP, et al. Analysis of variation in plasma concentrations of nelfinavir and its active metabolite M8 in HIV-positive patients. AIDS 2001; 15: 991-8
    • (2001) AIDS , vol.15 , pp. 991-998
    • Baede-Van Dijk, P.A.1    Hugen, P.W.2    Verweij-Van Wissen, C.P.3
  • 338
    • 0023355128 scopus 로고
    • Hepatic metabolism of tolbutamide: Characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition
    • Knodell RG, Hall SD, Wilkinson GR, et al. Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition. J Pharmacol Exp Ther 1987; 241: 1112-9
    • (1987) J Pharmacol Exp Ther , vol.241 , pp. 1112-1119
    • Knodell, R.G.1    Hall, S.D.2    Wilkinson, G.R.3
  • 339
    • 0023873591 scopus 로고
    • Tolbutamide hydroxylation by human liver microsomes: Kinetic characterization and relationship to other cytochrome P-450 dependent xenobiotic oxidations
    • Miners JO, Smith KJ, Robson RA, et al. Tolbutamide hydroxylation by human liver microsomes: kinetic characterization and relationship to other cytochrome P-450 dependent xenobiotic oxidations. Biochem Pharmacol 1988; 37: 1137-44
    • (1988) Biochem Pharmacol , vol.37 , pp. 1137-1144
    • Miners, J.O.1    Smith, K.J.2    Robson, R.A.3
  • 340
    • 0002565566 scopus 로고    scopus 로고
    • Involvement of cytochrome P450 2C19 in methylhydroxylation of tolbutamide in vitro
    • Desta Z, Soukhova N, Shin JG, et al. Involvement of cytochrome P450 2C19 in methylhydroxylation of tolbutamide in vitro [abstract]. Clin Pharmacol Ther 1999; 67: 167
    • (1999) Clin Pharmacol Ther , vol.67 , pp. 167
    • Desta, Z.1    Soukhova, N.2    Shin, J.G.3
  • 341
    • 0034010930 scopus 로고    scopus 로고
    • CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes
    • Wester MR, Lasker JM, Johnson EF, et al. CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes. Drug Metab Dispos 2000; 28: 354-9
    • (2000) Drug Metab Dispos , vol.28 , pp. 354-359
    • Wester, M.R.1    Lasker, J.M.2    Johnson, E.F.3
  • 342
    • 0036217595 scopus 로고    scopus 로고
    • Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans
    • Shon JH, Yoon YR, Kim KA, et al. Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans. Pharmacogenetics 2002; 12: 111-9
    • (2002) Pharmacogenetics , vol.12 , pp. 111-119
    • Shon, J.H.1    Yoon, Y.R.2    Kim, K.A.3
  • 343
    • 0031003669 scopus 로고    scopus 로고
    • Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4′-hydroxylation activities in livers of Japanese and Caucasian populations
    • Inoue K, Yamazaki H, Imiya K, et al. Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4′-hydroxylation activities in livers of Japanese and Caucasian populations. Pharmacogenetics 1997; 7: 103-13
    • (1997) Pharmacogenetics , vol.7 , pp. 103-113
    • Inoue, K.1    Yamazaki, H.2    Imiya, K.3
  • 344
    • 0030996734 scopus 로고    scopus 로고
    • No correlation between side-chain of propranolol oxidation and S-mephenytoin 4′-hydroxylase activity
    • Xie HG, Xu ZH, Huang SL, et al. No correlation between side-chain of propranolol oxidation and S-mephenytoin 4′-hydroxylase activity. Zhongguo Yao Li Xue Bao 1997; 18: 216-8
    • (1997) Zhongguo Yao Li Xue Bao , vol.18 , pp. 216-218
    • Xie, H.G.1    Xu, Z.H.2    Huang, S.L.3
  • 345
    • 0034083503 scopus 로고    scopus 로고
    • CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system
    • Ford GA, Wood SM, Daly AK. CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system. Br J Clin Pharmacol 2000; 50: 77-80
    • (2000) Br J Clin Pharmacol , vol.50 , pp. 77-80
    • Ford, G.A.1    Wood, S.M.2    Daly, A.K.3
  • 346
    • 0031015345 scopus 로고    scopus 로고
    • Human P450 metabolism of warfarin
    • Kaminsky LS, Zhang ZY. Human P450 metabolism of warfarin. Pharmacol Ther 1997; 73: 67-74
    • (1997) Pharmacol Ther , vol.73 , pp. 67-74
    • Kaminsky, L.S.1    Zhang, Z.Y.2
  • 347
    • 0023193252 scopus 로고
    • Genetic predisposition to bladder cancer: Ability to hydroxylate debrisoquine and mephenytoin as risk factors
    • Kaisary A, Smith P, Jaczq E, et al. Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors. Cancer Res 1987; 47: 5488-93
    • (1987) Cancer Res , vol.47 , pp. 5488-5493
    • Kaisary, A.1    Smith, P.2    Jaczq, E.3
  • 348
    • 0030965011 scopus 로고    scopus 로고
    • Lung cancer risk in relation to mephenytoin hydroxylation activity
    • Benhamou S, Bouchardy C, Dayer P. Lung cancer risk in relation to mephenytoin hydroxylation activity. Pharmacogenetics 1997; 7: 157-9
    • (1997) Pharmacogenetics , vol.7 , pp. 157-159
    • Benhamou, S.1    Bouchardy, C.2    Dayer, P.3
  • 349
    • 0030580125 scopus 로고    scopus 로고
    • Genotype analysis of the CYP2C19 gene in the Japanese population
    • Tsuneoka Y, Fukushima K, Matsuo Y, et al. Genotype analysis of the CYP2C19 gene in the Japanese population. Life Sci 1996; 59: 1711-5
    • (1996) Life Sci , vol.59 , pp. 1711-1715
    • Tsuneoka, Y.1    Fukushima, K.2    Matsuo, Y.3
  • 350
    • 0029815779 scopus 로고    scopus 로고
    • Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk
    • Brockmöller J, Cascorbi I, Kerb R, et al. Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk. Cancer Res 1996; 56: 3915-25
    • (1996) Cancer Res , vol.56 , pp. 3915-3925
    • Brockmöller, J.1    Cascorbi, I.2    Kerb, R.3
  • 351
    • 0033790667 scopus 로고    scopus 로고
    • Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukemia
    • Roddam PL, Rollinson S, Kane E, et al. Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukemia. Pharmacogenetics 2000; 10: 605-15
    • (2000) Pharmacogenetics , vol.10 , pp. 605-615
    • Roddam, P.L.1    Rollinson, S.2    Kane, E.3
  • 352
    • 0034714521 scopus 로고    scopus 로고
    • Genotype analysis of the CYP2C19 gene in HCV-seropositive patients with cirrhosis and hepatocellular carcinoma
    • Chau TK, Marakami S, Kawai B, et al. Genotype analysis of the CYP2C19 gene in HCV-seropositive patients with cirrhosis and hepatocellular carcinoma. Life Sci 2000; 67: 1719-24
    • (2000) Life Sci , vol.67 , pp. 1719-1724
    • Chau, T.K.1    Marakami, S.2    Kawai, B.3
  • 353
    • 0028625485 scopus 로고
    • Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate
    • Horsmans Y, Lannfelt L, Pessayre D, et al. Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate. J Hepatol 1994; 21: 1075-9
    • (1994) J Hepatol , vol.21 , pp. 1075-1079
    • Horsmans, Y.1    Lannfelt, L.2    Pessayre, D.3
  • 354
    • 0025162357 scopus 로고
    • Scleroderma is associated with differences in individual routes of drug metabolism: A study with dapsone, debrisoquin, and mephenytoin
    • May DG, Black CM, Olsen NJ, et al. Scleroderma is associated with differences in individual routes of drug metabolism: a study with dapsone, debrisoquin, and mephenytoin. Clin Pharmacol Ther 1990; 48: 286-95
    • (1990) Clin Pharmacol Ther , vol.48 , pp. 286-295
    • May, D.G.1    Black, C.M.2    Olsen, N.J.3
  • 355
    • 0031955095 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 CYP2C activity in psoriasis: Studies using proguanil as a probe compound
    • Helsby NA, Ward SA, Parslew RA, et al. Hepatic cytochrome P450 CYP2C activity in psoriasis: studies using proguanil as a probe compound. Acta Derm Venereol 1998; 78: 81-3
    • (1998) Acta Derm Venereol , vol.78 , pp. 81-83
    • Helsby, N.A.1    Ward, S.A.2    Parslew, R.A.3
  • 356
    • 0025768864 scopus 로고
    • Polymorphisms in oxidative drug metabolism: Relationship to food preference
    • Britto MR, McKean HE, Bruckner GG, et al. Polymorphisms in oxidative drug metabolism: relationship to food preference. Br J Clin Pharmacol 1991; 32: 235-7
    • (1991) Br J Clin Pharmacol , vol.32 , pp. 235-237
    • Britto, M.R.1    McKean, H.E.2    Bruckner, G.G.3


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