Contribution of gut bacteria to liver pathobiology

Gastroenterology Research and Practice

Volumn , Issue , 2010, Pages

  Hines, Ian N ^a   Son, Gakuhei ^a   Kremer, Michael ^b,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL LIVER DISEASE; AUTOIMMUNE DISEASE; CELL INTERACTION; CELL POPULATION; HUMAN; IMMUNOCOMPETENT CELL; INTESTINE FLORA; LIVER CELL CARCINOMA; LIVER DISEASE; LIVER FIBROSIS; LIVER ISCHEMIA; NONALCOHOLIC FATTY LIVER; NONHUMAN; PROTEIN EXPRESSION; REVIEW; VIRUS HEPATITIS;

EID: 77956825557     PISSN: 16876121     EISSN: 1687630X     Source Type: Journal    
DOI: 10.1155/2010/453563     Document Type: Review

References (127)

1. Guarner F., Malagelada J.-R., Gut flora in health and disease Lancet 2003 361 9356 512 519
2. O'Keefe S. J. D., Nutrition and colonic health: the critical role of the microbiota Current Opinion in Gastroenterology 2008 24 1 51 58
3. Musso G., Gambino R., Cassader M., Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanisms and implications for metabolic disorders Current Opinion in Lipidology 2010 21 1 76 83
4. Rawls J. F., Samuel B. S., Gordon J. I., Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota Proceedings of the National Academy of Sciences of the United States of America 2004 101 13 4596 4601
5. Hering N. A., Schulzke J.-D., Therapeutic options to modulate barrier defects in inflammatory bowel disease Digestive Diseases 2009 27 4 450 454
6. Turner J. R., Intestinal mucosal barrier function in health and disease Nature Reviews Immunology 2009 9 11 799 809
7. Murai M., Turovskaya O., Kim G., Madan R., Karp C. L., Cheroutre H., Kronenberg M., Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis Nature Immunology 2009 10 11 1178 1184
8. Garrett W. S., Gordon J. I., Glimcher L. H., Homeostasis and inflammation in the intestine Cell 2010 140 6 859 870
9. Moore W. E. C., Moore L. H., Intestinal floras of populations that have a high risk of colon cancer Applied and Environmental Microbiology 1995 61 9 3202 3207
10. Gorbach S. L., Tabaqchali S., Bacteria, bile, and the small bowel Gut 1969 10 12 963 972
11. Simon G. L., Gorbach S. L., The human intestinal microflora Digestive Diseases and Sciences 1986 31 supplement 9 147S 162S
12. Hill D. A., Hoffmann C., Abt M. C., Du Y., Kobuley D., Kirn T. J., Bushman F. D., Artis D., Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis Mucosal Immunology 2010 3 2 148 158
13. Meyers J. S., Ehrenpreis E. D., Craig R. M., Small intestinal bacterial overgrowth syndrome Current Treatment Options in Gastroenterology 2001 4 1 7 14
14. Ivanov I. I., Atarashi K., Manel N., Brodie E. L., Shima T., Karaoz U., Wei D., Goldfarb K. C., Santee C. A., Lynch S. V., Tanoue T., Imaoka A., Itoh K., Takeda K., Umesaki Y., Honda K., Littman D. R., Induction of intestinal Th17 cells by segmented filamentous bacteria Cell 2009 139 3 485 498
15. Wen L., Ley R. E., Volchkov P. YU., Stranges P. B., Avanesyan L., Stonebraker A. C., Hu C., Wong F. S., Szot G. L., Bluestone J. A., Gordon J. I., Chervonsky A. V., Innate immunity and intestinal microbiota in the development of Type 1 diabetes Nature 2008 455 7216 1109 1113
16. Eckburg P. B., Bik E. M., Bernstein C. N., Purdom E., Dethlefsen L., Sargent M., Gill S. R., Nelson K. E., Relman D. A., Diversity of the human intestinal microbial flora Science 2005 308 5728 1635 1638
17. Blaut M., Relationship of prebiotics and food to intestinal microflora European Journal of Nutrition 2002 41 supplement 1 11 16
18. Itoh K., Lee W. K., Kawamura H., Intestinal bacteria antagonistic to Clostridium difficile in mice Laboratory Animals 1987 21 1 20 25
19. Rohde C. L., Bartolini V., Jones N., The use of probiotics in the prevention and treatment of antibiotic-associated diarrhea with special interest in Clostridium difficile associated diarrhea Nutrition in Clinical Practice 2009 24 1 33 40
20. Taguchi H., Takahashi M., Yamaguchi H., Osaki T., Komatsu A., Fujioka Y., Kamiya S., Experimental infection of germ-free mice with hyper-toxigenic enterohaemorrhagic Escherichia coli O157:H7, strain 6 Journal of Medical Microbiology 2002 51 4 336 343
21. Gordon J. I., Hooper L. V., Shane McNevin M., Wong M., Bry L., Epithelial cell growth and differentiation III. Promoting diversity in the intestine: conversations between the microflora, epithelium, and diffuse GALT American Journal of Physiology 1997 273 3 G565 G570
22. Umesaki Y., Okada Y., Matsumoto S., Imaoka A., Setoyama H., Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the ex-germ-free mouse Microbiology and Immunology 1995 39 8 555 562
23. Luciano L., Hass R., Busche R., Engelhardt W. V., Reale E., Withdrawal of butyrate from the colonic mucosa triggers 'mass apoptosis' primarily in the G0/G1 phase of the cell cycle Cell and Tissue Research 1996 286 1 81 92
24. Ham M., Kaunitz J. D., Gastroduodenal defense Current Opinion in Gastroenterology 2007 23 6 607 616
25. Van der Sluis M., De Koning B. A. E., De Bruijn A. C. J. M., Velcich A., Meijerink J. P. P., Van Goudoever J. B., Bller H. A., Dekker J., Van Seuningen I., Renes I. B., Einerhand A. W. C., Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection Gastroenterology 2006 131 1 117 129
26. Kyo K., Muto T., Nagawa H., Lathrop G. M., Nakamura Y., Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease Journal of Human Genetics 2001 46 1 5 20
27. Al-Sadi R., Boivin M., Ma T., Mechanism of cytokine modulation of epithelial tight junction barrier Frontiers in Bioscience 2009 14 2765 2778
28. Foti M., Ricciardi-Castagnoli P., Antigen sampling by mucosal dendritic cells Trends in Molecular Medicine 2005 11 9 394 396
29. Telemo E., Korotkova M., Hanson L., Antigen presentation and processing in the intestinal mucosa and lymphocyte homing Annals of Allergy, Asthma and Immunology 2003 90 6, supplement 3 28 33
30. Himmel M. E., Hardenberg G., Piccirillo C. A., Steiner T. S., Levings M. K., The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease Immunology 2008 125 2 145 153
31. Hansen J. J., Holt L., Sartor R. B., Gene expression patterns in experimental colitis in IL-10-deficient mice Inflammatory Bowel Diseases 2009 15 6 890 899
32. Ostanin D. V., Bao J., Koboziev I., Gray L., Robinson-Jackson S. A., Kosloski-Davidson M., Price V. H., Grisham M. B., T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade American Journal of Physiology 2009 296 2 G135 G146
33. Yrios J. W., Balish E., Pathogenesis of Campylobacter spp. in athymic and euthymic germfree mice Infection and Immunity 1986 53 2 384 392 (Pubitemid 16073870)
34. Martin H. M., Campbell B. J., Hart C. A., Mpofu C., Nayar M., Singh R., Englyst H., Williams H. F., Rhodes J. M., Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer Gastroenterology 2004 127 1 80 93
35. Baffy G., Kupffer cells in non-alcoholic fatty liver disease: the emerging view Journal of Hepatology 2009 51 1 212 223
36. Van Egmond M., Van Garderen E., Van Spriel A. B., Damen C. A., Van Amersfoort E. S., Van Zandbergen G., Van Hattum J., Kuiper J., Van De Winkel J. G. J., Fc RI-positive liver Kupffer cells: reappraisal of the function of immunoglobulin A in immunity Nature Medicine 2000 6 6 680 685
37. Fox E. S., Thomas P., Broitman S. A., Clearance of gut-derived endotoxins by the liver. Release and modification of 3H,14C-lipopolysaccharide by isolated rat Kupffer cells Gastroenterology 1989 96 2 456 461
38. Okumura Y., Ishibashi H., Shirahama M., Kupffer cells modulate natural killer cell activity in vitro by producing prostaglandins Cellular Immunology 1987 107 1 89 98
39. Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y.-J., Pulendran B., Palucka K., Immunobiology of dendritic cells Annual Review of Immunology 2000 18 767 811
40. Kanto T., Hayashi N., Innate immunity in hepatitis C virus infection: interplay among dendritic cells, natural killer cells and natural killer T cells Hepatology Research 2007 37 supplement 3 S319 S326
41. Gumperz J. E., CD1d-restricted "NKT" cells and myeloid IL-12 production: an immunological crossroads leading to promotion or suppression of effective anti-tumor immune responses? Journal of Leukocyte Biology 2004 76 2 307 313
42. Orange J. S., Ballas Z. K., Natural killer cells in human health and disease Clinical Immunology 2006 118 1 1 10
43. Wisse E., Luo D., Vermijlen D., Kanellopoulou C., De Zanger R., Braet F., On the function of pit cells, the liver-specific natural killer cells Seminars in Liver Disease 1997 17 4 265 286
44. Granucci F., Zanoni I., Pavelka N., Van Dommelen S. L. H., Andoniou C. E., Belardelli F., Degli Esposti M. A., Ricciardi-Castagnoli P., A contribution of mouse dendritic cell-derived IL-2 for NK cell activation Journal of Experimental Medicine 2004 200 3 287 295
45. Wiltrout R. H., Herberman R. B., Zhang S. R., Role of organ-associated NK cells in decreased formation of experimental metastases in lung and liver Journal of Immunology 1985 134 6 4267 4275
46. Radaeva S., Sun R., Jaruga B., Nguyen V. T., Tian Z., Gao B., Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners Gastroenterology 2006 130 2 435 452
47. Gao B., Radaeva S., Park O., Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases Journal of Leukocyte Biology 2009 86 3 513 528
48. Li Z., Lin H., Yang S., Diehl A. M., Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system Gastroenterology 2002 123 4 1304 1310
49. Kremer M., Thomas E., Milton R. J., Perry A. W., Van Rooijen N., Wheeler M. D., Zacks S., Fried M., Rippe R. A., Hines I. N., Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis Hepatology 2010 51 1 130 141
50. Minagawa M., Deng Q., Liu Z.-X., Tsukamoto H., Dennert G., Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor- during alcohol consumption Gastroenterology 2004 126 5 1387 1399
51. Jiang W., Sun R., Zhou R., Wei H., Tian Z., TLR-9 activation aggravates concanavalin A-induced hepatitis via promoting accumulation and activation of liver CD4 + NKT cells Journal of Immunology 2009 182 6 3768 3774
52. Crispe I. N., The liver as a lymphoid organ Annual Review of Immunology 2009 27 147 163
53. Roger P.-M., Chaillou S., Breittmayer J.-P., Dahman M., St. Paul M.-C., Chevallier P., Benzaken S., Ticchioni M., Bernard A., Dellamonica P., Tran A., Intrahepatic CD4 + T-cell apoptosis is related to METAVIR score in patients with chronic hepatitis C virus Scandinavian Journal of Immunology 2005 62 2 168 175
54. Zwacka R. M., Zhang Y., Halldorson J., Schlossberg H., Dudus L., Engelhardt J. F., CD4 + T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver Journal of Clinical Investigation 1997 100 2 279 289
55. Safadi R., Ohta M., Alvarez C. E., Fiel M. I., Bansal M., Mehal W. Z., Friedman S. L., Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes Gastroenterology 2004 127 3 870 882
56. Takaku S., Nakagawa Y., Shimizu M., Norose Y., Maruyama I., Wakita T., Takano T., Kohara M., Takahashi H., Induction of hepatic injury by hepatitis C virus-specific CD8 + murine cytotoxic T lymphocytes in transgenic mice expressing the viral structural genes Biochemical and Biophysical Research Communications 2003 301 2 330 337
57. Lichtman S. N., Keku J., Schwab J. H., Sartor R. B., Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline Gastroenterology 1991 100 2 513 519
58. Shomer N. H., Fox J. G., Juedes A. E., Ruddle N. H., Helicobacter-induced chronic active lymphoid aggregates have characteristics of tertiary lymphoid tissue Infection and Immunity 2003 71 6 3572 3577
59. Moura S. B., Mendes E. N., Queiroz D. M. M., Nicoli J. R., Cabral M. M. D. A., Magalhaes P. P., Rocha G. A., Vieira. C., Microbiological and histological study of the gastrointestinal tract of germ-free mice infected with Helicobacter trogontum Research in Microbiology 1999 150 3 205 212
60. Scott J. R., Fox-Robichaud A. E., Hepatic leukocyte recruitment in a model of acute colitis American Journal of Physiology 2002 283 3 G561 G566
61. Navaneethan U., Shen B., Hepatopancreatobiliary manifestations and complications associated with inflammatory bowel disease. Inflammatory Bowel Disease. In press
62. John B., Crispe I. N., TLR-4 regulates CD8 + T cell trapping in the liver Journal of Immunology 2005 175 3 1643 1650
63. Numata Y., Tazuma S., Ueno Y., Nishioka T., Hyogo H., Chayama K., Therapeutic effect of repeated natural killer T cell stimulation in mouse cholangitis complicated by colitis Digestive Diseases and Sciences 2005 50 10 1844 1851
64. Bambha K., Kim W. R., Talwalkar J., Torgerson H., Benson J. T., Therneau T. M., Loftus E. V. Jr., Yawn B. P., Dickson E. R., Melton L. J. III, Incidence, clinical spectrum, and outcomes of primary sclerosing cholangitis in a united states community Gastroenterology 2003 125 5 1364 1369
65. Hines I. N., Wheeler M. D., Recent advances in alcoholic liver disease III. Role of the innate immune response in alcoholic hepatitis American Journal of Physiology 2004 287 2 G310 G314
66. Bode C., Kugler V., Bode J. C., Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess Journal of Hepatology 1987 4 1 8 14
67. Uesugi T., Froh M., Arteel G. E., Bradford B. U., Thurman R. G., Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice Hepatology 2001 34 1 101 108 (Pubitemid 32591488)
68. Enomoto N., Ikejima K., Yamashina S., Hirose M., Shimizu H., Kitamura T., Takei Y., Sato N., Thurman R. G., Kupffer cell sensitization by alcohol involves increased permeability to gut-derived endotoxin Alcoholism: Clinical and Experimental Research 2001 25 6, supplement 51S 54S
69. Enomoto N., Ikejima K., Kitamura T., Oide H., Takei Y., Sato N., Thurman R. G., Alcohol enhances lipopolysaccharide-induced increases in nitric oxide production by Kupffer cells via mechanisms dependent on endotoxin Alcoholism: Clinical and Experimental Research 2000 24 4, supplement 55S 58S
70. Wheeler M. D., Kono H., Yin M., Nakagami M., Uesugi T., Arteel G. E., Gbele E., Rusyn I., Yamashina S., Froh M., Adachi Y., Iimuro Y., Bradford B. U., Smutney O. M., Connor H. D., Mason R. P., Goyert S. M., Peters J. M., Gonzalez F. J., Samulski R. J., Thurman R. G., The role of kupffer cell oxidant production in early ethanol-induced liver disease Free Radical Biology and Medicine 2001 31 12 1544 1549
71. Purohit V., Bode J. C., Bode C., Brenner D. A., Choudhry M. A., Hamilton F., Kang Y. J., Keshavarzian A., Rao R., Sartor R. B., Swanson C., Turner J. R., Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium Alcohol 2008 42 5 349 361
72. Rao R., Endotoxemia and gut barrier dysfunction in alcoholic liver disease Hepatology 2009 50 2 638 644
73. Fukui H., Kitano H., Okamoto Y., Kikuchi E., Matsumoto M., Kikukawa M., Morimura M., Tsujita S., Nagamoto I., Nakatani T., Tsujii T., Interaction of Kupffer cells to splenic macrophages and hepatocytes in endotoxin clearance: effect of alcohol Journal of Gastroenterology and Hepatology 1995 10 1 S31 S34
74. Ma T. Y., Nguyen D., Bui V., Nguyen H., Hoa N., Ethanol modulation of intestinal epithelial tight junction barrier American Journal of Physiology 1999 276 4 G965 G974
75. Salaspuro M., Bacteriocolonic pathway for ethanol oxidation: characteristics and implications Annals of Medicine 1996 28 3 195 200
76. Koppe S. W. P., Sahai A., Malladi P., Whitington P. F., Green R. M., Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet Journal of Hepatology 2004 41 4 592 598
77. Satapathy S. K., Sakhuja P., Malhotra V., Sharma B. C., Sarin S. K., Beneficial effects of pentoxifylline on hepatic steatosis, fibrosis and necroinflammation in patients with non-alcoholic steatohepatitis Journal of Gastroenterology and Hepatology 2007 22 5 634 638
78. Diehl A. M., Lessons from animal models of NASH Hepatology Research 2005 33 2 138 144
79. Miele L., Valenza V., La Torre G., Montalto M., Cammarota G., Ricci R., Mascian R., Forgione A., Gabrieli M. L., Perotti G., Vecchio F. M., Rapaccini G., Gasbarrini G., Day C. P., Grieco A., Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease Hepatology 2009 49 6 1877 1887
80. Wu W.-C., Zhao W., Li S., Small intestinal bacteria overgrowth decreases small intestinal motility in the NASH rats World Journal of Gastroenterology 2008 14 2 313 317
81. Szabo G., Velayudham A., Romics L. Jr., Mandrekar P., Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4 Alcoholism: Clinical and Experimental Research 2005 29 11, supplement
82. Spruss A., Kanuri G., Wagnerberger S., Haub S., Bischoff S. C., Bergheim I., Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice Hepatology 2009 50 4 1094 1104
83. Miura K., Kodama Y., Inokuchi S., Schnabl B., Aoyama T., Ohnishi H., Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. In press
84. Wright R. S., Anderson J. W., Bridges S. R., Propionate inhibits hepatocyte lipid synthesis Proceedings of the Society for Experimental Biology and Medicine 1990 195 1 26 29
85. Cani P. D., Bibiloni R., Knauf C., Waget A., Neyrinck A. M., Delzenne N. M., Burcelin R., Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice Diabetes 2008 57 6 1470 1481
86. Cani P. D., Delzenne N. M., Amar J., Burcelin R., Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding Pathologie Biologie 2008 56 5 305 309
87. Cani P. D., Neyrinck A. M., Fava F., Knauf C., Burcelin R. G., Tuohy K. M., Gibson G. R., Delzenne N. M., Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia Diabetologia 2007 50 11 2374 2383
88. Hines I. N., Hoffman J. M., Scheerens H., Day B. J., Harada H., Pavlick K. P., Bharwani S., Wolf R., Gao B., Flores S., McCord J. M., Grisham M. B., Regulation of postischemic liver injury following different durations of ischemia American Journal of Physiology 2003 284 3 G536 G545
89. Farhood A., McGuire G. M., Manning A. M., Miyasaka M., Smith C. W., Jaeschke H., Intercellular adhesion molecule 1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver Journal of Leukocyte Biology 1995 57 3 368 374
90. Shen X.-D., Ke B., Zhai Y., Gao F., Busuttil R. W., Cheng G., Kupiec-Weglinski J. W., Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury American Journal of Transplantation 2005 5 8 1793 1800
91. Tsung A., Hoffman R. A., Izuishi K., Critchlow N. D., Nakao A., Chan M. H., Lotze M. T., Geller D. A., Billiar T. R., Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells Journal of Immunology 2005 175 11 7661 7668
92. Devey L., Ferenbach D., Mohr E., Sangster K., Bellamy C. O., Hughes J., Wigmore S. J., Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism Molecular Therapy 2009 17 1 65 72
93. Pillay S. P., Wynter C., Lynch S., Wall D., Balderson G., Strong R., Endotoxin levels in donors and recipients during orthotopic liver transplantation Australian and New Zealand Journal of Surgery 1997 67 4 187 191
94. Emre S., Sebastian A., Chodoff L., Boccagni P., Meyers B., Sheiner P. A., Mor E., Guy S. R., Atillasoy E., Schwartz M. E., Miller C. M., Selective decontamination of the digestive tract helps prevent bacterial infections in the early postoperative period after liver transplant Mount Sinai Journal of Medicine 1999 66 5-6 310 313
95. Arai M., Mochida S., Ohno A., Arai S., Fujiwara K., Selective bowel decontamination of recipients for prevention against liver injury following orthotopic liver transplantation: evaluation with rat models Hepatology 1998 27 1 123 127
96. Lee J.-S., Thorgeirsson S. S., Genome-scale profiling of gene expression in hepatocellular carcinoma: classification, survival prediction, and identification of therapeutic targets Gastroenterology 2004 127 5, supplement S51 S55
97. Groopman J. D., Kensler T. W., Wild C. P., Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries Annual Review of Public Health 2008 29 187 203
98. Romeo R., Colombo M., The natural history of hepatocellular carcinoma Toxicology 2002 181-182 39 42
99. Lopez J. B., Recent developments in the first detection of hepatocellular carcinoma The Clinical Biochemist. Reviews 2005 26 3 65 79
100. Fox J. G., Feng Y., Theve E. J., Raczynski A. R., Fiala J. L.A., Doernte A. L., Williams M., McFaline J. L., Essigmann J. M., Schauer D. B., Tannenbaum S. R., Dedon P. C., Weinman S. A., Lemon S. M., Fry R. C., Rogers A. B., Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens Gut 2010 59 1 88 97
101. Abu Al-Soud W., Stenram U., Ljungh A., Tranberg K.-G., Nilsson H.-O., Wadstrm T., DNA of Helicobacter spp. and common gut bacteria in primary liver carcinoma Digestive and Liver Disease 2008 40 2 126 131
102. Xuan S.-Y., Li N., Qiang X., Zhou R.-R., Shi Y.-X., Jiang W.-J., Helicobacter infection in hepatocellular carcinoma tissue World Journal of Gastroenterology 2006 12 15 2335 2340
103. Bataller R., Brenner D. A., Liver fibrosis Journal of Clinical Investigation 2005 115 2 209 218
104. Seki E., De Minicis S., sterreicher C. H., Kluwe J., Osawa Y., Brenner D. A., Schwabe R. F., TLR4 enhances TGF- signaling and hepatic fibrosis Nature Medicine 2007 13 11 1324 1332
105. Shi Z., Wakil A. E., Rockey D. C., Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses Proceedings of the National Academy of Sciences of the United States of America 1997 94 20 10663 10668
106. Isayama F., Hines I. N., Kremer M., Milton R. J., Byrd C. L., Perry A. W., McKim S. E., Parsons C., Rippe R. A., Wheeler M. D., LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice American Journal of Physiology 2006 290 6 G1318 G1328
107. Paik Y.-H., Lee K. S., Lee H. J., Yang K. M., Lee S. J., Lee D. K., Han K.-H., Chon C. Y., Lee S. I., Moon Y. M., Brenner D. A., Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid Laboratory Investigation 2006 86 7 676 686
108. Paik Y.-H., Schwabe R. F., Bataller R., Russo M. P., Jobin C., Brenner D. A., Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells Hepatology 2003 37 5 1043 1055
109. Bauer T. M., Steinbrckner B., Brinkmann F. E., Ditzen A. K., Schwacha H., Aponte J. J., Pelz K., Kist M., Blum H. E., Small intestinal bacterial overgrowth in patients with cirrhosis: prevalence and relation with spontaneous bacterial peritonitis American Journal of Gastroenterology 2001 96 10 2962 2967
110. Gunnarsdottir S. A., Sadik R., Shev S., Simrn M., Sjvall H., Stotzer P.-O., Abrahamsson H., Olsson R., Bjrnsson E. S., Small intestinal motility disturbances and bacterial overgrowth in patients with liver cirrhosis and portal hypertension American Journal of Gastroenterology 2003 98 6 1362 1370 (Pubitemid 36741535)
111. Miettinen T. A., Lipid absorption, bile acids, and cholesterol metabolism in patients with chronic liver disease Gut 1972 13 9 682 689
112. Sung J. Y., Shaffer E. A., Costerton J. W., Antibacterial activity of bile salts against common biliary pathogens. Effects of hydrophobicity of the molecule and in the presence of phospholipids Digestive Diseases and Sciences 1993 38 11 2104 2112
113. Inagaki T., Moschetta A., Lee Y.-K., Peng L., Zhao G., Downes M., Yu R. T., Shelton J. M., Richardson J. A., Repa J. J., Mangelsdorf D. J., Kliewer S. A., Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor Proceedings of the National Academy of Sciences of the United States of America 2006 103 10 3920 3925
114. Castilla-Cortzar I., Pascual M., Urdaneta E., Pardo J., Puche J. E., Vivas B., Daz-Casares A., Garca M., Daz-Snchez M., Varela-Nieto I., Castilla A., Gonzlez-Barn S., Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by insulin-like growth factor I BMC Gastroenterology 2004 4, article no. 12
115. Washington M. K., Autoimmune liver disease: overlap and outliers Modern Pathology 2007 20 supplement 1 S15 S30
116. Kremer M., Perry A. W., Milton R. J., Rippe R. A., Wheeler M. D., Hines I. N., Pivotal role of Smad3 in a mouse model of T cell-mediated hepatitis Hepatology 2008 47 1 113 126
117. Jaruga B., Hong F., Sun R., Radaeva S., Gao B., Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes Journal of Immunology 2003 171 6 3233 3244
118. Kondo T., Suda T., Fukuyama H., Adachi M., Nagata S., Essential roles in the Fas ligand in the development of hepatitis Nature Medicine 1997 3 4 409 413
119. Seino K.-I., Kayagaki N., Takeda K., Fukao K., Okumura K., Yagita H., Contribution of Fas ligand to T cell-mediated hepatic injury in mice Gastroenterology 1997 113 4 1315 1322
120. Takeda K., Hayakawa Y., Van Kaer L., Matsuda H., Yagita H., Okumura K., Critical contribution of liver natural killer T cells to a murine model of hepatitis Proceedings of the National Academy of Sciences of the United States of America 2000 97 10 5498 5503
121. Mizuhara H., Uno M., Seki N., Yamashita M., Yamaoka M., Ogawa T., Kaneda K., Fujii T., Senoh H., Fujiwara H., Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis Hepatology 1996 23 6 1608 1615
122. Hopf U., Stemerowicz R., Rodloff A., Galanos C., Moller B., Lobeck H., Freudenberg M., Huhn D., Relation between Escherichia coli R(rough)-forms in gut, lipid A in liver, and primary biliary cirrhosis Lancet 1989 2 8677 1419 1422
123. Silveira M. G., Lindor K. D., Primary sclerosing cholangitis Canadian Journal of Gastroenterology 2008 22 8 689 698
124. Wojczys R., Liver involvement and its course in experimental colitis in rats Hepato-Gastroenterology 1997 44 16 1193 1195
125. Fung J., Lai C.-L., Yuen M.-F., Hepatitis B and C virus-related carcinogenesis Clinical Microbiology and Infection 2009 15 11 964 970
126. Perrault M., Pcheur E.-I., The hepatitis C virus and its hepatic environment: a toxic but finely tuned partnership Biochemical Journal 2009 423 3 303 314
127. Machida K., Tsukamoto H., Mkrtchyan H., Duan L., Dynnyk A., Liu H. M., Asahina K., Govindarajan S., Ray R., James J.-H., Seki E., Deshaies R., Miyake K., Lai M. M.-C., Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog Proceedings of the National Academy of Sciences of the United States of America 2009 106 5 1548 1553