Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR

Toxicology Letters

Volumn 222, Issue 2, 2013, Pages 180-188

  Luckert, Claudia ^a   Ehlers, Anke ^a   Buhrke, Thorsten ^a   Seidel, Albrecht ^b   Lampen, Alfonso ^a   Hessel, Stefanie ^a  

^a FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^b Biochemical Institute for Environmental Carcinogens   (Germany)

Author keywords

CYP3A4 induction; Polycyclic aromatic hydrocarbons; PXR; Reporter gene assay

Indexed keywords

CYTOCHROME P450 3A4; DIBENZO[A,L]PYRENE; EPOXIDE; PHENANTHRENE; POLYCYCLIC AROMATIC HYDROCARBON; PREGNANE X RECEPTOR;

ARTICLE; BIOLOGICAL ACTIVITY; CELL STRAIN HEK293; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; METABOLITE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; TRANSACTIVATION; TRANSCRIPTION INITIATION; WESTERN BLOTTING; XENOBIOTIC METABOLISM;

(±)-ANTI-11,12-DIHYDROXY-13,14-EPOXY-11,12,13,14-TETRAHYDRODIBENZO[A,L]PYRENE; (±)-ANTI-3,4-DIHYDROXY-1,2-EPOXY-1,2,3,4-TETRAHYDROBENZO[C]PHENANTHRENE; (±)-ANTI-7,8-DIHYDROXY-9,10-EPOXY-7,8,9,10-TETRAHYDROBENZO[A]PYRENE; (±)-TRANS-11,12-DIHYDROXY-11,12-DIHYDRODIBENZO[A,L]PYRENE; (±)-TRANS-3,4-DIHYDROXY-3,4-DIHYDROBENZO[C]PHENANTHRENE; (±)-TRANS-7,8-DIHYDROXY-7,8-DIHYDROBENZO[A]PYRENE; 3-MC; 3-METHYLCHOLANTHRENE; AHR; ARYL HYDROCARBON RECEPTOR; BAP; BAPD; BAPDE; BCP; BCPD; BCPDE; BENZO[A]PYRENE; BENZO[C]PHENANTHRENE; CAR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYP; CYP3A4 INDUCTION; CYTOCHROME P(450) MONOOXYGENASE(S); DBALP; DBALPD; DBALPDE; DBD; DIBENZO[A,L]PYRENE; DIRECT REPEAT; DISTAL NUCLEAR RECEPTOR-BINDING ELEMENT(S); DNA-BINDING DOMAIN; DNR; DR; ER; EVERTED REPEAT; GLUTATHIONE S-TRANSFERASE(S); GST; LBD; LIGAND-BINDING DOMAIN; PAH; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Γ; POLYCYCLIC AROMATIC HYDROCARBON(S); POLYCYCLIC AROMATIC HYDROCARBONS; PPARΓ; PREGNANE X RECEPTOR; PXR; PXR RESPONSIVE ELEMENT(S); PXRE; QRT-PCR; REAL-TIME QUANTITATIVE PCR; REPORTER GENE ASSAY; UAS; UDP-GLUCURONOSYLTRANSFERASE(S); UGT; UPSTREAM ACTIVATION SEQUENCE; XENOBIOTIC-RESPONSIVE ENHANCER MODULE; XREM;

BENZO(A)PYRENE; BENZOPYRENES; CARCINOGENS, ENVIRONMENTAL; CELL SURVIVAL; CYTOCHROME P-450 CYP3A; DIHYDROXYDIHYDROBENZOPYRENES; ENZYME INDUCTION; EPOXY COMPOUNDS; GENES, REPORTER; HEK293 CELLS; HEP G2 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; POLYCYCLIC HYDROCARBONS, AROMATIC; PROMOTER REGIONS, GENETIC; RECEPTORS, STEROID; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION;

EID: 84882765531     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.06.243     Document Type: Article

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