Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction

Journal of Hepatology

Volumn 57, Issue 3, 2012, Pages 628-636

  Takayama, Kazuo ^a,b   Inamura, Mitsuru ^a,b   Kawabata, Kenji ^a,b   Sugawara, Michiko ^c   Kikuchi, Kiyomi ^c   Higuchi, Maiko ^b   Nagamoto, Yasuhito ^a,b   Watanabe, Hitoshi ^a,b   Tashiro, Katsuhisa ^b   Sakurai, Fuminori ^a   Hayakawa, Takao ^d,e   Furue, Miho Kusuda ^b,f   Mizuguchi, Hiroyuki ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^c EISAI CO LTD   (Japan)

^d PHARMACEUTICALS AND MEDICAL DEVICES AGENCY   (Japan)

^e KINKI UNIVERSITY   (Japan)

^f KYOTO UNIVERSITY   (Japan)

Author keywords

Adenovirus; Drug metabolism; Drug screening; FOXA2; Hepatocytes; HESCs; HiPSCs; HNF1

Indexed keywords

ALBUMIN; AMFEBUTAMONE; BUFURALOL; CYTOCHROME P450; CYTOCHROME P450 3A7; FIBROBLAST GROWTH FACTOR 1; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 3BETA; INDOCYANINE GREEN; LOW DENSITY LIPOPROTEIN; MIDAZOLAM; PACLITAXEL; PHENACETIN; TOLBUTAMIDE; TRANSCRIPTION FACTOR SOX17; UREA;

ARTICLE; CELL DIFFERENTIATION; CELL EXPANSION; CELL METABOLISM; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG METABOLISM; ENDODERM; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; LIVER CELL; LIVER DEVELOPMENT; LIVER METABOLISM; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; UPREGULATION;

BUPROPION; CELL DIFFERENTIATION; CELL LINE; EMBRYONIC STEM CELLS; ETHANOLAMINES; GENE TRANSFER TECHNIQUES; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HEPATOCYTES; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MIDAZOLAM; PACLITAXEL; PHENACETIN; TESTOSTERONE; TOLBUTAMIDE; TRANSDUCTION, GENETIC;

EID: 84865152827     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.04.038     Document Type: Article

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