Comparative expression of two alpha class glutathione S-transferases in human adult and prenatal liver tissues

Biochemical Pharmacology

Volumn 63, Issue 11, 2002, Pages 2025-2036

  Gallagher, Evan P ^a   Gardner, James L ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

4 Hydroxynonenal; Glutathione S transferases; Mitochondria; Northern analysis; Prenatal liver

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 4 HYDROXYNONENAL; DELTA5 ANDROSTENE 3,17 DIONE; GLUTATHIONE TRANSFERASE; HYDROPEROXIDE DERIVATIVE; ISOENZYME; MESSENGER RNA; PEROXIDASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; LIVER; MUTAGENESIS; NORTHERN BLOTTING; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION; STEADY STATE; TISSUE SPECIFICITY;

ADULT; BLOTTING, NORTHERN; CATALYSIS; CYTOSOL; GLUTATHIONE TRANSFERASE; HUMANS; LIVER; MITOCHONDRIA; SUBCELLULAR FRACTIONS; TISSUE DISTRIBUTION;

EID: 0036609083     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01017-1     Document Type: Article

References (39)

1. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
2. Increased resistance to oxidative stress in transfected cultured cells overexpressing glutathione S-transferase mGSTA4-4
3. Glutathione transferases - Structure and catalytic activity
4. Human glutathione transferase A4-4: An Alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation
5. The role of human glutathione S-transferases hGSTA1-1 and hGSTA2-2 in protection against oxidative stress
6. Glutathione S-transferase and glutathione peroxidase expression in normal and tumor human tissues
7. The developmental expression of alpha-, mu- and pi-class glutathione S-transferases in human liver
8. Genomic organization, 5′-flanking region and chromosomal organization of the human glutathione transferase A4 gene
9. Chemistry and biology of 4-hydroxynonenal, malondialdehyde and related aldehydes
10. Identification of cDNAs encoding two human Alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4
11. The role of biotransformation in developmental toxicity
12. Immunochemical evidence for the occurrence of mu class glutathione S-transferase in human fetal livers
13. Variations in the glutathione S-transferase subunits expressed in human livers
14. Development of a peptide antibody against human glutathione S-transferase A4 (hGSTA4-4) reveals preferential localization in hepatic mitochondria
15. Measurement of protein using bicinchoninic acid
16. Effects of phenytoin on oxidative stress biomarkers and tissue viability in cultured human prenatal liver slices
17. Assays for differentiation of glutathione S-transferase
18. Analysis of glutuatione-related enzymes
19. 4-Hydroxyalk-2-enals are substrates for glutathione transferase
20. Several closely related glutathione S-transferase isozymes catalyzing conjugation of 4-hydroxynonenal are differentially expressed in human tissues
21. Biochemical toxicology of chemical teratogenesis
22. The potential role of redox cycling as a mechanism for chemical teratogenesis
23. Xenobiotic biotransformation/bioactivation in organogenesis-stage conceptual tissues: Implications for embryotoxicity and teratogenesis
24. P450 genes: Structure, evolution, and regulation
25. Glutathione S-transferases in neonatal liver disease
26. Two distinct forms of glutathione transferase from human foetal liver. Purification and comparison with isoenzymes isolated from adult liver and placenta
27. Purification and characterization of a hepatic mitochondrial glutathione S-transferase exhibiting immunochemical relationship to the α-class of cytosolic isoenzymes
28. Preferential effects of nicotine and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase A4-4 induction and increased oxidative stress in the rat brain
29. A novel glutathione transferase (13-13) isolated from the matrix of rat liver mitochondria having structural similarity to class Theta enzymes
30. 4-Hydroxynonenal levels are enhanced in fetal liver mitochondria by in utero ethanol exposure
31. Co-metabolism of ethanol, ethanol-derived acetaldehyde, and 4-hydroxynonenal in isolated rat hepatocytes
32. Two distinctive 4-hydroxynonenal metabolizing glutathione S-transferase isoenzymes are differentially expressed in human tissues
33. 1 epoxide and other substrates
34. Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione S-transferase, and epoxide hydrolase enzymes: Relevance to xenobiotic metabolism and toxicity
35. Genetic monitoring of human polymorphic cancer susceptibility genes by polymerase chain reaction: Application to glutathione transferase μ
36. Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and susceptibility to bladder, testicular and prostate cancer
37. Glutathione S-transferase-mu in human lymphocyte and liver: Role in modulating formation of carcinogen-derived DNA adducts
38. The glutathione S-transferase mu polymorphism as a marker for susceptibility to lung carcinoma
39. Organ distribution of glutathione transferase isoenzymes in the human fetus: Differences between liver and extrahepatic tissues