The differential cytotoxicity of methotrexate in rat hepatocyte monolayer and spheroid cultures

Toxicology in Vitro

Volumn 14, Issue 5, 2000, Pages 475-485

  Walker, T M ^a   Rhodes, P C ^a   Westmoreland, C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Chronic toxicity; Long term liver culture; Methotrexate; Spheroids

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUTATHIONE; METHOTREXATE;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CHRONIC TOXICITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; LIVER CELL; LIVER TOXICITY; MALE; NONHUMAN; RAT; SPHEROID CELL; TOXICITY TESTING;

ADENOSINE TRIPHOSPHATE; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; L-LACTATE DEHYDROGENASE; LIVER; MALE; METHOTREXATE; RATS; RATS, WISTAR; SPHEROIDS, CELLULAR; TOXICITY TESTS;

ANIMALIA;

EID: 0033838279     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(00)00036-9     Document Type: Article

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