Twenty years of biochemistry of human p450s. Purification, expression, mechanism, and relevance to drugs

Drug Metabolism and Disposition

Volumn 26, Issue 12, 1998, Pages 1175-1178

  Peter Guengerich, F ^a   Hosea, Natilie A ^a   Parikh, Asit ^a   Chastine Bell Parikh, L ^a   Johnson, William W ^a,d   Gillam, Elizabeth M J ^b   Shimada, Tsutomu ^a,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c Osaka Pref Inst of Public Health   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DRUG;

DRUG METABOLISM; DRUG RESEARCH; ENZYME ACTIVITY; ENZYME PURIFICATION; GENOTOXICITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0032416603     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (12)

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2. S on steady-state kinetics. J Biol Chem 272:29643-29651.
3. Chun Y-J, Shimada T and Guengerich FP (1996) Construction of a human cytochrome P450 1A1: Rat NADPH-P450 reductase fusion protein cDNA, expression in Escherichia coli, purification, and catalytic properties of the enzyme in bacterial cells and after purification. Arch Biochem Biophys 330:48-58.
4. Chvapil M, Eskelson CD, Stiffel V, Owen JA and Droegemueller W (1980) Studies on nonoxynol-9: II. Intravaginal absorption, distribution, metabolism and excretion in rats and rabbits. Contraception 22:325-339.
5. Cupples CG, Cabrera M, Cruz C and Miller JH (1990) A set of lacZ mutations in Escherichia coli that allow rapid detection of specific frameshift mutations. Genetics 125:275-280.
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7. Dong M-S, Yamazaki H, Guo Z and Guengerich FP (1996) Recombinant human cytochrome P450 1A2 and an N-terminal truncated form: Construction, purification, aggregation properties, and interactions with flavodoxin, ferredoxin, and NADPH-cytochrome P450 reductase. Arch. Biochem. Biophys. 327:11-19.
8. Guengerich FP (1991) Reactions and significance of cytochrome P-450 enzymes. J Biol Chem 266:10019-10022.
9. Guengerich FP (1995) Human cytochrome P450 enzymes, in Cytochrome P450 (Ortiz de Montellano PR ed), pp 473-535, Plenum Press, New York.
10. Guengerich FP, Gillam EMJ and Shimada T (1996) New applications of bacterial systems to problems in toxicology. Crit Rev Toxicol 26:551-583.
11. Guengerich FP and Johnson WW (1997) Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: Rapid reduction in absence of substrate and variation among cytochrome P450 systems. Biochemistry 36:14741-14750.
12. Guengerich FP, Martin MV, Beaune PH, Kremers P, Wolff T and Waxman DJ (1986) Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. J Biol Chem 261:5051-5060.