Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells

Toxicological Sciences

Volumn 112, Issue 1, 2009, Pages 229-244

  Kim, Suntae ^a,b   Dere, Edward ^a,b   Burgoon, Lyle D ^a,b   Chang, Chia Cheng ^a,c   Zacharewski, Timothy R ^a,b  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Comparative; Human; Human liver stem cell; Liver; TCDD; Toxicogenomics

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; COMPLEMENTARY DNA; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DIMETHYL SULFOXIDE; GENE PRODUCT; PROTEIN ALDH1A3; PROTEIN SLC7A5; UNCLASSIFIED DRUG;

ARTICLE; BAYES THEOREM; C57BL 6 MOUSE; CANCER CELL CULTURE; CELL STRAIN HEPA1C1C7; CELL STRAIN HEPG2; CELL STRAIN HL1 1; CELL TRANSPORT; COMPARATIVE STUDY; CONTROLLED STUDY; DNA MICROARRAY; DOSE RESPONSE; GENE EXPRESSION PROFILING; GENE FUNCTION; GENETIC DIFFERENCE; GENETIC IDENTIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IN VIVO STUDY; LIPID METABOLISM; LIVER CELL; NUCLEOTIDE SEQUENCE; SIGNAL TRANSDUCTION; STEM CELL; TIME; TOXICOGENETICS; TRANSCRIPTION REGULATION; UNINDEXED SEQUENCE;

ANIMALS; GENE EXPRESSION PROFILING; HUMANS; LIVER; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, ARYL HYDROCARBON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; TETRACHLORODIBENZODIOXIN;

EID: 71049164157     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp189     Document Type: Article

References (41)

1. Abbott, A. (2003). Cell culture: Biology's new dimension. Nature 424, 870-872.
2. Ahuja, Y. R., Vijayalakshmi, V., and Polasa, K. (2007). Stem cell test: A practical tool in toxicogenomics. Toxicology 231, 1-10.
3. Boess, F., Kamber, M., Romer, S., Gasser, R., Muller, D., Albertini, S., and Suter, L. (2003). Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: Possible implications for toxicogenomics use of in vitro systems. Toxicol. Sci. 73, 386-402.
4. Boutros, P. C., Moffat, I. D., Franc, M. A., Tijet, N., Tuomisto, J., Pohjanvirta, R., and Okey, A. B. (2004). Dioxin-responsive AHRE-II gene battery: Identification by phylogenetic footprinting. Biochem. Biophys. Res. Commun. 321, 707-715.
5. Boverhof, D. R., Burgoon, L. D., Tashiro, C., Chittim, B., Harkema, J. R., Jump, D. B., and Zacharewski, T. R. (2005). Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-mediated hepatotoxicity. Toxicol. Sci. 85 1048-1063.
6. Boverhof, D. R., Burgoon, L. D., Tashiro, C., Sharratt, B., Chittim, B., Harkema, J. R., Mendrick, D. L., and Zacharewski, T. R. (2006). Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice. Toxicol. Sci. 94, 398-416.
7. Burgoon, L. D., Boutros, P. C., Dere, E., and Zacharewski, T. R. (2006). dbZach: A MIAME-compliant toxicogenomic supportive relational database. Toxicol. Sci. 90, 558-568.
8. Burgoon, L. D., and Zacharewski, T. R. (2007). dbZach toxicogenomic information management system. Pharmacogenomics 8, 287-291.
9. Carere, A., Stammati, A., and Zucco, F. (2002). In vitro toxicology methods: Impact on regulation from technical and scientific advancements. Toxicol. Lett. 127, 153-160.
10. Chang, C. C., Tsai, J. L., Kuo, K. K., Wang, K. H., Chiang, C. H., Kao, A. P., Tai, M. H., and Trosko, J. E. (2004). Expression of Oct-4, alpha fetoprotein and vimentin and lack of gap-junctional intercellular communication (GJIC) as common phenotypes for human adult liver stem cells and hepatoma cells. Proc. Am. Assoc. Cancer Res. 45, 642.
11. Davila, J. C., Cezar, G. G., Thiede, M., Strom, S., Miki, T., and Trosko, J. (2004). Use and application of stem cells in toxicology. Toxicol. Sci. 79, 214-223.
12. Denison, M. S., and Heath-Pagliuso, S. (1998). The Ah receptor: A regulator of the biochemical and toxicological actions of structurally diverse chemicals. Bull. Environ. Contam. Toxicol. 61, 557-568.
13. Dennis, G., Jr., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., and Lempicki, R. A. (2003). DAVID: Database for annotation, visualization, and integrated discovery. Genome Biol. 4, P3.
14. Dere, E., Boverhof, D. R., Burgoon, L. D., and Zacharewski, T. R. (2006). In vivo-in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue. BMC Genomics 7, 80.
15. Eckel, J. E., Gennings, C., Chinchilli, V. M., Burgoon, L. D., and Zacharewski, T. R. (2004). Empirical Bayes gene screening tool for timecourse or dose-response microarray data. J. Biopharm. Stat. 14, 647-670.
16. Eckel, J. E., Gennings, C., Therneau, T. M., Burgoon, L. D., Boverhof, D. R., and Zacharewski, T. R. (2005). Normalization of two-channel microarray experiments: A semiparametric approach. Bioinformatics (Oxford, Engl.) 21, 1078-1083.
17. Ek, M., Soderdahl, T., Kuppers-Munther, B., Edsbagge, J., Andersson, T. B., Bjorquist, P., Cotgreave, I., Jernstrom, B., Ingelman-Sundberg, M., and Johansson, I. (2007). Expression of drug metabolizing enzymes in hepatocyte-like cells derived from human embryonic stem cells. Biochem. Pharmacol. 74, 496-503.
18. Harris, A. J., Dial, S. L., and Casciano, D. A. (2004). Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells. Mutat. Res. 549, 79-99.
19. Knerr, S., and Schrenk, D. (2006). Carcinogenicity of 2,3,7,8-tetrachlorodibenzo- p-dioxin in experimental models. Mol. Nutr. Food Res. 50, 897-907.
20. Kopec, A. K., Boverhof, D. R., Burgoon, L. D., Ibrahim-Aibo, D., Harkema, J. R., Tashiro, C., Chittim, B., and Zacharewski, T. R. (2008). Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice. Toxicol. Sci. 102, 61-75.
21. Li, A. P. (2001). Screening for human ADME/Tox drug properties in drug discovery. Drug Discov. Today 6, 357-366.
22. MacGregor, J. T. (2003). SNPs and chips: Genomic data in safety evaluation and risk assessment. Toxicol. Sci. 73, 207-208.
23. MacGregor, J. T., Collins, J. M., Sugiyama, Y., Tyson, C. A., Dean, J., Smith, L., Andersen, M., Curren, R. D., Houston, J. B., Kadlubar, F. F., et al. (2001). In vitro human tissue models in risk assessment: Report of a consensus-building workshop. Toxicol. Sci. 59, 17-36.
24. McGregor, D. B., Partensky, C., Wilbourn, J., and Rice, J. M. (1998). An IARC evaluation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis. Environ. Health Perspect. 106(Suppl. 2), 755-760.
25. Monteiro, P., Gilot, D., Le Ferrec, E., Rauch, C., Lagadic-Gossmann, D., and Fardel, O. (2008). Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway. Mol. Pharmacol. 73, 769-777.
26. N'Jai, A., Boverhof, D. R., Dere, E., Burgoon, L. D., Tan, Y. S., Rowlands, J. C., Budinsky, R. A., Stebbins, K. E., and Zacharewski, T. R. (2008). Comparative temporal toxicogenomic analysis of TCDD- and TCDF-mediated hepatic effects in immature female C57BL/6 mice. Toxicol. Sci. 103, 285-297.
27. Okey, A. B. (2007). An aryl hydrocarbon receptor odyssey to the shores of toxicology: The Deichmann Lecture, International Congress of Toxicology- XI. Toxicol. Sci. 98, 5-38.
28. Olson, H., Betton, G., Robinson, D., Thomas, K., Monro, A., Kolaja, G., Lilly, P., Sanders, J., Sipes, G., Bracken, W., et al. (2000). Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul. Toxicol. Pharmacol. 32, 56-67.
29. Pritchard, J. F., Jurima-Romet, M., Reimer, M. L., Mortimer, E., Rolfe, B., and Cayen, M. N. (2003). Making better drugs: Decision gates in non-clinical drug development. Nat. Rev. Drug Discov. 2, 542-553.
30. Puga, A., Maier, A., and Medvedovic, M. (2000). The transcriptional signature of dioxin in human hepatoma HepG2 cells. Biochem. Pharmacol. 60, 1129-1142.
31. Reymann, S., and Borlak, J. (2006). Transcriptome profiling of human hepatocytes treated with Aroclor 1254 reveals transcription factor regulatory networks and clusters of regulated genes. BMC Genomics 7, 217.
32. Rohwedel, J., Guan, K., Hegert, C., and Wobus, A. M. (2001). Embryonic stem cells as an in vitro model for mutagenicity, cytotoxicity and embryotoxicity studies: Present state and future prospects. Toxicol. In Vitro 15, 741-753.
33. Rolletschek, A., Blyszczuk, P., and Wobus, A. M. (2004). Embryonic stem cell-derived cardiac, neuronal and pancreatic cells as model systems to study toxicological effects. Toxicol. Lett. 149, 361-369.
34. Rozen, S., and Skaletsky, H. (2000). Primer3 on theWWWfor general users and for biologist programmers. Methods Mol. Biol. (Clifton, NJ) 132, 365-386.
35. Saeed, A. I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J., Klapa, M., Currier, T., Thiagarajan, M., et al. (2003). TM4: A free, open-source system for microarray data management and analysis. BioTechniques 34, 374-378.
36. Silkworth, J. B., Koganti, A., Illouz, K., Possolo, A., Zhao, M., and Hamilton, S. B. (2005). Comparison of TCDD and PCB CYP1A induction sensitivities in fresh hepatocytes from human donors, Sprague-Dawley rats, and rhesus monkeys and HepG2 cells. Toxicol. Sci. 87, 508-519.
37. Sun, Y. V., Boverhof, D. R., Burgoon, L. D., Fielden, M. R., and Zacharewski, T. R. (2004). Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences. Nucleic Acids Res. 32, 4512-4523.
38. Tai, M. H., Chang, C. C., Kiupel, M., Webster, J. D., Olson, L. K., and Trosko, J. E. (2005). Oct4 expression in adult human stem cells: Evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis 26, 495-502.
39. Tannheimer, S. L., Barton, S. L., Ethier, S. P., and Burchiel, S. W. (1997). Carcinogenic polycyclic aromatic hydrocarbons increase intracellular Ca2_ and cell proliferation in primary human mammary epithelial cells. Carcinogenesis 18, 1177-1182.
40. Yang, Y. H., and Speed, T. (2002). Design issues for cDNA microarray experiments. Nat. Rev. 3, 579-588.
41. Zeiger, M., Haag, R., Hockel, J., Schrenk, D., and Schmitz, H. J. (2001). Inducing effects of dioxin-like polychlorinated biphenyls on CYP1A in the human hepatoblastoma cell line HepG2, the rat hepatoma cell line H4IIE, and rat primary hepatocytes: Comparison of relative potencies. Toxicol. Sci. 63, 65-73.