메뉴 건너뛰기




Volumn 15, Issue 3, 2015, Pages e305-e316

The role of inflammatory mediators in the pathogenesis of Alzheimer’s disease

Author keywords

Acute phase proteins; Alzheimer s disease; Chemokines; Complement system proteins; Cytokines; Inflammation mediators

Indexed keywords


EID: 84940029045     PISSN: 2075051X     EISSN: 20750528     Source Type: Journal    
DOI: 10.18295/squmj.2015.15.03.002     Document Type: Review
Times cited : (59)

References (117)
  • 1
    • 84858225391 scopus 로고    scopus 로고
    • 2012 Alzheimer's disease facts and figures
    • Alzheimer's Association. 2012 Alzheimer's disease facts and figures. Alzheimers Dement 2012; 8:131-68. doi: 10.1016/j. jalz.2012.02.001.
    • (2012) Alzheimers Dement , vol.8 , pp. 131-168
  • 2
    • 67649342391 scopus 로고    scopus 로고
    • The neuropsychological profile in dementia with Lewy bodies and Alzheimer's disease
    • Oda H, Yamamoto Y, Maeda K. The neuropsychological profile in dementia with Lewy bodies and Alzheimer's disease. Int J Geriatr Psychiatry 2009; 24:125-31. doi: 10.1002/gps.2078.
    • (2009) Int J Geriatr Psychiatry , vol.24 , pp. 125-131
    • Oda, H.1    Yamamoto, Y.2    Maeda, K.3
  • 4
    • 67650844275 scopus 로고    scopus 로고
    • Epidemiology of Alzheimer's disease: Occurrence, determinants, and strategies toward intervention
    • Qiu C, Kivipelto M, von Strauss E. Epidemiology of Alzheimer's disease: Occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci 2009; 11:111-28.
    • (2009) Dialogues Clin Neurosci , vol.11 , pp. 111-128
    • Qiu, C.1    Kivipelto, M.2    von Strauss, E.3
  • 5
    • 68849123079 scopus 로고    scopus 로고
    • Accumulation of tau induced in neurites by microglial proinflammatory mediators
    • Gorlovoy P, Larionov S, Pham TT, Neumann H. Accumulation of tau induced in neurites by microglial proinflammatory mediators. FASEB J 2009; 23:2502-13. doi: 10.1096/fj.08- 123877.
    • (2009) FASEB J , vol.23 , pp. 2502-2513
    • Gorlovoy, P.1    Larionov, S.2    Pham, T.T.3    Neumann, H.4
  • 6
    • 84868113465 scopus 로고    scopus 로고
    • The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis
    • Azizi G, Mirshafiey A. The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis. Immunopharmacol Immunotoxicol 2012; 34:881-95. doi: 10.3109/08923973.2012.705292.
    • (2012) Immunopharmacol Immunotoxicol , vol.34 , pp. 881-895
    • Azizi, G.1    Mirshafiey, A.2
  • 7
    • 84893396852 scopus 로고    scopus 로고
    • The significance of matrix metalloproteinases in the immunopathogenesis and treatment of multiple sclerosis
    • Mirshafiey A, Asghari B, Ghalamfarsa G, Jadidi-Niaragh F, Azizi G. The significance of matrix metalloproteinases in the immunopathogenesis and treatment of multiple sclerosis. Sultan Qaboos Univ Med J 2014; 14:e13-25.
    • (2014) Sultan Qaboos Univ Med J , vol.14 , pp. e13-e25
    • Mirshafiey, A.1    Asghari, B.2    Ghalamfarsa, G.3    Jadidi-Niaragh, F.4    Azizi, G.5
  • 8
    • 79952574501 scopus 로고    scopus 로고
    • Epidemiology of Alzheimer disease
    • Reitz C, Brayne C, Mayeux R. Epidemiology of Alzheimer disease. Nat Rev Neurol 2011; 7:137-52. doi: 10.1038/ nrneurol.2011.2.
    • (2011) Nat Rev Neurol , vol.7 , pp. 137-152
    • Reitz, C.1    Brayne, C.2    Mayeux, R.3
  • 9
    • 4944258716 scopus 로고    scopus 로고
    • The role of inflammation in Alzheimer's disease
    • Tuppo EE, Arias HR. The role of inflammation in Alzheimer's disease. Int J Biochem Cell Biol 2005; 37:289-305. doi: 10. 1016/j.biocel.2004.07.009.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 289-305
    • Tuppo, E.E.1    Arias, H.R.2
  • 11
    • 0031593592 scopus 로고    scopus 로고
    • Neuropathology of Alzheimer's disease: A critical update
    • Jellinger KA, Bancher C. Neuropathology of Alzheimer's disease: A critical update. J Neural Transm Suppl 1998; 54:77-95. doi: 10.1007/978-3-7091-7508-8_8.
    • (1998) J Neural Transm Suppl , vol.54 , pp. 77-95
    • Jellinger, K.A.1    Bancher, C.2
  • 12
    • 84885456046 scopus 로고    scopus 로고
    • The amyloid cascade-inflammatory hypothesis of Alzheimer disease: Implications for therapy
    • McGeer PL, McGeer EG. The amyloid cascade-inflammatory hypothesis of Alzheimer disease: Implications for therapy. Acta Neuropathol 2013; 126:479-97. doi: 10.1007/s00401-013-1177-7.
    • (2013) Acta Neuropathol , vol.126 , pp. 479-497
    • McGeer, P.L.1    McGeer, E.G.2
  • 13
    • 84926467444 scopus 로고    scopus 로고
    • Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis
    • Orsini F, De Blasio D, Zangari R, Zanier ER, De Simoni MG. Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis. Front Cell Neurosci 2014; 8:380. doi: 10.3389/fncel.2014.00380.
    • (2014) Front Cell Neurosci , vol.8 , pp. 380
    • Orsini, F.1    De Blasio, D.2    Zangari, R.3    Zanier, E.R.4    De Simoni, M.G.5
  • 14
    • 34547678667 scopus 로고    scopus 로고
    • Mechanisms of over-activated innate immune system regulation in autoimmune and neurodegenerative disorders
    • Blach-Olszewska Z, Leszek J. Mechanisms of over-activated innate immune system regulation in autoimmune and neurodegenerative disorders. Neuropsychiatr Dis Treat 2007; 3:365-72.
    • (2007) Neuropsychiatr Dis Treat , vol.3 , pp. 365-372
    • Blach-Olszewska, Z.1    Leszek, J.2
  • 15
    • 84904414201 scopus 로고    scopus 로고
    • The potential role of chemokines in Alzheimer's disease pathogenesis
    • Azizi G, Khannazer N, Mirshafiey A. The potential role of chemokines in Alzheimer's disease pathogenesis. Am J Alzheimers Dis Other Demen 2014: 29:415-25. doi: 10.1177/1533317513518651.
    • (2014) Am J Alzheimers Dis Other Demen , vol.29 , pp. 415-425
    • Azizi, G.1    Khannazer, N.2    Mirshafiey, A.3
  • 16
    • 0034235794 scopus 로고    scopus 로고
    • Cutting edge: Hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation
    • Bromley SK, Peterson DA, Gunn MD, Dustin ML. Cutting edge: Hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation. J Immunol 2000; 165:15-19. doi: 10.4049/jimmunol.165.1.15.
    • (2000) J Immunol , vol.165 , pp. 15-19
    • Bromley, S.K.1    Peterson, D.A.2    Gunn, M.D.3    Dustin, M.L.4
  • 17
    • 77956961694 scopus 로고    scopus 로고
    • Neuroinflammatory processes in Alzheimer's disease
    • Heneka MT, O'Banion MK, Terwel D, Kummer MP. Neuroinflammatory processes in Alzheimer's disease. J Neural Transm 2010; 117:919-47. doi: 10.1007/s00702-010-0438-z.
    • (2010) J Neural Transm , vol.117 , pp. 919-947
    • Heneka, M.T.1    O'Banion, M.K.2    Terwel, D.3    Kummer, M.P.4
  • 18
    • 84861078831 scopus 로고    scopus 로고
    • A review: Inflammatory process in Alzheimer's disease, role of cytokines
    • Rubio-Perez JM, Morillas-Ruiz JM. A review: Inflammatory process in Alzheimer's disease, role of cytokines. ScientificWorldJournal 2012; 2012:756357. doi: 10.1100/2012/756357.
    • (2012) ScientificWorldJournal , vol.2012
    • Rubio-Perez, J.M.1    Morillas-Ruiz, J.M.2
  • 20
    • 77953143687 scopus 로고    scopus 로고
    • Inflammation in Alzheimer's disease: Relevance to pathogenesis and therapy
    • Zotova E, Nicoll JA, Kalaria R, Holmes C, Boche D. Inflammation in Alzheimer's disease: Relevance to pathogenesis and therapy. Alzheimers Res Ther 2010; 2:1. doi: 10.1186/alzrt24.
    • (2010) Alzheimers Res Ther , vol.2 , pp. 1
    • Zotova, E.1    Nicoll, J.A.2    Kalaria, R.3    Holmes, C.4    Boche, D.5
  • 21
    • 84897859634 scopus 로고    scopus 로고
    • Microglial phagocytosis of live neurons
    • Brown GC, Neher JJ. Microglial phagocytosis of live neurons. Nat Rev Neurosci 2014; 15:209-16. doi: 10.1038/nrn3710.
    • (2014) Nat Rev Neurosci , vol.15 , pp. 209-216
    • Brown, G.C.1    Neher, J.J.2
  • 22
    • 84899930321 scopus 로고    scopus 로고
    • Intrathecal antagonism of microglial TLR4 reduces inflammatory damage to bloodspinal cord barrier following ischemia/reperfusion injury in rats
    • Li XQ, Wang J, Fang B, Tan WF, Ma H. Intrathecal antagonism of microglial TLR4 reduces inflammatory damage to bloodspinal cord barrier following ischemia/reperfusion injury in rats. Mol Brain 2014; 7:28. doi: 10.1186/1756-6606-7-28.
    • (2014) Mol Brain , vol.7 , pp. 28
    • Li, X.Q.1    Wang, J.2    Fang, B.3    Tan, W.F.4    Ma, H.5
  • 23
    • 79251641533 scopus 로고    scopus 로고
    • Microglial P2X7 receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease
    • Lee HG, Won SM, Gwag BJ, Lee YB. Microglial P2X7 receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease. Exp Mol Med 2011; 43:7-14. doi: 10.3858/ emm.2011.43.1.001.
    • (2011) Exp Mol Med , vol.43 , pp. 7-14
    • Lee, H.G.1    Won, S.M.2    Gwag, B.J.3    Lee, Y.B.4
  • 24
    • 21044448540 scopus 로고    scopus 로고
    • Mechanisms of cell signaling and inflammation in Alzheimer's disease
    • Ho GJ, Drego R, Hakimian E, Masliah E. Mechanisms of cell signaling and inflammation in Alzheimer's disease. Curr Drug Targets Inflamm Allergy 2005; 4:247-56. doi: 10.2174/1568010053586237.
    • (2005) Curr Drug Targets Inflamm Allergy , vol.4 , pp. 247-256
    • Ho, G.J.1    Drego, R.2    Hakimian, E.3    Masliah, E.4
  • 25
    • 84881281872 scopus 로고    scopus 로고
    • Elusive Alzheimer's disease: Can immune signatures help our understanding of this challenging disease? Part 2: New immune paradigm
    • Fulop T, Lacombe G, Cunnane S, Le Page A, Dupuis G, Frost EH, et al. Elusive Alzheimer's disease: Can immune signatures help our understanding of this challenging disease? Part 2: New immune paradigm. Discov Med 2013; 15:33-42.
    • (2013) Discov Med , vol.15 , pp. 33-42
    • Fulop, T.1    Lacombe, G.2    Cunnane, S.3    Le Page, A.4    Dupuis, G.5    Frost, E.H.6
  • 26
    • 75449102536 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Querfurth HW, LaFerla FM. Alzheimer's disease. N Engl J Med 2010; 362:329-44. doi: 10.1056/NEJMra0909142.
    • (2010) N Engl J Med , vol.362 , pp. 329-344
    • Querfurth, H.W.1    LaFerla, F.M.2
  • 28
    • 0022211456 scopus 로고
    • Senile dementia of Alzheimer's type (SDAT): Reduced T8+-cellmediated suppressor activity
    • Skias D, Bania M, Reder AT, Luchins D, Antel JP. Senile dementia of Alzheimer's type (SDAT): Reduced T8+-cellmediated suppressor activity. Neurology 1985; 35:1635-8. doi: 10.1212/WNL.35.11.1635.
    • (1985) Neurology , vol.35 , pp. 1635-1638
    • Skias, D.1    Bania, M.2    Reder, A.T.3    Luchins, D.4    Antel, J.P.5
  • 31
    • 0141954270 scopus 로고    scopus 로고
    • Telomere dysfunction of lymphocytes in patients with Alzheimer disease
    • Zhang J, Kong Q, Zhang Z, Ge P, Ba D, He W. Telomere dysfunction of lymphocytes in patients with Alzheimer disease. Cogn Behav Neurol 2003,16:170-6. doi: 10.1097/00146965- 200309000-00004.
    • (2003) Cogn Behav Neurol , vol.16 , pp. 170-176
    • Zhang, J.1    Kong, Q.2    Zhang, Z.3    Ge, P.4    Ba, D.5    He, W.6
  • 32
    • 84862736185 scopus 로고    scopus 로고
    • Mechanisms regulating regional localization of inflammation during CNS autoimmunity
    • Pierson E, Simmons SB, Castelli L, Goverman JM. Mechanisms regulating regional localization of inflammation during CNS autoimmunity. Immunol Rev 2012; 248:205-15. doi: 10.1111/j.1600-065X.2012.01126.x.
    • (2012) Immunol Rev , vol.248 , pp. 205-215
    • Pierson, E.1    Simmons, S.B.2    Castelli, L.3    Goverman, J.M.4
  • 33
    • 84879819519 scopus 로고    scopus 로고
    • CD4 T cells in immunity and immunotherapy of Alzheimer's disease
    • Monsonego A, Nemirovsky A, Harpaz I. CD4 T cells in immunity and immunotherapy of Alzheimer's disease. Immunology 2013; 139:438-46. doi: 10.1111/imm.12103.
    • (2013) Immunology , vol.139 , pp. 438-446
    • Monsonego, A.1    Nemirovsky, A.2    Harpaz, I.3
  • 34
    • 19944431509 scopus 로고    scopus 로고
    • Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta
    • Racke MM, Boone LI, Hepburn DL, Parsadainian M, Bryan MT, Ness DK, et al. Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta. J Neurosci 2005; 25:629-36. doi: 10.1523/JNEUROSCI.4337-04.2005.
    • (2005) J Neurosci , vol.25 , pp. 629-636
    • Racke, M.M.1    Boone, L.I.2    Hepburn, D.L.3    Parsadainian, M.4    Bryan, M.T.5    Ness, D.K.6
  • 35
    • 79953297907 scopus 로고    scopus 로고
    • Inflammation and oxidative damage in Alzheimer's disease: Friend or foe?
    • Galimberti D, Scarpini E. Inflammation and oxidative damage in Alzheimer's disease: Friend or foe? Front Biosci (Schol Ed) 2011; 3:252-66. doi: 10.2741/s149.
    • (2011) Front Biosci (Schol Ed) , vol.3 , pp. 252-266
    • Galimberti, D.1    Scarpini, E.2
  • 36
    • 66949146836 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease
    • Sokolova A, Hill MD, Rahimi F, Warden LA, Halliday GM, Shepherd CE. Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease. Brain Pathol 2009; 19:392-8. doi: 10.1111/j.1750-3639.2008.00188.x.
    • (2009) Brain Pathol , vol.19 , pp. 392-398
    • Sokolova, A.1    Hill, M.D.2    Rahimi, F.3    Warden, L.A.4    Halliday, G.M.5    Shepherd, C.E.6
  • 37
    • 84922735010 scopus 로고    scopus 로고
    • IFN-γ and TNF-α are involved during Alzheimer disease progression and correlate with nitric oxide production: A study in Algerian patients
    • Belkhelfa M, Rafa H, Medjeber O, Arroul-Lammali A, Behairi N, Abada-Bendib M, et al. IFN-γ and TNF-α are involved during Alzheimer disease progression and correlate with nitric oxide production: A study in Algerian patients. J Interferon Cytokine Res 2014; 34:839-47. doi: 10.1089/ jir.2013.0085.
    • (2014) J Interferon Cytokine Res , vol.34 , pp. 839-847
    • Belkhelfa, M.1    Rafa, H.2    Medjeber, O.3    Arroul-Lammali, A.4    Behairi, N.5    Abada-Bendib, M.6
  • 38
    • 84907978433 scopus 로고    scopus 로고
    • Vaccination induced changes in pro-inflammatory cytokine levels as an early putative biomarker for cognitive improvement in a transgenic mouse model for Alzheimer disease
    • Lin X, Bai G, Lin L, Wu H, Cai J, Ugen KE, et al. Vaccination induced changes in pro-inflammatory cytokine levels as an early putative biomarker for cognitive improvement in a transgenic mouse model for Alzheimer disease. Hum Vaccin Immunother 2014; 10:2024-31. doi: 10.4161/hv.28735.
    • (2014) Hum Vaccin Immunother , vol.10 , pp. 2024-2031
    • Lin, X.1    Bai, G.2    Lin, L.3    Wu, H.4    Cai, J.5    Ugen, K.E.6
  • 39
    • 76149092520 scopus 로고    scopus 로고
    • Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: Evidence against inflammation as a driving force for amyloid deposition
    • Chakrabarty P, Jansen-West K, Beccard A, Ceballos-Diaz C, Levites Y, Verbeeck C, et al. Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: Evidence against inflammation as a driving force for amyloid deposition. FASEB J 2010; 24:548-59. doi: 10.1096/fj.09-141754.
    • (2010) FASEB J , vol.24 , pp. 548-559
    • Chakrabarty, P.1    Jansen-West, K.2    Beccard, A.3    Ceballos-Diaz, C.4    Levites, Y.5    Verbeeck, C.6
  • 40
    • 58249130474 scopus 로고    scopus 로고
    • Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease
    • Yu JT, Tan L, Song JH, Sun YP, Chen W, Miao D, et al. Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease. Brain Res 2009; 1253:169-75. doi: 10.1016/j.brainres.2008.11.083.
    • (2009) Brain Res , vol.1253 , pp. 169-175
    • Yu, J.T.1    Tan, L.2    Song, J.H.3    Sun, Y.P.4    Chen, W.5    Miao, D.6
  • 42
    • 84860501544 scopus 로고    scopus 로고
    • Relationship between inflammatory mediators, Aβ levels and ApoE genotype in Alzheimer disease
    • Reale M, Kamal MA, Velluto L, Gambi D, Di Nicola M, Greig NH. Relationship between inflammatory mediators, Aβ levels and ApoE genotype in Alzheimer disease. Curr Alzheimer Res 2012; 9:447-57. doi: 10.2174/156720512800492549.
    • (2012) Curr Alzheimer Res , vol.9 , pp. 447-457
    • Reale, M.1    Kamal, M.A.2    Velluto, L.3    Gambi, D.4    Di Nicola, M.5    Greig, N.H.6
  • 45
    • 0029876963 scopus 로고    scopus 로고
    • The production of an amyloidogenic metabolite of the Alzheimer amyloid beta precursor protein (APP) in thyroid cells is stimulated by interleukin 1 beta, but inhibited by interferon gamma
    • Schmitt TL, Steiner E, Klinger P, Sztankay A, Grubeck- Loebenstein B. The production of an amyloidogenic metabolite of the Alzheimer amyloid beta precursor protein (APP) in thyroid cells is stimulated by interleukin 1 beta, but inhibited by interferon gamma. J Clin Endocrinol Metab 1996; 81:1666-9. doi: 10.1210/jcem.81.4.8636387.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1666-1669
    • Schmitt, T.L.1    Steiner, E.2    Klinger, P.3    Sztankay, A.4    Grubeck- Loebenstein, B.5
  • 46
    • 77950817259 scopus 로고    scopus 로고
    • Transforming growth factor beta2 level is elevated in neurons of Alzheimer's disease brains
    • Noguchi A, Nawa M, Aiso S, Okamoto K, Matsuoka M. Transforming growth factor beta2 level is elevated in neurons of Alzheimer's disease brains. Int J Neurosci 2010; 120:168-75. doi: 10.3109/00207450903139689.
    • (2010) Int J Neurosci , vol.120 , pp. 168-175
    • Noguchi, A.1    Nawa, M.2    Aiso, S.3    Okamoto, K.4    Matsuoka, M.5
  • 47
    • 55549121899 scopus 로고    scopus 로고
    • TGF beta2-induced changes in LRP-1/T beta R-V and the impact on lysosomal A beta uptake and neurotoxicity
    • Eslami P, Johnson MF, Terzakaryan E, Chew C, Harris-White ME. TGF beta2-induced changes in LRP-1/T beta R-V and the impact on lysosomal A beta uptake and neurotoxicity. Brain Res 2008; 1241:176-87. doi: 10.1016/j.brainres.2008.08.086.
    • (2008) Brain Res , vol.1241 , pp. 176-187
    • Eslami, P.1    Johnson, M.F.2    Terzakaryan, E.3    Chew, C.4    Harris-White, M.E.5
  • 48
    • 84859444926 scopus 로고    scopus 로고
    • Dysfunction of TGF-beta1 signaling in Alzheimer's disease: Perspectives for neuroprotection
    • Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, et al. Dysfunction of TGF-beta1 signaling in Alzheimer's disease: Perspectives for neuroprotection. Cell Tissue Res 2012; 347:291-301. doi: 10.1007/s00441-011-1230-6.
    • (2012) Cell Tissue Res , vol.347 , pp. 291-301
    • Caraci, F.1    Spampinato, S.2    Sortino, M.A.3    Bosco, P.4    Battaglia, G.5    Bruno, V.6
  • 49
    • 77949890133 scopus 로고    scopus 로고
    • Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease
    • Hickman SE, El Khoury J. Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease. CNS Neurol Disord Drug Targets 2010; 9:168-73. doi: 10.2174/ 187152710791011982.
    • (2010) CNS Neurol Disord Drug Targets , vol.9 , pp. 168-173
    • Hickman, S.E.1    El Khoury, J.2
  • 50
    • 60849135712 scopus 로고    scopus 로고
    • Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factor alpha signaling during peripheral organ inflammation
    • D'Mello C, Le T, Swain MG. Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factor alpha signaling during peripheral organ inflammation. J Neurosci 2009; 29:2089-102. doi: 10.1523/JNEUROSCI.3567-08.2009.
    • (2009) J Neurosci , vol.29 , pp. 2089-2102
    • D'Mello, C.1    Le, T.2    Swain, M.G.3
  • 51
    • 84880184473 scopus 로고    scopus 로고
    • Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain
    • Selenica ML, Alvarez JA, Nash KR, Lee DC, Cao C, Lin X, et al. Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain. J Neuroinflammation 2013; 10:86. doi: 10.1186/1742-2094-10-86.
    • (2013) J Neuroinflammation , vol.10 , pp. 86
    • Selenica, M.L.1    Alvarez, J.A.2    Nash, K.R.3    Lee, D.C.4    Cao, C.5    Lin, X.6
  • 52
    • 70449529890 scopus 로고    scopus 로고
    • RANTES upregulation in the Alzheimer's disease brain: A possible neuroprotective role
    • Tripathy D, Thirumangalakudi L, Grammas P. RANTES upregulation in the Alzheimer's disease brain: A possible neuroprotective role. Neurobiol Aging 2010; 31:8-16. doi: 10.1016/j.neurobiolaging.2008.03.009.
    • (2010) Neurobiol Aging , vol.31 , pp. 8-16
    • Tripathy, D.1    Thirumangalakudi, L.2    Grammas, P.3
  • 53
    • 34248146559 scopus 로고    scopus 로고
    • Modulation of interleukin-1beta mediated inflammatory response in human astrocytes by flavonoids: Implications in neuroprotection
    • Sharma V, Mishra M, Ghosh S, Tewari R, Basu A, Seth P, et al. Modulation of interleukin-1beta mediated inflammatory response in human astrocytes by flavonoids: Implications in neuroprotection. Brain Res Bull 2007; 73:55-63. doi: 10.1016/j. brainresbull.2007.01.016.
    • (2007) Brain Res Bull , vol.73 , pp. 55-63
    • Sharma, V.1    Mishra, M.2    Ghosh, S.3    Tewari, R.4    Basu, A.5    Seth, P.6
  • 54
    • 43149091698 scopus 로고    scopus 로고
    • Plasma levels of the beta chemokine regulated upon activation, normal T cell expressed, and secreted (RANTES) correlate with severe brain injury
    • Lumpkins K, Bochicchio GV, Zagol B, Ulloa K, Simard JM, Schaub S, et al. Plasma levels of the beta chemokine regulated upon activation, normal T cell expressed, and secreted (RANTES) correlate with severe brain injury. J Trauma 2008; 64:358-61. doi: 10.1097/TA.0b013e318160df9b.
    • (2008) J Trauma , vol.64 , pp. 358-361
    • Lumpkins, K.1    Bochicchio, G.V.2    Zagol, B.3    Ulloa, K.4    Simard, J.M.5    Schaub, S.6
  • 56
    • 52449118875 scopus 로고    scopus 로고
    • Decreased CXCL12 (SDF-1) plasma levels in early Alzheimer's disease: A contribution to a deficient hematopoietic brain support?
    • Laske C, Stellos K, Eschweiler GW, Leyhe T, Gawaz M. Decreased CXCL12 (SDF-1) plasma levels in early Alzheimer's disease: A contribution to a deficient hematopoietic brain support? J Alzheimers Dis 2008; 15:83-95.
    • (2008) J Alzheimers Dis , vol.15 , pp. 83-95
    • Laske, C.1    Stellos, K.2    Eschweiler, G.W.3    Leyhe, T.4    Gawaz, M.5
  • 57
    • 84866753559 scopus 로고    scopus 로고
    • Chemokine CXCL12 in neurodegenerative diseases: An SOS signal for stem cell-based repair
    • Li M, Hale JS, Rich JN, Ransohoff RM, Lathia JD. Chemokine CXCL12 in neurodegenerative diseases: An SOS signal for stem cell-based repair. Trends Neurosci 2012; 35:619-28. doi: 10.1016/j.tins.2012.06.003.
    • (2012) Trends Neurosci , vol.35 , pp. 619-628
    • Li, M.1    Hale, J.S.2    Rich, J.N.3    Ransohoff, R.M.4    Lathia, J.D.5
  • 58
    • 84867917999 scopus 로고    scopus 로고
    • CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway
    • Zhu B, Xu D, Deng X, Chen Q, Huang Y, Peng H, et al. CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway. Stem Cells 2012; 30:2571-83. doi: 10.1002/stem.1239.
    • (2012) Stem Cells , vol.30 , pp. 2571-2583
    • Zhu, B.1    Xu, D.2    Deng, X.3    Chen, Q.4    Huang, Y.5    Peng, H.6
  • 59
    • 80855148191 scopus 로고    scopus 로고
    • Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1α, suppress amyloid β-induced neurotoxicity
    • Raman D, Milatovic SZ, Milatovic D, Splittgerber R, Fan GH, Richmond A. Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1α, suppress amyloid β-induced neurotoxicity. Toxicol Appl Pharmacol 2011; 256:300-13. doi: 10.1016/j.taap.2011.06.006.
    • (2011) Toxicol Appl Pharmacol , vol.256 , pp. 300-313
    • Raman, D.1    Milatovic, S.Z.2    Milatovic, D.3    Splittgerber, R.4    Fan, G.H.5    Richmond, A.6
  • 60
    • 41949125406 scopus 로고    scopus 로고
    • Changes in the levels of plasma soluble fractalkine in patients with mild cognitive impairment and Alzheimer's disease
    • Kim TS, Lim HK, Lee JY, Kim DJ, Park S, Lee C, et al. Changes in the levels of plasma soluble fractalkine in patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett 2008; 436:196-200. doi: 10.1016/j.neulet.2008.03.019.
    • (2008) Neurosci Lett , vol.436 , pp. 196-200
    • Kim, T.S.1    Lim, H.K.2    Lee, J.Y.3    Kim, D.J.4    Park, S.5    Lee, C.6
  • 61
    • 80052714655 scopus 로고    scopus 로고
    • CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease
    • Cho SH, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, et al. CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. J Biol Chem 2011; 286:32713-22. doi: 10.1074/jbc.M111.254268.
    • (2011) J Biol Chem , vol.286 , pp. 32713-32722
    • Cho, S.H.1    Sun, B.2    Zhou, Y.3    Kauppinen, T.M.4    Halabisky, B.5    Wes, P.6
  • 62
    • 64249099065 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer's disease
    • Popp J, Bacher M, Kölsch H, Noelker C, Deuster O, Dodel R, et al. Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer's disease. J Psychiatr Res 2009; 43:749-53. doi: 10.1016/j.jpsychires.2008.10.006.
    • (2009) J Psychiatr Res , vol.43 , pp. 749-753
    • Popp, J.1    Bacher, M.2    Kölsch, H.3    Noelker, C.4    Deuster, O.5    Dodel, R.6
  • 63
    • 78650639936 scopus 로고    scopus 로고
    • MIF as a disease target: ISO-1 as a proof-of-concept therapeutic
    • Al-Abed Y, VanPatten S. MIF as a disease target: ISO-1 as a proof-of-concept therapeutic. Future Med Chem 2011; 3: 45-63. doi: 10.4155/fmc.10.281.
    • (2011) Future Med Chem , vol.3 , pp. 45-63
    • Al-Abed, Y.1    VanPatten, S.2
  • 64
    • 77649131948 scopus 로고    scopus 로고
    • The role of macrophage migration inhibitory factor in Alzheimer's disease
    • Bacher M, Deuster O, Aljabari B, Egensperger R, Neff F, Jessen F, et al. The role of macrophage migration inhibitory factor in Alzheimer's disease. Mol Med 2010; 16:116-21. doi: 10.2119/molmed.2009.00123.
    • (2010) Mol Med , vol.16 , pp. 116-121
    • Bacher, M.1    Deuster, O.2    Aljabari, B.3    Egensperger, R.4    Neff, F.5    Jessen, F.6
  • 65
    • 0034660602 scopus 로고    scopus 로고
    • Glutamine synthetase, hemoglobin alpha-chain, and macrophage migration inhibitory factor binding to amyloid beta-protein: Their identification in rat brain by a novel affinity chromatography and in Alzheimer's disease brain by immunoprecipitation
    • Oyama R, Yamamoto H, Titani K. Glutamine synthetase, hemoglobin alpha-chain, and macrophage migration inhibitory factor binding to amyloid beta-protein: Their identification in rat brain by a novel affinity chromatography and in Alzheimer's disease brain by immunoprecipitation. Biochim Biophys Acta 2000; 1479:91-102. doi: 10.1016/S0167-4838(00)00057-1.
    • (2000) Biochim Biophys Acta , vol.1479 , pp. 91-102
    • Oyama, R.1    Yamamoto, H.2    Titani, K.3
  • 67
    • 0031848322 scopus 로고    scopus 로고
    • Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains
    • Xia MQ, Qin SX, Wu LJ, Mackay CR, Hyman BT. Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am J Pathol 1998; 153:31-7.
    • (1998) Am J Pathol , vol.153 , pp. 31-37
    • Xia, M.Q.1    Qin, S.X.2    Wu, L.J.3    Mackay, C.R.4    Hyman, B.T.5
  • 68
    • 33847128514 scopus 로고    scopus 로고
    • Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease
    • Man SM, Ma YR, Shang DS, Zhao WD, Li B, Guo DW, et al. Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease. Neurobiol Aging 2007; 28:485-96. doi: 10.1016/j. neurobiolaging.2006.02.013.
    • (2007) Neurobiol Aging , vol.28 , pp. 485-496
    • Man, S.M.1    Ma, Y.R.2    Shang, D.S.3    Zhao, W.D.4    Li, B.5    Guo, D.W.6
  • 69
    • 39649090292 scopus 로고    scopus 로고
    • Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population
    • Li K, Dai D, Yao L, Gu X, Luan K, Tian W, et al. Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population. Neurosci Lett 2008; 433:125-8. doi: 10.1016/j. neulet.2008.01.002.
    • (2008) Neurosci Lett , vol.433 , pp. 125-128
    • Li, K.1    Dai, D.2    Yao, L.3    Gu, X.4    Luan, K.5    Tian, W.6
  • 70
    • 73549087659 scopus 로고    scopus 로고
    • Role of the macrophage inflammatory protein-1alpha/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by beta-amyloid peptide
    • Passos GF, Figueiredo CP, Prediger RD, Pandolfo P, Duarte FS, Medeiros R, et al. Role of the macrophage inflammatory protein-1alpha/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by beta-amyloid peptide. Am J Pathol 2009; 175:1586-97. doi: 10.2353/ajpath.2009.081113.
    • (2009) Am J Pathol , vol.175 , pp. 1586-1597
    • Passos, G.F.1    Figueiredo, C.P.2    Prediger, R.D.3    Pandolfo, P.4    Duarte, F.S.5    Medeiros, R.6
  • 71
    • 65949124441 scopus 로고    scopus 로고
    • Implication of complement system and its regulators in Alzheimer's disease
    • Kolev MV, Ruseva MM, Harris CL, Morgan BP, Donev RM. Implication of complement system and its regulators in Alzheimer's disease. Curr Neuropharmacol 2009; 7:1-8. doi: 10.2174/157015909787602805.
    • (2009) Curr Neuropharmacol , vol.7 , pp. 1-8
    • Kolev, M.V.1    Ruseva, M.M.2    Harris, C.L.3    Morgan, B.P.4    Donev, R.M.5
  • 72
    • 84886060575 scopus 로고    scopus 로고
    • What does complement do in Alzheimer's disease? Old molecules with new insights
    • Shen Y, Yang L, Li R. What does complement do in Alzheimer's disease? Old molecules with new insights. Transl Neurodegener 2013; 2:21. doi: 10.1186/2047-9158-2-21.
    • (2013) Transl Neurodegener , vol.2 , pp. 21
    • Shen, Y.1    Yang, L.2    Li, R.3
  • 73
    • 73949103664 scopus 로고    scopus 로고
    • C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production
    • Fraser DA, Pisalyaput K, Tenner AJ. C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production. J Neurochem 2010; 112:733-43. doi: 10.1111/j.1471-4159.2009.06494.x.
    • (2010) J Neurochem , vol.112 , pp. 733-743
    • Fraser, D.A.1    Pisalyaput, K.2    Tenner, A.J.3
  • 74
    • 55849114955 scopus 로고    scopus 로고
    • The complement cascade: Yin-Yang in neuroinflammationneuro- protection and -degeneration
    • Alexander JJ, Anderson AJ, Barnum SR, Stevens B, Tenner AJ. The complement cascade: Yin-Yang in neuroinflammationneuro- protection and -degeneration. J Neurochem 2008; 107:1169-87. doi: 10.1111/j.1471-4159.2008.05668.x.
    • (2008) J Neurochem , vol.107 , pp. 1169-1187
    • Alexander, J.J.1    Anderson, A.J.2    Barnum, S.R.3    Stevens, B.4    Tenner, A.J.5
  • 75
    • 84872067877 scopus 로고    scopus 로고
    • C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity
    • Benoit ME, Hernandez MX, Dinh ML, Benavente F, Vasquez O, Tenner AJ. C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity. J Biol Chem 2013; 288:654-65. doi: 10.1074/jbc.M112.400168.
    • (2013) J Biol Chem , vol.288 , pp. 654-665
    • Benoit, M.E.1    Hernandez, M.X.2    Dinh, M.L.3    Benavente, F.4    Vasquez, O.5    Tenner, A.J.6
  • 76
    • 79952273376 scopus 로고    scopus 로고
    • Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression
    • Benoit ME, Tenner AJ. Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression. J Neurosci 2011; 31:3459-69. doi: 10.1523/JNEUROSCI.3932-10.2011.
    • (2011) J Neurosci , vol.31 , pp. 3459-3469
    • Benoit, M.E.1    Tenner, A.J.2
  • 77
    • 42349104349 scopus 로고    scopus 로고
    • Plaque complement activation and cognitive loss in Alzheimer's disease
    • Loeffler DA, Camp DM, Bennett DA. Plaque complement activation and cognitive loss in Alzheimer's disease. J Neuroinflammation 2008; 5:9. doi: 10.1186/1742-2094-5-9.
    • (2008) J Neuroinflammation , vol.5 , pp. 9
    • Loeffler, D.A.1    Camp, D.M.2    Bennett, D.A.3
  • 79
    • 67649787242 scopus 로고    scopus 로고
    • Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old
    • Kravitz BA, Corrada MM, Kawas CH. Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old. Alzheimers Dement 2009; 5:318-23. doi: 10.1016/j. jalz.2009.04.1230.
    • (2009) Alzheimers Dement , vol.5 , pp. 318-323
    • Kravitz, B.A.1    Corrada, M.M.2    Kawas, C.H.3
  • 80
  • 81
    • 84859802979 scopus 로고    scopus 로고
    • Amyloid plaques dissociate pentameric to monomeric C-reactive protein: A novel pathomechanism driving cortical inflammation in Alzheimer's disease?
    • Strang F, Scheichl A, Chen YC, Wang X, Htun NM, Bassler N, et al. Amyloid plaques dissociate pentameric to monomeric C-reactive protein: A novel pathomechanism driving cortical inflammation in Alzheimer's disease? Brain Pathol 2012; 22:337-46. doi: 10.1111/j.1750-3639.2011.00539.x.
    • (2012) Brain Pathol , vol.22 , pp. 337-346
    • Strang, F.1    Scheichl, A.2    Chen, Y.C.3    Wang, X.4    Htun, N.M.5    Bassler, N.6
  • 82
    • 84856754551 scopus 로고    scopus 로고
    • Role of interleukin 6 and alpha-globulins in differentiating Alzheimer and vascular dementias
    • Helmy AA, Naseer MM, Shafie SE, Nada MA. Role of interleukin 6 and alpha-globulins in differentiating Alzheimer and vascular dementias. Neurodegener Dis 2012; 9:81-6. doi: 10.1159/000329568.
    • (2012) Neurodegener Dis , vol.9 , pp. 81-86
    • Helmy, A.A.1    Naseer, M.M.2    Shafie, S.E.3    Nada, M.A.4
  • 84
    • 70349086077 scopus 로고    scopus 로고
    • Systemic inflammation and the risk of Alzheimer's disease and dementia: A prospective population-based study
    • Sundelöf J, Kilander L, Helmersson J, Larsson A, Rönnemaa E, Degerman-Gunnarsson M, et al. Systemic inflammation and the risk of Alzheimer's disease and dementia: A prospective population-based study. J Alzheimers Dis 2009; 18:79-87. doi: 10.3233/JAD-2009-1126.
    • (2009) J Alzheimers Dis , vol.18 , pp. 79-87
    • Sundelöf, J.1    Kilander, L.2    Helmersson, J.3    Larsson, A.4    Rönnemaa, E.5    Degerman-Gunnarsson, M.6
  • 85
    • 84866004606 scopus 로고    scopus 로고
    • The immunopathogenic role of reactive oxygen species in Alzheimer disease
    • Mohsenzadegan M, Mirshafiey A. The immunopathogenic role of reactive oxygen species in Alzheimer disease. Iran J Allergy Asthma Immunol 2012; 11:203-16. doi: 011.03/ijaai.203216.
    • (2012) Iran J Allergy Asthma Immunol , vol.11 , pp. 203-216
    • Mohsenzadegan, M.1    Mirshafiey, A.2
  • 86
    • 77956313661 scopus 로고    scopus 로고
    • ABCG2 reduces ROS-mediated toxicity and inflammation: A potential role in Alzheimer's disease
    • Shen S, Callaghan D, Juzwik C, Xiong H, Huang P, Zhang W. ABCG2 reduces ROS-mediated toxicity and inflammation: a potential role in Alzheimer's disease. J Neurochem 2010; 114:1590-1604. doi: 10.1111/j.1471-4159.2010.06887.x.
    • (2010) J Neurochem , vol.114 , pp. 1590-1604
    • Shen, S.1    Callaghan, D.2    Juzwik, C.3    Xiong, H.4    Huang, P.5    Zhang, W.6
  • 87
    • 65649142529 scopus 로고    scopus 로고
    • ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the bloodbrain barrier for Abeta(1-40) peptides
    • Xiong H, Callaghan D, Jones A, Bai J, Rasquinha I, Smith C, et al. ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the bloodbrain barrier for Abeta(1-40) peptides. J Neurosci 2009; 29:5463-75. doi: 10.1523/JNEUROSCI.5103-08.2009.
    • (2009) J Neurosci , vol.29 , pp. 5463-5475
    • Xiong, H.1    Callaghan, D.2    Jones, A.3    Bai, J.4    Rasquinha, I.5    Smith, C.6
  • 88
    • 0032806532 scopus 로고    scopus 로고
    • The activation of protein kinase C induces higher production of reactive oxygen species by mononuclear cells in patients with multiple sclerosis than in controls
    • Vladimirova O, Lu FM, Shawver L, Kalman B. The activation of protein kinase C induces higher production of reactive oxygen species by mononuclear cells in patients with multiple sclerosis than in controls. Inflamm Res 1999; 48:412-16. doi: 10.1007/ s000110050480.
    • (1999) Inflamm Res , vol.48 , pp. 412-416
    • Vladimirova, O.1    Lu, F.M.2    Shawver, L.3    Kalman, B.4
  • 89
    • 84899821025 scopus 로고    scopus 로고
    • Oxidative stress mediated mitochondrial and vascular lesions as markers in the pathogenesis of Alzheimer disease
    • Aliev G, Priyadarshini M, Reddy VP, Grieg NH, Kaminsky Y, Cacabelos R, et al. Oxidative stress mediated mitochondrial and vascular lesions as markers in the pathogenesis of Alzheimer disease. Curr Med Chem 2014; 21:2208-17. doi: 10.2174/09298 67321666131227161303.
    • (2014) Curr Med Chem , vol.21 , pp. 2208-2217
    • Aliev, G.1    Priyadarshini, M.2    Reddy, V.P.3    Grieg, N.H.4    Kaminsky, Y.5    Cacabelos, R.6
  • 90
    • 84904768694 scopus 로고    scopus 로고
    • Osteoporosis and Alzheimer pathology: Role of cellular stress response and hormetic redox signaling in aging and bone remodeling
    • Cornelius C, Koverech G, Crupi R, Di Paola R, Koverech A, Lodato F, et al. Osteoporosis and Alzheimer pathology: Role of cellular stress response and hormetic redox signaling in aging and bone remodeling. Front Pharmacol 2014; 5:120. doi: 10.3389/fphar.2014.00120.
    • (2014) Front Pharmacol , vol.5 , pp. 120
    • Cornelius, C.1    Koverech, G.2    Crupi, R.3    Di Paola, R.4    Koverech, A.5    Lodato, F.6
  • 91
    • 0042233910 scopus 로고    scopus 로고
    • The molecular mechanisms by which nitric oxide controls mitochondrial complex IV
    • Sarti P, Arese M, Giuffre A. The molecular mechanisms by which nitric oxide controls mitochondrial complex IV. Ital J Biochem 2003; 52:37-42.
    • (2003) Ital J Biochem , vol.52 , pp. 37-42
    • Sarti, P.1    Arese, M.2    Giuffre, A.3
  • 92
    • 64449083752 scopus 로고    scopus 로고
    • Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease
    • Sheng B, Gong K, Niu Y, Liu L, Yan Y, Lu G, et al. Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease. Free Radic Biol Med 2009; 46:1362-75. doi: 10.1016/j.freeradbiomed.2009.02.018.
    • (2009) Free Radic Biol Med , vol.46 , pp. 1362-1375
    • Sheng, B.1    Gong, K.2    Niu, Y.3    Liu, L.4    Yan, Y.5    Lu, G.6
  • 93
    • 0029671454 scopus 로고    scopus 로고
    • Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein
    • Bodovitz S, Klein WL. Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein. J Biol Chem 1996; 271:4436-40.
    • (1996) J Biol Chem , vol.271 , pp. 4436-4440
    • Bodovitz, S.1    Klein, W.L.2
  • 94
    • 57349195595 scopus 로고    scopus 로고
    • The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis
    • Mirshafiey A, Mohsenzadegan M. The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis. Iran J Allergy Asthma Immunol 2008; 7:195-202. doi: 07.04/ ijaai.195202.
    • (2008) Iran J Allergy Asthma Immunol , vol.7 , pp. 195-202
    • Mirshafiey, A.1    Mohsenzadegan, M.2
  • 95
    • 84861183285 scopus 로고    scopus 로고
    • Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease
    • Ferretti MT, Bruno MA, Ducatenzeiler A, Klein WL, Cuello AC. Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease. Neurobiol Aging 2012; 33:1329-42. doi: 10.1016/j.neurobiolaging.2011.01.007.
    • (2012) Neurobiol Aging , vol.33 , pp. 1329-1342
    • Ferretti, M.T.1    Bruno, M.A.2    Ducatenzeiler, A.3    Klein, W.L.4    Cuello, A.C.5
  • 96
    • 26444548179 scopus 로고    scopus 로고
    • Differential effects of COX inhibitors against beta-amyloid-induced neurotoxicity in human neuroblastoma cells
    • Ferrera P, Arias C. Differential effects of COX inhibitors against beta-amyloid-induced neurotoxicity in human neuroblastoma cells. Neurochem Int 2005; 47:589-96. doi: 10.1016/j.neuint.200 5.06.012.
    • (2005) Neurochem Int , vol.47 , pp. 589-596
    • Ferrera, P.1    Arias, C.2
  • 97
    • 73449101844 scopus 로고    scopus 로고
    • Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation
    • Lee M, Sparatore A, Del Soldato P, McGeer E, McGeer PL. Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation. Glia 2010; 58:103-13. doi: 10.1002/glia.20905.
    • (2010) Glia , vol.58 , pp. 103-113
    • Lee, M.1    Sparatore, A.2    Del Soldato, P.3    McGeer, E.4    McGeer, P.L.5
  • 98
    • 84871955193 scopus 로고    scopus 로고
    • Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease
    • Shi J, Wang Q, Johansson JU, Liang X, Woodling NS, Priyam P, et al. Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease. Ann Neurol 2012; 72:788-98. doi: 10.1002/ana.23677.
    • (2012) Ann Neurol , vol.72 , pp. 788-798
    • Shi, J.1    Wang, Q.2    Johansson, J.U.3    Liang, X.4    Woodling, N.S.5    Priyam, P.6
  • 99
    • 84931315758 scopus 로고    scopus 로고
    • Accessed: Feb 2015
    • Alzheimer's Association. FDA-Approved treatments for Alzheimer's. From: www.alz.org/national/documents/topicsheet_ treatments.pdf Accessed: Feb 2015.
    • FDA-Approved treatments for Alzheimer's
  • 100
    • 84901357991 scopus 로고    scopus 로고
    • Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine
    • Zemek F, Drtinova L, Nepovimova E, Sepsova V, Korabecny J, Klimes J, et al. Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine. Expert Opin Drug Saf 2014; 13:759-74. doi: 10.1517/14740338.2014.914168.
    • (2014) Expert Opin Drug Saf , vol.13 , pp. 759-774
    • Zemek, F.1    Drtinova, L.2    Nepovimova, E.3    Sepsova, V.4    Korabecny, J.5    Klimes, J.6
  • 101
    • 84875655895 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: A brief review of the basic science and clinical literature
    • Wyss-Coray T, Rogers J. Inflammation in Alzheimer disease: A brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med 2012; 2:a006346. doi: 10.1101/ cshperspect.a006346.
    • (2012) Cold Spring Harb Perspect Med , vol.2
    • Wyss-Coray, T.1    Rogers, J.2
  • 102
    • 76449094399 scopus 로고    scopus 로고
    • Inflammation and anti-inflammatory strategies for Alzheimer's disease: A mini-review
    • McNaull BB, Todd S, McGuinness B, Passmore AP. Inflammation and anti-inflammatory strategies for Alzheimer's disease: A mini-review. Gerontology 2010; 56:3-14. doi: 10.1 159/000237873.
    • (2010) Gerontology , vol.56 , pp. 3-14
    • McNaull, B.B.1    Todd, S.2    McGuinness, B.3    Passmore, A.P.4
  • 103
    • 84866773764 scopus 로고    scopus 로고
    • Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease
    • Yu D, Corbett B, Yan Y, Zhang GX, Reinhart P, Cho SJ, et al. Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease. Neurobiol Aging 2012; 33:2942-7. doi: 10.1016/j.neurobiolaging.2012.02.023.
    • (2012) Neurobiol Aging , vol.33 , pp. 2942-2947
    • Yu, D.1    Corbett, B.2    Yan, Y.3    Zhang, G.X.4    Reinhart, P.5    Cho, S.J.6
  • 104
    • 80053383308 scopus 로고    scopus 로고
    • Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of preclinical Alzheimer disease: Findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial
    • Leoutsakos JM, Muthen BO, Breitner JC, Lyketsos CG; ADAPT Research Team. Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of preclinical Alzheimer disease: Findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial. Int J Geriatr Psychiatry 2012; 27:364-74. doi: 10.1002/ gps.2723.
    • (2012) Int J Geriatr Psychiatry , vol.27 , pp. 364-374
    • Leoutsakos, J.M.1    Muthen, B.O.2    Breitner, J.C.3    Lyketsos, C.G.4
  • 105
    • 84861314593 scopus 로고    scopus 로고
    • Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease
    • Jaturapatporn D, Isaac MG, McCleery J, Tabet N. Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease. Cochrane Database Syst Rev 2012; 2:CD006378. doi: 10.1002/14651858.CD006378.pub2.
    • (2012) Cochrane Database Syst Rev , vol.2 , pp. 6378
    • Jaturapatporn, D.1    Isaac, M.G.2    McCleery, J.3    Tabet, N.4
  • 106
    • 84886937126 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer's disease: Hoops and hurdles
    • Lemere CA. Immunotherapy for Alzheimer's disease: Hoops and hurdles. Mol Neurodegener 2013; 8:36. doi: 10.1186/1750- 1326-8-36.
    • (2013) Mol Neurodegener , vol.8 , pp. 36
    • Lemere, C.A.1
  • 108
    • 84865529158 scopus 로고    scopus 로고
    • Clinical and biomarker changes in dominantly inherited Alzheimer's disease
    • Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 2012; 367:795-804. doi: 10.1056/NEJMoa1202753.
    • (2012) N Engl J Med , vol.367 , pp. 795-804
    • Bateman, R.J.1    Xiong, C.2    Benzinger, T.L.3    Fagan, A.M.4    Goate, A.5    Fox, N.C.6
  • 109
    • 84886281639 scopus 로고    scopus 로고
    • Advances in the development of vaccines for Alzheimer's disease
    • Lambracht-Washington D, Rosenberg RN. Advances in the development of vaccines for Alzheimer's disease. Discov Med 2013; 15:319-26.
    • (2013) Discov Med , vol.15 , pp. 319-326
    • Lambracht-Washington, D.1    Rosenberg, R.N.2
  • 110
    • 33646524039 scopus 로고    scopus 로고
    • Abeta42 gene vaccination reduces brain amyloid plaque burden in transgenic mice
    • Qu B, Boyer PJ, Johnston SA, Hynan LS, Rosenberg RN. Abeta42 gene vaccination reduces brain amyloid plaque burden in transgenic mice. J Neurol Sci 2006; 244:151-8.
    • (2006) J Neurol Sci , vol.244 , pp. 151-158
    • Qu, B.1    Boyer, P.J.2    Johnston, S.A.3    Hynan, L.S.4    Rosenberg, R.N.5
  • 111
    • 59649124722 scopus 로고    scopus 로고
    • Reduced oligomeric and vascular amyloid-beta following immunization of TgCRND8 mice with an Alzheimer's DNA vaccine
    • DaSilva KA, Brown ME, McLaurin J. Reduced oligomeric and vascular amyloid-beta following immunization of TgCRND8 mice with an Alzheimer's DNA vaccine. Vaccine 2009; 27:1365-76. doi: 10.1016/j.vaccine.2008.12.044.
    • (2009) Vaccine , vol.27 , pp. 1365-1376
    • DaSilva, K.A.1    Brown, M.E.2    McLaurin, J.3
  • 112
    • 84871721526 scopus 로고    scopus 로고
    • Alzheimer's disease: Recent advances and future perspectives
    • Ubhi K, Masliah E. Alzheimer's disease: Recent advances and future perspectives. J Alzheimers Dis 2013; 33:S185-94. doi: 10. 3233/JAD-2012-129028.
    • (2013) J Alzheimers Dis , vol.33 , pp. S185-S194
    • Ubhi, K.1    Masliah, E.2
  • 113
  • 114
    • 26444587508 scopus 로고    scopus 로고
    • Macroautophagy: A novel Beta-amyloid peptidegenerating pathway activated in Alzheimer's disease
    • Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, et al. Macroautophagy: A novel Beta-amyloid peptidegenerating pathway activated in Alzheimer's disease. J Cell Biol 2005; 171:87-98. doi: 10.1083/jcb.200505082.
    • (2005) J Cell Biol , vol.171 , pp. 87-98
    • Yu, W.H.1    Cuervo, A.M.2    Kumar, A.3    Peterhoff, C.M.4    Schmidt, S.D.5    Lee, J.H.6
  • 115
    • 77951227122 scopus 로고    scopus 로고
    • Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and tau: Effects on cognitive impairments
    • Caccamo A, Majumder S, Richardson A, Strong R, Oddo S. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and tau: Effects on cognitive impairments. J Biol Chem 2010; 285:13107-20. doi: 10.1074/ jbc.M110.100420.
    • (2010) J Biol Chem , vol.285 , pp. 13107-13120
    • Caccamo, A.1    Majumder, S.2    Richardson, A.3    Strong, R.4    Oddo, S.5
  • 116
    • 84914159944 scopus 로고    scopus 로고
    • Double negative (CD19+IgG+IgD-CD27-) B lymphocytes: A new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients
    • Martorana A, Balistreri CR, Bulati M, Buffa S, Azzarello DM, Camarda C, et al. Double negative (CD19+IgG+IgD-CD27-) B lymphocytes: A new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients. Immunol Lett 2014; 162:303-9. doi: 10.1016/j. imlet.2014.06.003.
    • (2014) Immunol Lett , vol.162 , pp. 303-309
    • Martorana, A.1    Balistreri, C.R.2    Bulati, M.3    Buffa, S.4    Azzarello, D.M.5    Camarda, C.6
  • 117
    • 70349412916 scopus 로고    scopus 로고
    • A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people
    • Colonna-Romano G, Bulati M, Aquino A, Pellicanò M, Vitello S, Lio D, et al. A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people. Mech Ageing Dev 2009; 130:681-90. doi: 10.1016/j. mad.2009.08.003.
    • (2009) Mech Ageing Dev , vol.130 , pp. 681-690
    • Colonna-Romano, G.1    Bulati, M.2    Aquino, A.3    Pellicanò, M.4    Vitello, S.5    Lio, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.