Amyloid plaques dissociate pentameric to monomeric C-reactive protein: A novel pathomechanism driving cortical inflammation in Alzheimer's disease?

Brain Pathology

Volumn 22, Issue 3, 2012, Pages 337-346

  Strang, Frederik ^a,c   Scheichl, Amelie ^a   Chen, Yung Chih ^a,b   Wang, Xiaowei ^a,b   Htun, Nay Min ^a,b   Bassler, Nicole ^a   Eisenhardt, Steffen U ^a,d   Habersberger, Jonathon ^a,b   Peter, Karlheinz ^a,b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Alzheimer's disease; C reactive protein; Inflammation; Monomeric C reactive protein

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; C REACTIVE PROTEIN; COMPLEMENT COMPONENT C1Q;

AGED; ALZHEIMER DISEASE; AMYLOID PLAQUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; INFLAMMATION; PATHOGENESIS; PROTEIN LOCALIZATION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; C-REACTIVE PROTEIN; FEMALE; HUMANS; INFLAMMATION; MALE; PLAQUE, AMYLOID;

EID: 84859802979     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2011.00539.x     Document Type: Article

References (40)

1. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease (1997) Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. Neurobiol Aging 18(Suppl. 4):S1-S2.
2. Akiyama H, Arai T, Kondo H, Tanno E, Haga C, Ikeda K (2000) Cell mediators of inflammation in the Alzheimer disease brain. Alzheimer Dis Assoc Disord 14(Suppl. 1):S47-S53. (Pubitemid 30406772)
3. Biro A, Rovo Z, Papp D, Cervenak L, Varga L, Fust G et al (2007) Studies on the interactions between C-reactive protein and complement proteins. Immunology 121:40-50. (Pubitemid 46537662)
4. Casas JP, Shah T, Hingorani AD, Danesh J, Pepys MB (2008) C-reactive protein and coronary heart disease: a critical review. J Intern Med 264:295-314.
5. Citron M (2010) Alzheimer's disease: strategies for disease modification. Nat Rev Drug Discov 9:387-398.
6. Ciubotaru I, Potempa LA, Wander RC (2005) Production of modified C-reactive protein in U937-derived macrophages. Exp Biol Med (Maywood) 230:762-770. (Pubitemid 41565946)
7. Dimopoulos N, Piperi C, Salonicioti A, Mitropoulos P, Kallai E, Liappas I et al (2006) Indices of low-grade chronic inflammation correlate with early cognitive deterioration in an elderly Greek population. Neurosci Lett 398:118-123.
8. Duong T, Nikolaeva M, Acton PJ (1997) C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease. Brain Res 749:152-156. (Pubitemid 27096469)
9. Eisenhardt SU, Habersberger J, Murphy A, Chen YC, Woollard KJ, Bassler N et al (2009) Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques. Circ Res 105:128-137.
10. Eisenhardt SU, Habersberger J, Peter K (2009) Monomeric C-reactive protein generation on activated platelets: the missing link between inflammation and atherothrombotic risk. Trends Cardiovasc Med 19:232-237.
11. Gill R, Kemp JA, Sabin C, Pepys MB (2004) Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats. J Cereb Blood Flow Metab 24:1214-1218. (Pubitemid 39482482)
12. Griselli M, Herbert J, Hutchinson WL, Taylor KM, Sohail M, Krausz T, Pepys MB (1999) C-reactive protein and complement are important mediators of tissue damage in acute myocardial infarction. J Exp Med 190:1733-1740.
13. Gupta A, Watkins A, Thomas P, Majer R, Habubi N, Morris G, Pansari K (2005) Coagulation and inflammatory markers in Alzheimer's and vascular dementia. Int J Clin Pract 59: 52-57. (Pubitemid 40260114)
14. Hendrie HC (1998) Epidemiology of dementia and Alzheimer's disease. Am J Geriatr Psychiatry 6(2 Suppl. 1):S3-18.
15. Iwamoto N, Nishiyama E, Ohwada J, Arai H (1994) Demonstration of CRP immunoreactivity in brains of Alzheimer's disease: immunohistochemical study using formic acid pretreatment of tissue sections. Neurosci Lett 177:23-26. (Pubitemid 24269420)
16. Ji SR, Wu Y, Potempa LA, Liang YH, Zhao J (2006) Effect of modified C-reactive protein on complement activation: a possible complement regulatory role of modified or monomeric C-reactive protein in atherosclerotic lesions. Arterioscler Thromb Vasc Biol 26:935-941.
17. Ji SR, Wu Y, Zhu L, Potempa LA, Sheng FL, Lu W, Zhao J (2007) Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRP(m). FASEB J 21:284-294. (Pubitemid 46052567)
18. Kresl JJ, Potempa LA, Anderson BE (1998) Conversion of native oligomeric to a modified monomeric form of human C-reactive protein. Int J Biochem Cell Biol 30:1415-1426. (Pubitemid 129750174)
19. Lin HB, Yang XM, Li TJ, Cheng YF, Zhang HT, Xu JP (2009) Memory deficits and neurochemical changes induced by C-reactive protein in rats: implication in Alzheimer's disease. Psychopharmacology (Berl) 204:705-714.
20. Makinen S, van Groen T, Clarke J, Thornell A, Corbett D, Hiltunen M et al (2008) Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 28:263-268. (Pubitemid 351161286)
21. Molins B, Pena E, Vilahur G, Mendieta C, Slevin M, Badimon L (2008) C-reactive protein isoforms differ in their effects on thrombus growth. Arterioscler Thromb Vasc Biol 28:2239-2246.
22. Morganti-Kossmann MC, Rancan M, Otto VI, Stahel PF, Kossmann T (2001) Role of cerebral inflammation after traumatic brain injury: a revisited concept. Shock 16:165-177. (Pubitemid 33598193)
23. Mulder SD, Hack CE, van der Flier WM, Scheltens P, Blankenstein MA, Veerhuis R (2010) Evaluation of intrathecal serum amyloid P (SAP) and C-reactive protein (CRP) synthesis in Alzheimer's disease with the use of index values. J Alzheimers Dis 22:1073-1079.
24. Paravastu AK, Petkova AT, Tycko R (2006) Polymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide. Biophys J 90:4618-4629. (Pubitemid 43830905)
25. Pepys MB, Hirschfield GM (2003) C-reactive protein: a critical update. J Clin Invest 111:1805-1812. (Pubitemid 38057722)
26. Pepys MB, Hirschfield GM, Tennent GA, Gallimore JR, Kahan MC, Bellotti V et al (2006) Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 440:1217-1221.
27. Potempa LA, Siegel JN, Fiedel BA, Potempa RT, Gewurz H (1987) Expression, detection and assay of a neoantigen (Neo-CRP) associated with a free, human C-reactive protein subunit. Mol Immunol 24:531-541. (Pubitemid 17062643)
28. Rogers J, Cooper NR, Webster S, Schultz J, McGeer PL, Styren SD et al (1992) Complement activation by beta-amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 89:10016-10020.
29. Selkoe DJ (1999) Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399(Suppl. 6738):A23-A31.
30. Slevin M, Matou-Nasri S, Turu M, Luque A, Rovira N, Badimon L et al (2010) Modified C-reactive protein is expressed by stroke neovessels and is a potent activator of angiogenesis in vitro. Brain Pathol 20:151-165.
31. Stolp HB, Dziegielewska KM (2009) Review: role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases. Neuropathol Appl Neurobiol 35:132-146.
32. Taylor KE, van den Berg CW (2007) Structural and functional comparison of native pentameric, denatured monomeric and biotinylated C-reactive protein. Immunology 120:404-411. (Pubitemid 46232915)
33. Veerhuis R (2011) Histological and direct evidence for the role of complement in the neuroinflammation of AD. Curr Alzheimer Res 8:34-58.
34. Waldvogel HJ, Curtis MA, Baer K, Rees MI, Faull RL (2006) Immunohistochemical staining of post-mortem adult human brain sections. Nat Protoc 1:2719-2732.
35. Walsh DM, Selkoe DJ (2007) A beta oligomers - a decade of discovery. J Neurochem 101:1172-1184.
36. Wood JA, Wood PL, Ryan R, Graff-Radford NR, Pilapil C, Robitaille Y, Quirion R (1993) Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1 beta or IL-1RA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein. Brain Res 629:245-252. (Pubitemid 23337798)
37. Xu G, Zhou Z, Zhu W, Fan X, Liu X (2009) Plasma C-reactive protein is related to cognitive deterioration and dementia in patients with mild cognitive impairment. J Neurol Sci 284:77-80.
38. Yasojima K, Schwab C, McGeer EG, McGeer PL (2000) Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer's disease. Brain Res 887:80-89. (Pubitemid 32008026)
39. Yasojima K, Schwab C, McGeer EG, McGeer PL (2001) Generation of C-reactive protein and complement components in atherosclerotic plaques. Am J Pathol 158:1039-1051. (Pubitemid 32221796)
40. Zaciragic A, Lepara O, Valjevac A, Arslanagic S, Fajkic A, Hadzovic-Dzuvo A et al (2007) Elevated serum C-reactive protein concentration in Bosnian patients with probable Alzheimer's disease. J Alzheimers Dis 12:151-156. (Pubitemid 47509372)