Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease

Neurobiology of Aging

Volumn 33, Issue 12, 2012, Pages 2942-2947

  Yu, Dongzi ^a,d   Corbett, Brian ^b,c   Yan, Yaping ^c   Zhang, Guang Xian ^c   Reinhart, Peter ^a,e   Cho, Seongeun J ^a,f   Chin, Jeannie ^a,b,c  

^a PFIZER INC   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d EMD Serono Research Institute Inc   (United States)

^e Proteostasis Therapeutics   (United States)

^f CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

AD transgenic mice; Blood brain barrier; Cerebrovascular dysfunction; Cerebrovascular inflammation; EAE; Endothelial cells; MECA 32; Neuroinflammation; Soluble A ; Von Willibrand factor

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CELL ANTIGEN; ENDOTHELIAL CELL ANTIGEN 32; PRESENILIN 1; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENCEPHALITIS; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOLECULAR PATHOLOGY; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRANSGENIC MOUSE; UPREGULATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIGENS, SURFACE; BLOOD-BRAIN BARRIER; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURITIS, AUTOIMMUNE, EXPERIMENTAL; PRESENILIN-1; UP-REGULATION; VASCULITIS, CENTRAL NERVOUS SYSTEM;

EID: 84866773764     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.02.023     Document Type: Article

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