Intrathecal antagonism of microglial TLR4 reduces inflammatory damage to blood-spinal cord barrier following ischemia/reperfusion injury in rats

Molecular Brain

Volumn 7, Issue 1, 2014, Pages

  Li, Xiao Qian ^a   Wang, Jun ^a   Fang, Bo ^a   Tan, Wen Fei ^a   Ma, Hong ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Blood spinal cord barrier; Intrathecal transplantation; Microglia; Minocycline; Spinal cord ischemia reperfusion injury; Toll like receptor 4

Indexed keywords

CASPASE 3; EVANS BLUE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; IONIZED CALCIUM BINDING ADAPTOR MOLECULE 1; MESSENGER RNA; MINOCYCLINE; PYRROLIDINE DITHIOCARBAMATE; RESATORVID; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA OCCLUSION; APOPTOSIS; ARTICLE; BLOOD; BLOOD SPINAL CORD BARRIER; CELL ACTIVATION; CONTROLLED STUDY; DRUG ANTAGONISM; ENZYME ACTIVITY; EXPERIMENTAL SPINAL CORD INJURY; GENE EXPRESSION; GRAY MATTER; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROGLIA; NEUROPROTECTION; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SPINAL CORD; UPREGULATION;

RATTUS;

ANIMALS; CALCIUM-BINDING PROTEINS; INFLAMMATION; INTERLEUKIN-1BETA; MALE; MICROFILAMENT PROTEINS; MICROGLIA; NEURONS; NF-KAPPA B; PERMEABILITY; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPINAL CORD; TOLL-LIKE RECEPTOR 4;

EID: 84899930321     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/1756-6606-7-28     Document Type: Article

References (32)

1. Results of open thoracoabdominal aortic aneurysm repair. Lemaire SA, HPrice MDH, HGreen SYH, HZarda SH, HCoselli JSH, Ann Cardiothorac Surg 2012 1 286 292 23977510
2. Neuroprotection against spinal cord ischemia-reperfusion injury induced by different ischemic postconditioning methods: roles of phosphatidylinositol 3-kinase-akt and extracellular signal-regulated kinase. HJiang XH, HAi CH, HShi EH, HNakajima YH, HMa HH, Anesthesiology 2009 111 1197 1205 10.1097/ALN. 0b013e3181bf1d93 19934862
3. Development and treatments of inflammatory cells and cytokines in spinal cord ischemia-reperfusion injury. HZhu PH, Li JX, HFujino MH, HZhuang JH, HLi XKH, Mediators Inflamm 2013 2013 701970 doi:10.1155/2013/701970. Epub 2013 Jul 14 23956505
4. Efficacy of iloprost and montelukast combination on spinal cord ischemia/reperfusion injury in a rat model. HLafci GH, Gedik HS, HKorkmaz KH, HErdem HH, HCicek OFH, HNacar OAH, HYildirim LH, HKaya EH, HAnkarali HH, J Cardiothorac Surg 2013 8 64 10.1186/1749-8090-8-64 23557242
5. Ischemic preconditioning protects against spinal cord ischemia-reperfusion injury in rabbits by attenuating blood spinal cord barrier disruption. Fang B, Li XM, Sun XJ, Bao NR, Ren XY, Lv HW, Ma H, Int J Mol Sci 2013 14 10343 10354 10.3390/ijms140510343 23685868
6. Intrathecal transplantation of bone marrow stromal cells attenuates blood-spinal cord barrier disruption induced by spinal cord ischemia-reperfusion injury in rabbits. Fang B, Wang H, Sun XJ, Li XQ, Ai CY, Tan WF, White PF, Ma H, J Vasc Surg 2013 58 1043 1052 10.1016/j.jvs.2012.11.087 23478501
7. Microglia and ischemic stroke: a double-edged sword. Patel AR, Ritzel R, McCullough LD, Liu F, Int J Physiol Pathophysiol Pharmacol 2013 27 73 90
8. Role of baicalin in regulation toll-like 2/4 after ischemic neuronal injury. HLi HYH, HYuan ZYH, HWang YGH, HWan HJH, HHu JH, HChai YSH, HChai YSH, HLei FH, HXing DMH HDULJH, Chin Med J 2012 125 1586 1593 22800826
9. System infection and inflammation in acute CNS injury and chronic neurodegeneration: underlying mechanisms. Teeling JL, Perry VH, Neuroscience 2009 158 1062 1073 10.1016/j.neuroscience.2008.07.031 18706982
10. Toll-like receptors and innate immunity. Kumar H, Kawai T, Akira S, Biochem Biophys Res Commun 2009 388 621 625 10.1016/j.bbrc.2009.08.062 19686699
11. Toll-like receptors in ischemia-reperfusion injury. Arumugam TV, Okun E, Tang SC, Thundyil J, Taylor SM, Woodruff TM, Shock 2009 32 4 16 10.1097/SHK.0b013e318193e333 19008778
12. Endothelium-derived toll-like receptor-4 are the key molecule in LPS-induced neutrophil sequestration into lungs. Andonegui G, Bonder CS, Green F, Mullaly SC, Zbytnuik L, Raharjo E, HKubes PH, J Clin Invest 2003 111 1011 1020 10.1172/JCI16510 12671050
13. TLR2 and TLR4 in the brain injury caused by cerebral ischemia and reperfusion. Wang Y, Ge P, Zhu Y, Mediators Inflamm 2013 2013 124614 10.1155/2013/124614. Epub 2013 Jun 23 23864765
14. Toll-like receptor signaling pathway and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury. HWang YH, HAbarbanell AMH, HHerrmann JLH, HWeil BRH, HPoynter JH, HManukyan MCH, HCrisostomo PRH, HMeldrum DRH, Shock 2010 43 548 557
15. Impact of minocycline on neurodegenerative diseases in rodents: a meta-analysis. Li C, Yuan K, Schluesener H, Rev Neurosci 2013 24 553 562 24077620
16. Spinal cord ischemia. Development of a model in the mouse. Lang-Lazdunski L, Matsushita K, Hirt L, Waeber C, Vonsattle JP, Moskowitz MA, Dietrich WD, Stroke 2000 31 208 213 10.1161/01.STR.31.1.208 10625739
17. Spinal toll like receptor 3 is involved in chronic pancreatitis-induced mechanical allodynia of rat. Qian NS, Liao YH, Feng QX, Tang Y, Dou KF, Tao KS, Mol Pain 2011 22 7 15
18. Intestinal ischemia/reperfusion enhances microglial activation and induces cerebral injury and memory dysfunction in rats. Zhou J, Huang WQ, Li C, Wu GY, Wen S, Lei WL, Liu KX, Crit Care Med 2012 40 2438 2448 10.1097/CCM.0b013e3182546855 22647410
19. EMP- induced alterations of tight junction protein expression and disruption of the blood-brain barrier. Ding GR, Qiu LB, Wang XW, Li KC, Zhou YC, Zhou Y, Zhang J, Zhou JX, Li YR, Guo GZ, Toxicol Lett 2010 196 154 160 10.1016/j.toxlet.2010.04.011 20412840
20. Fluoxetine inhibits matrix metalloprotease activation and prevents disruption of blood-spinal cord barrier after spinal cord injury. Lee JY, Kim HS, Choi HY, Oh TH, Yune TY, Brain 2012 135 2375 2389 10.1093/brain/aws171 22798270
21. Increased morphological diversity of microglia in the activated hypothalamic supraoptic nucleus. Ayoub AE, Salm AK, J Neurosci 2003 23 7759 7766 12944504
22. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. Tikka T, Fiebich BL, Goldsteins G, Keinanen R, Koistinaho J, J Neurosci 2001 21 2580 2588 11306611
23. Interleukin-1beta -induced changes in blood-brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: a magnetic resonance study. Blamire AM, Anthony DC, Rajagopalan B, Sibson NR, Perry VH, Styles P, J Neurosci 2000 20 8153 8159 11050138
24. Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation. Van Vliet EA, Forte G, Holtman L, Den Burger JC, Sinjewel A, De Vries HE, Aronica E, Gorter JA, Epilepsia 2012 53 1254 1263 10.1111/j.1528-1167.2012.03513.x 22612226
25. Evidence for suppression of spinal glial activation by dexmedetomidine in a rat model of monoarthritis. Xu B, Zhang WS, Yang JL, Lû N, Deng XM, Xu H, Zhang YQ, Clin Exp Pharmacol Physiol 2010 37 158 166 10.1111/j.1440-1681. 2010.05426.x
26. Toll-like receptor 4-mediated myeloid differentiation factor 88-dependent signaling pathway is activated by cerebral ischemia-reperfusion in hippocampal CA1 region in mice. Gao Y, Fang XB, Sun H, Wang Y, Yao LJ, Li JP, Tong Y, Zhang B, Liu Y, Biol Pharm Bull 2009 32 1665 1671 10.1248/bpb.32.1665 19801825
27. Intrathecal infusion of pyrrolidine dithiocarbamate for the prevention and reversal of neuropathic pain in rats using a sciatic chronic constriction injury model. Pan YD, Guo QL, Wang E, HYe ZH, He ZH, Zou WY, Cheng ZG, Wang YJ, Reg Anesth Pain Med 2010 35 231 237 10.1097/AAP.0b013e3181df245b 20921832
28. Lipopolysaccharide enhances Wnt5a expression through toll-like receptor 4, myeloiddifferentiating factor 88, phosphatidylinositol 3-OH kinase/AKT and nuclear factor kappa Bpathways in human dental pulp stem cells. He W, Wang Z, Zhou Z, Zhang Y, Zhu Q, Wei K, Lin Y, Cooper PR, Smith AJ, Yu Q, J Endod 2014 40 69 75 10.1016/j.joen.2013.09.011 24331994
29. Inhibition of NF-kappaB prevents mechanical allodynia induced by spinal ventral root transectionand suppresses the re-expression of Nav1.3 in DRG neurons in vivo and in vitro. Zang Y, He XH, Xin WJ, Pang RP, Wei XH, Zhou LJ, Li YY, Liu XG, Brain Res 2010 1363 151 158 20858468
30. Microglial-neuronal interactions during neurodegenerative diseases. Colton CA, J Neuroimmune Pharmacol 2013 8 4 6
31. Toll-like recepor 4-dependent microglial activation mediates spinal cord ischemia-reperfusion injury. Bell MT, Puskas F, Agoston VA, Cleveland JC Jr, Freeman KA, Gamboni F, Herson PS, Meng X, Smith PD, Weyant MJ, Fullerton DA, Reece TB, Circulation 2013 128 152 S156 10.1161/CIRCULATIONAHA.112.000024 24030400
32. Neuron-derived IgG protects dopaminergic neurons from insult by 6-OHDA and activates microglia through the FcγR I and TLR4 pathways. Zhang J, Niu N, Wang M, McNutt MA, Zhang D, Zhang B, Lu S, Liu Y, Liu Z, Int J Biochem Cell Biol 2013 45 1911 1920 10.1016/j.biocel.2013.06.005 23791745