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Volumn 13, Issue 6, 2014, Pages 759-774

Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine

Author keywords

Acetylcholinesterase; Alzheimer's diseases; Donepezil; Galantamine; Memantine; Rivastigmine

Indexed keywords

CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; MEMANTINE; RIVASTIGMINE; AMINO ACID RECEPTOR BLOCKING AGENT;

EID: 84901357991     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2014.914168     Document Type: Review
Times cited : (286)

References (105)
  • 2
    • 79960165065 scopus 로고    scopus 로고
    • The economic impact of dementia in Europe in 2008-cost estimates from the Eurocode project
    • Wimo A, Jonsson L, Gustavsson A, et al. The economic impact of dementia in Europe in 2008-cost estimates from the Eurocode project. Int J Geriatr Psychiatry 2011;26(8):825-32
    • (2011) Int J Geriatr Psychiatry , vol.26 , Issue.8 , pp. 825-832
    • Wimo, A.1    Jonsson, L.2    Gustavsson, A.3
  • 3
    • 33846637262 scopus 로고    scopus 로고
    • The incidence of dementia in England and Wales: Findings from the five identical sites of the MRC CFA Study
    • Matthews F, Brayne C. The incidence of dementia in England and Wales: Findings from the five identical sites of the MRC CFA Study. PLoS Med 2005;2:e193
    • (2005) PLoS Med , vol.2
    • Matthews, F.1    Brayne, C.2
  • 4
    • 53749093126 scopus 로고    scopus 로고
    • Sociodemographic and clinical correlates of utility scores in Alzheimer's disease
    • Miller EA, Schneider LS, Zbrozek A, Rosenheck RA. Sociodemographic and clinical correlates of utility scores in Alzheimer's disease. Value Health 2008;11:1120-30
    • (2008) Value Health , vol.11 , pp. 1120-1130
    • Miller, E.A.1    Schneider, L.S.2    Zbrozek, A.3    Rosenheck, R.A.4
  • 5
    • 2442718681 scopus 로고    scopus 로고
    • The relationship between quality of life Mini-Mental State Examination, and the Instrumental Activities of Daily Living in patients with Alzheimer's disease
    • Wlodarczyk JH, Brodaty H, Hawthorne G, et al. The relationship between quality of life, Mini-Mental State Examination, and the Instrumental Activities of Daily Living in patients with Alzheimer's disease. Arch Gerontol Geriatr 2004;39:25-33
    • (2004) Arch Gerontol Geriatr , vol.39 , pp. 25-33
    • Wlodarczyk, J.H.1    Brodaty, H.2    Hawthorne, G.3
  • 6
    • 16244381254 scopus 로고    scopus 로고
    • Ability to perform activities of daily living is the main factor affecting quality of life in patients with dementia
    • Andersen CK, Wittrup-Jensen KU, Lolk A, et al. Ability to perform activities of daily living is the main factor affecting quality of life in patients with dementia. Health Qual Life Outcomes 2004;2:52
    • (2004) Health Qual Life Outcomes , vol.2 , pp. 52
    • Andersen, C.K.1    Wittrup-Jensen, K.U.2    Lolk, A.3
  • 9
    • 33745050716 scopus 로고    scopus 로고
    • Added therapeutic value of memantine in the treatment of moderate to severe Alzheimer's disease
    • DOI 10.2165/00044011-200626060-00001
    • Heinen-Kammerer T, Rulhoff H, Nelles S, et al. Added therapeutic value of memantine in the treatment of moderate to severe Alzheimer's disease. Clin Drug Investig 2006;26(6):303-14 (Pubitemid 43876564
    • (2006) Clinical Drug Investigation , vol.26 , Issue.6 , pp. 303-314
    • Heinen-Kammerer, T.1    Rulhoff, H.2    Nelles, S.3    Rychlik, R.4
  • 10
    • 79959389773 scopus 로고    scopus 로고
    • Lack of evidence for the efficacy of memantine in mild alzheimer disease
    • Schneider LS, Dagerman KS, Higgins JP, McShane R. Lack of evidence for the efficacy of memantine in mild Alzheimer disease. Arch Neurol 2011;68(8):991-8
    • (2011) Arch Neurol , vol.68 , Issue.8 , pp. 991-998
    • Schneider, L.S.1    Dagerman, K.S.2    Higgins, J.P.3    McShane, R.4
  • 11
    • 84863717143 scopus 로고    scopus 로고
    • A review of the effects of memantine on clinical progression in Alzheimer's disease
    • Wilkinson D. A review of the effects of memantine on clinical progression in Alzheimer's disease. Int J Geriatr Psychiatry 2012;27(8):769-76
    • (2012) Int J Geriatr Psychiatry , vol.27 , Issue.8 , pp. 769-776
    • Wilkinson, D.1
  • 13
    • 42149142899 scopus 로고    scopus 로고
    • Memantine treatment in patients with mild to moderate Alzheimer's disease already receiving a cholinesterase inhibitor: A randomized, double-blind, placebocontrolled trial
    • Memantine MEM-MD-12 Study Group.
    • Porsteinsson AP, Grossberg GT, Mintzer J, Olin JT; Memantine MEM-MD-12 Study Group. Memantine treatment in patients with mild to moderate Alzheimer's disease already receiving a cholinesterase inhibitor: A randomized, double-blind, placebocontrolled trial. Curr Alzheimer Res 2008;5(1):83-9
    • (2008) Curr Alzheimer Res , vol.5 , Issue.1 , pp. 83-89
    • Porsteinsson, A.P.1    Grossberg, G.T.2    Mintzer, J.3    Olin, J.T.4
  • 14
    • 0346656610 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibition in Alzheimer's disease
    • Ibach B, Haen E. Acetylcholinesterase inhibition in Alzheimer's disease. Curr Pharm Des 2004;10:231-51
    • (2004) Curr Pharm Des , vol.10 , pp. 231-251
    • Ibach, B.1    Haen, E.2
  • 15
    • 4143103645 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibitors: Novel activities of old molecules
    • DOI 10.1016/j.phrs.2003.12.027, PII S1043661804000908
    • Racchi M, Mazzucchelli M, Porrello E, et al. Acetylcholinesterase inhibitors: Novel activities of old molecules. Pharmacol Res 2004;50:441-51 (Pubitemid 39089089
    • (2004) Pharmacological Research , vol.50 , Issue.4 , pp. 441-451
    • Racchi, M.1    Mazzucchelli, M.2    Porrello, E.3    Lanni, C.4    Govoni, S.5
  • 16
    • 78650755460 scopus 로고    scopus 로고
    • Donepezil: A review of pharmacological characteristics and role in the management of Alzheimer disease
    • Jelic V, Darreh-Shori T. Donepezil: A review of pharmacological characteristics and role in the management of Alzheimer disease. Clin Med Insights: Ther 2010;2:771-88
    • (2010) Clin Med Insights: Ther , vol.2 , pp. 771-788
    • Jelic, V.1    Darreh-Shori, T.2
  • 19
    • 84870050015 scopus 로고    scopus 로고
    • Structures of human acetylcholinesterase in complex with pharmacologically important ligands
    • Cheung J, Rudolph MJ, Burhsteyn F, et al. Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J Med Chem 2012;55:10282-6
    • (2012) J Med Chem , vol.55 , pp. 10282-10286
    • Cheung, J.1    Rudolph, M.J.2    Burhsteyn, F.3
  • 21
    • 0037298750 scopus 로고    scopus 로고
    • β-Amyloid aggregation induced by human acetylcholinesterase: Inhibition studies
    • DOI 10.1016/S0006-2952(02)01514-9, PII S0006295202015149
    • Bartolini M, Bertucci C, Cavrini V, et al. beta-Amyloid aggregation induced by human acetylcholinesterase: Inhibition studies. Biochem Pharmacol 2003;65:407-16 (Pubitemid 36084557
    • (2003) Biochemical Pharmacology , vol.65 , Issue.3 , pp. 407-416
    • Bartolini, M.1    Bertucci, C.2    Cavrini, V.3    Andrisano, V.4
  • 22
    • 0029863697 scopus 로고    scopus 로고
    • Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme
    • DOI 10.1016/S0896-6273(00)80108-7
    • Inestrosa N, Alvarez A, Perez C, et al. Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme. Neuron 1996;16:881-91 (Pubitemid 26124065
    • (1996) Neuron , vol.16 , Issue.4 , pp. 881-891
    • Inestrosa, N.C.1    Alvarez, A.2    Perez, C.A.3    Moreno, R.D.4    Vicente, M.5    Linker, C.6    Casanueva, O.I.7    Soto, C.8    Garrido, J.9
  • 24
    • 0038618612 scopus 로고    scopus 로고
    • Acetylcholinesterase promotes beta-Amyloid plaques in cerebral cortex
    • DOI 10.1016/S0197-4580(02)00230-0
    • Rees T, Hammond PI, Soreq H, et al. Acetylcholinesterase promotes beta-Amyloid plaques in cerebral cortex. Neuorbiol Aging 2003;24:777-87 (Pubitemid 37288853
    • (2003) Neurobiology of Aging , vol.24 , Issue.6 , pp. 777-787
    • Rees, T.1    Hammond, P.I.2    Soreq, H.3    Younkin, S.4    Brimijoin, S.5
  • 26
    • 12844271665 scopus 로고    scopus 로고
    • A preclinical view of cholinesterase inhibitors in neuroprotection: Do they provide more than symptomatic benefits in Alzheimer's disease?
    • Francis PT, Nordberg A, Arnold SE. A preclinical view of cholinesterase inhibitors in neuroprotection: Do they provide more than symptomatic benefits in Alzheimer's disease?. Trends Pharmacol Sci 2005;26:104-11
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 104-111
    • Francis, P.T.1    Nordberg, A.2    Arnold, S.E.3
  • 27
    • 0038643858 scopus 로고    scopus 로고
    • Protective effect of donepezil in a primary culture of rat cortical neurons exposed to oxygen-glucose deprivation
    • DOI 10.1016/S0014-2999(03)01865-X
    • Akasofu S, Kosasa T, Kimura M, Kubota A. Protective effect of donepezil in a primary culture of rat cortical neurons exposed to oxygen-glucose deprivation. Eur J Pharmacol 2003;472(1-2):57-63 (Pubitemid 36830992
    • (2003) European Journal of Pharmacology , vol.472 , Issue.1-2 , pp. 57-63
    • Akasofu, S.1    Kosasa, T.2    Kimura, M.3    Kubota, A.4
  • 28
    • 77955783556 scopus 로고    scopus 로고
    • Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of a7 nicotinic receptors and internalization of NMDA receptors
    • Shen H, Kihara T, Hongo H, et al. Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of a7 nicotinic receptors and internalization of NMDA receptors. Br J Phamracol 2010;161:127-39
    • (2010) Br J Phamracol , vol.161 , pp. 127-139
    • Shen, H.1    Kihara, T.2    Hongo, H.3
  • 29
    • 0032507596 scopus 로고    scopus 로고
    • Tacrine and donepezil attenuate the neurotoxic effect of A beta 25 35) in rat PC12 cells
    • Svensson AL, Nordberg A. Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells. Neuroreport 1998;9:1519-22
    • (1998) Neuroreport , vol.9 , pp. 1519-1522
    • Svensson, A.L.1    Nordberg, A.2
  • 30
    • 38049080550 scopus 로고    scopus 로고
    • Challenges and opportunities-Lessons from donepezil therapy
    • Sabbagh MN, Richardson S, Relkin N. Challenges and opportunities-Lessons from donepezil therapy. Alzheimers Dement 2008;4:109-18
    • (2008) Alzheimers Dement , vol.4 , pp. 109-118
    • Sabbagh, M.N.1    Richardson, S.2    Relkin, N.3
  • 31
    • 84868151501 scopus 로고    scopus 로고
    • A noradrenergic theory of cognitive reserve: Implications for Alzheimer's disease
    • Robertson IH. A noradrenergic theory of cognitive reserve: Implications for Alzheimer's disease. Neurobiol Aging 2013;34:298-308
    • (2013) Neurobiol Aging , vol.34 , pp. 298-308
    • Robertson, I.H.1
  • 32
    • 84879714443 scopus 로고    scopus 로고
    • Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care
    • Trillo L, Das D, Hsieh W, et al. Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care. Neuroscience 2013;37:1363-79
    • (2013) Neuroscience , vol.37 , pp. 1363-1379
    • Trillo, L.1    Das, D.2    Hsieh, W.3
  • 35
    • 66349111984 scopus 로고    scopus 로고
    • Donepezil in the treatment of patients with Alzheimer's disease
    • Tsuno N. Donepezil in the treatment of patients with Alzheimer's disease. Expert Rev Neurother 2009;9:591-8
    • (2009) Expert Rev Neurother , vol.9 , pp. 591-598
    • Tsuno, N.1
  • 36
    • 84870941918 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Washington DC. Available From [Last accessed 12 November 2013
    • ClinicalTrials.gov. A service of the U.S. National Institutes of Health. Washington, DC. Available from: Http://www.clinicaltrials.gov/ct2/results?. term=donepezil [Last accessed 12 November 2013
    • A Service Of The U.S. National Institutes Of Health
  • 37
    • 34249902022 scopus 로고    scopus 로고
    • Rivastigmine in the treatment of patients with Alzheimeŕs disease
    • Müller T. Rivastigmine in the treatment of patients with Alzheimeŕs disease. Neuropsychiatr Dis Treat 2007;3(2):211-18
    • (2007) Neuropsychiatr Dis Treat , vol.3 , Issue.2 , pp. 211-218
    • Müller, T.1
  • 38
    • 0031718551 scopus 로고    scopus 로고
    • Clinical pharmacology of rivastigmine: A new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease
    • DOI 10.1016/S0149-2918(98)80127-6
    • Polinsky RJ. Clinical pharmacology of rivastigmine: A new-generation acetylcholinesterase inhibitor for the treatment of Alzheimeŕs disease. Clin Ther 1998;20(4):634-47 (Pubitemid 28421485
    • (1998) Clinical Therapeutics , vol.20 , Issue.4 , pp. 634-647
    • Polinsky, R.J.1
  • 40
    • 0042286681 scopus 로고    scopus 로고
    • Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular form in normal and Alzheimeŕs disease brain
    • Rokonczay Z. Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular form in normal and Alzheimeŕs disease brain. Acta Biol Hung 2003;54(2):183-9
    • (2003) Acta Biol Hung , vol.54 , Issue.2 , pp. 183-189
    • Rokonczay, Z.1
  • 41
    • 84881544585 scopus 로고    scopus 로고
    • Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with alzheimeŕs disease
    • Darreh-Shori T, Vijayaraghavan S, Aeinehband S, et al. Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimeŕs disease. Neurobiol Aging 2013;34(11):2465-81
    • (2013) Neurobiol Aging , vol.34 , Issue.11 , pp. 2465-2481
    • Darreh-Shori, T.1    Vijayaraghavan, S.2    Aeinehband, S.3
  • 42
    • 38449088916 scopus 로고    scopus 로고
    • Rivastigmine in the treatment of Alzheimeŕs disease: An update
    • Onor ML, Trevisiol M, Aguglia E. Rivastigmine in the treatment of Alzheimeŕs disease: An update. Clin Interv Aging 2007;2(1):17-32
    • (2007) Clin Interv Aging , vol.2 , Issue.1 , pp. 17-32
    • Onor, M.L.1    Trevisiol, M.2    Aguglia, E.3
  • 43
    • 0031458235 scopus 로고    scopus 로고
    • Butyrylcholinesterase in the life cycle of amyloid plaques
    • DOI 10.1002/ana.410420613
    • Guillzet AL, Smiley JF, Mash DC, Mesulam M. Butyrylcholinesterase in the life cycle of amyloid plaques. Ann Neurol 1997;42(6):909-18 (Pubitemid 28008422
    • (1997) Annals of Neurology , vol.42 , Issue.6 , pp. 909-918
    • Guillozet, A.L.1    Smiley, J.F.2    Mash, D.C.3    Mesulam, M.-M.4
  • 44
    • 0027973241 scopus 로고
    • Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia
    • DOI 10.1002/ana.410360506
    • Mesulam M, Geula C. Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia. Ann Neurol 1994;36:722-7 (Pubitemid 24337630
    • (1994) Annals of Neurology , vol.36 , Issue.5 , pp. 722-727
    • Mesulam, M.-M.1    Geula, C.2
  • 45
    • 0344238739 scopus 로고    scopus 로고
    • 1-42 (CSF-Abeta42), tau and apolipoprotein E genotype in long-Term rivastigmine and tacrine treated Alzheimer disease (AD) patients
    • DOI 10.1016/S0304-3940(02)01384-8
    • Stefanova E, Blennow K, Almkvist O, et al. Cerebral glucose metabolism, cerebrospinal fluid-beta-Amyloid1-42/CSF-Abeta42), tau and apolipoprotein E genotype in long-Term rivastigmine and tacrine treated Alzheimeŕs disease (AD) patients. Neurosci Lett 2003;338:159-63 (Pubitemid 36140161
    • (2003) Neuroscience Letters , vol.338 , Issue.2 , pp. 159-163
    • Stefanova, E.1    Blennow, K.2    Almkvist, O.3    Hellstrom-Lindahl, E.4    Nordberg, A.5
  • 46
    • 79960676808 scopus 로고    scopus 로고
    • Rivastigmine lowers Abeta and increases sAPPa levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons
    • Bailey J, Ray B, Greig N, et al. Rivastigmine lowers Abeta and increases sAPPa levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 2011;6(7):e21954
    • (2011) PLoS One , vol.6 , Issue.7
    • Bailey, J.1    Ray, B.2    Greig, N.3
  • 48
    • 72049097693 scopus 로고    scopus 로고
    • Rivastigmine transdermal patch skin tolerability: Results of a 1-year clinical trial in atients with mild-To-moderate alzheimeŕs disease
    • Cummings JL, Farlow MR, Meng X, et al. Rivastigmine transdermal patch skin tolerability: Results of a 1-year clinical trial in atients with mild-To-moderate Alzheimeŕs disease. Clin Drug Investig 2010;30(1):41-9
    • (2010) Clin Drug Investig , vol.30 , Issue.1 , pp. 41-49
    • Cummings, J.L.1    Farlow, M.R.2    Meng, X.3
  • 49
    • 84884821372 scopus 로고    scopus 로고
    • A 24-week randomized controlled trial of rivastigmine patch 13.3 mg24h versus 4.6mg24h in severe alzheimeŕs dementia
    • Farlow MR, Grossberg GT, Sadowsky CH, et al. A 24-week, randomized, controlled trial of rivastigmine patch 13.3 mg/24h versus 4.6mg/24h in severe Alzheimeŕs dementia. CNS Neurosci Ther 2013;19(10):745-52
    • (2013) CNS Neurosci Ther , vol.19 , Issue.10 , pp. 745-752
    • Farlow, M.R.1    Grossberg, G.T.2    Sadowsky, C.H.3
  • 50
    • 84883390332 scopus 로고    scopus 로고
    • Efficacy if higher dose 13.3 mg/24h rivastigmine patch on instrumentál activities of daily living in patients with mild-To-moderate Alzheimeŕs disease
    • Grossberg G, Cummings J, Frlich L, et al. Efficacy if higher dose 13.3 mg/24h rivastigmine patch on instrumentál activities of daily living in patients with mild-To-moderate Alzheimeŕs disease. Am J Alzheimers Dis Other Demen 2013;28:583-91
    • (2013) Am J Alzheimers Dis Other Demen , vol.28 , pp. 583-591
    • Grossberg, G.1    Cummings, J.2    Frolich, L.3
  • 51
    • 33745894355 scopus 로고    scopus 로고
    • Transdermal treatment options for neurological disorders: Impact on the elderly
    • DOI 10.2165/00002512-200623050-00001
    • Priano L, Gasco ML, Mauro A. Transdermal treatment options for neurological disorders: Impact on the elderly. Drugs Aging 2006;23(5):357-75 (Pubitemid 44050424
    • (2006) Drugs and Aging , vol.23 , Issue.5 , pp. 357-375
    • Priano, L.1    Gasco, M.R.2    Mauro, A.3
  • 52
    • 37548999377 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the novel daily rivastigmine transdermal patch compared with twice-daily capsules in Alzheimer's disease patients
    • Lefevre G, Sedek G, Jhee SS, et al. Pharmacokinetics and pharmacodynamics of the novel daily rivastigmine transdermal patch compared with twice-daily capsules in Alzheimer's disease patients. Clin Pharmacol Ther 2008;83(1):106-14
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.1 , pp. 106-114
    • Lefevre, G.1    Sedek, G.2    Jhee, S.S.3
  • 53
    • 34547634202 scopus 로고    scopus 로고
    • IDEAL: A 6-month, doble-blind, placebo-controlled study of the first skin patch for Alzheimeŕs disease
    • Winblad B, Grossberg G, Frohlich L, et al. IDEAL: A 6-month, doble-blind, placebo-controlled study of the first skin patch for Alzheimeŕs disease. Neurology 2007;69(4):S14-22
    • (2007) Neurology , vol.69 , Issue.4
    • Winblad, B.1    Grossberg, G.2    Frohlich, L.3
  • 54
    • 0034113018 scopus 로고    scopus 로고
    • Lack of adverse pharmacodynamic drug interactions with rivastigmine and twenty-Two classes of medications
    • DOI 10.1002/(SICI)1099-1166(200003) 15:3<242::AID-GPS110>3.0.CO;2-7
    • Grossberg GT, Stahelin HB, Messina JC, et al. Lack of adverse pharmacodynamics drug interactions with rivastigmine and twenty-Two classes of medications. Int J Geriatr Psychiatry 2000;15:242-7 (Pubitemid 30179175
    • (2000) International Journal of Geriatric Psychiatry , vol.15 , Issue.3 , pp. 242-247
    • Grossberg, G.T.1    Stahelin, H.B.2    Messina, J.C.3    Anand, R.4    Veach, J.5
  • 55
    • 3242690679 scopus 로고    scopus 로고
    • Co-Administration of memantine has no effect on the in vitro or ex vivo determined acetylcholinesterase inhibition of rivastigmine in the rat brain
    • Enz A, Gartsch C. Co-Administration of memantine has no effect on the in vitro or ex vivo determined acetylcholinesterase inhibition of rivastigmine in the rat brain. Neuropharmacology 2004;47(3):408-23
    • (2004) Neuropharmacology , vol.47 , Issue.3 , pp. 408-423
    • Enz, A.1    Gartsch, C.2
  • 56
    • 37049065522 scopus 로고
    • Phenol oxidation and biosynthesis. Part V. The synthesis of galanthamine
    • Barton DHR, Kirby GW. Phenol oxidation and biosynthesis. Part V. The synthesis of galanthamine. J Chem Soc 1962;806-17
    • (1962) J Chem Soc , pp. 806-817
    • Barton, D.H.R.1    Kirby, G.W.2
  • 58
    • 84901380543 scopus 로고
    • Effects of galantamine on the acetylcholine sensitivity of skeletal musculature
    • Mashkovskii MD. Effects of galantamine on the acetylcholine sensitivity of skeletal musculature. Pharmacol Toxicol 1955;18:18-21
    • (1955) Pharmacol Toxicol , vol.18 , pp. 18-21
    • Mashkovskii, M.D.1
  • 59
    • 0036349129 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors
    • Jann MW, Shidey KL, Small GW. Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors. Clin Pharmacokinet 2002;41:719-39 (Pubitemid 34948194
    • (2002) Clinical Pharmacokinetics , vol.41 , Issue.10 , pp. 719-739
    • Jann, M.W.1    Shirley, K.L.2    Small, G.W.3
  • 60
    • 0036959214 scopus 로고    scopus 로고
    • Nicotinic cholinergic modulation: Galantamine as a prototype
    • Woodruff-Pak D, Lander C, Geerts H. Nicotinic cholinergic modulation: Galantamine as a prototype. CNS Drug Rev 2002;8:405-26 (Pubitemid 36114720
    • (2002) CNS Drug Reviews , vol.8 , Issue.4 , pp. 405-426
    • Woodruff-Pak, D.S.1    Lander, C.2    Geerts, H.3
  • 61
    • 77951560923 scopus 로고    scopus 로고
    • A review of clinical pharmacocinetics and pharmacodynamics of galantamine, a reversible acetylcholinesterase inhibitor for the treatment of Alzheimeŕs disease, in healthy subject and patients
    • Huang F, Fu Y. A review of clinical pharmacocinetics and pharmacodynamics of galantamine, a reversible acetylcholinesterase inhibitor for the treatment of Alzheimeŕs disease, in healthy subject and patients. Curr Clin Pharmacol 2010;5:115-24
    • (2010) Curr Clin Pharmacol , vol.5 , pp. 115-124
    • Huang, F.1    Fu, Y.2
  • 62
    • 0033408510 scopus 로고    scopus 로고
    • Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A°resolution
    • DOI 10.1016/S0014-5793(99)01637-3, PII S0014579399016373
    • Greenblatt HM, Kryger G, Lewis T, et al. Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3A °resolution. FEBS Lett 1999;463:321-6 (Pubitemid 30001943
    • (1999) FEBS Letters , vol.463 , Issue.3 , pp. 321-326
    • Greenblatt, H.M.1    Kryger, G.2    Lewis, T.3    Silman, I.4    Sussman, J.L.5
  • 64
    • 0034732104 scopus 로고    scopus 로고
    • Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease
    • DOI 10.1016/S0014-2999(00)00093-5, PII S0014299900000935
    • Maelicke A, Albuquerque EX. Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimeŕs disease. Eur J Pharmacol 2000;393:165-70 (Pubitemid 30193413
    • (2000) European Journal of Pharmacology , vol.393 , Issue.1-3 , pp. 165-170
    • Maelicke, A.1    Albuquerque, E.X.2
  • 65
    • 80053896402 scopus 로고    scopus 로고
    • Donepezil, but not galanthamine, blocs muscarinic receptor-mediated in vitro and in vivo responses
    • Ago Y, Koda K, Ota Y, et al. Donepezil, but not galanthamine, blocs muscarinic receptor-mediated in vitro and in vivo responses. Synapse 2011;65:1373-7
    • (2011) Synapse , vol.65 , pp. 1373-1377
    • Ago, Y.1    Koda, K.2    Ota, Y.3
  • 66
    • 0035251762 scopus 로고    scopus 로고
    • Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: Effects on the course of Alzheimer's disease
    • DOI 10.1016/S0006-3223(00)01101-X, PII S000632230001101X
    • Coyle J, Kershaw P. Galanthamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: Effects on the course of Alzheimeŕs disease. Biol Psychiatry 2001;49:289-99 (Pubitemid 32178438
    • (2001) Biological Psychiatry , vol.49 , Issue.3 , pp. 289-299
    • Coyle, J.1    Kershaw, P.2
  • 68
    • 63149169837 scopus 로고    scopus 로고
    • Roles of nicotinic receptors in acetylcholinesterase inhibitor-induces neuroprotection and nicotinic receptor up-regulation
    • Takada-Takatori Y, Kume T, Izumi Y, et al. Roles of nicotinic receptors in acetylcholinesterase inhibitor-induces neuroprotection and nicotinic receptor up-regulation. Biol Pharm Bull 2009;32:318-24
    • (2009) Biol Pharm Bull , vol.32 , pp. 318-324
    • Takada-Takatori, Y.1    Kume, T.2    Izumi, Y.3
  • 69
    • 84869994179 scopus 로고    scopus 로고
    • Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease
    • Simoni E, Daniele S, Bottegoni G, et al. Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. J Med Chem 2012;55:9708-21
    • (2012) J Med Chem , vol.55 , pp. 9708-9721
    • Simoni, E.1    Daniele, S.2    Bottegoni, G.3
  • 70
    • 84893466236 scopus 로고    scopus 로고
    • Galantamione potentiates the neuroprotectibe effect of memantine against NMDA-induces excitotoxicity
    • Lopes JP, Tarozzo G, Reggiani A, et al. Galantamione potentiates the neuroprotectibe effect of memantine against NMDA-induces excitotoxicity. Brain Behav 2013;3:67-74
    • (2013) Brain Behav , vol.3 , pp. 67-74
    • Lopes, J.P.1    Tarozzo, G.2    Reggiani, A.3
  • 71
    • 63349094728 scopus 로고    scopus 로고
    • Galantamine inhibits beta-Amyloid aggregation and cytotoxicity
    • Matharu B, Gibson G, Parsons R, et al. Galantamine inhibits beta-Amyloid aggregation and cytotoxicity. J Neurol Sci 2009;280:49-58
    • (2009) J Neurol Sci , vol.280 , pp. 49-58
    • Matharu, B.1    Gibson, G.2    Parsons, R.3
  • 72
    • 0035875962 scopus 로고    scopus 로고
    • Beta-Amyloid activates the mitogen-Activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In Vitro and in Vivo mechanisms related to Alzheimer's disease
    • Dineley KT, Westerman M, Bui D, et al. Beta-Amyloid activates the mitogenactivated protein kinase cascade via hippocampal alpha 7 nicotinic acetylcholine receptors: In vitro and in vivo mechanism related to Alzheimeŕs disease. J Neurol Sci 2001;21:4125-33 (Pubitemid 32538537
    • (2001) Journal of Neuroscience , vol.21 , Issue.12 , pp. 4125-4133
    • Dineley, K.T.1    Westerman, M.2    Bui, D.3    Bell, K.4    Ashe, K.H.5    Sweatt, J.D.6
  • 73
    • 59149090400 scopus 로고    scopus 로고
    • Galanthamine prospects against oxidative stress induced by amyloid-beta peptide in cortical neurons
    • Melo JB, Sousa C, Garcao P, et al. Galanthamine prospects against oxidative stress induced by amyloid-beta peptide in cortical neurons. Eur J Neurosci 2009;29:455-64
    • (2009) Eur J Neurosci , vol.29 , pp. 455-464
    • Melo, J.B.1    Sousa, C.2    Garcao, P.3
  • 74
    • 84875240805 scopus 로고    scopus 로고
    • Protective effect of galantamine against oxidative damage using human lymphocytes: A novel in vitro model
    • Triana-Vidal LE, Carvajal-Varona SM. Protective effect of galantamine against oxidative damage using human lymphocytes: A novel in vitro model. Arch Med Res 2013;44:85-92
    • (2013) Arch Med Res , vol.44 , pp. 85-92
    • Triana-Vidal, L.E.1    Carvajal-Varona, S.M.2
  • 75
    • 2542509442 scopus 로고    scopus 로고
    • Increased levels of tau protein in SH-SY5Y cells after treatment with cholinesterase inhibitors and nicotinic agonists
    • DOI 10.1046/j.1471-4159.2000.740777.x
    • Hellstr€om-Lindahl E, Moore H, Nordberg A. Increased levels of tau protein in SH-SY5Y cells after treatment with cholinesterase inhibitors and nicotinic agonists. J Neurochem 2001;74:777-84 (Pubitemid 30053751
    • (2000) Journal of Neurochemistry , vol.74 , Issue.2 , pp. 777-784
    • Hellstrom-Lindahl, E.1    Moore, H.2    Nordberg, A.3
  • 76
    • 0034720816 scopus 로고    scopus 로고
    • Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension
    • Raskind MA, Peskind ER, Wessel T, et al. Galanthamine in AD: A 6-month randomized, placebo-controlled trial with 6-month extension. The Galanthamine USA-1 Study Group. Neurology 2000;54:2261-8 (Pubitemid 30416276
    • (2000) Neurology , vol.54 , Issue.12 , pp. 2261-2268
    • Raskind, M.A.1    Peskind, E.R.2    Wessel, T.3    Yuan, W.4
  • 77
    • 77951158078 scopus 로고    scopus 로고
    • Galantamine-ER for th treatment of mild-To-moderate Alzheimeŕs disease
    • Seltzer B. Galantamine-ER for th treatment of mild-To-moderate Alzheimeŕs disease. Clin Interv Aging 2010;5:1-6
    • (2010) Clin Interv Aging , vol.5 , pp. 1-6
    • Seltzer, B.1
  • 81
    • 0036316415 scopus 로고    scopus 로고
    • Further characterization of the molecular interaction between PSD-95 and NMDA receptors: The effect of the NR1 splice variant and evidence for modulation of channel gating
    • DOI 10.1046/j.1471-4159.2002.00923.x
    • Rutter AR, Freeman FM, Stephenson FA. Further characterization of the molecular interaction between PSD-95 and NMDA receptors: The effect of the NR1 splice variant and evidence for modulation of channel gating. J Neurochem 2002;81:1298-307 (Pubitemid 34809263
    • (2002) Journal of Neurochemistry , vol.81 , Issue.6 , pp. 1298-1307
    • Rutter, A.R.1    Freeman, F.M.2    Stephenson, F.A.3
  • 82
    • 84863536950 scopus 로고    scopus 로고
    • Nmethyl d-Aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimers disease, vascular dementia and Parkinsons disease
    • Olivares DK, Deshpande V, Shi YK, et al. Nmethyl d-Aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimers disease, vascular dementia and Parkinsons disease. Curr Alzheimer Res 2012;9:746-58
    • (2012) Curr Alzheimer Res , vol.9 , pp. 746-758
    • Olivares, D.K.1    Deshpande, V.2    Shi, Y.K.3
  • 83
    • 84887967530 scopus 로고    scopus 로고
    • The serine shuttle between glia and neurons: Implications for neurotransmission and neurodegeneration
    • Wolosker H, Radzishevsky I. The serine shuttle between glia and neurons: Implications for neurotransmission and neurodegeneration. Biochem Soc Trans 2013;41(6):1546-50
    • (2013) Biochem Soc Trans , vol.41 , Issue.6 , pp. 1546-1550
    • Wolosker, H.1    Radzishevsky, I.2
  • 84
    • 0023871416 scopus 로고
    • Memantine (1-Amino-3,5-dimethyladamantane) blocks the serotonin-induced depolarization response in a neuronal cell line
    • Reiser G, Binm€oller FJ, Koch R. Memantine (1-Amino-3,5- dimethyladamantane) blocks the serotonin-induced depolarization response in a neuronal cell line. Brain Res 1988;443(1-2):338-44 (Pubitemid 18062804
    • (1988) Brain Research , vol.443 , Issue.1-2 , pp. 338-344
    • Reiser, G.1    Binmoller, F.-J.2    Koch, R.3
  • 85
    • 0035933672 scopus 로고    scopus 로고
    • The N-methyl-D-Aspartate receptor channel blockers memantine MRZ 2/579 and other amino-Alkyl-cyclohexanes antagonise 5-HT (3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner
    • Rammes G, Rupprecht R, Ferrari U, et al. The N-methyl-D-Aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-Alkyl- cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner. Neurosci Lett 2001;306(1-2):81-4
    • (2001) Neurosci Lett , vol.306 , Issue.1-2 , pp. 81-84
    • Rammes, G.1    Rupprecht, R.2    Ferrari, U.3
  • 86
    • 0031977071 scopus 로고    scopus 로고
    • Open-channel blockers at the human alpha4beta2 neuronal nicotinic acetylcholine receptor
    • Buisson B, Bertrand D. Open-channel blockers at the human alpha4beta2 neuronal nicotinic acetylcholine receptor. Mol Pharmacol 1998;53(3):555-63 (Pubitemid 28162880
    • (1998) Molecular Pharmacology , vol.53 , Issue.3 , pp. 555-563
    • Buisson, B.1    Bertrand, D.2
  • 87
    • 14344253935 scopus 로고    scopus 로고
    • Memantine blocks alpha7.* nicotinic acetylcholine receptors more potently than N-methyl-D-Aspartate receptors in rat hippocampal neurons
    • DOI 10.1124/jpet.104.077172
    • Aracava Y, Pereira EF, Maelicke A, Albuquerque EX. Memantine blocks alpha7. * nicotinic acetylcholine receptors more potently than n-methyl-D-Aspartate receptors in rat hippocampal neurons. J pharmacol Exp Ther 2005;312(3):1195-205 (Pubitemid 40293781
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.312 , Issue.3 , pp. 1195-1205
    • Aracava, Y.1    Pereira, E.F.R.2    Maelicke, A.3    Albuquerque, E.X.4
  • 88
    • 37549005135 scopus 로고    scopus 로고
    • Memantine agonist action at dopamine D2High receptors
    • Seeman P, Caruso C, Lasaga M. Memantine agonist action at dopamine D2High receptors. Synapse 2008;62(2):149-53
    • (2008) Synapse , vol.62 , Issue.2 , pp. 149-153
    • Seeman, P.1    Caruso, C.2    Lasaga, M.3
  • 89
    • 78049480679 scopus 로고    scopus 로고
    • Fingolimod (FTY720): Discovery and development of an oral drug to treat multiple sclerosis
    • Brinkmann V, Billich A, Baumruker T, et al. Fingolimod (FTY720): Discovery and development of an oral drug to treat multiple sclerosis. Nat Rev Drug Discov 2010;9:883-97
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 883-897
    • Brinkmann, V.1    Billich, A.2    Baumruker, T.3
  • 90
    • 84880165113 scopus 로고    scopus 로고
    • Demystifying trial networks and network meta-Analysis
    • Mills EJ, Thorlund K, Ioannidis JP. Demystifying trial networks and network meta-Analysis. BMJ 2013;346:f2914
    • (2013) BMJ , vol.346
    • Mills, E.J.1    Thorlund, K.2    Ioannidis, J.P.3
  • 91
    • 79959925787 scopus 로고    scopus 로고
    • Interpreting indirect treatment comparisons and network meta-Analysis for health-care decision making: Report of the ISPOR Task Force on indirect treatment comparisons good research practices-part 1
    • Jansen JP, Fleurence R, Devine B, et al. Interpreting indirect treatment comparisons and network meta-Analysis for health-care decision making: Report of the ISPOR Task Force on indirect treatment comparisons good research practices-part 1. Value Health 2011;14:417-28
    • (2011) Value Health , vol.14 , pp. 417-428
    • Jansen, J.P.1    Fleurence, R.2    Devine, B.3
  • 92
    • 79959960493 scopus 로고    scopus 로고
    • Interpreting indirect treatment comparisons and network meta-Analysis for health-care decision making: Report of the ISPOR Task Force on indirect treatment comparisons good research practices-part 2
    • Hoaglin DC, Hawkins N, Jansen JP, et al. Interpreting indirect treatment comparisons and network meta-Analysis for health-care decision making: Report of the ISPOR Task Force on indirect treatment comparisons good research practices-part 2. Value Health 2011;14:429-37
    • (2011) Value Health , vol.14 , pp. 429-437
    • Hoaglin, D.C.1    Hawkins, N.2    Jansen, J.P.3
  • 93
    • 84862619683 scopus 로고    scopus 로고
    • The effectiveness and cost-effectiveness of donepezil galantamine rivastigmine and memantine for the treatment of alzheimer's disease (review of technology appraisal no 111) a systematic review and economic model
    • Bond M, Rogers G, Peters J, et al The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of Technology Appraisal No. 111): A systematic review and economic model. Health Technol Assess 2012;16(21):1-470
    • (2012) Health Technol Assess , vol.16 , Issue.21 , pp. 1-470
    • Bond, M.1    Rogers, G.2    Peters, J.3
  • 94
    • 33644826545 scopus 로고    scopus 로고
    • Differential effects or rivastigmine, galantamine and donepezil on behavioral and psychological symptoms in patients with Alzheimer's disease: 18-month, randomized, open-label trial
    • DOI 10.1185/135525705X40436
    • Cumbo E. Differential effects or rivastigmine, galantamine and donepezil on behavioral and psychological symptoms in patients with Alzheimer's disease: 18-month, randomized, open-label trial. Prim Care Community Psychiatr 2005;10:95-102 (Pubitemid 43355657
    • (2005) Primary Care and Community Psychiatry , vol.10 , Issue.3 , pp. 95-102
    • Cumbo, E.1
  • 98
    • 62249171200 scopus 로고    scopus 로고
    • Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients
    • Nordberg A, Darreh-Shori T, Peskind E, et al. Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients. Curr Alzheimer Res 2009;6:4-14
    • (2009) Curr Alzheimer Res , vol.6 , pp. 4-14
    • Nordberg, A.1    Darreh-Shori, T.2    Peskind, E.3
  • 99
    • 33644974191 scopus 로고    scopus 로고
    • Effects of galantamine versus donepezil on sleep in patients with mild to moderate Alzheimer disease and their caregivers: A double-blind, head-To-head, randomized pilot study
    • DOI 10.1097/01.wad.0000189052.48688.36, PII 0000209320051000000010
    • Ancoli-Israel S, Amatniek J, Ascher S, et al. Effects of galantamine versus donepezil on sleep in patients with mild to moderate Alzheimer disease and their caregivers: A double-blind, head-To-head, randomized pilot study. Alzheimer Dis Assoc Disord 2005;19:240-5 (Pubitemid 44366625
    • (2005) Alzheimer Disease and Associated Disorders , vol.19 , Issue.4 , pp. 240-245
    • Ancoli-Israel, S.1    Amatniek, J.2    Ascher, S.3    Sadik, K.4    Ramaswamy, K.5
  • 100
    • 84901297350 scopus 로고    scopus 로고
    • Available from [Assessed on 20 Januray 2014
    • Available from: Http://www.consortstatement. org/ [Assessed on 20 Januray 2014
  • 104
    • 33749355349 scopus 로고    scopus 로고
    • QALYs: Are they helpful to decision makers?
    • Springer
    • McGregor M, Caro JJ. QALYs: Are they helpful to decision makers?. Pharmacoeconomics. Springer; 2006;24(10):947-52
    • (2006) Pharmacoeconomics. , vol.24 , Issue.10 , pp. 947-952
    • McGregor, M.1    Caro, J.J.2
  • 105
    • 0037133519 scopus 로고    scopus 로고
    • Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine
    • DOI 10.1021/bi020016x
    • Bar-on P, Millard CB, Harel M, et al. Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine. Biochemistry 2002;41:3555-64 (Pubitemid 34224667
    • (2002) Biochemistry , vol.41 , Issue.11 , pp. 3555-3564
    • Bar-On, P.1    Millard, C.B.2    Harel, M.3    Dvir, H.4    Enz, A.5    Sussman, J.L.6    Silman, I.7


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