Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old

Alzheimer's and Dementia

Volumn 5, Issue 4, 2009, Pages 318-323

  Kravitz, B Adar ^a   Corrada, Maria M ^a   Kawas, Claudia H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

C reactive protein; Dementia; Inflammation; Nonagenarian; Serum

Indexed keywords

C REACTIVE PROTEIN;

AGED; ARTICLE; CONTROLLED STUDY; DEMENTIA; ELDERLY CARE; FEMALE; HIGH RISK POPULATION; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; SEX DIFFERENCE;

AGE DISTRIBUTION; AGE FACTORS; AGED, 80 AND OVER; AGING; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; COMORBIDITY; CROSS-SECTIONAL STUDIES; DEMENTIA; ENCEPHALITIS; FEMALE; HUMANS; MALE; MEMORY DISORDERS; PREDICTIVE VALUE OF TESTS; PREVALENCE; SENSITIVITY AND SPECIFICITY; SEX DISTRIBUTION; SEX FACTORS; UP-REGULATION;

EID: 67649787242     PISSN: 15525260     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jalz.2009.04.1230     Document Type: Article

References (25)

1. Akiyama H., Barger S., Barnum S., Bradt B., Bauer J., Cole G.M., et al. Inflammation and Alzheimer's disease. Neurobiol Aging 21 (2000) 383-421
2. Pepys M.B., and Hirschfield G.M. C-reactive protein: a critical update. J Clin Invest 111 (2003) 1805-1812
3. Iwamoto N., Nishiyama E., Ohwada J., and Arai H. Demonstration of CRP immunoreactivity in brains of Alzheimer's disease: immunohistochemical study using formic acid pretreatment of tissue sections. Neurosci Lett 177 (1994) 23-26
4. Duong T., Nikolaeva M., and Acton P.J. C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease. Brain Res 749 (1997) 152-156
5. Malaguarnera M., Bella R., Alagona G., Ferri R., Carnemolla A., and Pennisi G. Helicobacter pylori and Alzheimer's disease: a possible link. Eur J Intern Med 15 (2004) 381-386
6. Gupta A., Watkins A., Thomas P., Majer R., Habubi N., Morris G., et al. Coagulation and inflammatory markers in Alzheimer's and vascular dementia. Int J Clin Pract 59 (2005) 52-57
7. Dimopoulos N., Piperi C., Salonicioti A., Mitropoulos P., Kallai E., Liappas I., et al. Indices of low-grade chronic inflammation correlate with early cognitive deterioration in an elderly Greek population. Neurosci Lett 398 (2006) 118-123
8. Schmidt R., Schmidt H., Curb J.D., Masaki K., White L.R., and Launer L.J. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study. Ann Neurol 52 (2002) 168-174
9. Engelhart M.J., Geerlings M.I., Meijer J., Kiliaan A., Ruitenberg A., van Swieten J.C., et al. Inflammatory proteins in plasma and the risk of dementia: the Rotterdam Study. Arch Neurol 61 (2004) 668-672
10. Ravaglia G., Forti P., Maioli F., Chiappelli M., Montesi F., Tumini E., et al. Blood inflammatory markers and risk of dementia: the Conselice Study of Brain Aging. Neurobiol Aging 28 (2007) 1810-1820
11. Woloshin S., and Schwartz L.M. Distribution of C-reactive protein values in the United States. N Engl J Med 352 (2005) 1611-1613
12. Wan H., Sengupta M., Velkoff V.A., and DeBarros K.A. United States Census Bureau. 65+ in the United States: 2005. Current Population Reports (2005), Government Printing Office, Washington, DC p.23-209
13. Bruunsgaard H., Andersen-Ranberg K., Jeune B., Pedersen A.N., Skinhoj P., and Pedersen B.K. A high plasma concentration of TNF-alpha is associated with dementia in centenarians. J Gerontol [A] Biol Sci Med Sci 54 (1999) M357-M364
14. Bruunsgaard H., Benfield T.L., Andersen-Ranberg K., Hjelmborg J.V.B., Pedersen A.N., Schroll M., et al. The tumor necrosis factor alpha 308 G > A polymorphism is associated with dementia in the oldest old. J Am Geriatr Soc 52 (2004) 1361-1366
15. Whittle C., Corrada M.M., Dick M., Ziegler R., Kahle-Wrobleski K., Paganini-Hill A., et al. Neuropsychological data in non-demented oldest-old: the 90+ Study. J Clin Exp Neuropsychol 29 (2007) 290-299
16. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (2004), American Psychiatric Association, Washington, DC
17. Folstein M.F., Folstein S.E., and McHugh P.R. Mini-Mental State: a practical method for grading the state of patients for the clinician. J Psychiatr Res 12 (1975) 189-198
18. Morris J.C. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43 (1993) 2412-2414
19. Azad N.A., Al Bugami M., and Loy-English I. Gender differences in dementia risk factors. Gend Med 4 (2007) 120-129
20. Duong T., Acton P.J., and Johnson R.A. The in vitro neuronal toxicity of pentraxins associated with Alzheimer's disease brain lesions. Brain Res 813 (1998) 303-312
21. Ferri C., Croce G., Cofini V., De Berardinis G., Grassi D., Casale R., et al. C-reactive protein: interaction with the vascular endothelium and possible role in human atherosclerosis. Curr Pharm Des 13 (2007) 1631-1645
22. Jialal I., Devaraj S., and Singh U. C-reactive protein and the vascular endothelium: implications for plaque instability. J Am Coll Cardiol 47 (2006) 1379-1381
23. Uchikado H., Akiyama H., Kondo H., Ikeda K., Tsuchiya K., Kato M., et al. Activation of vascular endothelial cells and perivascular cells by systemic inflammation-an immunohistochemical study of postmortem human brain tissues. Acta Neuropathol (Berl) 107 (2004) 341-351
24. Blauw G.J., Bollen E., van Buchem M.A., and Westendorp R.G.J. Dementia at old age: a clinical end-point of atherosclerotic disease. Eur Heart J 3 Suppl (2001) N16-N19
25. Pearson T.A., Mensah G.A., Alexander R.W., Anderson J.L., Cannon III R.O., Criqui M., et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107 (2003) 499-511