ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Aβ 1-40 peptides

Journal of Neuroscience

Volumn 29, Issue 17, 2009, Pages 5463-5475

  Xiong, Huaqi ^a   Callaghan, Debbie ^a   Jones, Aimee ^a   Bai, Jianying ^a   Rasquinha, Ingrid ^a   Smith, Catherine ^a   Pei, Ke ^a   Walker, Douglas ^c   Lue, Lih Fen ^c   Stanimirovic, Danica ^a,b   Zhang, Wandong ^a,b  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c SUN HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; BIOLOGICAL MARKER; BREAST CANCER RESISTANCE PROTEIN;

AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN DEVELOPMENT; BRAIN HYPOXIA; BRAIN ISCHEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MICROGLIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; UPREGULATION; VASCULAR AMYLOIDOSIS; VASCULAR DISEASE; WESTERN BLOTTING; WILD TYPE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BLOOD-BRAIN BARRIER; CELL LINE; CELLS, CULTURED; CEREBRAL AMYLOID ANGIOPATHY; DRUG RESISTANCE, MULTIPLE; HUMANS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOPLASM PROTEINS; PEPTIDE FRAGMENTS; UP-REGULATION;

EID: 65649142529     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5103-08.2009     Document Type: Article

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