메뉴 건너뛰기




Volumn 14, Issue 1, 2014, Pages

The significance of matrix metalloproteinases in the immunopathogenesis and treatment of multiple sclerosis

Author keywords

Blood brain barrier; Central nervous system; Inflammation; Matrix metalloproteinases; Multiple sclerosis

Indexed keywords


EID: 84893396852     PISSN: 2075051X     EISSN: 20750528     Source Type: Journal    
DOI: 10.12816/0003332     Document Type: Review
Times cited : (61)

References (111)
  • 1
    • 84855947966 scopus 로고    scopus 로고
    • Investigation of astrocyte - Oligodendrocyte interactions in human cultures
    • John GR. Investigation of astrocyte - Oligodendrocyte interactions in human cultures. Methods Mol Biol 2012; 814:401-14
    • (2012) Methods Mol Biol , vol.814 , pp. 401-414
    • John, G.R.1
  • 2
    • 80054885633 scopus 로고    scopus 로고
    • Role of glial cells in innate immunity and their role in CNS demyelination
    • Sriram S. Role of glial cells in innate immunity and their role in CNS demyelination. J Neuroimmunol 2011; 239:13-20
    • (2011) J Neuroimmunol , vol.239 , pp. 13-20
    • Sriram, S.1
  • 3
    • 77950610036 scopus 로고    scopus 로고
    • The changing demographic pattern of multiple sclerosis epidemiology
    • Koch-Henriksen N, Sorensen PS. The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurol 2010; 9:520-32
    • (2010) Lancet Neurol , vol.9 , pp. 520-532
    • Koch-Henriksen, N.1    Sorensen, P.S.2
  • 4
    • 33644607018 scopus 로고    scopus 로고
    • Multiple sclerosis: The plaque and its pathogenesis
    • Frohman EM, Racke MK, Raine CS. Multiple sclerosis: The plaque and its pathogenesis. N Engl J Med 2006; 354:942-55
    • (2006) N Engl J Med , vol.354 , pp. 942-955
    • Frohman, E.M.1    Racke, M.K.2    Raine, C.S.3
  • 6
    • 79958721221 scopus 로고    scopus 로고
    • Th17 cell, the new player of neuroinflammatory process in multiple sclerosis
    • Jadidi-Niaragh F, Mirshafiey A. Th17 cell, the new player of neuroinflammatory process in multiple sclerosis. Scand J Immunol 2011; 74:1-13
    • (2011) Scand J Immunol , vol.74 , pp. 1-13
    • Jadidi-Niaragh, F.1    Mirshafiey, A.2
  • 7
    • 77951879282 scopus 로고    scopus 로고
    • Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis
    • Murphy AC, Lalor SJ, Lynch MA, Mills KH. Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis. Brain Behav Immun 2010; 24:641-51
    • (2010) Brain Behav Immun , vol.24 , pp. 641-651
    • Murphy, A.C.1    Lalor, S.J.2    Lynch, M.A.3    Mills, K.H.4
  • 8
    • 83055184202 scopus 로고    scopus 로고
    • Identification of a microglia phenotype supportive of remyelination
    • Olah M, Amor S, Brouwer N, Vinet J, Eggen B, Biber K, et al. Identification of a microglia phenotype supportive of remyelination. Glia 2012; 60:306-21
    • (2012) Glia , vol.60 , pp. 306-321
    • Olah, M.1    Amor, S.2    Brouwer, N.3    Vinet, J.4    Eggen, B.5    Biber, K.6
  • 9
    • 56649100738 scopus 로고    scopus 로고
    • Human mast cells stimulate activated T cells: Implications for multiple sclerosis
    • Theoharides TC, Kempuraj D, Kourelis T, Manola A. Human mast cells stimulate activated T cells: Implications for multiple sclerosis. Ann N Y Acad Sci 2008; 1144:74-82
    • (2008) Ann N Y Acad Sci , vol.1144 , pp. 74-82
    • Theoharides, T.C.1    Kempuraj, D.2    Kourelis, T.3    Manola, A.4
  • 10
    • 77950018920 scopus 로고    scopus 로고
    • Act 1, scene brain: Astrocytes play a lead role
    • Rodgers JM, Zhou L, Miller SD. Act 1, scene brain: Astrocytes play a lead role. Immunity 2010; 32:302-4
    • (2010) Immunity , vol.32 , pp. 302-304
    • Rodgers, J.M.1    Zhou, L.2    Miller, S.D.3
  • 11
    • 79952590728 scopus 로고    scopus 로고
    • Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L
    • Kim DY, Hong GU, Ro JY. Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L. J Neuroinflammation 2011; 8:25
    • (2011) J Neuroinflammation , vol.8 , pp. 25
    • Kim, D.Y.1    Hong, G.U.2    Ro, J.Y.3
  • 12
    • 80052246111 scopus 로고    scopus 로고
    • Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
    • Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FM. Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat Neurosci 2011; 14:1142-9
    • (2011) Nat Neurosci , vol.14 , pp. 1142-1149
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    McNagny, K.M.4    Rossi, F.M.5
  • 13
    • 78650303038 scopus 로고    scopus 로고
    • Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway
    • Guo X, Harada C, Namekata K, Matsuzawa A, Camps M, Ji H, et al. Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol Med 2010; 2:504-15
    • (2010) EMBO Mol Med , vol.2 , pp. 504-515
    • Guo, X.1    Harada, C.2    Namekata, K.3    Matsuzawa, A.4    Camps, M.5    Ji, H.6
  • 14
    • 77955844059 scopus 로고    scopus 로고
    • Emerging concepts in autoimmune encephalomyelitis beyond the CD4/T(H)1 paradigm
    • Batoulis H, Addicks K, Kuerten S. Emerging concepts in autoimmune encephalomyelitis beyond the CD4/T(H)1 paradigm. Ann Anat 2010; 192:179-93
    • (2010) Ann Anat , vol.192 , pp. 179-193
    • Batoulis, H.1    Addicks, K.2    Kuerten, S.3
  • 15
    • 79960395608 scopus 로고    scopus 로고
    • Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression
    • Li H, Nourbakhsh B, Safavi F, Li K, Xu H, Cullimore M, et al. Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression. J Immunol 2011; 187:274-82
    • (2011) J Immunol , vol.187 , pp. 274-282
    • Li, H.1    Nourbakhsh, B.2    Safavi, F.3    Li, K.4    Xu, H.5    Cullimore, M.6
  • 16
    • 77953639372 scopus 로고    scopus 로고
    • Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: A role for neutrophil recruitment?
    • Sayed BA, Christy AL, Walker ME, Brown MA. Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: A role for neutrophil recruitment? J Immunol 2010; 184:6891-900
    • (2010) J Immunol , vol.184 , pp. 6891-6900
    • Sayed, B.A.1    Christy, A.L.2    Walker, M.E.3    Brown, M.A.4
  • 17
    • 84874606664 scopus 로고    scopus 로고
    • Disruption of the blood-brain barrier in inflammatory neurological diseases]
    • Shimizu F, Kanda T. [Disruption of the blood-brain barrier in inflammatory neurological diseases]. Brain Nerve 2013; 65:165-76
    • (2013) Brain Nerve , vol.65 , pp. 165-176
    • Shimizu, F.1    Kanda, T.2
  • 18
    • 33644840029 scopus 로고    scopus 로고
    • The pathology of multiple sclerosis: Evidence for heterogeneity
    • Morales Y, Parisi JE, Lucchinetti CF. The pathology of multiple sclerosis: Evidence for heterogeneity. Adv Neurol 2006; 98:27-45
    • (2006) Adv Neurol , vol.98 , pp. 27-45
    • Morales, Y.1    Parisi, J.E.2    Lucchinetti, C.F.3
  • 20
    • 0025847582 scopus 로고
    • Matrix metalloproteinases and their inhibitors in connective tissue remodeling
    • Woessner JF Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 1991; 5:2145-54
    • (1991) FASEB J , vol.5 , pp. 2145-2154
    • Woessner Jr., J.F.1
  • 21
    • 0029396428 scopus 로고
    • Matrix metalloproteinases
    • Birkedal-Hansen H. Matrix metalloproteinases. Adv Dent Res 1995; 9:16
    • (1995) Adv Dent Res , vol.9 , pp. 16
    • Birkedal-Hansen, H.1
  • 22
    • 0037693895 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry
    • Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry. Circ Res 2003; 92:827-39
    • (2003) Circ Res , vol.92 , pp. 827-839
    • Visse, R.1    Nagase, H.2
  • 23
    • 31344458952 scopus 로고    scopus 로고
    • Structure and function of matrix metalloproteinases and TIMPs
    • Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 2006; 69:562-73
    • (2006) Cardiovasc Res , vol.69 , pp. 562-573
    • Nagase, H.1    Visse, R.2    Murphy, G.3
  • 24
    • 39449111918 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9/gelatinase B is a putative therapeutic target of chronic obstructive pulmonary disease and multiple sclerosis
    • Muroski ME, Roycik MD, Newcomer RG, Van den Steen PE, Opdenakker G, Monroe HR, et al. Matrix metalloproteinase-9/gelatinase B is a putative therapeutic target of chronic obstructive pulmonary disease and multiple sclerosis. Curr Pharm Biotechnol 2008; 9:34-46
    • (2008) Curr Pharm Biotechnol , vol.9 , pp. 34-46
    • Muroski, M.E.1    Roycik, M.D.2    Newcomer, R.G.3    Van den Steen, P.E.4    Opdenakker, G.5    Monroe, H.R.6
  • 25
    • 0344443218 scopus 로고    scopus 로고
    • Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis
    • Bar-Or A, Nuttall RK, Duddy M, Alter A, Kim HJ, Ifergan I, et al. Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. Brain 2003; 126:2738-49
    • (2003) Brain , vol.126 , pp. 2738-2749
    • Bar-Or, A.1    Nuttall, R.K.2    Duddy, M.3    Alter, A.4    Kim, H.J.5    Ifergan, I.6
  • 26
    • 34447301502 scopus 로고    scopus 로고
    • Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF-alpha
    • Nguyen HX, O'Barr TJ, Anderson AJ. Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF-alpha. J Neurochem 2007; 102:900-12
    • (2007) J Neurochem , vol.102 , pp. 900-912
    • Nguyen, H.X.1    O'Barr, T.J.2    Anderson, A.J.3
  • 28
    • 0026442957 scopus 로고
    • Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders
    • Gijbels K, Masure S, Carton H, Opdenakker G. Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders. J Neuroimmunol 1992; 41:29-34
    • (1992) J Neuroimmunol , vol.41 , pp. 29-34
    • Gijbels, K.1    Masure, S.2    Carton, H.3    Opdenakker, G.4
  • 29
    • 0027368518 scopus 로고
    • Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein
    • Gijbels K, Proost P, Masure S, Carton H, Billiau A, Opdenakker G. Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein. J Neurosci Res 1993; 36:432-40
    • (1993) J Neurosci Res , vol.36 , pp. 432-440
    • Gijbels, K.1    Proost, P.2    Masure, S.3    Carton, H.4    Billiau, A.5    Opdenakker, G.6
  • 30
    • 0035405886 scopus 로고    scopus 로고
    • Metalloproteinases in biology and pathology of the nervous system
    • Yong VW, Power C, Forsyth P, Edwards DR. Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci 2001; 2:502-11
    • (2001) Nat Rev Neurosci , vol.2 , pp. 502-511
    • Yong, V.W.1    Power, C.2    Forsyth, P.3    Edwards, D.R.4
  • 31
    • 0036892580 scopus 로고    scopus 로고
    • Matrix metalloproteinases and neuroinflammation in multiple sclerosis
    • Rosenberg GA. Matrix metalloproteinases and neuroinflammation in multiple sclerosis. Neuroscientist 2002; 8:586-95
    • (2002) Neuroscientist , vol.8 , pp. 586-595
    • Rosenberg, G.A.1
  • 32
    • 0029867128 scopus 로고    scopus 로고
    • Matrix metalloproteinases in the normal human central nervous system, microglial nodules, and multiple sclerosis lesions
    • Maeda A, Sobel RA. Matrix metalloproteinases in the normal human central nervous system, microglial nodules, and multiple sclerosis lesions. J Neuropathol Exp Neurol 1996; 55:300-9
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 300-309
    • Maeda, A.1    Sobel, R.A.2
  • 33
    • 0032881663 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia
    • Conant K, McArthur JC, Griffin DE, Sjulson L, Wahl LM, Irani DN. Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia. Ann Neurol 1999; 46:391-8
    • (1999) Ann Neurol , vol.46 , pp. 391-398
    • Conant, K.1    McArthur, J.C.2    Griffin, D.E.3    Sjulson, L.4    Wahl, L.M.5    Irani, D.N.6
  • 34
    • 0034046651 scopus 로고    scopus 로고
    • Cytotoxicity by matrix metalloprotease-1 in organotypic spinal cord and dissociated neuronal cultures
    • Vos CM, Sjulson L, Nath A, McArthur JC, Pardo CA, Rothstein J, et al. Cytotoxicity by matrix metalloprotease-1 in organotypic spinal cord and dissociated neuronal cultures. Exp Neurol 2000; 163:324-30
    • (2000) Exp Neurol , vol.163 , pp. 324-330
    • Vos, C.M.1    Sjulson, L.2    Nath, A.3    McArthur, J.C.4    Pardo, C.A.5    Rothstein, J.6
  • 36
    • 0036470147 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 undergoes expression and activation during dendritic remodeling in adult hippocampus
    • Szklarczyk A, Lapinska J, Rylski M, McKay RD, Kaczmarek L. Matrix metalloproteinase-9 undergoes expression and activation during dendritic remodeling in adult hippocampus. J Neurosci 2002; 22:920-30
    • (2002) J Neurosci , vol.22 , pp. 920-930
    • Szklarczyk, A.1    Lapinska, J.2    Rylski, M.3    McKay, R.D.4    Kaczmarek, L.5
  • 37
    • 71049149292 scopus 로고    scopus 로고
    • Inflammatory proprotein convertasematrix metalloproteinase proteolytic pathway in antigenpresenting cells as a step to autoimmune multiple sclerosis
    • Shiryaev SA, Remacle AG, Savinov AY, Chernov AV, Cieplak P, Radichev IA, et al. Inflammatory proprotein convertasematrix metalloproteinase proteolytic pathway in antigenpresenting cells as a step to autoimmune multiple sclerosis. J Biol Chem 2009; 284:30615-26
    • (2009) J Biol Chem , vol.284 , pp. 30615-30626
    • Shiryaev, S.A.1    Remacle, A.G.2    Savinov, A.Y.3    Chernov, A.V.4    Cieplak, P.5    Radichev, I.A.6
  • 38
    • 64049085808 scopus 로고    scopus 로고
    • Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis
    • Shiryaev SA, Savinov AY, Cieplak P, Ratnikov BI, Motamedchaboki K, Smith JW, et al. Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis. PLoS One 2009; 4:e4952
    • (2009) PLoS One , vol.4
    • Shiryaev, S.A.1    Savinov, A.Y.2    Cieplak, P.3    Ratnikov, B.I.4    Motamedchaboki, K.5    Smith, J.W.6
  • 39
    • 0037622124 scopus 로고    scopus 로고
    • Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions
    • Vos CM, van Haastert ES, de Groot CJ, van der Valk P, de Vries HE. Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions. J Neuroimmunol 2003; 138:106-14
    • (2003) J Neuroimmunol , vol.138 , pp. 106-114
    • Vos, C.M.1    van Haastert, E.S.2    de Groot, C.J.3    van der Valk, P.4    de Vries, H.E.5
  • 40
    • 0028907318 scopus 로고
    • Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease
    • Strongin AY, Collier I, Bannikov G, Marmer BL, Grant GA, Goldberg GI. Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease. J Biol Chem 1995; 270:5331-8
    • (1995) J Biol Chem , vol.270 , pp. 5331-5338
    • Strongin, A.Y.1    Collier, I.2    Bannikov, G.3    Marmer, B.L.4    Grant, G.A.5    Goldberg, G.I.6
  • 41
    • 0034949509 scopus 로고    scopus 로고
    • Multiple sclerosis: Elevated expression of matrix metalloproteinases in blood monocytes
    • Kouwenhoven M, Ozenci V, Gomes A, Yarilin D, Giedraitis V, Press R, et al. Multiple sclerosis: Elevated expression of matrix metalloproteinases in blood monocytes. J Autoimmun 2001; 16:463-70
    • (2001) J Autoimmun , vol.16 , pp. 463-470
    • Kouwenhoven, M.1    Ozenci, V.2    Gomes, A.3    Yarilin, D.4    Giedraitis, V.5    Press, R.6
  • 43
    • 61849164425 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 and matrix metalloproteinase-2 as biomarkers of various courses in multiple sclerosis
    • Benesova Y, Vasku A, Novotna H, Litzman J, Stourac P, Beranek M, et al. Matrix metalloproteinase-9 and matrix metalloproteinase-2 as biomarkers of various courses in multiple sclerosis. Mult Scler 2009; 15:316-22
    • (2009) Mult Scler , vol.15 , pp. 316-322
    • Benesova, Y.1    Vasku, A.2    Novotna, H.3    Litzman, J.4    Stourac, P.5    Beranek, M.6
  • 44
    • 33645764948 scopus 로고    scopus 로고
    • Protein co-expression with axonal injury in multiple sclerosis plaques
    • Diaz-Sanchez M, Williams K, DeLuca GC, Esiri MM. Protein co-expression with axonal injury in multiple sclerosis plaques. Acta Neuropathol 2006; 111:289-99
    • (2006) Acta Neuropathol , vol.111 , pp. 289-299
    • Diaz-Sanchez, M.1    Williams, K.2    Deluca, G.C.3    Esiri, M.M.4
  • 45
    • 65349171869 scopus 로고    scopus 로고
    • Potential relevance of cerebrospinal fluid and serum levels and intrathecal synthesis of active matrix metalloproteinase-2 (MMP-2) as markers of disease remission in patients with multiple sclerosis
    • Fainardi E, Castellazzi M, Tamborino C, Trentini A, Manfrinato MC, Baldi E, et al. Potential relevance of cerebrospinal fluid and serum levels and intrathecal synthesis of active matrix metalloproteinase-2 (MMP-2) as markers of disease remission in patients with multiple sclerosis. Mult Scler 2009; 15:547-54
    • (2009) Mult Scler , vol.15 , pp. 547-554
    • Fainardi, E.1    Castellazzi, M.2    Tamborino, C.3    Trentini, A.4    Manfrinato, M.C.5    Baldi, E.6
  • 47
    • 0035170589 scopus 로고    scopus 로고
    • T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: Involvement of metalloproteinases
    • Newman TA, Woolley ST, Hughes PM, Sibson NR, Anthony DC, Perry VH. T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: Involvement of metalloproteinases. Brain 2001; 124:2203-14
    • (2001) Brain , vol.124 , pp. 2203-2214
    • Newman, T.A.1    Woolley, S.T.2    Hughes, P.M.3    Sibson, N.R.4    Anthony, D.C.5    Perry, V.H.6
  • 48
    • 0034790897 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their tissue inhibitors as markers of disease subtype and response to interferon-beta therapy in relapsing and secondary-progressive multiple sclerosis patients
    • Galboiz Y, Shapiro S, Lahat N, Rawashdeh H, Miller A. Matrix metalloproteinases and their tissue inhibitors as markers of disease subtype and response to interferon-beta therapy in relapsing and secondary-progressive multiple sclerosis patients. Ann Neurol 2001; 50:443-51
    • (2001) Ann Neurol , vol.50 , pp. 443-451
    • Galboiz, Y.1    Shapiro, S.2    Lahat, N.3    Rawashdeh, H.4    Miller, A.5
  • 50
    • 0026660964 scopus 로고
    • Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9
    • Ogata Y, Enghild JJ, Nagase H. Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9. J Biol Chem 1992; 267:3581-4
    • (1992) J Biol Chem , vol.267 , pp. 3581-3584
    • Ogata, Y.1    Enghild, J.J.2    Nagase, H.3
  • 51
    • 84867072196 scopus 로고    scopus 로고
    • Matrix metalloproteinase-3 in the central nervous system: A look on the bright side
    • Van Hove I, Lemmens K, Van de Velde S, Verslegers M, Moons L. Matrix metalloproteinase-3 in the central nervous system: A look on the bright side. J Neurochem 2012; 123:203-16
    • (2012) J Neurochem , vol.123 , pp. 203-216
    • van Hove, I.1    Lemmens, K.2    Van de Velde, S.3    Verslegers, M.4    Moons, L.5
  • 52
    • 32344445287 scopus 로고    scopus 로고
    • Serum matrix metalloproteinase-3 levels correlate with disease activity in relapsing-remitting multiple sclerosis
    • Kanesaka T, Mori M, Hattori T, Oki T, Kuwabara S. Serum matrix metalloproteinase-3 levels correlate with disease activity in relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 2006; 77:185-8
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , pp. 185-188
    • Kanesaka, T.1    Mori, M.2    Hattori, T.3    Oki, T.4    Kuwabara, S.5
  • 53
    • 51649102877 scopus 로고    scopus 로고
    • Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia
    • Woo MS, Park JS, Choi IY, Kim WK, Kim HS. Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia. J Neurochem 2008; 106:770-80
    • (2008) J Neurochem , vol.106 , pp. 770-780
    • Woo, M.S.1    Park, J.S.2    Choi, I.Y.3    Kim, W.K.4    Kim, H.S.5
  • 54
    • 17044432238 scopus 로고    scopus 로고
    • Matrix metalloproteinase-3: A novel signaling proteinase from apoptotic neuronal cells that activates microglia
    • Kim YS, Kim SS, Cho JJ, Choi DH, Hwang O, Shin DH, et al. Matrix metalloproteinase-3: A novel signaling proteinase from apoptotic neuronal cells that activates microglia. J Neurosci 2005; 25:3701-11
    • (2005) J Neurosci , vol.25 , pp. 3701-3711
    • Kim, Y.S.1    Kim, S.S.2    Cho, J.J.3    Choi, D.H.4    Hwang, O.5    Shin, D.H.6
  • 55
    • 0034008683 scopus 로고    scopus 로고
    • Why are growth factors important in oligodendrocyte physiology?
    • Dubois-Dalcq M, Murray K. Why are growth factors important in oligodendrocyte physiology? Pathol Biol (Paris) 2000; 48:80-6
    • (2000) Pathol Biol (Paris) , vol.48 , pp. 80-86
    • Dubois-Dalcq, M.1    Murray, K.2
  • 56
    • 0842313088 scopus 로고    scopus 로고
    • Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes
    • Fowlkes JL, Serra DM, Bunn RC, Thrailkill KM, Enghild JJ, Nagase H. Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes. Endocrinology 2004; 145:620-6
    • (2004) Endocrinology , vol.145 , pp. 620-626
    • Fowlkes, J.L.1    Serra, D.M.2    Bunn, R.C.3    Thrailkill, K.M.4    Enghild, J.J.5    Nagase, H.6
  • 57
    • 0035479845 scopus 로고    scopus 로고
    • Matrix metalloproteinases: They're not just for matrix anymore!
    • McCawley LJ, Matrisian LM. Matrix metalloproteinases: They're not just for matrix anymore! Curr Opin Cell Biol 2001,13:534-40
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 534-540
    • McCawley, L.J.1    Matrisian, L.M.2
  • 58
    • 80052161486 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their tissue inhibitors in cuprizone-induced demyelination and remyelination of brain white and gray matter
    • Skuljec J, Gudi V, Ulrich R, Frichert K, Yildiz O, Pul R, et al. Matrix metalloproteinases and their tissue inhibitors in cuprizone-induced demyelination and remyelination of brain white and gray matter. J Neuropathol Exp Neurol 2011; 70:758-69
    • (2011) J Neuropathol Exp Neurol , vol.70 , pp. 758-769
    • Skuljec, J.1    Gudi, V.2    Ulrich, R.3    Frichert, K.4    Yildiz, O.5    Pul, R.6
  • 59
    • 0034842248 scopus 로고    scopus 로고
    • The expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in lesions and normal appearing white matter of multiple sclerosis
    • Lindberg RL, De Groot CJ, Montagne L, Freitag P, van der Valk P, Kappos L, et al. The expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in lesions and normal appearing white matter of multiple sclerosis. Brain 2001; 124:1743-53
    • (2001) Brain , vol.124 , pp. 1743-1753
    • Lindberg, R.L.1    de Groot, C.J.2    Montagne, L.3    Freitag, P.4    van der Valk, P.5    Kappos, L.6
  • 60
    • 0031963338 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis
    • Kieseier BC, Kiefer R, Clements JM, Miller K, Wells GM, Schweitzer T, et al. Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis. Brain 1998; 121:159-66
    • (1998) Brain , vol.121 , pp. 159-166
    • Kieseier, B.C.1    Kiefer, R.2    Clements, J.M.3    Miller, K.4    Wells, G.M.5    Schweitzer, T.6
  • 61
    • 0344420053 scopus 로고    scopus 로고
    • Functional roles and therapeutic targeting of gelatinase B and chemokines in multiple sclerosis
    • Opdenakker G, Nelissen I, Van Damme J. Functional roles and therapeutic targeting of gelatinase B and chemokines in multiple sclerosis. Lancet Neurol 2003; 2:747-56
    • (2003) Lancet Neurol , vol.2 , pp. 747-756
    • Opdenakker, G.1    Nelissen, I.2    van Damme, J.3
  • 62
    • 0029907622 scopus 로고    scopus 로고
    • The expression of tissue-type plasminogen activator, matrix metalloproteases and endogenous inhibitors in the central nervous system in multiple sclerosis: Comparison of stages in lesion evolution
    • Cuzner ML, Gveric D, Strand C, Loughlin AJ, Paemen L, Opdenakker G, et al. The expression of tissue-type plasminogen activator, matrix metalloproteases and endogenous inhibitors in the central nervous system in multiple sclerosis: Comparison of stages in lesion evolution. J Neuropathol Exp Neurol 1996; 55:1194-204
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 1194-1204
    • Cuzner, M.L.1    Gveric, D.2    Strand, C.3    Loughlin, A.J.4    Paemen, L.5    Opdenakker, G.6
  • 63
    • 0033622321 scopus 로고    scopus 로고
    • CCR5 delta32, matrix metalloproteinase-9 and disease activity in multiple sclerosis
    • Sellebjerg F, Madsen HO, Jensen CV, Jensen J, Garred P. CCR5 delta32, matrix metalloproteinase-9 and disease activity in multiple sclerosis. J Neuroimmunol 2000; 102:98-106
    • (2000) J Neuroimmunol , vol.102 , pp. 98-106
    • Sellebjerg, F.1    Madsen, H.O.2    Jensen, C.V.3    Jensen, J.4    Garred, P.5
  • 64
    • 40449126196 scopus 로고    scopus 로고
    • Distinct roles of matrix metalloproteases in the earlyand late-phase development of neuropathic pain
    • Kawasaki Y, Xu ZZ, Wang X, Park JY, Zhuang ZY, Tan PH, et al. Distinct roles of matrix metalloproteases in the earlyand late-phase development of neuropathic pain. Nat Med 2008; 14:331-6
    • (2008) Nat Med , vol.14 , pp. 331-336
    • Kawasaki, Y.1    Xu, Z.Z.2    Wang, X.3    Park, J.Y.4    Zhuang, Z.Y.5    Tan, P.H.6
  • 65
    • 58149160463 scopus 로고    scopus 로고
    • Pathological findings in rats with experimental allergic encephalomyelitis
    • Dong M, Liu R, Guo L, Li C, Tan G. Pathological findings in rats with experimental allergic encephalomyelitis. APMIS 2008; 116:972-84
    • (2008) APMIS , vol.116 , pp. 972-984
    • Dong, M.1    Liu, R.2    Guo, L.3    Li, C.4    Tan, G.5
  • 66
    • 0033942044 scopus 로고    scopus 로고
    • In vivo neutrophil recruitment by granulocyte chemotactic protein-2 is assisted by gelatinase B/MMP-9 in the mouse
    • D'Haese A, Wuyts A, Dillen C, Dubois B, Billiau A, Heremans H, et al. In vivo neutrophil recruitment by granulocyte chemotactic protein-2 is assisted by gelatinase B/MMP-9 in the mouse. J Interferon Cytokine Res 2000; 20:667-74
    • (2000) J Interferon Cytokine Res , vol.20 , pp. 667-674
    • D'Haese, A.1    Wuyts, A.2    Dillen, C.3    Dubois, B.4    Billiau, A.5    Heremans, H.6
  • 67
    • 0033405694 scopus 로고    scopus 로고
    • Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions
    • Dubois B, Masure S, Hurtenbach U, Paemen L, Heremans H, van den Oord J, et al. Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions. J Clin Invest 1999; 104:1507-15
    • (1999) J Clin Invest , vol.104 , pp. 1507-1515
    • Dubois, B.1    Masure, S.2    Hurtenbach, U.3    Paemen, L.4    Heremans, H.5    van den Oord, J.6
  • 68
    • 33645869560 scopus 로고    scopus 로고
    • Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
    • Agrawal S, Anderson P, Durbeej M, van Rooijen N, Ivars F, Opdenakker G, et al. Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J Exp Med 2006; 203:1007-19
    • (2006) J Exp Med , vol.203 , pp. 1007-1019
    • Agrawal, S.1    Anderson, P.2    Durbeej, M.3    van Rooijen, N.4    Ivars, F.5    Opdenakker, G.6
  • 69
    • 0033081796 scopus 로고    scopus 로고
    • Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system
    • Cuzner ML, Opdenakker G. Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system. J Neuroimmunol 1999; 94:1-14
    • (1999) J Neuroimmunol , vol.94 , pp. 1-14
    • Cuzner, M.L.1    Opdenakker, G.2
  • 70
    • 0029034457 scopus 로고
    • Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2)
    • Fridman R, Toth M, Pena D, Mobashery S. Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2). Cancer Res 1995; 55:2548-55
    • (1995) Cancer Res , vol.55 , pp. 2548-2555
    • Fridman, R.1    Toth, M.2    Pena, D.3    Mobashery, S.4
  • 71
    • 0036186977 scopus 로고    scopus 로고
    • Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis
    • Van den Steen PE, Proost P, Grillet B, Brand DD, Kang AH, Van Damme J, et al. Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis. FASEB J 2002; 16:379-89
    • (2002) FASEB J , vol.16 , pp. 379-389
    • Van den Steen, P.E.1    Proost, P.2    Grillet, B.3    Brand, D.D.4    Kang, A.H.5    van Damme, J.6
  • 72
    • 77955022345 scopus 로고    scopus 로고
    • Alterations in serum MMP-8, MMP-9, IL- 12p40 and IL-23 in multiple sclerosis patients treated with interferon-beta1b
    • Alexander JS, Harris MK, Wells SR, Mills G, Chalamidas K, Ganta VC, et al. Alterations in serum MMP-8, MMP-9, IL- 12p40 and IL-23 in multiple sclerosis patients treated with interferon-beta1b. Mult Scler 2010; 16:801-9
    • (2010) Mult Scler , vol.16 , pp. 801-809
    • Alexander, J.S.1    Harris, M.K.2    Wells, S.R.3    Mills, G.4    Chalamidas, K.5    Ganta, V.C.6
  • 73
    • 84868513673 scopus 로고    scopus 로고
    • CCR2(+)CCR5(+) T cells produce matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis
    • Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, et al. CCR2(+)CCR5(+) T cells produce matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis. J Immunol 2012; 189:5057-65
    • (2012) J Immunol , vol.189 , pp. 5057-5065
    • Sato, W.1    Tomita, A.2    Ichikawa, D.3    Lin, Y.4    Kishida, H.5    Miyake, S.6
  • 75
    • 33744811943 scopus 로고    scopus 로고
    • Cerebrospinal fluid and serum levels and intrathecal production of active matrix metalloproteinase-9 (MMP-9) as markers of disease activity in patients with multiple sclerosis
    • Fainardi E, Castellazzi M, Bellini T, Manfrinato MC, Baldi E, Casetta I, et al. Cerebrospinal fluid and serum levels and intrathecal production of active matrix metalloproteinase-9 (MMP-9) as markers of disease activity in patients with multiple sclerosis. Mult Scler 2006; 12:294-301
    • (2006) Mult Scler , vol.12 , pp. 294-301
    • Fainardi, E.1    Castellazzi, M.2    Bellini, T.3    Manfrinato, M.C.4    Baldi, E.5    Casetta, I.6
  • 76
    • 0032948343 scopus 로고    scopus 로고
    • Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis. A longitudinal clinical and MRI study
    • Lee MA, Palace J, Stabler G, Ford J, Gearing A, Miller K. Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis. A longitudinal clinical and MRI study. Brain 1999; 122:191-7
    • (1999) Brain , vol.122 , pp. 191-197
    • Lee, M.A.1    Palace, J.2    Stabler, G.3    Ford, J.4    Gearing, A.5    Miller, K.6
  • 78
    • 67349181321 scopus 로고    scopus 로고
    • Lack of TIMP- 1 increases severity of experimental autoimmune encephalomyelitis: Effects of darbepoetin alfa on TIMP-1 null and wild-type mice
    • Thorne M, Moore CS, Robertson GS. Lack of TIMP- 1 increases severity of experimental autoimmune encephalomyelitis: Effects of darbepoetin alfa on TIMP-1 null and wild-type mice. J Neuroimmunol 2009; 211:92-100
    • (2009) J Neuroimmunol , vol.211 , pp. 92-100
    • Thorne, M.1    Moore, C.S.2    Robertson, G.S.3
  • 79
    • 56349091308 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis
    • Benesova Y, Vasků A, Stourac P, Hladikova M, Beranek M, Kadanka Z, et al. Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis. J Neuroimmunol 2008; 205:105-9
    • (2008) J Neuroimmunol , vol.205 , pp. 105-109
    • Benesova, Y.1    Vasků, A.2    Stourac, P.3    Hladikova, M.4    Beranek, M.5    Kadanka, Z.6
  • 80
    • 69949190038 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease
    • Fernandes KS, Brum DG, Sandrim VC, Guerreiro CT, Barreira AA, Tanus-Santos JE. Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease. J Neuroimmunol 2009; 214:128-31
    • (2009) J Neuroimmunol , vol.214 , pp. 128-131
    • Fernandes, K.S.1    Brum, D.G.2    Sandrim, V.C.3    Guerreiro, C.T.4    Barreira, A.A.5    Tanus-Santos, J.E.6
  • 82
    • 26444447974 scopus 로고    scopus 로고
    • An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization
    • Weaver A, Goncalves da Silva A, Nuttall RK, Edwards DR, Shapiro SD, Rivest S, et al. An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization. FASEB J 2005; 19:1668-70
    • (2005) FASEB J , vol.19 , pp. 1668-1670
    • Weaver, A.1    Goncalves da Silva, A.2    Nuttall, R.K.3    Edwards, D.R.4    Shapiro, S.D.5    Rivest, S.6
  • 83
    • 0033256294 scopus 로고    scopus 로고
    • Leukolysin/MMP25/MT6-MMP: A novel matrix metalloproteinase specifically expressed in the leukocyte lineage
    • Pei D. Leukolysin/MMP25/MT6-MMP: A novel matrix metalloproteinase specifically expressed in the leukocyte lineage. Cell Res 1999; 9:291-303
    • (1999) Cell Res , vol.9 , pp. 291-303
    • Pei, D.1
  • 84
    • 36148965872 scopus 로고    scopus 로고
    • Downregulation of membrane type-matrix metalloproteinases in the inflamed or injured central nervous system
    • Toft-Hansen H, Babcock AA, Millward JM, Owens T. Downregulation of membrane type-matrix metalloproteinases in the inflamed or injured central nervous system. J Neuroinflammation 2007; 4:24
    • (2007) J Neuroinflammation , vol.4 , pp. 24
    • Toft-Hansen, H.1    Babcock, A.A.2    Millward, J.M.3    Owens, T.4
  • 85
    • 78650780565 scopus 로고    scopus 로고
    • New strategies for the next generation of matrix-metalloproteinase inhibitors: Selectively targeting membrane-anchored MMPs with therapeutic antibodies
    • 2011
    • Devy L, Dransfield DT. New strategies for the next generation of matrix-metalloproteinase inhibitors: Selectively targeting membrane-anchored MMPs with therapeutic antibodies. Biochem Res Int 2011; 2011:191670
    • (2011) Biochem Res Int , pp. 191670
    • Devy, L.1    Dransfield, D.T.2
  • 86
    • 82955203465 scopus 로고    scopus 로고
    • Probing cytokines, chemokines and matrix metalloproteinases towards better immunotherapies of multiple sclerosis
    • Opdenakker G, Van Damme J. Probing cytokines, chemokines and matrix metalloproteinases towards better immunotherapies of multiple sclerosis. Cytokine Growth Factor Rev 2011,22:359-365
    • (2011) Cytokine Growth Factor Rev , vol.22 , pp. 359-365
    • Opdenakker, G.1    van Damme, J.2
  • 87
    • 0032439091 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors
    • Brown PD. Matrix metalloproteinase inhibitors. Breast Cancer Res Treat 1998; 52:125-36
    • (1998) Breast Cancer Res Treat , vol.52 , pp. 125-136
    • Brown, P.D.1
  • 88
    • 36849030749 scopus 로고    scopus 로고
    • MMPs in the central nervous system: Where the good guys go bad
    • Agrawal SM, Lau L, Yong VW. MMPs in the central nervous system: Where the good guys go bad. Semin Cell Dev Biol 2008; 19:42-51
    • (2008) Semin Cell Dev Biol , vol.19 , pp. 42-51
    • Agrawal, S.M.1    Lau, L.2    Yong, V.W.3
  • 89
    • 0029586589 scopus 로고
    • Matrix metalloproteinase inhibition: A review of anti-tumour activity
    • Brown PD, Giavazzi R. Matrix metalloproteinase inhibition: A review of anti-tumour activity. Ann Oncol 1995; 6:967-74
    • (1995) Ann Oncol , vol.6 , pp. 967-974
    • Brown, P.D.1    Giavazzi, R.2
  • 90
    • 0027944171 scopus 로고
    • Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases
    • Gijbels K, Galardy RE, Steinman L. Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases. J Clin Invest 1994; 94:2177-82
    • (1994) J Clin Invest , vol.94 , pp. 2177-2182
    • Gijbels, K.1    Galardy, R.E.2    Steinman, L.3
  • 91
    • 0034703180 scopus 로고    scopus 로고
    • Distinct roles for matrix metalloproteinase-2 and alpha4 integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitis
    • Graesser D, Mahooti S, Madri JA. Distinct roles for matrix metalloproteinase-2 and alpha4 integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitis. J Neuroimmunol 2000; 109:121-31
    • (2000) J Neuroimmunol , vol.109 , pp. 121-131
    • Graesser, D.1    Mahooti, S.2    Madri, J.A.3
  • 92
    • 0029046464 scopus 로고
    • Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790
    • Hewson AK, Smith T, Leonard JP, Cuzner ML. Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790. Inflamm Res 1995; 44:345-9
    • (1995) Inflamm Res , vol.44 , pp. 345-349
    • Hewson, A.K.1    Smith, T.2    Leonard, J.P.3    Cuzner, M.L.4
  • 94
    • 0029585742 scopus 로고
    • Prevention of acute autoimmune encephalomyelitis and abrogation of relapses in murine models of multiple sclerosis by the protease inhibitor D-penicillamine
    • Norga K, Paemen L, Masure S, Dillen C, Heremans H, Billiau A, et al. Prevention of acute autoimmune encephalomyelitis and abrogation of relapses in murine models of multiple sclerosis by the protease inhibitor D-penicillamine. Inflamm Res 1995; 44:529-34
    • (1995) Inflamm Res , vol.44 , pp. 529-534
    • Norga, K.1    Paemen, L.2    Masure, S.3    Dillen, C.4    Heremans, H.5    Billiau, A.6
  • 96
    • 0036260089 scopus 로고    scopus 로고
    • Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis
    • Brundula V, Rewcastle NB, Metz LM, Bernard CC, Yong VW. Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis. Brain 2002; 125:1297-308
    • (2002) Brain , vol.125 , pp. 1297-1308
    • Brundula, V.1    Rewcastle, N.B.2    Metz, L.M.3    Bernard, C.C.4    Yong, V.W.5
  • 97
    • 11144354138 scopus 로고    scopus 로고
    • Minocycline reduces gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis
    • Metz LM, Zhang Y, Yeung M, Patry DG, Bell RB, Stoian CA, et al. Minocycline reduces gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis. Ann Neurol 2004; 55:756
    • (2004) Ann Neurol , vol.55 , pp. 756
    • Metz, L.M.1    Zhang, Y.2    Yeung, M.3    Patry, D.G.4    Bell, R.B.5    Stoian, C.A.6
  • 98
    • 34249039892 scopus 로고    scopus 로고
    • The clinical response to minocycline in multiple sclerosis is accompanied by beneficial immune changes: A pilot study
    • Zabad RK, Metz LM, Todoruk TR, Zhang Y, Mitchell JR, Yeung M, et al. The clinical response to minocycline in multiple sclerosis is accompanied by beneficial immune changes: A pilot study. Mult Scler 2007; 13:517-26
    • (2007) Mult Scler , vol.13 , pp. 517-526
    • Zabad, R.K.1    Metz, L.M.2    Todoruk, T.R.3    Zhang, Y.4    Mitchell, J.R.5    Yeung, M.6
  • 99
    • 0030498666 scopus 로고    scopus 로고
    • Interferon beta-1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase-9
    • Stuve O, Dooley NP, Uhm JH, Antel JP, Francis GS, Williams G, et al. Interferon beta-1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase-9. Ann Neurol 1996; 40:853-63
    • (1996) Ann Neurol , vol.40 , pp. 853-863
    • Stuve, O.1    Dooley, N.P.2    Uhm, J.H.3    Antel, J.P.4    Francis, G.S.5    Williams, G.6
  • 100
    • 0030483220 scopus 로고    scopus 로고
    • Interferon beta-1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis
    • Leppert D, Waubant E, Burk MR, Oksenberg JR, Hauser SL. Interferon beta-1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis. Ann Neurol 1996; 40:846-52
    • (1996) Ann Neurol , vol.40 , pp. 846-852
    • Leppert, D.1    Waubant, E.2    Burk, M.R.3    Oksenberg, J.R.4    Hauser, S.L.5
  • 101
    • 0037167526 scopus 로고    scopus 로고
    • Differential mechanisms of action of interferonbeta and glatiramer aetate in MS
    • Yong VW. Differential mechanisms of action of interferonbeta and glatiramer aetate in MS. Neurology 2002; 59:802-8
    • (2002) Neurology , vol.59 , pp. 802-808
    • Yong, V.W.1
  • 102
    • 0020591390 scopus 로고
    • Prophylactic topical acyclovir for frequent recurrent herpes simplex infection with and without erythema multiforme
    • (Clin Res Ed)
    • Fawcett HA, Wansbrough-Jones MH, Clark AE, Leigh IM. Prophylactic topical acyclovir for frequent recurrent herpes simplex infection with and without erythema multiforme. Br Med J (Clin Res Ed) 1983; 287:798-9
    • (1983) Br Med J , vol.287 , pp. 798-799
    • Fawcett, H.A.1    Wansbrough-Jones, M.H.2    Clark, A.E.3    Leigh, I.M.4
  • 103
    • 0032716573 scopus 로고    scopus 로고
    • Changes of serum sICAM-1 and MMP-9 induced by rIFNbeta-1b treatment in relapsing-remitting MS
    • Trojano M, Avolio C, Liuzzi GM, Ruggieri M, Defazio G, Liguori M, et al. Changes of serum sICAM-1 and MMP-9 induced by rIFNbeta-1b treatment in relapsing-remitting MS. Neurology 1999; 53:1402-8
    • (1999) Neurology , vol.53 , pp. 1402-1408
    • Trojano, M.1    Avolio, C.2    Liuzzi, G.M.3    Ruggieri, M.4    Defazio, G.5    Liguori, M.6
  • 104
    • 0038015502 scopus 로고    scopus 로고
    • Gelatinase B/matrix metalloproteinase-9 cleaves interferon-beta and is a target for immunotherapy
    • Nelissen I, Martens E, Van den Steen PE, Proost P, Ronsse I, Opdenakker G. Gelatinase B/matrix metalloproteinase-9 cleaves interferon-beta and is a target for immunotherapy. Brain 2003,126:1371-81
    • (2003) Brain , vol.126 , pp. 1371-1381
    • Nelissen, I.1    Martens, E.2    Van den Steen, P.E.3    Proost, P.4    Ronsse, I.5    Opdenakker, G.6
  • 105
    • 34447104602 scopus 로고    scopus 로고
    • Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators
    • Yong VW, Zabad RK, Agrawal S, Goncalves Dasilva A, Metz LM. Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators. J Neurol Sci 2007; 259:79-84
    • (2007) J Neurol Sci , vol.259 , pp. 79-84
    • Yong, V.W.1    Zabad, R.K.2    Agrawal, S.3    Dasilva, A.4    Metz, L.M.5
  • 106
    • 22144496427 scopus 로고    scopus 로고
    • Effective combination of minocycline and interferon-beta in a model of multiple sclerosis
    • Giuliani F, Fu SA, Metz LM, Yong VW. Effective combination of minocycline and interferon-beta in a model of multiple sclerosis. J Neuroimmunol 2005; 165:83-91
    • (2005) J Neuroimmunol , vol.165 , pp. 83-91
    • Giuliani, F.1    Fu, S.A.2    Metz, L.M.3    Yong, V.W.4
  • 107
    • 78651515693 scopus 로고    scopus 로고
    • EMMPRIN: A novel regulator of leukocyte transmigration into the CNS in multiple sclerosis and experimental autoimmune encephalomyelitis
    • Agrawal SM, Silva C, Tourtellotte WW, Yong VW. EMMPRIN: A novel regulator of leukocyte transmigration into the CNS in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci 2011; 31:669-77
    • (2011) J Neurosci , vol.31 , pp. 669-677
    • Agrawal, S.M.1    Silva, C.2    Tourtellotte, W.W.3    Yong, V.W.4
  • 109
    • 53349172646 scopus 로고    scopus 로고
    • Central nervous system effects of current and emerging multiple sclerosis-directed immunotherapies
    • Antel JP, Miron VE. Central nervous system effects of current and emerging multiple sclerosis-directed immunotherapies. Clin Neurol Neurosurg 2008; 110:951-7
    • (2008) Clin Neurol Neurosurg , vol.110 , pp. 951-957
    • Antel, J.P.1    Miron, V.E.2
  • 110
    • 79960734932 scopus 로고    scopus 로고
    • Intravenous immunoglobulin therapy prevents development of autoimmune encephalomyelitis and suppresses activation of matrix metalloproteinases
    • Niimi N, Kohyama K, Kamei S, Matsumoto Y. Intravenous immunoglobulin therapy prevents development of autoimmune encephalomyelitis and suppresses activation of matrix metalloproteinases. Neuropathology 2011; 31:392-400
    • (2011) Neuropathology , vol.31 , pp. 392-400
    • Niimi, N.1    Kohyama, K.2    Kamei, S.3    Matsumoto, Y.4
  • 111
    • 0028328881 scopus 로고
    • Cytokine-regulated proteases in autoimmune diseases
    • Opdenakker G, Van Damme J. Cytokine-regulated proteases in autoimmune diseases. Immunol Today 1994; 15:103-7.
    • (1994) Immunol Today , vol.15 , pp. 103-107
    • Opdenakker, G.1    van Damme, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.