Plasma levels of the beta chemokine regulated upon activation, normal T cell expressed, and secreted (RANTES) correlate with severe brain injury

Journal of Trauma - Injury, Infection and Critical Care

Volumn 64, Issue 2, 2008, Pages 358-361

  Lumpkins, Kimberly ^a   Bochicchio, Grant V ^a,c   Zagol, Bradley ^a   Ulloa, Kristian ^a   Simard, J Marc ^b   Schaub, Stacey ^a   Meyer, Walter ^a   Scalea, Thomas ^a  

^a R ADAMS COWLEY SHOCK TRAUMA CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

Cytokine; RANTES; Traumatic brain injury

Indexed keywords

BETA CHEMOKINE; RANTES; BIOLOGICAL MARKER;

ADULT; ARTICLE; BRAIN HERNIA; BRAIN RADIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORRELATIONAL STUDY; CRITICAL ILLNESS; DEMOGRAPHY; DIFFUSE AXONAL INJURY; DISEASE CLASSIFICATION; DISEASE SEVERITY; FEMALE; GENE CONTROL; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIPLE REGRESSION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE ACTIVATION; TRAUMATIC BRAIN INJURY; ANALYSIS OF VARIANCE; BLOOD; BRAIN INJURY; CLASSIFICATION; EVALUATION; INJURY SCALE; MIDDLE AGED; REGRESSION ANALYSIS;

ADULT; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; BRAIN INJURIES; CHEMOKINE CCL5; CRITICAL ILLNESS; FEMALE; HUMANS; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; TRAUMA SEVERITY INDICES;

EID: 43149091698     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e318160df9b     Document Type: Article

References (12)

1. Appay V, Rowland-Jones S. RANTES: a versatile and controversial chemokine. Trends Immunol. 2001;22:83-87.
2. Song A, Nokolcheva T, Krensky AM. Transcriptional regulation of RANTES expression in T lymphocytes. Immunol Rev. 2000;177:236-245.
3. Frank S, Kampfer H, Wetzler C, et al. Large induction of the chemotactic cytokine RANTES during cutaneous wound repair: a regulatory role for nitric oxide in keratinocyte-derived RANTES expression. Biochem J. 2000;347:265-273.
4. Sarfo BY, Singh S, Lillard JW, et al. The cerebral-malaria-associated expression of RANTES, CCR3 and CC5 in post-mortem tissue samples. Ann Trop Med Parasitol. 2004;98:297-303.
5. Lee HP, Jun YC, Choi JK, et al. The expression of RANTES and chemokine receptors in the brains of scrapie-infected mice. J Neuroimmunol. 2005;158:26-33.
6. Ghirnikar RS, Lee YL, He TR, et al. Chemokine expression in rat stab wound brain injury. J Neurosci Res. 1996;46:727-733.
7. Sewell DL, Nacewicz B, Liu F, et al. Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist. J Neuroimmunol. 2004;155:55-63.
8. Fitch MT, Doller C, Combs CK, et al. Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J Neurosci. 1999;19:8182.
9. Ghirnikar RS, Lee YL, Eng LF. Inflammation in traumatic brain injury: role of cytokines and chemokines. Neurochem Res. 1998;23:329-340.
10. Omari KM, Chui R, Dorovini-Zis K. Induction of beta chemokine secretion by human brain microvessel endothelial cells via CD40/CD40L interactions. J Neuroimmunol. 2004;146:203-208.
11. Kossman T, Stahel PF, Morganti-Kossman MC, et al. Elevated levels of the complement components C3 and factor B in ventricular cerebrospinal fluid of patients with traumatic brain injury. J Neuroimmunol. 1997;73:63-69.
12. Faden AI. Neuroprotection and traumatic brain injury: theoretical option or realistic proposition. Curr Opin Neurol. 2002;15:707-712.