Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease

Experimental Neurology

Volumn 235, Issue 2, 2012, Pages 491-496

  Geekiyanage, Hirosha ^a   Jicha, Gregory A ^b   Nelson, Peter T ^c   Chan, Christina ^a,d,e  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d Michigan State University   (United States)

^e Michigan State University   (United States)

Author keywords

Alzheimer's disease; Blood serum; MicroRNA

Indexed keywords

MICRORNA; MICRORNA 126; MICRORNA 137; MICRORNA 181C; MICRORNA 191; MICRORNA 22; MICRORNA 29A; MICRORNA 29B; MICRORNA 39; MICRORNA 9; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; BRAIN CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; DISEASE MARKER; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE LOCATION; HUMAN; MALE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SCORING SYSTEM; SEX DIFFERENCE; TISSUE DISTRIBUTION;

AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; BIOLOGICAL MARKERS; DIETARY FATS; DOWN-REGULATION; FEMALE; GENETIC MARKERS; HUMANS; MALE; MICE; MICRORNAS;

EID: 84860369464     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.11.026     Document Type: Article

References (65)

1. Alberca R., Montes-Latorre E., Gil-Neciga E., Mir-Rivera P., Lozano-San Martin P. Alzheimer's disease and women. Rev. Neurol. 2002, 35:571-579.
2. Androulidaki A., Iliopoulos D., Arranz A., Doxaki C., Schworer S., Zacharioudaki V., Margioris A.N., Tsichlis P.N., Tsatsanis C. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 2009, 31:220-231.
3. Anon Consensus report of the working group on: "Molecular and Biochemical Markers of Alzheimer's Disease". The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group. Neurobiol. Aging 1998, 19:109-116.
4. Arroyo J.D., Chevillet J.R., Kroh E.M., Ruf I.K., Pritchard C.C., Gibson D.F., Mitchell P.S., Bennett C.F., Pogosova-Agadjanyan E.L., Stirewalt D.L., Tait J.F., Tewari M. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A 2011, 108:5003-5008.
5. Bachman D.L., Wolf P.A., Linn R., Knoefel J.E., Cobb J., Belanger A., D'Agostino R.B., White L.R. Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study. Neurology 1992, 42:115-119.
6. Baker L.D., Bayer-Carter J.L., Skinner J., Montine T.J., Cholerton B.A., Callaghan M., Leverenz J., Walter B.K., Tsai E., Postupna N., Lampe J., Craft S. High-Intensity Physical Activity Modulates Diet Effects on Cerebrospinal Amyloid-beta Levels in Normal Aging and Mild Cognitive Impairment 2011, J Alzheimers Dis.
7. Ballard C., Gauthier S., Corbett A., Brayne C., Aarsland D., Jones E. Alzheimer's disease. Lancet 2011, 377:1019-1031.
8. Barber R.C. Biomarkers for early detection of Alzheimer disease. J Am Osteopath Assoc 2010, 110:S10-15.
9. Bayer-Carter J.L., Green P.S., Montine T.J., VanFossen B., Baker L.D., Watson G.S., Bonner L.M., Callaghan M., Leverenz J.B., Walter B.K., Tsai E., Plymate S.R., Postupna N., Wilkinson C.W., Zhang J., Lampe J., Kahn S.E., Craft S. Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment. Arch Neurol 2011, 68:743-752.
10. Beeri M.S., Ravona-Springer R., Silverman J.M., Haroutunian V. The effects of cardiovascular risk factors on cognitive compromise. Dialogues Clin. Neurosci. 2009, 11:201-212.
11. Blennow K., Hampel H., Weiner M., Zetterberg H. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat Rev Neurol 2010, 6:131-144.
12. Brookmeyer R., Gray S., Kawas C. Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am. J. Public Health 1998, 88:1337-1342.
13. Burns A., Zaudig M. Mild cognitive impairment in older people. Lancet 2002, 360:1963-1965.
14. Camper-Kirby D., Welch S., Walker A., Shiraishi I., Setchell K.D., Schaefer E., Kajstura J., Anversa P., Sussman M.A. Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ. Res. 2001, 88:1020-1027.
15. Carlsson C.M. Type 2 diabetes mellitus, dyslipidemia, and Alzheimer's disease. J Alzheimers Dis 2010, 20:711-722.
16. Caselli R.J., Dueck A.C., Locke D.E., Sabbagh M.N., Ahern G.L., Rapcsak S.Z., Baxter L.C., Yaari R., Woodruff B.K., Hoffman-Snyder C., Rademakers R., Findley S., Reiman E.M. Cerebrovascular risk factors and preclinical memory decline in healthy APOE epsilon4 homozygotes. Neurology 2011, 76:1078-1084.
17. Cogswell J.P., Ward J., Taylor I.A., Waters M., Shi Y., Cannon B., Kelnar K., Kemppainen J., Brown D., Chen C., Prinjha R.K., Richardson J.C., Saunders A.M., Roses A.D., Richards C.A. Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J. Alzheimers Dis. 2008, 14:27-41.
18. de Souza L.C., Chupin M., Lamari F., Jardel C., Leclercq D., Colliot O., Lehericy S., Dubois B., Sarazin M. CSF tau markers are correlated with hippocampal volume in Alzheimer's disease 2011, Neurobiol Aging.
19. Dougall N.J., Bruggink S., Ebmeier K.P. Systematic review of the diagnostic accuracy of 99mTc-HMPAO-SPECT in dementia. Am. J. Geriatr. Psychiatry 2004, 12:554-570.
20. Ettorre E., Cerra E., Marigliano B., Vigliotta M., Vulcano A., Fossati C., De Benedetto G., Servello A., Andreozzi P., Marigliano V. Role of cardiovascular risk factors (CRF) in the patients with mild cognitive impairment (MCI) 2011, Arch Gerontol Geriatr.
21. Ewers M., Mielke M.M., Hampel H. Blood-based biomarkers of microvascular pathology in Alzheimer's disease. Exp Gerontol 2010, 45:75-79.
22. Ferri C.P., Prince M., Brayne C., Brodaty H., Fratiglioni L., Ganguli M., Hall K., Hasegawa K., Hendrie H., Huang Y., Jorm A., Mathers C., Menezes P.R., Rimmer E., Scazufca M. Global prevalence of dementia: a Delphi consensus study. Lancet 2005, 366:2112-2117.
23. Geekiyanage H., Chan C. MicroRNA-137/181c Regulates Serine Palmitoyltransferase and In Turn Amyloid {beta}, Novel Targets in Sporadic Alzheimer's Disease. J Neurosci 2011, 31:14820-14830.
24. Gilad S., Meiri E., Yogev Y., Benjamin S., Lebanony D., Yerushalmi N., Benjamin H., Kushnir M., Cholakh H., Melamed N., Bentwich Z., Hod M., Goren Y., Chajut A. Serum microRNAs are promising novel biomarkers. PLoS One 2008, 3:e3148.
25. Gu H.F., Alvarsson A., Efendic S., Brismar K. SOX2 has gender-specific genetic effects on diabetic nephropathy in samples from patients with type 1 diabetes mellitus in the GoKinD study. Gend. Med. 2009, 6:555-564.
26. Haas R.H., Rice M.A., Trauner D.A., Merritt T.A. Therapeutic effects of a ketogenic diet in Rett syndrome. Am. J. Med. Genet. Suppl. 1986, 1:225-246.
27. Hampel H., Shen Y., Walsh D.M., Aisen P., Shaw L.M., Zetterberg H., Trojanowski J.Q., Blennow K. Biological markers of amyloid beta-related mechanisms in Alzheimer's disease. Exp Neurol 2010, 223:334-346.
28. Hansson O., Stomrud E., Vanmechelen E., Ostling S., Gustafson D.R., Zetterberg H., Blennow K., Skoog I. Evaluation of Plasma Abeta as Predictor of Alzheimer's Disease in Older Individuals Without Dementia: A Population-Based Study 2011, J Alzheimers Dis.
29. Hebert S.S., Horre K., Nicolai L., Papadopoulou A.S., Mandemakers W., Silahtaroglu A.N., Kauppinen S., Delacourte A., De Strooper B. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:6415-6420.
30. Henderson V.W., Buckwalter J.G. Cognitive deficits of men and women with Alzheimer's disease. Neurology 1994, 44:90-96.
31. Irizarry M.C. Biomarkers of Alzheimer disease in plasma. NeuroRx 2004, 1:226-234.
32. Jicha G.A., Abner E.L., Schmitt F.A., Kryscio R.J., Riley K.P., Cooper G.E., Stiles N., Mendiondo M.S., Smith C.D., Van Eldik L.J., Nelson P.T. Preclinical AD Workgroup staging: pathological correlates and potential challenges. Neurobiol Aging 2011, http://www.ncbi.nlm.nih.gov/pubmed/21507528.
33. Julien C., Tremblay C., Phivilay A., Berthiaume L., Emond V., Julien P., Calon F. High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model. Neurobiol Aging 2010, 31:1516-1531.
34. Kosaka N., Iguchi H., Yoshioka Y., Takeshita F., Matsuki Y., Ochiya T. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem 2010, 285:17442-17452.
35. Kroh E.M., Parkin R.K., Mitchell P.S., Tewari M. Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR). Methods 2010, 50:298-301.
36. Lagos-Quintana M., Rauhut R., Lendeckel W., Tuschl T. Identification of novel genes coding for small expressed RNAs. Science 2001, 294:853-858.
37. Laneve P., Gioia U., Andriotto A., Moretti F., Bozzoni I., Caffarelli E. A minicircuitry involving REST and CREB controls miR-9-2 expression during human neuronal differentiation. Nucleic Acids Res 2010, 38:6895-6905.
38. Liebhaber G.M., Riemann E., Baumeister F.A. Ketogenic diet in Rett syndrome. J. Child Neurol. 2003, 18:74-75.
39. Lukiw W.J. Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. NeuroReport 2007, 18:297-300.
40. McClean P.L., Parthsarathy V., Faivre E., Holscher C. The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J Neurosci 2011, 31:6587-6594.
41. McPherson S., Back C., Buckwalter J.G., Cummings J.L. Gender-related cognitive deficits in Alzheimer's disease. Int. Psychogeriatr. 1999, 11:117-122.
42. Mott J.L., Kurita S., Cazanave S.C., Bronk S.F., Werneburg N.W., Fernandez-Zapico M.E. Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB. J Cell Biochem 2010, 110:1155-1164.
43. Mungas D., Reed B.R., Jagust W.J., DeCarli C., Mack W.J., Kramer J.H., Weiner M.W., Schuff N., Chui H.C. Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease. Neurology 2002, 59:867-873.
44. Oksman M., Iivonen H., Hogyes E., Amtul Z., Penke B., Leenders I., Broersen L., Lutjohann D., Hartmann T., Tanila H. Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. Neurobiol. Dis. 2006, 23:563-572.
45. Patwardhan M.B., McCrory D.C., Matchar D.B., Samsa G.P., Rutschmann O.T. Alzheimer disease: operating characteristics of PET-a meta-analysis. Radiology 2004, 231:73-80.
46. Pogribny I.P., Starlard-Davenport A., Tryndyak V.P., Han T., Ross S.A., Rusyn I., Beland F.A. Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest 2010, 90:1437-1446.
47. Qiagen Profiling miRNA in Serum and Plasma: Perils and Pitfalls on the Road to Biomarker Development 2011.
48. Refolo L.M., Malester B., LaFrancois J., Bryant-Thomas T., Wang R., Tint G.S., Sambamurti K., Duff K., Pappolla M.A. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol. Dis. 2000, 7:321-331.
49. Ripich D.N., Petrill S.A., Whitehouse P.J., Ziol E.W. Gender differences in language of AD patients: a longitudinal study. Neurology 1995, 45:299-302.
50. Samaco R.C., Nagarajan R.P., Braunschweig D., LaSalle J.M. Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders. Hum. Mol. Genet. 2004, 13:629-639.
51. Scheltens P., Fox N., Barkhof F., De Carli C. Structural magnetic resonance imaging in the practical assessment of dementia: beyond exclusion. Lancet Neurol. 2002, 1:13-21.
52. Schonrock N., Ke Y.D., Humphreys D., Staufenbiel M., Ittner L.M., Preiss T., Gotz J. Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta. PLoS One 2010, 5:e11070.
53. Sjogren M., Davidsson P., Wallin A., Granerus A.K., Grundstrom E., Askmark H., Vanmechelen E., Blennow K. Decreased CSF-beta-amyloid 42 in Alzheimer's disease and amyotrophic lateral sclerosis may reflect mismetabolism of beta-amyloid induced by disparate mechanisms. Dement. Geriatr. Cogn. Disord. 2002, 13:112-118.
54. Slevin M., Krupinski J. A role for monomeric C-reactive protein in regulation of angiogenesis, endothelial cell inflammation and thrombus formation in cardiovascular/cerebrovascular disease?. Histol. Histopathol. 2009, 24:1473-1478.
55. Szulwach K.E., Li X., Smrt R.D., Li Y., Luo Y., Lin L., Santistevan N.J., Li W., Zhao X., Jin P. Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol 2010, 189:127-141.
56. Tremblay F., Lavigne C., Jacques H., Marette A. Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities. Diabetes 2001, 50:1901-1910.
57. Turchinovich A., Weiz L., Langheinz A., Burwinkel B. Characterization of extracellular circulating microRNA. Nucleic Acids Res 2011, 39:7223-7233.
58. Vickers K.C., Palmisano B.T., Shoucri B.M., Shamburek R.D., Remaley A.T. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 2011, 13:423-433.
59. Wahlund L.O., Julin P., Johansson S.E., Scheltens P. Visual rating and volumetry of the medial temporal lobe on magnetic resonance imaging in dementia: a comparative study. J. Neurol. Neurosurg. Psychiatry 2000, 69:630-635.
60. Wang W.X., Rajeev B.W., Stromberg A.J., Ren N., Tang G., Huang Q., Rigoutsos I., Nelson P.T. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J. Neurosci. 2008, 28:1213-1223.
61. Wang G.K., Zhu J.Q., Zhang J.T., Li Q., Li Y., He J., Qin Y.W., Jing Q. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J 2010, 31:659-666.
62. Wang K., Zhang S., Weber J., Baxter D., Galas D.J. Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res 2010, 38:7248-7259.
63. Wen Y., Yang S., Liu R., Perez E., Yi K.D., Koulen P., Simpkins J.W. Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia. Brain Res. 2004, 1008:147-154.
64. Zeng L., Liu J., Wang Y., Wang L., Weng S., Tang Y., Zheng C., Cheng Q., Chen S., Yang G.Y. MicroRNA-210 as a novel blood biomarker in acute cerebral ischemia. Front Biosci (Elite Ed) 2011, 3:1265-1272.
65. Zhang X., Dong F., Ren J., Driscoll M.J., Culver B. High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex. Exp. Neurol. 2005, 191:318-325.