The AlkB family of Fe(II)/α-ketoglutarate-dependent dioxygenases: Repairing nucleic acid alkylation damage and beyond

Journal of Biological Chemistry

Volumn 290, Issue 34, 2015, Pages 20734-20742

  Fedeles, Bogdan I ^a   Singh, Vipender ^a   Delaney, James C ^a,b   Li, Deyu ^a,c   Essigmann, John M ^a  

^a Massachusetts Institute of Technology   (United States)

^b VISTERRA INC   (United States)

^c UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; DNA; ENZYMES; ESCHERICHIA COLI; MAMMALS; REPAIR; SUBSTRATES;

ADAPTIVE RESPONSE; BACTERIAL GENOMES; DNA-REPAIR ENZYMES; EXPERIMENTAL STRATEGY; KETOGLUTARATE; REPAIR ENZYMES; STRUCTURAL FEATURE; SUBSTRATE SPECIFICITY;

IRON COMPOUNDS;

2 OXOGLUTARIC ACID; ALKB PROTEIN; BACTERIAL PROTEIN; DIOXYGENASE; FERROUS ION; UNCLASSIFIED DRUG; ALKB PROTEIN, E COLI; ALKBH4 PROTEIN, HUMAN; ALPHA-KETOGLUTARIC ACID; ESCHERICHIA COLI PROTEIN; IRON; ISOENZYME; MIXED FUNCTION OXIDASE; SINGLE STRANDED DNA;

BACTERIAL GENETICS; DEALKYLATION; DNA ALKYLATION; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME STRUCTURE; ESCHERICHIA COLI; GENETIC ANALYSIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; SHORT SURVEY; STRUCTURE ANALYSIS; ALKYLATION; CHEMICAL STRUCTURE; ENZYMOLOGY; GENE EXPRESSION; GENETICS; METABOLISM; MULTIGENE FAMILY; OXIDATION REDUCTION REACTION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA;

ALKYLATION; DIOXYGENASES; DNA DAMAGE; DNA REPAIR; DNA, SINGLE-STRANDED; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION; HUMANS; IRON; ISOENZYMES; KETOGLUTARIC ACIDS; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; MULTIGENE FAMILY; OXIDATION-REDUCTION; SUBSTRATE SPECIFICITY;

EID: 84939856406     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.R115.656462     Document Type: Short Survey

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