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Volumn 14, Issue 3, 2015, Pages 169-179

Role of the N6-methyladenosine RNA mark in gene regulation and its implications on development and disease

Author keywords

FTO; m6A; METTL3; Post transcriptional regulation; RNA methylation

Indexed keywords

6 N METHYLADENOSINE; FUNGAL RNA; PLANT RNA; RNA; TRANSCRIPTOME; VIRUS RNA; ADENOSINE; METHYLTRANSFERASE; N(6)-METHYLADENOSINE;

EID: 84938290567     PISSN: 20412649     EISSN: 20412657     Source Type: Journal    
DOI: 10.1093/bfgp/elu039     Document Type: Article
Times cited : (72)

References (65)
  • 1
    • 34547792388 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer: the DNA hypermethylome
    • Esteller M. Epigenetic gene silencing in cancer: the DNA hypermethylome. Hum Mol Genet 2007;16(Spec No 1):R50-9.
    • (2007) Hum Mol Genet , vol.16 , Issue.SPEC NO 1 , pp. R50-R59
    • Esteller, M.1
  • 2
    • 23044500926 scopus 로고    scopus 로고
    • Linking covalent histone modifications to epigenetics: the rigidity and plasticity of the marks
    • Wang Y, Wysocka J, Perlin JR, et al. Linking covalent histone modifications to epigenetics: the rigidity and plasticity of the marks. Cold SpringHarb SympQuant Biol 2004;69: 161-9.
    • (2004) Cold SpringHarb SympQuant Biol , vol.69 , pp. 161-169
    • Wang, Y.1    Wysocka, J.2    Perlin, J.R.3
  • 3
    • 0016285746 scopus 로고
    • Identification of methylated nucleosides in messenger RNA from Novikoffhepatoma cells
    • Desrosiers R, Friderici K, Rottman F. Identification of methylated nucleosides in messenger RNA from Novikoffhepatoma cells. ProcNatl Acad Sci USA 1974;71:3971-5.
    • (1974) ProcNatl Acad Sci USA , vol.71 , pp. 3971-3975
    • Desrosiers, R.1    Friderici, K.2    Rottman, F.3
  • 4
    • 0016314015 scopus 로고
    • Sequences containing methylated nucleotides at the 5' termini of messenger RNAs: possible implications for processing
    • Rottman F, Shatkin AJ, Perry RP. Sequences containing methylated nucleotides at the 5' termini of messenger RNAs: possible implications for processing. Cell 1974;3: 197-9.
    • (1974) Cell , vol.3 , pp. 197-199
    • Rottman, F.1    Shatkin, A.J.2    Perry, R.P.3
  • 5
    • 77953682110 scopus 로고    scopus 로고
    • Detection of RNA modifications
    • Kellner S, Burhenne J, Helm M. Detection of RNA modifications. RNA Biol 2010;7:237-47.
    • (2010) RNA Biol , vol.7 , pp. 237-247
    • Kellner, S.1    Burhenne, J.2    Helm, M.3
  • 6
    • 84863821425 scopus 로고    scopus 로고
    • Use of specific chemical reagents for detection of modified nucleotides in RNA
    • Behm-Ansmant I, Helm M, Motorin Y. Use of specific chemical reagents for detection of modified nucleotides in RNA. JNucleic Acids 2011;2011:408053.
    • (2011) JNucleic Acids , vol.2011
    • Behm-Ansmant, I.1    Helm, M.2    Motorin, Y.3
  • 7
    • 84862649489 scopus 로고    scopus 로고
    • Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons
    • Meyer KD, Saletore Y, Zumbo P, et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell 2012;149:1635-46.
    • (2012) Cell , vol.149 , pp. 1635-1646
    • Meyer, K.D.1    Saletore, Y.2    Zumbo, P.3
  • 8
    • 84866419591 scopus 로고    scopus 로고
    • Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
    • Lian CG, Xu Y, Ceol C, et al. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell 2012;150: 1135-46.
    • (2012) Cell , vol.150 , pp. 1135-1146
    • Lian, C.G.1    Xu, Y.2    Ceol, C.3
  • 9
    • 84869392308 scopus 로고    scopus 로고
    • Mapping recently identified nucleotide variants in the genome and transcriptome
    • Song CX, Yi C, He C. Mapping recently identified nucleotide variants in the genome and transcriptome. Nat Biotechnol 2012;30:1107-16.
    • (2012) Nat Biotechnol , vol.30 , pp. 1107-1116
    • Song, C.X.1    Yi, C.2    He, C.3
  • 10
    • 0016823567 scopus 로고
    • Biosynthetic pathway of ribothymidine in B. subtilis and M. lysodeikticus involving different coenzymes for transfer RNA and ribosomal RNA
    • Schmidt W, Arnold HH, Kersten H. Biosynthetic pathway of ribothymidine in B. subtilis and M. lysodeikticus involving different coenzymes for transfer RNA and ribosomal RNA. Nucleic Acids Res 1975;2:1043-51.
    • (1975) Nucleic Acids Res , vol.2 , pp. 1043-1051
    • Schmidt, W.1    Arnold, H.H.2    Kersten, H.3
  • 11
    • 0016724732 scopus 로고
    • Systematic difference in the methylation of ribosomal ribonucleic acid from gram-positive and gram-negative bacteria
    • Tanaka T, Weisblum B. Systematic difference in the methylation of ribosomal ribonucleic acid from gram-positive and gram-negative bacteria. J Bacteriol 1975;123:771-4.
    • (1975) J Bacteriol , vol.123 , pp. 771-774
    • Tanaka, T.1    Weisblum, B.2
  • 12
    • 0017410441 scopus 로고
    • Immunospecific retention of oligonucleotides possessing N6-methyladenosine and 7-methylguanosine
    • Munns TW, Sims HF, Liszewski MK. Immunospecific retention of oligonucleotides possessing N6-methyladenosine and 7-methylguanosine. J Biol Chem 1977;252:3102-4.
    • (1977) J Biol Chem , vol.252 , pp. 3102-3104
    • Munns, T.W.1    Sims, H.F.2    Liszewski, M.K.3
  • 13
    • 0019332910 scopus 로고
    • The nucleotide sequence of nuclear U6 (4.7 S) RNA
    • Epstein P, Reddy R, Henning D, et al. The nucleotide sequence of nuclear U6 (4.7 S) RNA. J BiolChem 1980;255: 8901-6.
    • (1980) J BiolChem , vol.255 , pp. 8901-8906
    • Epstein, P.1    Reddy, R.2    Henning, D.3
  • 14
    • 0019324355 scopus 로고
    • The nucleotide sequence of nuclear 4.8S RNA of mouse cells
    • Harada F, Kato N, Nishimura S. The nucleotide sequence of nuclear 4.8S RNA of mouse cells. Biochem Biophys Res Commun 1980;95:1332-40.
    • (1980) Biochem Biophys Res Commun , vol.95 , pp. 1332-1340
    • Harada, F.1    Kato, N.2    Nishimura, S.3
  • 15
    • 0016809932 scopus 로고
    • The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminus
    • Perry RP, Kelley DE, Friderici K, et al. The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminus. Cell 1975;4:387-94.
    • (1975) Cell , vol.4 , pp. 387-394
    • Perry, R.P.1    Kelley, D.E.2    Friderici, K.3
  • 16
    • 0023662810 scopus 로고
    • Antibodies specific for N6-methyladenosine react with intact snRNPs U2 and U4/U6
    • Bringmann P, Luhrmann R. Antibodies specific for N6-methyladenosine react with intact snRNPs U2 and U4/U6. FEBS Lett 1987;213:309-15.
    • (1987) FEBS Lett , vol.213 , pp. 309-315
    • Bringmann, P.1    Luhrmann, R.2
  • 17
    • 0029061729 scopus 로고
    • Accurate and efficient N-6-adenosine methylation in spliceosomal U6 small nuclear RNA by HeLa cell extract in vitro
    • Shimba S, Bokar JA, Rottman F, etal. Accurate and efficient N-6-adenosine methylation in spliceosomal U6 small nuclear RNA by HeLa cell extract in vitro. Nucleic Acids Res 1995;23:2421-6.
    • (1995) Nucleic Acids Res , vol.23 , pp. 2421-2426
    • Shimba, S.1    Bokar, J.A.2    Rottman, F.3
  • 18
    • 0018198062 scopus 로고
    • Modified nucleotides in T1 RNase oligonucleotides of 18S ribosomal RNA of the Novikoffhepatoma
    • Choi YC, Busch H. Modified nucleotides in T1 RNase oligonucleotides of 18S ribosomal RNA of the Novikoffhepatoma. Biochemistry 1978;17:2551-60.
    • (1978) Biochemistry , vol.17 , pp. 2551-2560
    • Choi, Y.C.1    Busch, H.2
  • 19
    • 84860779086 scopus 로고    scopus 로고
    • Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
    • Dominissini D, Moshitch-Moshkovitz S, Schwartz S, et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 2012;485:201-6.
    • (2012) Nature , vol.485 , pp. 201-206
    • Dominissini, D.1    Moshitch-Moshkovitz, S.2    Schwartz, S.3
  • 20
    • 84899586607 scopus 로고    scopus 로고
    • The dynamic epitranscriptome: N6-methyladenosine and gene expression control
    • Meyer KD, Jaffrey SR. The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat RevMol Cell Biol 2014;15:313-26.
    • (2014) Nat RevMol Cell Biol , vol.15 , pp. 313-326
    • Meyer, K.D.1    Jaffrey, S.R.2
  • 21
    • 0036788427 scopus 로고    scopus 로고
    • Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase
    • Bujnicki JM, Feder M, Radlinska M, et al. Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase. J Mol Evol 2002;55:431-44.
    • (2002) J Mol Evol , vol.55 , pp. 431-444
    • Bujnicki, J.M.1    Feder, M.2    Radlinska, M.3
  • 22
    • 84893310526 scopus 로고    scopus 로고
    • N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
    • Wang Y, Li Y, Toth JI, et al. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat Cell Biol 2014;16:191-8.
    • (2014) Nat Cell Biol , vol.16 , pp. 191-198
    • Wang, Y.1    Li, Y.2    Toth, J.I.3
  • 23
    • 84893746230 scopus 로고    scopus 로고
    • Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
    • Ping XL, Sun BF, Wang L, et al. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res 2014;24:177-89.
    • (2014) Cell Res , vol.24 , pp. 177-189
    • Ping, X.L.1    Sun, B.F.2    Wang, L.3
  • 24
    • 81355146483 scopus 로고    scopus 로고
    • N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
    • Jia G, Fu Y, Zhao X, et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol 2011;7:885-7.
    • (2011) Nat Chem Biol , vol.7 , pp. 885-887
    • Jia, G.1    Fu, Y.2    Zhao, X.3
  • 25
    • 84872274463 scopus 로고    scopus 로고
    • ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
    • Zheng G, Dahl JA, Niu Y, et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell 2013;49:18-29.
    • (2013) Mol Cell , vol.49 , pp. 18-29
    • Zheng, G.1    Dahl, J.A.2    Niu, Y.3
  • 26
    • 84892372347 scopus 로고    scopus 로고
    • N6-methyladenosinedependent regulation of messenger RNA stability
    • Wang X, Lu Z, Gomez A, et al. N6-methyladenosinedependent regulation of messenger RNA stability. Nature 2014;505:117-20.
    • (2014) Nature , vol.505 , pp. 117-120
    • Wang, X.1    Lu, Z.2    Gomez, A.3
  • 27
    • 84887875528 scopus 로고    scopus 로고
    • RNA-methylationdependent RNA processing controls the speed of the circadian clock
    • Fustin JM, Doi M, Yamaguchi Y, et al. RNA-methylationdependent RNA processing controls the speed of the circadian clock. Cell 2013;155:793-806.
    • (2013) Cell , vol.155 , pp. 793-806
    • Fustin, J.M.1    Doi, M.2    Yamaguchi, Y.3
  • 28
    • 0021890204 scopus 로고
    • Precise localization of m6A in Rous sarcoma virus RNA reveals clustering of methylation sites: implications for RNA processing
    • Kane SE, Beemon K. Precise localization of m6A in Rous sarcoma virus RNA reveals clustering of methylation sites: implications for RNA processing. Mol Cell Biol 1985;5: 2298-306.
    • (1985) Mol Cell Biol , vol.5 , pp. 2298-2306
    • Kane, S.E.1    Beemon, K.2
  • 29
    • 0018657266 scopus 로고
    • Identification and mapping of N6-methyladenosine containing sequences in simian virus 40 RNA
    • Canaani D, Kahana C, Lavi S, et al. Identification and mapping of N6-methyladenosine containing sequences in simian virus 40 RNA. Nucleic Acids Res 1979;6:2879-99.
    • (1979) Nucleic Acids Res , vol.6 , pp. 2879-2899
    • Canaani, D.1    Kahana, C.2    Lavi, S.3
  • 30
    • 0018793158 scopus 로고
    • N-6-methyl-adenosine in adenovirus type 2 nuclear RNA is conserved in the formation of messenger RNA
    • Chen-Kiang S, Nevins JR, Darnell JE, Jr. N-6-methyl-adenosine in adenovirus type 2 nuclear RNA is conserved in the formation of messenger RNA. JMolBiol 1979;135:733-52.
    • (1979) JMolBiol , vol.135 , pp. 733-752
    • Chen-Kiang, S.1    Nevins, J.R.2    Darnell, J.E.3
  • 31
    • 0017251640 scopus 로고
    • The methylation of adenovirus-specific nuclear and cytoplasmic RNA
    • Sommer S, Salditt-GeorgieffM, Bachenheimer S, et al. The methylation of adenovirus-specific nuclear and cytoplasmic RNA. Nucleic Acids Res 1976;3:749-65.
    • (1976) Nucleic Acids Res , vol.3 , pp. 749-765
    • Sommer, S.1    Salditt-Georgieff, M.2    Bachenheimer, S.3
  • 32
    • 0020074714 scopus 로고
    • Accumulation of spliced avian retrovirus mRNA is inhibited in S-adenosylmethionine-depleted chicken embryo fibroblasts
    • Stoltzfus CM, Dane RW. Accumulation of spliced avian retrovirus mRNA is inhibited in S-adenosylmethionine-depleted chicken embryo fibroblasts. J Virol 1982;42: 918-31.
    • (1982) J Virol , vol.42 , pp. 918-931
    • Stoltzfus, C.M.1    Dane, R.W.2
  • 33
    • 0021022446 scopus 로고
    • Methylations of adenosine residues (m6A) in pre-mRNA are important for formation of late simian virus 40 mRNAs
    • Finkel D, Groner Y. Methylations of adenosine residues (m6A) in pre-mRNA are important for formation of late simian virus 40 mRNAs. Virology 1983; 131:409-25.
    • (1983) Virology , vol.131 , pp. 409-425
    • Finkel, D.1    Groner, Y.2
  • 34
    • 84890107723 scopus 로고    scopus 로고
    • Highresolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis
    • Schwartz S, Agarwala SD, Mumbach MR, et al. Highresolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell 2013;155:1409-21.
    • (2013) Cell , vol.155 , pp. 1409-1421
    • Schwartz, S.1    Agarwala, S.D.2    Mumbach, M.R.3
  • 35
    • 84864037029 scopus 로고    scopus 로고
    • RNA methylation by the MIS complex regulates a cell fate decision in yeast
    • Agarwala SD, Blitzblau HG, Hochwagen A, et al. RNA methylation by the MIS complex regulates a cell fate decision in yeast. PLoS Genet 2012;8:e1002732.
    • (2012) PLoS Genet , vol.8
    • Agarwala, S.D.1    Blitzblau, H.G.2    Hochwagen, A.3
  • 36
    • 0037109157 scopus 로고    scopus 로고
    • Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene
    • Clancy MJ, Shambaugh ME, Timpte CS, et al. Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene. NucleicAcidsRes 2002;30: 4509-18.
    • (2002) NucleicAcidsRes , vol.30 , pp. 4509-4518
    • Clancy, M.J.1    Shambaugh, M.E.2    Timpte, C.S.3
  • 37
    • 33750814968 scopus 로고    scopus 로고
    • Antisense transcription controls cell fate in Saccharomyces cerevisiae
    • Hongay CF, GrisafiPL, Galitski T, et al. Antisense transcription controls cell fate in Saccharomyces cerevisiae. Cell 2006; 127:735-45.
    • (2006) Cell , vol.127 , pp. 735-745
    • Hongay, C.F.1    Grisafi, P.L.2    Galitski, T.3
  • 38
    • 0026561541 scopus 로고
    • IME4, a gene that mediates MAT and nutritional control of meiosis in Saccharomyces cerevisiae
    • Shah JC, Clancy MJ. IME4, a gene that mediates MAT and nutritional control of meiosis in Saccharomyces cerevisiae. Mol Cell Biol 1992;12:1078-86.
    • (1992) Mol Cell Biol , vol.12 , pp. 1078-1086
    • Shah, J.C.1    Clancy, M.J.2
  • 39
    • 77952002827 scopus 로고    scopus 로고
    • The YTH domain is a novel RNA binding domain
    • Zhang Z, Theler D, Kaminska KH, et al. The YTH domain is a novel RNA binding domain. J Biol Chem 2010;285: 14701-10.
    • (2010) J Biol Chem , vol.285 , pp. 14701-14710
    • Zhang, Z.1    Theler, D.2    Kaminska, K.H.3
  • 40
    • 33746005932 scopus 로고    scopus 로고
    • Selective elimination of messenger RNA prevents an incidence of untimely meiosis
    • Harigaya Y, Tanaka H, Yamanaka S, et al. Selective elimination of messenger RNA prevents an incidence of untimely meiosis. Nature 2006;442:45-50.
    • (2006) Nature , vol.442 , pp. 45-50
    • Harigaya, Y.1    Tanaka, H.2    Yamanaka, S.3
  • 41
    • 84891485596 scopus 로고    scopus 로고
    • Adenosine methylation in Arabidopsis mRNA is associated with the 3' end and reduced levels cause developmental defects
    • Bodi Z, Zhong S, Mehra S, et al. Adenosine methylation in Arabidopsis mRNA is associated with the 3' end and reduced levels cause developmental defects. FrontPlantSci 2012;3:48.
    • (2012) FrontPlantSci , vol.3 , pp. 48
    • Bodi, Z.1    Zhong, S.2    Mehra, S.3
  • 42
    • 57749089784 scopus 로고    scopus 로고
    • MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor
    • Zhong S, Li H, Bodi Z, et al. MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor. Plant Cell 2008; 20:1278-88.
    • (2008) Plant Cell , vol.20 , pp. 1278-1288
    • Zhong, S.1    Li, H.2    Bodi, Z.3
  • 43
    • 1942437673 scopus 로고    scopus 로고
    • The immunophilininteracting protein AtFIP37 from Arabidopsis is essential for plant development and is involved in trichome endoreduplication
    • Vespa L, Vachon G, Berger F, et al. The immunophilininteracting protein AtFIP37 from Arabidopsis is essential for plant development and is involved in trichome endoreduplication. Plant Physiol 2004;134:1283-92.
    • (2004) Plant Physiol , vol.134 , pp. 1283-1292
    • Vespa, L.1    Vachon, G.2    Berger, F.3
  • 44
    • 36348929415 scopus 로고    scopus 로고
    • The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel
    • Sergiev PV, Serebryakova MV, Bogdanov AA, et al. The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel. JMol Biol 2008;375:291-300.
    • (2008) JMol Biol , vol.375 , pp. 291-300
    • Sergiev, P.V.1    Serebryakova, M.V.2    Bogdanov, A.A.3
  • 45
    • 84865133343 scopus 로고    scopus 로고
    • The last rRNA methyltransferase of E. coli revealed: the yhiR gene encodes adenine-N6 methyltransferase specific for modification of A2030 of 23S ribosomal RNA
    • Golovina AY, Dzama MM, Osterman IA, et al. The last rRNA methyltransferase of E. coli revealed: the yhiR gene encodes adenine-N6 methyltransferase specific for modification of A2030 of 23S ribosomal RNA. RNA 2012;18:1725-34.
    • (2012) RNA , vol.18 , pp. 1725-1734
    • Golovina, A.Y.1    Dzama, M.M.2    Osterman, I.A.3
  • 46
    • 84872032385 scopus 로고    scopus 로고
    • Transcriptome-wide mapping of N(6)-methyladenosine by m(6)A-seq based on immunocapturing and massively parallel sequencing
    • Dominissini D, Moshitch-Moshkovitz S, Salmon-Divon M, et al. Transcriptome-wide mapping of N(6)-methyladenosine by m(6)A-seq based on immunocapturing and massively parallel sequencing. Nat Protoc 2013;8:176-89.
    • (2013) Nat Protoc , vol.8 , pp. 176-189
    • Dominissini, D.1    Moshitch-Moshkovitz, S.2    Salmon-Divon, M.3
  • 47
    • 84875649230 scopus 로고    scopus 로고
    • Analysis of RNA base modification and structural rearrangement by singlemolecule real-time detection of reverse transcription
    • Vilfan ID, Tsai YC, Clark TA, et al. Analysis of RNA base modification and structural rearrangement by singlemolecule real-time detection of reverse transcription. JNanobiotechnology 2013;11:8.
    • (2013) JNanobiotechnology , vol.11 , pp. 8
    • Vilfan, I.D.1    Tsai, Y.C.2    Clark, T.A.3
  • 48
    • 84888423912 scopus 로고    scopus 로고
    • Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA
    • Liu N, Parisien M, Dai Q, et al. Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA. RNA 2013;19: 1848-56.
    • (2013) RNA , vol.19 , pp. 1848-1856
    • Liu, N.1    Parisien, M.2    Dai, Q.3
  • 49
    • 84895813879 scopus 로고    scopus 로고
    • Method for site-specific detection of m6A nucleoside presence in RNA based on high-resolution melting (HRM) analysis
    • Golovina AY, Dzama MM, Petriukov KS, et al. Method for site-specific detection of m6A nucleoside presence in RNA based on high-resolution melting (HRM) analysis. Nucleic Acids Res 2014;42:e27.
    • (2014) Nucleic Acids Res , vol.42
    • Golovina, A.Y.1    Dzama, M.M.2    Petriukov, K.S.3
  • 50
    • 84936744064 scopus 로고    scopus 로고
    • Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions
    • Sugimoto Y, Konig J, Hussain S, et al. Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions. Genome Biol 2012;13:R67.
    • (2012) Genome Biol , vol.13 , pp. R67
    • Sugimoto, Y.1    Konig, J.2    Hussain, S.3
  • 51
    • 77953928753 scopus 로고    scopus 로고
    • HITS-CLIP: panoramic views of protein-RNA regulation in living cells
    • Darnell RB. HITS-CLIP: panoramic views of protein-RNA regulation in living cells. Wiley Interdiscip Rev RNA 2010;1:266-86.
    • (2010) Wiley Interdiscip Rev RNA , vol.1 , pp. 266-286
    • Darnell, R.B.1
  • 52
    • 84887412533 scopus 로고    scopus 로고
    • A single-molecule long-read survey of the human transcriptome
    • Sharon D, Tilgner H, Grubert F, et al. A single-molecule long-read survey of the human transcriptome. Nat Biotechnol 2013;31:1009-14.
    • (2013) Nat Biotechnol , vol.31 , pp. 1009-1014
    • Sharon, D.1    Tilgner, H.2    Grubert, F.3
  • 53
    • 84890286068 scopus 로고    scopus 로고
    • Characterization of the human ESC transcriptome by hybrid sequencing
    • Au KF, Sebastiano V, Afshar PT, et al. Characterization of the human ESC transcriptome by hybrid sequencing. Proc Natl Acad Sci USA 2013;110:E4821-30.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. E4821-E4830
    • Au, K.F.1    Sebastiano, V.2    Afshar, P.T.3
  • 54
    • 84875377560 scopus 로고    scopus 로고
    • N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function
    • Niu Y, Zhao X, Wu YS, et al. N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function. Genomics Proteomics Bioinformatics 2013;11: 8-17.
    • (2013) Genomics Proteomics Bioinformatics , vol.11 , pp. 8-17
    • Niu, Y.1    Zhao, X.2    Wu, Y.S.3
  • 55
    • 0030712151 scopus 로고    scopus 로고
    • Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
    • Bokar JA, Shambaugh ME, Polayes D, et al. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA 1997;3:1233-47.
    • (1997) RNA , vol.3 , pp. 1233-1247
    • Bokar, J.A.1    Shambaugh, M.E.2    Polayes, D.3
  • 56
    • 84897855294 scopus 로고    scopus 로고
    • Obesity-associated variants within FTO form long-range functional connections with IRX3
    • Smemo S, Tena JJ, Kim KH, et al. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature 2014;507:371-5.
    • (2014) Nature , vol.507 , pp. 371-375
    • Smemo, S.1    Tena, J.J.2    Kim, K.H.3
  • 57
    • 0042161864 scopus 로고    scopus 로고
    • The thermodynamic stability of RNA duplexes and hairpins containing N6-alkyladenosines and 2-methylthio-N6-alkyladenosines
    • Kierzek E, Kierzek R. The thermodynamic stability of RNA duplexes and hairpins containing N6-alkyladenosines and 2-methylthio-N6-alkyladenosines. Nucleic Acids Res 2003;31:4472-80.
    • (2003) Nucleic Acids Res , vol.31 , pp. 4472-4480
    • Kierzek, E.1    Kierzek, R.2
  • 59
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA
    • Kariko K, Buckstein M, Ni H, et al. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 2005;23:165-75.
    • (2005) Immunity , vol.23 , pp. 165-175
    • Kariko, K.1    Buckstein, M.2    Ni, H.3
  • 60
    • 78650494568 scopus 로고    scopus 로고
    • The application of Toll like receptors for cancer therapy
    • So EY, Ouchi T. The application of Toll like receptors for cancer therapy. IntJ Biol Sci 2010;6:675-81.
    • (2010) IntJ Biol Sci , vol.6 , pp. 675-681
    • So, E.Y.1    Ouchi, T.2
  • 61
    • 63449126998 scopus 로고    scopus 로고
    • Toll-like receptors and their role in carcinogenesis and anti-tumor treatment
    • Wolska A, Lech-Maranda E, Robak T. Toll-like receptors and their role in carcinogenesis and anti-tumor treatment. CellMol Biol Lett 2009;14:248-72.
    • (2009) CellMol Biol Lett , vol.14 , pp. 248-272
    • Wolska, A.1    Lech-Maranda, E.2    Robak, T.3
  • 62
    • 84878011018 scopus 로고    scopus 로고
    • Toll-like receptors in human papillomavirus infection
    • Zhou Q, Zhu K, Cheng H. Toll-like receptors in human papillomavirus infection. Arch Immunol Ther Exp (Warsz) 2013;61:203-15.
    • (2013) Arch Immunol Ther Exp (Warsz) , vol.61 , pp. 203-215
    • Zhou, Q.1    Zhu, K.2    Cheng, H.3
  • 63
    • 0028963496 scopus 로고
    • Erythromycin resistance by ribosome modification
    • Weisblum B. Erythromycin resistance by ribosome modification. Antimicrob Agents Chemother 1995;39: 577-85.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 577-585
    • Weisblum, B.1
  • 65
    • 84898814417 scopus 로고    scopus 로고
    • Gene expression regulation mediated through reversible m(6)A RNA methylation
    • Fu Y, Dominissini D, Rechavi G, et al. Gene expression regulation mediated through reversible m(6)A RNA methylation. Nat Rev Genet 2014;15:293-306.
    • (2014) Nat Rev Genet , vol.15 , pp. 293-306
    • Fu, Y.1    Dominissini, D.2    Rechavi, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.