Switching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residues

Angewandte Chemie - International Edition

Volumn 53, Issue 14, 2014, Pages 3659-3662

  Zhu, Chenxu ^a   Yi, Chengqi ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

protein structures; RNA recognition; RNA DNA demethylases; selective inhibition; substrate specificity

Indexed keywords

CHEMICAL REACTIONS; ENZYME KINETICS;

EXCHANGE PROGRAMS; INHIBITOR DESIGN; PROTEIN STRUCTURES; RNA RECOGNITION; SELECTIVE INHIBITION; SELECTIVE INHIBITORS; SUBSTRATE RECOGNITION; SUBSTRATE SPECIFICITY;

SUBSTRATES;

ALKBH2 PROTEIN, HUMAN; DIOXYGENASE; DNA; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RNA;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DNA METHYLATION; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN STRUCTURES; RNA RECOGNITION; RNA/DNA DEMETHYLASES; SELECTIVE INHIBITION;

PROTEIN STRUCTURES; RNA RECOGNITION; RNA/DNA DEMETHYLASES; SELECTIVE INHIBITION; SUBSTRATE SPECIFICITY;

AMINO ACID SEQUENCE; DIOXYGENASES; DNA; DNA METHYLATION; DNA REPAIR ENZYMES; HUMANS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; RNA; SUBSTRATE SPECIFICITY;

EID: 84897404290     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201310050     Document Type: Article

References (38)

1. W. A. Pastor, L. Aravind, A. Rao, Nat. Rev. Mol. Cell Biol. 2013, 14, 341-356
2. Y. Fu, C. He, Curr. Opin. Chem. Biol. 2012, 16, 516-524.
3. P. O. Falnes, R. F. Johansen, E. Seeberg, Nature 2002, 419, 178-182
4. S. C. Trewick, T. F. Henshaw, R. P. Hausinger, T. Lindahl, B. Sedgwick, Nature 2002, 419, 174-178
5. P. A. Aas, et al., Nature 2003, 421, 859-863
6. R. Ougland, C. M. Zhang, A. Liiv, R. F. Johansen, E. Seeberg, Y. M. Hou, J. Remme, P. O. Falnes, Mol. Cell 2004, 16, 107-116
7. P. Falnes, M. Bjørås, P. A. Aas, O. Sundheim, E. Seeberg, Nucleic Acids Res. 2004, 32, 3456-3461.
8. J. Ringvoll, L. M. Nordstrand, et al., EMBO J. 2006, 25, 2189-2198
9. T. Duncan, S. C. Trewick, P. Koivisto, P. A. Bates, T. Lindahl, B. Sedgwick, Proc. Natl. Acad. Sci. USA 2002, 99, 16660-16665
10. S. Dango, N. Mosammaparast, M. E. Sowa, L. J. Xiong, F. Wu, K. Park, M. Rubin, S. Gygi, J. W. Harper, Y. Shi, Mol. Cell 2011, 44, 373-384.
11. T. M. Frayling, et al., Science 2007, 316, 889-894
12. C. Dina, et al., Nat. Genet. 2007, 39, 724-726
13. A. Scuteri, et al., PLoS Genet. 2007, 3, e 115
14. J. Fischer, L. Koch, C. Emmerling, J. Vierkotten, T. Peters, J. C. Brüning, U. Rüther, Nature 2009, 458, 894-898
15. C. Church, et al., Nat. Genet. 2010, 42, 1086-1092.
16. T. Gerken, et al., Science 2007, 318, 1469-1472
17. G. Jia, C. G. Yang, S. Yang, X. Jian, C. Yi, Z. Zhou, C. He, FEBS Lett. 2008, 582, 3313-3319.
18. G. Jia, Y. Fu, X. Zhao, Q. Dai, G. Zheng, Y. Yang, C. Yi, T. Lindahl, T. Pan, Y. G. Yang, C. He, Nat. Chem. Biol. 2011, 7, 885-887.
19. G. Zheng, J. A. Dahl, et al., Mol. Cell 2013, 49, 18-29.
20. B. Sedgwick, Nat. Rev. Mol. Cell Biol. 2004, 5, 148-157
21. F. Drabløs, E. Feyzi, P. A. Aas, C. B. Vaagbo, B. Kavli, M. S. Bratlie, J. Pena-Diaz, M. Otterlei, G. Slupphaug, H. E. Krokan, DNA Repair 2004, 3, 1389-1407
22. Y. Mishina, E. M. Duguid, C. He, Chem. Rev. 2006, 106, 215-232.
23. K. D. Meyer, Y. Saletore, P. Zumbo, O. Elemento, C. E. Mason, S. R. Jaffrey, Cell 2012, 149, 1635-1646
24. G. Jia, Y. Fu, C. He, Trends Genet. 2013, 29, 108-115
25. G. Zheng, J. A. Dahl, Y. Niu, Y. Fu, A. Klungland, Y. G. Yang, C. He, RNA Biol. 2013, 10, 915-918
26. D. Dominissini, et al., Nature 2012, 485, 201-206.
27. Z. Han, T. Niu, J. Chang, X. Lei, M. Zhao, Q. Wang, W. Cheng, J. Wang, Y. Feng, J. Chai, Nature 2010, 464, 1205-1209.
28. O. Sundheim, C. B. Vagbo, M. Bjoras, M. M. Sousa, V. Talstad, P. A. Aas, F. Drablos, H. E. Krokan, J. A. Tainer, G. Slupphaug, EMBO J. 2006, 25, 3389-3397.
29. B. Yu, W. C. Edstrom, J. Benach, Y. Hamuro, P. C. Weber, B. R. Gibney, J. F. Hunt, Nature 2006, 439, 879-884
30. C. G. Yang, C. Yi, E. M. Duguid, C. T. Sullivan, X. Jian, P. A. Rice, C. He, Nature 2008, 452, 961-965
31. C. Yi, G. Jia, G. Hou, Q. Dai, W. Zhang, G. Zheng, X. Jian, C. G. Yang, Q. Cui, C. He, Nature 2010, 468, 330-333
32. C. Yi, et al., Nat. Struct. Mol. Biol. 2012, 19, 671-676
33. P. J. Holland, T. Hollis, PLoS One 2010, 5, e 8680
34. B. Yu, J. F. Hunt, Proc. Natl. Acad. Sci. USA 2009, 106, 14315-14320
35. A. M. Maciejewska, et al., J. Biol. Chem. 2013, 288, 432-441.
36. D. Li, J. C. Delaney, C. M. Page, X. Yang, A. S. Chen, C. Wong, C. L. Drennan, J. M. Essigmann, J. Am. Chem. Soc. 2012, 134, 8896-8901.
37. B. Chen, et al., J. Am. Chem. Soc. 2012, 134, 17963-17971
38. W. Aik, M. Demetriades, M. K. Hamdan, E. A. Bagg, K. K. Yeoh, C. Lejeune, Z. Zhang, M. A. McDonough, C. J. Schofield, J. Med. Chem. 2013, 56, 3680-3688.