메뉴 건너뛰기




Volumn 14, Issue 5, 2014, Pages

FTO and obesity: Mechanisms of association

Author keywords

Epitranscriptome; FTO; Obesity; RNA methylation

Indexed keywords

IRON; MESSENGER RNA; RNA; SINGLE STRANDED DNA; SINGLE STRANDED RNA; FTO PROTEIN, HUMAN; FTO PROTEIN, MOUSE; LYASE; MIXED FUNCTION OXIDASE; PROTEIN;

EID: 84899129580     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-014-0486-0     Document Type: Review
Times cited : (130)

References (94)
  • 1
    • 33745238043 scopus 로고    scopus 로고
    • The WHO report "Preventing chronic diseases: A vital investment" and us
    • DOI 10.1007/s00038-005-0015-7
    • Morabia A, Abel T. The WHO report "Preventing chronic diseases: a vital investment" and us. Soz Praventivmed. 2006;51:74. (Pubitemid 43923170)
    • (2006) Sozial- und Praventivmedizin , vol.51 , Issue.2 , pp. 74
    • Morabia, A.1    Abel, T.2
  • 3
    • 84879356369 scopus 로고    scopus 로고
    • T-HOD: A literature-based candidate gene database for hypertension, obesity and diabetes
    • The authors established the T-HOD database providing the most detailed summary of obesity associated gene loci and polymorphisms uncovered to date
    • • Dai HJ, Wu JC, Tsai RT, et al. T-HOD: a literature-based candidate gene database for hypertension, obesity and diabetes. Database. 2013;2013:bas061. The authors established the T-HOD database providing the most detailed summary of obesity associated gene loci and polymorphisms uncovered to date.
    • (2013) Database , vol.2013
    • Dai, H.J.1    Wu, J.C.2    Tsai, R.T.3
  • 5
    • 42249110521 scopus 로고    scopus 로고
    • FTO: The first gene contributing to common forms of human obesity
    • DOI 10.1111/j.1467-789X.2008.00481.x
    • Loos RJ, Bouchard C. FTO: the first gene contributing to common forms of human obesity. Obes Rev. 2008;9:246-50. (Pubitemid 351550693)
    • (2008) Obesity Reviews , vol.9 , Issue.3 , pp. 246-250
    • Loos, R.J.F.1    Bouchard, C.2
  • 6
    • 34547625955 scopus 로고    scopus 로고
    • Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    • Scuteri A, Sanna S, Chen WM, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 2007;3:e115.
    • (2007) PLoS Genet , vol.3
    • Scuteri, A.1    Sanna, S.2    Chen, W.M.3
  • 7
    • 41749090524 scopus 로고    scopus 로고
    • Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants
    • Hinney A, Nguyen TT, Scherag A, et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One. 2007;2:e1361.
    • (2007) PLoS One , vol.2
    • Hinney, A.1    Nguyen, T.T.2    Scherag, A.3
  • 10
    • 84867330691 scopus 로고    scopus 로고
    • FTO genotype is associated with phenotypic variability of body mass index
    • Yang J, Loos RJ, Powell JE, et al. FTO genotype is associated with phenotypic variability of body mass index. Nature. 2012;490:267-72.
    • (2012) Nature , vol.490 , pp. 267-272
    • Yang, J.1    Loos, R.J.2    Powell, J.E.3
  • 11
    • 84866142193 scopus 로고    scopus 로고
    • Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: A systematic review and meta-analysis
    • Wojciechowski P, Lipowska A, Rys P, et al. Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis. Diabetologia. 2012;55:2636-45.
    • (2012) Diabetologia , vol.55 , pp. 2636-2645
    • Wojciechowski, P.1    Lipowska, A.2    Rys, P.3
  • 12
    • 48749132799 scopus 로고    scopus 로고
    • Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure
    • Speakman JR, Rance KA, Johnstone AM. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity. 2008;16:1961-5.
    • (2008) Obesity , vol.16 , pp. 1961-1965
    • Speakman, J.R.1    Rance, K.A.2    Johnstone, A.M.3
  • 13
    • 77950408832 scopus 로고    scopus 로고
    • FTO effect on energy demand vs food intake
    • discussion E2
    • Speakman JR. FTO effect on energy demand vs food intake. Nature. 2010;464:E1; discussion E2.
    • (2010) Nature , vol.464
    • Speakman, J.R.1
  • 14
    • 58149508094 scopus 로고    scopus 로고
    • The FTO gene and measured food intake in children
    • Wardle J, Llewellyn C, Sanderson S, et al. The FTO gene and measured food intake in children. Int J Obes. 2009;33:42-5.
    • (2009) Int J Obes , vol.33 , pp. 42-45
    • Wardle, J.1    Llewellyn, C.2    Sanderson, S.3
  • 15
    • 57749121512 scopus 로고    scopus 로고
    • An obesity-associated FTO gene variant and increased energy intake in children
    • Cecil JE, Tavendale R, Watt P, et al. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med. 2008;359:2558-66.
    • (2008) N Engl J Med , vol.359 , pp. 2558-2566
    • Cecil, J.E.1    Tavendale, R.2    Watt, P.3
  • 16
    • 84873628546 scopus 로고    scopus 로고
    • The rs9939609 gene variant in FTO modified the metabolic response of weight loss after a 3-month intervention with a hypocaloric diet
    • de Luis DA, Aller R, Conde R, et al. The rs9939609 gene variant in FTO modified the metabolic response of weight loss after a 3-month intervention with a hypocaloric diet. J Investig Med. 2013;61:22-6.
    • (2013) J Investig Med , vol.61 , pp. 22-26
    • De Luis, D.A.1    Aller, R.2    Conde, R.3
  • 17
    • 67649852402 scopus 로고    scopus 로고
    • Variation in the FTO gene influences food intake but not energy expenditure
    • Haupt A, Thamer C, Staiger H, et al. Variation in the FTO gene influences food intake but not energy expenditure. Exp Clin Endocrinol Diabetes. 2009;117:194-7.
    • (2009) Exp Clin Endocrinol Diabetes , vol.117 , pp. 194-197
    • Haupt, A.1    Thamer, C.2    Staiger, H.3
  • 18
    • 38449097877 scopus 로고    scopus 로고
    • Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population
    • Li H, Wu Y, Loos RJ, et al. Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes. 2008;57:264-8.
    • (2008) Diabetes , vol.57 , pp. 264-268
    • Li, H.1    Wu, Y.2    Loos, R.J.3
  • 19
    • 50949104331 scopus 로고    scopus 로고
    • Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population
    • Chang YC, Liu PH, Lee WJ, et al. Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. Diabetes. 2008;57:2245-52.
    • (2008) Diabetes , vol.57 , pp. 2245-2252
    • Chang, Y.C.1    Liu, P.H.2    Lee, W.J.3
  • 20
    • 77749233777 scopus 로고    scopus 로고
    • Obesity susceptibility genetic variants identified from recent genome-wide association studies: Implications in a Chinese population
    • Cheung CY, Tso AW, Cheung BM, et al. Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a Chinese population. J Clin Endocrinol Metab. 2010;95:1395-403.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1395-1403
    • Cheung, C.Y.1    Tso, A.W.2    Cheung, B.M.3
  • 21
    • 78650959240 scopus 로고    scopus 로고
    • Regulation of FTO and FTMexpression during human pre-adipocyte differentiation
    • Tews D, Fischer-Posovszky P, Wabitsch M. Regulation of FTO and FTMexpression during human pre-adipocyte differentiation. Horm Metab Res. 2011;43:17-21.
    • (2011) Horm Metab Res , vol.43 , pp. 17-21
    • Tews, D.1    Fischer-Posovszky, P.2    Wabitsch, M.3
  • 22
    • 42949102733 scopus 로고    scopus 로고
    • The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis
    • Wahlen K, Sjolin E, Hoffstedt J. The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis. J Lipid Res. 2008;49:607-11.
    • (2008) J Lipid Res , vol.49 , pp. 607-611
    • Wahlen, K.1    Sjolin, E.2    Hoffstedt, J.3
  • 23
    • 77958485625 scopus 로고    scopus 로고
    • Gene expression of FTO in human subcutaneous adipose tissue, peripheral blood mononuclear cells and adipocyte cell line
    • Lappalainen T, Kolehmainen M, Schwab U, et al. Gene expression of FTO in human subcutaneous adipose tissue, peripheral blood mononuclear cells and adipocyte cell line. J Nutrigenet Nutrigenomics. 2010;3:37-45.
    • (2010) J Nutrigenet Nutrigenomics , vol.3 , pp. 37-45
    • Lappalainen, T.1    Kolehmainen, M.2    Schwab, U.3
  • 24
    • 70349642879 scopus 로고    scopus 로고
    • Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue
    • Grunnet LG, Nilsson E, Ling C, et al. Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue. Diabetes. 2009;58:2402-8.
    • (2009) Diabetes , vol.58 , pp. 2402-2408
    • Grunnet, L.G.1    Nilsson, E.2    Ling, C.3
  • 25
    • 41149087641 scopus 로고    scopus 로고
    • Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans
    • Kloting N, Schleinitz D, Ruschke K, et al. Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans. Diabetologia. 2008;51:641-7.
    • (2008) Diabetologia , vol.51 , pp. 641-647
    • Kloting, N.1    Schleinitz, D.2    Ruschke, K.3
  • 26
    • 78651326750 scopus 로고    scopus 로고
    • Association between the FTO rs9939609 polymorphism and leptin in European adolescents: A possible link with energy balance control. The HELENA study
    • Labayen I, Ruiz JR, Ortega FB, et al. Association between the FTO rs9939609 polymorphism and leptin in European adolescents: a possible link with energy balance control. The HELENA study. Int J Obes. 2011;35:66-71.
    • (2011) Int J Obes , vol.35 , pp. 66-71
    • Labayen, I.1    Ruiz, J.R.2    Ortega, F.B.3
  • 27
    • 53849088890 scopus 로고    scopus 로고
    • The fat mass- and obesity-associated locus and dietary intake in children
    • Timpson NJ, Emmett PM, Frayling TM, et al. The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr. 2008;88:971-8.
    • (2008) Am J Clin Nutr , vol.88 , pp. 971-978
    • Timpson, N.J.1    Emmett, P.M.2    Frayling, T.M.3
  • 30
    • 73949129674 scopus 로고    scopus 로고
    • Subcutaneous and visceral adipose tissue FTO gene expression and adiposity, insulin action, glucose metabolism, and inflammatory adipokines in type 2 diabetes mellitus and in health
    • Samaras K, Botelho NK, Chisholm DJ, et al. Subcutaneous and visceral adipose tissue FTO gene expression and adiposity, insulin action, glucose metabolism, and inflammatory adipokines in type 2 diabetes mellitus and in health. Obes Surg. 2010;20:108-13.
    • (2010) Obes Surg , vol.20 , pp. 108-113
    • Samaras, K.1    Botelho, N.K.2    Chisholm, D.J.3
  • 31
    • 84879707663 scopus 로고    scopus 로고
    • Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome
    • Li T,Wu K, You L, et al. Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome. PLoS One. 2013;8:e66250.
    • (2013) PLoS One , vol.8
    • Li, T.1    Wu, K.2    You, L.3
  • 32
    • 84879501187 scopus 로고    scopus 로고
    • Obesity-related genetic variants, human pigmentation, and risk of melanoma
    • Li X, Liang L, Zhang M, et al. Obesity-related genetic variants, human pigmentation, and risk of melanoma. Hum Genet. 2013.
    • (2013) Hum Genet
    • Li, X.1    Liang, L.2    Zhang, M.3
  • 33
    • 84875722359 scopus 로고    scopus 로고
    • A variant in FTO shows association with melanoma risk not due to BMI
    • Iles MM, Law MH, Stacey SN, et al. A variant in FTO shows association with melanoma risk not due to BMI. Nat Genet. 2013;45:428-32, 432e1.
    • (2013) Nat Genet , vol.45
    • Iles, M.M.1    Law, M.H.2    Stacey, S.N.3
  • 34
    • 79953842952 scopus 로고    scopus 로고
    • The role of the fat mass and obesity associated gene (FTO) in breast cancer risk
    • Kaklamani V, Yi N, Sadim M, et al. The role of the fat mass and obesity associated gene (FTO) in breast cancer risk. BMC Med Genet. 2011;12:52.
    • (2011) BMC Med Genet , vol.12 , pp. 52
    • Kaklamani, V.1    Yi, N.2    Sadim, M.3
  • 35
    • 79951574847 scopus 로고    scopus 로고
    • The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women
    • Lurie G, Gaudet MM, Spurdle AB, et al. The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women. PLoS One. 2011;6:e16756.
    • (2011) PLoS One , vol.6
    • Lurie, G.1    Gaudet, M.M.2    Spurdle, A.B.3
  • 36
    • 80655149499 scopus 로고    scopus 로고
    • Association of obesity-related genetic variants with endometrial cancer risk: A report from the Shanghai Endometrial Cancer Genetics Study
    • Delahanty RJ, Beeghly-Fadiel A, Xiang YB, et al. Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study. Am J Epidemiol. 2011;174:1115-26.
    • (2011) Am J Epidemiol , vol.174 , pp. 1115-1126
    • Delahanty, R.J.1    Beeghly-Fadiel, A.2    Xiang, Y.B.3
  • 37
    • 79955752416 scopus 로고    scopus 로고
    • Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer
    • Tang H, Dong X, Hassan M, et al. Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2011;20:779-92.
    • (2011) Cancer Epidemiol Biomarkers Prev , vol.20 , pp. 779-792
    • Tang, H.1    Dong, X.2    Hassan, M.3
  • 38
    • 79956263021 scopus 로고    scopus 로고
    • Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: An analysis of PanScan-I data
    • Pierce BL, Austin MA, Ahsan H. Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data. Cancer Causes Control. 2011;22:877-83.
    • (2011) Cancer Causes Control , vol.22 , pp. 877-883
    • Pierce, B.L.1    Austin, M.A.2    Ahsan, H.3
  • 39
    • 76149126736 scopus 로고    scopus 로고
    • Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study
    • Meyer TE, Boerwinkle E, Morrison AC, et al. Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study. Cancer Epidemiol Biomarkers Prev. 2010;19:558-65.
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 558-565
    • Meyer, T.E.1    Boerwinkle, E.2    Morrison, A.C.3
  • 40
    • 78149419139 scopus 로고    scopus 로고
    • Associations between an obesity related genetic variant (FTO rs9939609) and prostate cancer risk
    • Lewis SJ, Murad A, Chen L, et al. Associations between an obesity related genetic variant (FTO rs9939609) and prostate cancer risk. PLoS One. 2010;5:e13485.
    • (2010) PLoS One , vol.5
    • Lewis, S.J.1    Murad, A.2    Chen, L.3
  • 41
    • 83555173280 scopus 로고    scopus 로고
    • The obesity gene and colorectal cancer risk: A population study in Northern Italy
    • Tarabra E, Actis GC, Fadda M, et al. The obesity gene and colorectal cancer risk: a population study in Northern Italy. Eur J Intern Med. 2012;23:65-9.
    • (2012) Eur J Intern Med , vol.23 , pp. 65-69
    • Tarabra, E.1    Actis, G.C.2    Fadda, M.3
  • 42
    • 79955776932 scopus 로고    scopus 로고
    • FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans
    • Nock NL, Plummer SJ, Thompson CL, et al. FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans. Carcinogenesis. 2011;32:748-56.
    • (2011) Carcinogenesis , vol.32 , pp. 748-756
    • Nock, N.L.1    Plummer, S.J.2    Thompson, C.L.3
  • 43
    • 68849083791 scopus 로고    scopus 로고
    • Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype
    • Brennan P, McKay J, Moore L, et al. Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype. Int J Epidemiol. 2009;38:971-5.
    • (2009) Int J Epidemiol , vol.38 , pp. 971-975
    • Brennan, P.1    McKay, J.2    Moore, L.3
  • 44
    • 85027951288 scopus 로고    scopus 로고
    • Association between FTO gene polymorphism and cancer risk: Evidence from 16,277 cases and 31, 153 controls
    • Li GQ, Chen QW, Wang L, et al. Association between FTO gene polymorphism and cancer risk: evidence from 16,277 cases and 31, 153 controls. Tumor Biol. 2012;33:1237-43.
    • (2012) Tumor Biol , vol.33 , pp. 1237-1243
    • Li, G.Q.1    Chen, Q.W.2    Wang, L.3
  • 45
    • 77952340870 scopus 로고    scopus 로고
    • A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    • Ho AJ, Stein JL, Hua X, et al. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A. 2010;107:8404-9.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 8404-8409
    • Ho, A.J.1    Stein, J.L.2    Hua, X.3
  • 46
    • 79951867607 scopus 로고    scopus 로고
    • The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: A prospective cohort study
    • Keller L, Xu W, Wang HX, et al. The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study. J Alzheimers Dis. 2011;23:461-9.
    • (2011) J Alzheimers Dis , vol.23 , pp. 461-469
    • Keller, L.1    Xu, W.2    Wang, H.X.3
  • 47
    • 67349211789 scopus 로고    scopus 로고
    • Inactivation of the FTO gene protects from obesity
    • Fischer J, Koch L, Emmerling C, et al. Inactivation of the FTO gene protects from obesity. Nature. 2009;458:894-8.
    • (2009) Nature , vol.458 , pp. 894-898
    • Fischer, J.1    Koch, L.2    Emmerling, C.3
  • 48
    • 84883169345 scopus 로고    scopus 로고
    • FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes
    • Tews D, Fischer-Posovszky P, Fromme T, et al. FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes. Endocrinology. 2013.
    • (2013) Endocrinology
    • Tews, D.1    Fischer-Posovszky, P.2    Fromme, T.3
  • 49
    • 78649512744 scopus 로고    scopus 로고
    • The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice
    • Gao X, Shin YH, Li M, et al. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One. 2010;5:e14005.
    • (2010) PLoS One , vol.5
    • Gao, X.1    Shin, Y.H.2    Li, M.3
  • 50
    • 70149100469 scopus 로고    scopus 로고
    • A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene
    • Church C, Lee S, Bagg EA, et al. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet. 2009;5:e1000599.
    • (2009) PLoS Genet , vol.5
    • Church, C.1    Lee, S.2    Bagg, E.A.3
  • 51
    • 78649459183 scopus 로고    scopus 로고
    • Overexpression of FTO leads to increased food intake and results in obesity
    • Church C, Moir L, McMurray F, et al. Overexpression of FTO leads to increased food intake and results in obesity. Nat Genet. 2010;42:1086-92.
    • (2010) Nat Genet , vol.42 , pp. 1086-1092
    • Church, C.1    Moir, L.2    McMurray, F.3
  • 52
    • 84873520661 scopus 로고    scopus 로고
    • Adult onset global loss of the FTO gene alters body composition and metabolism in the mouse
    • McMurray F, Church CD, Larder R, et al. Adult onset global loss of the FTO gene alters body composition and metabolism in the mouse. PLoS Genet. 2013;9:e1003166.
    • (2013) PLoS Genet , vol.9
    • McMurray, F.1    Church, C.D.2    Larder, R.3
  • 53
    • 84880916638 scopus 로고    scopus 로고
    • The fat mass and obesity associated gene (FTO) regulates activity of the dopaminergic midbrain circuitry
    • These authors reported, for the first time, that FTO regulates the demethylation of specific mRNAs in vivo and dopaminergic transmission activity
    • •• Hess ME, Hess S, Meyer KD, et al. The fat mass and obesity associated gene (FTO) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci. 2013;16:1042-8. These authors reported, for the first time, that FTO regulates the demethylation of specific mRNAs in vivo and dopaminergic transmission activity.
    • (2013) Nat Neurosci , vol.16 , pp. 1042-1048
    • Hess, M.E.1    Hess, S.2    Meyer, K.D.3
  • 54
    • 77951666149 scopus 로고    scopus 로고
    • Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
    • Johnson PM, Kenny PJ. Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci. 2010;13:635-41.
    • (2010) Nat Neurosci , vol.13 , pp. 635-641
    • Johnson, P.M.1    Kenny, P.J.2
  • 56
    • 77958150921 scopus 로고    scopus 로고
    • The obesity-associated FTO gene is a transcriptional co-activator
    • Wu Q, Saunders RA, Szkudlarek-Mikho M, et al. The obesity-associated FTO gene is a transcriptional co-activator. Biochem Biophys Res Commun. 2010;401:390-5.
    • (2010) Biochem Biophys Res Commun , vol.401 , pp. 390-395
    • Wu, Q.1    Saunders, R.A.2    Szkudlarek-Mikho, M.3
  • 57
    • 77955261951 scopus 로고    scopus 로고
    • Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: Correlations with age or BMI of islet donors
    • Kirkpatrick CL, Marchetti P, Purrello F, et al. Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors. PLoS One. 2010;5:e11053.
    • (2010) PLoS One , vol.5
    • Kirkpatrick, C.L.1    Marchetti, P.2    Purrello, F.3
  • 58
    • 77957277779 scopus 로고    scopus 로고
    • Relationship between blood glucose levels and hepatic FTO mRNA expression in mice
    • Poritsanos NJ, Lew PS, Mizuno TM. Relationship between blood glucose levels and hepatic FTO mRNA expression in mice. Biochem Biophys Res Commun. 2010;400:713-7.
    • (2010) Biochem Biophys Res Commun , vol.400 , pp. 713-717
    • Poritsanos, N.J.1    Lew, P.S.2    Mizuno, T.M.3
  • 59
    • 84874113202 scopus 로고    scopus 로고
    • FTO levels affect RNA modification and the transcriptome
    • Berulava T, Ziehe M, Klein-Hitpass L, et al. FTO levels affect RNA modification and the transcriptome. Eur J Hum Genet. 2012;21:317-23.
    • (2012) Eur J Hum Genet , vol.21 , pp. 317-323
    • Berulava, T.1    Ziehe, M.2    Klein-Hitpass, L.3
  • 60
    • 77649303960 scopus 로고    scopus 로고
    • Hypothalamic-specific manipulation of FTO, the ortholog of the human obesity gene FTO, affects food intake in rats
    • Tung YC, Ayuso E, Shan X, et al. Hypothalamic-specific manipulation of FTO, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One. 2010;5:e8771.
    • (2010) PLoS One , vol.5
    • Tung, Y.C.1    Ayuso, E.2    Shan, X.3
  • 61
    • 82355194591 scopus 로고    scopus 로고
    • FTO is expressed in neurons throughout the brain and its expression is unaltered by fasting
    • McTaggart JS, Lee S, Iberl M, et al. FTO is expressed in neurons throughout the brain and its expression is unaltered by fasting. PLoS One. 2011;6:e27968.
    • (2011) PLoS One , vol.6
    • McTaggart, J.S.1    Lee, S.2    Iberl, M.3
  • 62
    • 84877577199 scopus 로고    scopus 로고
    • FTO expression is regulated by availability of essential amino acids
    • Cheung MK, Gulati P, O'Rahilly S, et al. FTO expression is regulated by availability of essential amino acids. Int J Obes. 2013;37:744-7.
    • (2013) Int J Obes , vol.37 , pp. 744-747
    • Cheung, M.K.1    Gulati, P.2    O'Rahilly, S.3
  • 63
    • 84873735640 scopus 로고    scopus 로고
    • Role for the obesity-related FTO gene in the cellular sensing of amino acids
    • Gulati P, Cheung MK, Antrobus R, et al. Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc Natl Acad Sci U S A. 2013;110:2557-62.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 2557-2562
    • Gulati, P.1    Cheung, M.K.2    Antrobus, R.3
  • 64
    • 79957945033 scopus 로고    scopus 로고
    • Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction
    • Wang P, Yang FJ, Du H, et al. Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction. Mol Med. 2011;17:523-32.
    • (2011) Mol Med , vol.17 , pp. 523-532
    • Wang, P.1    Yang, F.J.2    Du, H.3
  • 65
    • 81055124147 scopus 로고    scopus 로고
    • Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway
    • Rask-Andersen M, Almen MS, Olausen HR, et al. Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway. BMC Neurosci. 2011;12:117.
    • (2011) BMC Neurosci , vol.12 , pp. 117
    • Rask-Andersen, M.1    Almen, M.S.2    Olausen, H.R.3
  • 66
    • 84877091458 scopus 로고    scopus 로고
    • Fasting induced cytoplasmic FTO expression in some neurons of rat hypothalamus
    • Vujovic P, Stamenkovic S, Jasnic N, et al. Fasting induced cytoplasmic FTO expression in some neurons of rat hypothalamus. PLoS One. 2013;8:e63694.
    • (2013) PLoS One , vol.8
    • Vujovic, P.1    Stamenkovic, S.2    Jasnic, N.3
  • 67
    • 81355146483 scopus 로고    scopus 로고
    • N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
    • This finding unveiled the physiological RNA modification substrate, m6A, of FTO in vivo and in vitro for the first time
    • •• Jia GF, Fu Y, Zhao X, et al. N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chem Biol. 2011;7:885-7. This finding unveiled the physiological RNA modification substrate, m6A, of FTO in vivo and in vitro for the first time.
    • (2011) Nature Chem Biol , vol.7 , pp. 885-887
    • Jia, G.F.1    Fu, Y.2    Zhao, X.3
  • 69
    • 54849381000 scopus 로고    scopus 로고
    • Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO
    • Jia G, Yang CG, Yang S, et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 2008;582:3313-9.
    • (2008) FEBS Lett , vol.582 , pp. 3313-3319
    • Jia, G.1    Yang, C.G.2    Yang, S.3
  • 70
    • 77951623073 scopus 로고    scopus 로고
    • Crystal structure of the FTO protein reveals basis for its substrate specificity
    • Han Z, Niu T, Chang J, et al. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature. 2010;464:1205-9.
    • (2010) Nature , vol.464 , pp. 1205-1209
    • Han, Z.1    Niu, T.2    Chang, J.3
  • 71
    • 84862649489 scopus 로고    scopus 로고
    • Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons
    • It is one of the 2 papers describing the genome-wide distribution of m6A sites in mRNAs. It further shows that m6A sites are enriched near stop codons and in 3′ UTRs
    • •• Meyer KD, Saletore Y, Zumbo P, et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons. Cell. 2012;149:1635-46. It is one of the 2 papers describing the genome-wide distribution of m6A sites in mRNAs. It further shows that m6A sites are enriched near stop codons and in 3′ UTRs.
    • (2012) Cell , vol.149 , pp. 1635-1646
    • Meyer, K.D.1    Saletore, Y.2    Zumbo, P.3
  • 72
    • 85027958937 scopus 로고    scopus 로고
    • The birth of the Epitranscriptome: Deciphering the function of RNA modifications
    • Saletore Y, Meyer K, Korlach J, et al. The birth of the Epitranscriptome: deciphering the function of RNA modifications. Genome Biol. 2012;13:175.
    • (2012) Genome Biol , vol.13 , pp. 175
    • Saletore, Y.1    Meyer, K.2    Korlach, J.3
  • 73
    • 84894599601 scopus 로고    scopus 로고
    • Sprouts of RNA epigenetics: The discovery of mammalian RNA demethylases
    • Zheng G, Dahl JA, Niu Y, et al. Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases. RNA Biol. 2013;10.
    • (2013) RNA Biol , vol.10
    • Zheng, G.1    Dahl, J.A.2    Niu, Y.3
  • 74
    • 84875530060 scopus 로고    scopus 로고
    • N6-methyl-adenosine modification in messenger and long non-coding RNA
    • Pan T. N6-methyl-adenosine modification in messenger and long non-coding RNA. Trends Biochem Sci. 2013;38:204-9.
    • (2013) Trends Biochem Sci , vol.38 , pp. 204-209
    • Pan, T.1
  • 76
    • 84872847340 scopus 로고    scopus 로고
    • Reversible RNA adenosine methylation in biological regulation
    • Jia G, Fu Y, He C. Reversible RNA adenosine methylation in biological regulation. Trends Genet. 2013;29:108-15.
    • (2013) Trends Genet , vol.29 , pp. 108-115
    • Jia, G.1    Fu, Y.2    He, C.3
  • 77
    • 84872268888 scopus 로고    scopus 로고
    • Nucleic acid modifications with epigenetic significance
    • Fu Y, He C. Nucleic acid modifications with epigenetic significance. Curr Opin Chem Biol. 2012;16:516-24.
    • (2012) Curr Opin Chem Biol , vol.16 , pp. 516-524
    • Fu, Y.1    He, C.2
  • 78
    • 84877750692 scopus 로고    scopus 로고
    • 6-formyladenosine in mammalian RNA
    • The authors uncovered new intermediate modifications in the demethylation process from m6A to A by FTO
    • 6-formyladenosine in mammalian RNA. Nat Commun. 2013;4:1798. The authors uncovered new intermediate modifications in the demethylation process from m6A to A by FTO.
    • (2013) Nat Commun , vol.4 , pp. 1798
    • Fu, Y.1    Jia, G.F.2    Pang, X.Q.3
  • 79
    • 0016770156 scopus 로고
    • Methylated nucleotides block 5′ terminus of HeLa cell messenger RNA
    • Wei CM, Gershowitz A, Moss B. Methylated nucleotides block 5′ terminus of HeLa cell messenger RNA. Cell. 1975;4:379-86.
    • (1975) Cell , vol.4 , pp. 379-386
    • Wei, C.M.1    Gershowitz, A.2    Moss, B.3
  • 80
    • 0016809932 scopus 로고
    • The methylated constituents of L cell messenger RNA: Evidence for an unusual cluster at the 5′ terminus
    • Perry RP, Kelley DE, Friderici K, et al. The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5′ terminus. Cell. 1975;4:387-94.
    • (1975) Cell , vol.4 , pp. 387-394
    • Perry, R.P.1    Kelley, D.E.2    Friderici, K.3
  • 81
    • 0016751899 scopus 로고
    • Characterization of Novikoff hepatoma mRNA methylation and heterogeneity in the methylated 5′ terminus
    • Desrosiers RC, Friderici KH, Rottman FM. Characterization of Novikoff hepatoma mRNA methylation and heterogeneity in the methylated 5′ terminus. Biochemistry. 1975;14:4367-74.
    • (1975) Biochemistry , vol.14 , pp. 4367-4374
    • Desrosiers, R.C.1    Friderici, K.H.2    Rottman, F.M.3
  • 82
    • 84860779086 scopus 로고    scopus 로고
    • 6A-seq
    • This is the first report on the landscape of m6A in mRNAs through an antibody-based genome-wide sequencing method
    • 6A-seq. Nature. 2012;485:201-6. This is the first report on the landscape of m6A in mRNAs through an antibody-based genome-wide sequencing method.
    • (2012) Nature , vol.485 , pp. 201-206
    • Dominissini, D.1    Moshitch-Moshkovitz, S.2    Schwartz, S.3
  • 83
    • 84890120542 scopus 로고    scopus 로고
    • The biology of FTO: From nucleic acid demethylase to amino acid sensor
    • Gulati P, Yeo GS. The biology of FTO: from nucleic acid demethylase to amino acid sensor. Diabetologia. 2013.
    • (2013) Diabetologia
    • Gulati, P.1    Yeo, G.S.2
  • 84
    • 0030712151 scopus 로고    scopus 로고
    • 6-adenosine)-methyltransferase
    • Bokar JA, Shambaugh ME, Polayes D, et al. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)- methyltransferase. RNA. 1997;3:1233-47. (Pubitemid 27495096)
    • (1997) RNA , vol.3 , Issue.11 , pp. 1233-1247
    • Bokar, J.A.1    Shambaugh, M.E.2    Polayes, D.3    Matera, A.G.4    Rottman, F.M.5
  • 85
    • 84872274463 scopus 로고    scopus 로고
    • ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
    • Zheng G, Dahl JA, Niu Y, et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013;49:18-29.
    • (2013) Mol Cell , vol.49 , pp. 18-29
    • Zheng, G.1    Dahl, J.A.2    Niu, Y.3
  • 86
    • 84897110592 scopus 로고    scopus 로고
    • A METTL3-METTL14 complex mediates mammalian nuclear RNA N-adenosine methylation
    • Liu J, Yue Y, Han D, et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N-adenosine methylation. Nat Chem Biol. 2013;10:93-5.
    • (2013) Nat Chem Biol , vol.10 , pp. 93-95
    • Liu, J.1    Yue, Y.2    Han, D.3
  • 87
    • 84893746230 scopus 로고    scopus 로고
    • Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
    • Ping XL, Sun BF, Wang L, et al. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res. 2014;24:177-89.
    • (2014) Cell Res , vol.24 , pp. 177-189
    • Ping, X.L.1    Sun, B.F.2    Wang, L.3
  • 88
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • DOI 10.1038/nature02625
    • Egger G, Liang G, Aparicio A, et al. Epigenetics in human disease and prospects for epigenetic therapy. Nature. 2004;429:457-63. (Pubitemid 38715140)
    • (2004) Nature , vol.429 , Issue.6990 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 89
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol. 2010;28:1057-68.
    • (2010) Nat Biotechnol , vol.28 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 90
    • 84861997955 scopus 로고    scopus 로고
    • The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
    • Baltz AG, Munschauer M, Schwanhausser B, et al. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol Cell. 2012;46:674-90.
    • (2012) Mol Cell , vol.46 , pp. 674-690
    • Baltz, A.G.1    Munschauer, M.2    Schwanhausser, B.3
  • 91
    • 84875649230 scopus 로고    scopus 로고
    • Analysis of RNA base modification and structural rearrangement by single-molecule real-time detection of reverse transcription
    • Vilfan ID, Tsai YC, Clark TA, et al. Analysis of RNA base modification and structural rearrangement by single-molecule real-time detection of reverse transcription. J Nanobiotechnology. 2013;11:8.
    • (2013) J Nanobiotechnology , vol.11 , pp. 8
    • Vilfan, I.D.1    Tsai, Y.C.2    Clark, T.A.3
  • 92
    • 84872450066 scopus 로고    scopus 로고
    • Enhanced 5-methylcytosine detection in single-molecule, real-time sequencing via Tet1 oxidation
    • Clark TA, Lu X, Luong K, et al. Enhanced 5-methylcytosine detection in single-molecule, real-time sequencing via Tet1 oxidation. BMC Biol. 2013;11:4.
    • (2013) BMC Biol , vol.11 , pp. 4
    • Clark, T.A.1    Lu, X.2    Luong, K.3
  • 93
    • 84856453032 scopus 로고    scopus 로고
    • Sensitive and specific single-molecule sequencing of 5- hydroxymethylcytosine
    • Song CX, Clark TA, Lu XY, et al. Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine. Nat Methods. 2012;9:75-7.
    • (2012) Nat Methods , vol.9 , pp. 75-77
    • Song, C.X.1    Clark, T.A.2    Lu, X.Y.3
  • 94
    • 84868130511 scopus 로고    scopus 로고
    • Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor
    • Chen B, Ye F, Yu L, et al. Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor. J Am Chem Soc. 2012;134:17963-71.
    • (2012) J Am Chem Soc , vol.134 , pp. 17963-17971
    • Chen, B.1    Ye, F.2    Yu, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.