메뉴 건너뛰기




Volumn 15, Issue 5, 2014, Pages 313-326

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

Author keywords

[No Author keywords available]

Indexed keywords

6 N METHYLADENOSINE; MESSENGER RNA; METHYLTRANSFERASE; POLYADENYLATED RNA; RIBOSOME RNA; TRANSCRIPTOME; ADENOSINE; ALKBH5 PROTEIN, HUMAN; DIOXYGENASE; DRUG DERIVATIVE; FTO PROTEIN, HUMAN; MEMBRANE PROTEIN; METTL3 PROTEIN, HUMAN; N(6) METHYLADENOSINE; N(6)-METHYLADENOSINE; PROTEIN;

EID: 84899586607     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm3785     Document Type: Review
Times cited : (816)

References (123)
  • 1
    • 0026747761 scopus 로고
    • Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA
    • Lewis, J. D. et al. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 69, 905-914 (1992).
    • (1992) Cell , vol.69 , pp. 905-914
    • Lewis, J.D.1
  • 2
    • 20444383859 scopus 로고    scopus 로고
    • Protein phosphorylation in signaling - 50 years and counting
    • Pawson, T. & Scott, J. D. Protein phosphorylation in signaling - 50 years and counting. Trends Biochem. Sci. 30, 286-290 (2005).
    • (2005) Trends Biochem. Sci. , vol.30 , pp. 286-290
    • Pawson, T.1    Scott, J.D.2
  • 3
    • 84862649489 scopus 로고    scopus 로고
    • Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons
    • Meyer, K. D. et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons. Cell 149, 1635-1646 (2012).
    • (2012) Cell , vol.149 , pp. 1635-1646
    • Meyer, K.D.1
  • 5
    • 81355146483 scopus 로고    scopus 로고
    • 6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
    • 6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chem. Biol. 7, 885-887 (2011).
    • (2011) Nature Chem. Biol. , vol.7 , pp. 885-887
    • Jia, G.1
  • 6
    • 84872274463 scopus 로고    scopus 로고
    • ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
    • Zheng, G. et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol. Cell 49, 18-29 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 18-29
    • Zheng, G.1
  • 7
    • 0016373910 scopus 로고
    • Existence of methylated messenger RNA in mouse L cells
    • Perry, R. P. & Kelley, D. E. Existence of methylated messenger RNA in mouse L cells. Cell 1, 37-42 (1974).
    • (1974) Cell , vol.1 , pp. 37-42
    • Perry, R.P.1    Kelley, D.E.2
  • 8
    • 0016285746 scopus 로고
    • Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells
    • Desrosiers, R., Friderici, K. & Rottman, F. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc. Natl Acad. Sci. USA 71, 3971-3975 (1974).
    • (1974) Proc. Natl Acad. Sci. USA , vol.71 , pp. 3971-3975
    • Desrosiers, R.1    Friderici, K.2    Rottman, F.3
  • 9
    • 0016692308 scopus 로고
    • Methylated simian virus 40-specific RNA from nuclei and cytoplasm of infected BSC-1 cells
    • Lavi, S. & Shatkin, A. J. Methylated simian virus 40-specific RNA from nuclei and cytoplasm of infected BSC-1 cells. Proc. Natl Acad. Sci. USA 72, 2012-2016 (1975).
    • (1975) Proc. Natl Acad. Sci. USA , vol.72 , pp. 2012-2016
    • Lavi, S.1    Shatkin, A.J.2
  • 10
    • 0016432834 scopus 로고
    • Methylated nucleotides block 5′-terminus of vaccinia virus messenger RNA
    • Wei, C. M. & Moss, B. Methylated nucleotides block 5′-terminus of vaccinia virus messenger RNA. Proc. Natl Acad. Sci. USA 72, 318-322 (1975).
    • (1975) Proc. Natl Acad. Sci. USA , vol.72 , pp. 318-322
    • Wei, C.M.1    Moss, B.2
  • 11
    • 0042942531 scopus 로고
    • Methylated, blocked 5 termini in HeLa cell mRNA
    • Furuichi, Y. et al. Methylated, blocked 5 termini in HeLa cell mRNA. Proc. Natl Acad. Sci. USA 72, 1904-1908 (1975).
    • (1975) Proc. Natl Acad. Sci. USA , vol.72 , pp. 1904-1908
    • Furuichi, Y.1
  • 12
    • 0016793057 scopus 로고
    • Modified nucleosides and bizarre 5′-termini in mouse myeloma mRNA
    • Adams, J. M. & Cory, S. Modified nucleosides and bizarre 5′-termini in mouse myeloma mRNA. Nature 255, 28-33 (1975).
    • (1975) Nature , vol.255 , pp. 28-33
    • Adams, J.M.1    Cory, S.2
  • 13
    • 0016712078 scopus 로고
    • The methylation state of poly A-containing messenger RNA from cultured hamster cells
    • Dubin, D. T. & Taylor, R. H. The methylation state of poly A-containing messenger RNA from cultured hamster cells. Nucleic Acids Res. 2, 1653-1668 (1975).
    • (1975) Nucleic Acids Res. , vol.2 , pp. 1653-1668
    • Dubin, D.T.1    Taylor, R.H.2
  • 14
    • 0016592074 scopus 로고
    • 2'-dimethyladenosine a novel methylated ribonucleoside next to the 5′ terminal of animal cell and virus mRNAs
    • 2'-dimethyladenosine a novel methylated ribonucleoside next to the 5′ terminal of animal cell and virus mRNAs. Nature 257, 251-253 (1975).
    • (1975) Nature , vol.257 , pp. 251-253
    • Wei, C.1    Gershowitz, A.2    Moss, B.3
  • 15
    • 0016823567 scopus 로고
    • Biosynthetic pathway of ribothymidine in B. Subtilis and M. Lysodeikticus involving different coenzymes for transfer RNA and ribosomal RNA
    • Schmidt, W., Arnold, H. H. & Kersten, H. Biosynthetic pathway of ribothymidine in B. subtilis and M. lysodeikticus involving different coenzymes for transfer RNA and ribosomal RNA. Nucleic Acids Res. 2, 1043-1051 (1975).
    • (1975) Nucleic Acids Res. , vol.2 , pp. 1043-1051
    • Schmidt, W.1    Arnold, H.H.2    Kersten, H.3
  • 16
    • 0016724732 scopus 로고
    • Systematic difference in the methylation of ribosomal ribonucleic acid from gram-positive and gram-negative bacteria
    • Tanaka, T. & Weisblum, B. Systematic difference in the methylation of ribosomal ribonucleic acid from gram-positive and gram-negative bacteria. J. Bacteriol. 123, 771-774 (1975).
    • (1975) J. Bacteriol. , vol.123 , pp. 771-774
    • Tanaka, T.1    Weisblum, B.2
  • 18
    • 0019332910 scopus 로고
    • The nucleotide sequence of nuclear U6 (4.7 S) RNA
    • Epstein, P., Reddy, R., Henning, D. & Busch, H. The nucleotide sequence of nuclear U6 (4.7 S) RNA. J. Biol. Chem. 255, 8901-8906 (1980).
    • (1980) J. Biol. Chem. , vol.255 , pp. 8901-8906
    • Epstein, P.1    Reddy, R.2    Henning, D.3    Busch, H.4
  • 19
    • 0019324355 scopus 로고
    • The nucleotide sequence of nuclear 4.8S RNA of mouse cells
    • Harada, F., Kato, N. & Nishimura, S. The nucleotide sequence of nuclear 4.8S RNA of mouse cells. Biochem. Biophys. Res. Commun. 95, 1332-1340 (1980).
    • (1980) Biochem. Biophys. Res. Commun. , vol.95 , pp. 1332-1340
    • Harada, F.1    Kato, N.2    Nishimura, S.3
  • 20
    • 0017350708 scopus 로고
    • Sequence specificity of internal methylation in B77 avian sarcoma virus RNA subunits
    • Dimock, K. & Stoltzfus, C. M. Sequence specificity of internal methylation in B77 avian sarcoma virus RNA subunits. Biochemistry 16, 471-478 (1977).
    • (1977) Biochemistry , vol.16 , pp. 471-478
    • Dimock, K.1    Stoltzfus, C.M.2
  • 21
    • 0017622044 scopus 로고
    • 6-methyladenosine in the Rous sarcoma virus genome
    • 6-methyladenosine in the Rous sarcoma virus genome. J. Mol. Biol. 113, 165-179 (1977).
    • (1977) J. Mol. Biol. , vol.113 , pp. 165-179
    • Beemon, K.1    Keith, J.2
  • 22
    • 0016751654 scopus 로고
    • Blocked, methylated 5′-terminal sequence in avian sarcoma virus RNA
    • Furuichi, Y., Shatkin, A. J., Stavnezer, E. & Bishop, J. M. Blocked, methylated 5′-terminal sequence in avian sarcoma virus RNA. Nature 257, 618-620 (1975).
    • (1975) Nature , vol.257 , pp. 618-620
    • Furuichi, Y.1    Shatkin, A.J.2    Stavnezer, E.3    Bishop, J.M.4
  • 23
    • 0017251640 scopus 로고
    • The methylation of adenovirus-specific nuclear and cytoplasmic RNA
    • Sommer, S. et al. The methylation of adenovirus-specific nuclear and cytoplasmic RNA. Nucleic Acids Res. 3, 749-765 (1976).
    • (1976) Nucleic Acids Res. , vol.3 , pp. 749-765
    • Sommer, S.1
  • 25
    • 0016809932 scopus 로고
    • The methylated constituents of L cell messenger RNA: Evidence for an unusual cluster at the 5' terminus
    • Perry, R. P., Kelley, D. E., Friderici, K. & Rottman, F. The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminus. Cell 4, 387-394 (1975).
    • (1975) Cell , vol.4 , pp. 387-394
    • Perry, R.P.1    Kelley, D.E.2    Friderici, K.3    Rottman, F.4
  • 26
    • 0018198062 scopus 로고
    • Modified nucleotides in T1 RNase oligonucleotides of 18S ribosomal RNA of the Novikoff hepatoma
    • Choi, Y. C. & Busch, H. Modified nucleotides in T1 RNase oligonucleotides of 18S ribosomal RNA of the Novikoff hepatoma. Biochemistry 17, 2551-2560 (1978).
    • (1978) Biochemistry , vol.17 , pp. 2551-2560
    • Choi, Y.C.1    Busch, H.2
  • 27
    • 0023662810 scopus 로고
    • 6-methyladenosine react with intact snRNPs U2 and U4/U6
    • 6-methyladenosine react with intact snRNPs U2 and U4/U6. FEBS Lett. 213, 309-315 (1987).
    • (1987) FEBS Lett. , vol.213 , pp. 309-315
    • Bringmann, P.1    Luhrmann, R.2
  • 28
    • 0029061729 scopus 로고
    • Accurate and efficient N-6-adenosine methylation in spliceosomal U6 small nuclear RNA by HeLa cell extract in vitro
    • Shimba, S., Bokar, J. A., Rottman, F. & Reddy, R. Accurate and efficient N-6-adenosine methylation in spliceosomal U6 small nuclear RNA by HeLa cell extract in vitro. Nucleic Acids Res. 23, 2421-2426 (1995).
    • (1995) Nucleic Acids Res. , vol.23 , pp. 2421-2426
    • Shimba, S.1    Bokar, J.A.2    Rottman, F.3    Reddy, R.4
  • 29
    • 0015582818 scopus 로고
    • Mitochondrial protein synthesis: RNA with the properties of eukaryotic messenger RNA
    • Perlman, S., Abelson, H. T. & Penman, S. Mitochondrial protein synthesis: RNA with the properties of eukaryotic messenger RNA. Proc. Natl Acad. Sci. USA 70, 350-353 (1973).
    • (1973) Proc. Natl Acad. Sci. USA , vol.70 , pp. 350-353
    • Perlman, S.1    Abelson, H.T.2    Penman, S.3
  • 30
    • 41549094036 scopus 로고    scopus 로고
    • Polyadenylation in mammalian mitochondria: Insights from recent studies
    • Nagaike, T., Suzuki, T. & Ueda, T. Polyadenylation in mammalian mitochondria: insights from recent studies. Biochim. Biophys. Acta 1779, 266-269 (2008).
    • (2008) Biochim. Biophys. Acta , vol.1779 , pp. 266-269
    • Nagaike, T.1    Suzuki, T.2    Ueda, T.3
  • 32
    • 0017257102 scopus 로고
    • Methyl labeling of HeLa cell hnRNA: A comparison with mRNA
    • Salditt-Georgieff, M. et al. Methyl labeling of HeLa cell hnRNA: a comparison with mRNA. Cell 7, 227-237 (1976).
    • (1976) Cell , vol.7 , pp. 227-237
    • Salditt-Georgieff, M.1
  • 33
    • 0142104045 scopus 로고    scopus 로고
    • Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
    • Okazaki, Y. et al. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature 420, 563-573 (2002).
    • (2002) Nature , vol.420 , pp. 563-573
    • Okazaki, Y.1
  • 34
    • 0038688072 scopus 로고    scopus 로고
    • Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection
    • Numata, K. et al. Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection. Genome Res. 13, 1301-1306 (2003).
    • (2003) Genome Res. , vol.13 , pp. 1301-1306
    • Numata, K.1
  • 35
    • 30044434769 scopus 로고    scopus 로고
    • Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome
    • Ravasi, T. et al. Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Res. 16, 11-19 (2006).
    • (2006) Genome Res. , vol.16 , pp. 11-19
    • Ravasi, T.1
  • 36
    • 70449953975 scopus 로고    scopus 로고
    • The complex eukaryotic transcriptome: Unexpected pervasive transcription and novel small RNAs
    • Jacquier, A. The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs. Nature Rev. Genet. 10, 833-844 (2009).
    • (2009) Nature Rev. Genet. , vol.10 , pp. 833-844
    • Jacquier, A.1
  • 38
    • 0023644594 scopus 로고
    • 6-methyladenosine sites caused by GAC to GAU mutations
    • 6-methyladenosine sites caused by GAC to GAU mutations. J. Biol. Chem. 262, 3422-3427 (1987).
    • (1987) J. Biol. Chem. , vol.262 , pp. 3422-3427
    • Kane, S.E.1    Beemon, K.2
  • 39
    • 0021890204 scopus 로고
    • 6A in Rous sarcoma virus RNA reveals clustering of methylation sites: Implications for RNA processing
    • 6A in Rous sarcoma virus RNA reveals clustering of methylation sites: implications for RNA processing. Mol. Cell. Biol. 5, 2298-2306 (1985).
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 2298-2306
    • Kane, S.E.1    Beemon, K.2
  • 40
    • 0025193111 scopus 로고
    • 6-methyladenosine residues in an intron-specific region of prolactin pre-mRNA
    • 6- methyladenosine residues in an intron-specific region of prolactin pre-mRNA. Mol. Cell. Biol. 10, 4456-4465 (1990).
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 4456-4465
    • Carroll, S.M.1    Narayan, P.2    Rottman, F.M.3
  • 42
    • 84880916638 scopus 로고    scopus 로고
    • The fat mass and obesity associated gene (FTO) regulates activity of the dopaminergic midbrain circuitry
    • Hess, M. E. et al. The fat mass and obesity associated gene (FTO) regulates activity of the dopaminergic midbrain circuitry. Nature Neurosci. 16, 1042-1048 (2013).
    • (2013) Nature Neurosci , vol.16 , pp. 1042-1048
    • Hess, M.E.1
  • 43
    • 85027958937 scopus 로고    scopus 로고
    • The birth of the epitranscriptome: Deciphering the function of RNA modifications
    • Saletore, Y. et al. The birth of the epitranscriptome: deciphering the function of RNA modifications. Genome Biol. 13, 175 (2012).
    • (2012) Genome Biol. , vol.13 , pp. 175
    • Saletore, Y.1
  • 44
    • 34250805982 scopus 로고    scopus 로고
    • MicroRNA targeting specificity in mammals: Determinants beyond seed pairing
    • Grimson, A. et al. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol. Cell 27, 91-105 (2007).
    • (2007) Mol. Cell , vol.27 , pp. 91-105
    • Grimson, A.1
  • 45
    • 84861997955 scopus 로고    scopus 로고
    • The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
    • Baltz, A. G. et al. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46, 674-690 (2012).
    • (2012) Mol. Cell , vol.46 , pp. 674-690
    • Baltz, A.G.1
  • 46
    • 84861121932 scopus 로고    scopus 로고
    • Global analysis of RNA secondary structure in two metazoans
    • Li, F. et al. Global analysis of RNA secondary structure in two metazoans. Cell Rep. 1, 69-82 (2012).
    • (2012) Cell Rep. , vol.1 , pp. 69-82
    • Li, F.1
  • 47
    • 35348955882 scopus 로고    scopus 로고
    • A universal framework for regulatory element discovery across all genomes and data types
    • Elemento, O., Slonim, N. & Tavazoie, S. A universal framework for regulatory element discovery across all genomes and data types. Mol. Cell 28, 337-350 (2007).
    • (2007) Mol. Cell , vol.28 , pp. 337-350
    • Elemento, O.1    Slonim, N.2    Tavazoie, S.3
  • 48
    • 0017296194 scopus 로고
    • 5′-terminal and internal methylated nucleotide sequences in HeLa cell mRNA
    • Wei, C. M., Gershowitz, A. & Moss, B. 5′-terminal and internal methylated nucleotide sequences in HeLa cell mRNA. Biochemistry 15, 397-401 (1976).
    • (1976) Biochemistry , vol.15 , pp. 397-401
    • Wei, C.M.1    Gershowitz, A.2    Moss, B.3
  • 49
    • 0017367836 scopus 로고
    • 6-methyladenosine sites of HeLa cell messenger ribonucleic acid
    • 6-methyladenosine sites of HeLa cell messenger ribonucleic acid. Biochemistry 16, 1672-1676 (1977).
    • (1977) Biochemistry , vol.16 , pp. 1672-1676
    • Wei, C.M.1    Moss, B.2
  • 50
    • 0017708804 scopus 로고
    • Comparison of methylated sequences in messenger RNA and heterogeneous nuclear RNA from mouse L cells
    • Schibler, U., Kelley, D. E. & Perry, R. P. Comparison of methylated sequences in messenger RNA and heterogeneous nuclear RNA from mouse L cells. J. Mol. Biol. 115, 695-714 (1977).
    • (1977) J. Mol. Biol. , vol.115 , pp. 695-714
    • Schibler, U.1    Kelley, D.E.2    Perry, R.P.3
  • 53
    • 27644589675 scopus 로고    scopus 로고
    • The diverse functions of histone lysine methylation
    • Martin, C. & Zhang, Y. The diverse functions of histone lysine methylation. Nature Rev. Mol. Cell Biol. 6, 838-849 (2005).
    • (2005) Nature Rev. Mol. Cell Biol. , vol.6 , pp. 838-849
    • Martin, C.1    Zhang, Y.2
  • 57
    • 57749089784 scopus 로고    scopus 로고
    • MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor
    • Zhong, S. et al. MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor. Plant Cell 20, 1278-1288 (2008).
    • (2008) Plant Cell , vol.20 , pp. 1278-1288
    • Zhong, S.1
  • 59
    • 80052601644 scopus 로고    scopus 로고
    • Drosophila inducer of meiosis 4 (IME4) is required for Notch signaling during oogenesis
    • Hongay, C. F. & Orr-Weaver, T. L. Drosophila inducer of meiosis 4 (IME4) is required for Notch signaling during oogenesis. Proc. Natl Acad. Sci. USA 108, 14855-14860 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 14855-14860
    • Hongay, C.F.1    Orr-Weaver, T.L.2
  • 60
    • 84865677098 scopus 로고    scopus 로고
    • A census of human soluble protein complexes
    • Havugimana, P. C. et al. A census of human soluble protein complexes. Cell 150, 1068-1081 (2012).
    • (2012) Cell , vol.150 , pp. 1068-1081
    • Havugimana, P.C.1
  • 61
    • 84893746230 scopus 로고    scopus 로고
    • 6- methyladenosine methyltransferase
    • 6-methyladenosine methyltransferase. Cell Res. 24, 177-189 (2014).
    • (2014) Cell Res. , vol.24 , pp. 177-189
    • Ping, X.L.1
  • 62
    • 84897110592 scopus 로고    scopus 로고
    • 6-adenosine methylation
    • 6-adenosine methylation. Nature Chem. Biol. 10, 93-95 (2014).
    • (2014) Nature Chem. Biol. , vol.10 , pp. 93-95
    • Liu, J.1
  • 63
    • 84893310526 scopus 로고    scopus 로고
    • 6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
    • 6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nature Cell Biol. 16, 191-198 (2014).
    • (2014) Nature Cell Biol. , vol.16 , pp. 191-198
    • Wang, Y.1
  • 64
    • 84864037029 scopus 로고    scopus 로고
    • RNA methylation by the MIS complex regulates a cell fate decision in yeast
    • Agarwala, S. D., Blitzblau, H. G., Hochwagen, A. & Fink, G. R. RNA methylation by the MIS complex regulates a cell fate decision in yeast. PLoS Genet. 8, e1002732 (2012).
    • (2012) PLoS Genet. , vol.8
    • Agarwala, S.D.1    Blitzblau, H.G.2    Hochwagen, A.3    Fink, G.R.4
  • 65
    • 84887833997 scopus 로고    scopus 로고
    • Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle
    • Horiuchi, K. et al. Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. J. Biol. Chem. 288, 33292-33302 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 33292-33302
    • Horiuchi, K.1
  • 66
    • 0024259949 scopus 로고
    • An in vitro system for accurate methylation of internal adenosine residues in messenger RNA
    • Narayan, P. & Rottman, F. M. An in vitro system for accurate methylation of internal adenosine residues in messenger RNA. Science 242, 1159-1162 (1988).
    • (1988) Science , vol.242 , pp. 1159-1162
    • Narayan, P.1    Rottman, F.M.2
  • 67
    • 78650034777 scopus 로고    scopus 로고
    • Towards a knowledge-based human protein atlas
    • Uhlen, M. et al. Towards a knowledge-based Human Protein Atlas. Nature Biotech. 28, 1248-1250 (2010).
    • (2010) Nature Biotech , vol.28 , pp. 1248-1250
    • Uhlen, M.1
  • 69
    • 0034742508 scopus 로고    scopus 로고
    • 6-adenosine)-methyltransferase S-adenosyl-l-methionine binding subunit mRNA in cultured cells
    • 6-adenosine)-methyltransferase S-adenosyl-l-methionine binding subunit mRNA in cultured cells. Int. J. Biochem. Cell Biol. 33, 984-999 (2001).
    • (2001) Int. J. Biochem. Cell Biol. , vol.33 , pp. 984-999
    • Leach, R.A.1    Tuck, M.T.2
  • 71
    • 2642656314 scopus 로고    scopus 로고
    • The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs
    • Czaplinski, K. et al. The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. Genes Dev. 12, 1665-1677 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 1665-1677
    • Czaplinski, K.1
  • 72
    • 2342640073 scopus 로고    scopus 로고
    • Does protein synthesis occur in the nucleus?
    • Dahlberg, J. E. & Lund, E. Does protein synthesis occur in the nucleus? Curr. Opin. Cell Biol. 16, 335-338 (2004).
    • (2004) Curr. Opin. Cell Biol. , vol.16 , pp. 335-338
    • Dahlberg, J.E.1    Lund, E.2
  • 74
    • 0026463886 scopus 로고
    • Partial purification of a 6-methyladenine mRNA methyltransferase which modifies internal adenine residues
    • Tuck, M. T. Partial purification of a 6-methyladenine mRNA methyltransferase which modifies internal adenine residues. Biochem. J. 288, 233-240 (1992).
    • (1992) Biochem. J. , vol.288 , pp. 233-240
    • Tuck, M.T.1
  • 75
    • 84890107723 scopus 로고    scopus 로고
    • High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis
    • Schwartz, S. et al. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell 155, 1409-1421 (2013).
    • (2013) Cell , vol.155 , pp. 1409-1421
    • Schwartz, S.1
  • 76
    • 39049154918 scopus 로고    scopus 로고
    • The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily
    • Sanchez-Pulido, L. & Andrade-Navarro, M. A. The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. BMC Biochem. 8, 23 (2007).
    • (2007) BMC Biochem , vol.8 , pp. 23
    • Sanchez-Pulido, L.1    Andrade-Navarro, M.A.2
  • 77
    • 36749041363 scopus 로고    scopus 로고
    • The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    • Gerken, T. et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318, 1469-1472 (2007).
    • (2007) Science , vol.318 , pp. 1469-1472
    • Gerken, T.1
  • 78
    • 0037068433 scopus 로고    scopus 로고
    • AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli
    • Falnes, P. O., Johansen, R. F. & Seeberg, E. AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature 419, 178-182 (2002).
    • (2002) Nature , vol.419 , pp. 178-182
    • Falnes, P.O.1    Johansen, R.F.2    Seeberg, E.3
  • 79
    • 0037068446 scopus 로고    scopus 로고
    • Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
    • Trewick, S. C., Henshaw, T. F., Hausinger, R. P., Lindahl, T. & Sedgwick, B. Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature 419, 174-178 (2002).
    • (2002) Nature , vol.419 , pp. 174-178
    • Trewick, S.C.1    Henshaw, T.F.2    Hausinger, R.P.3    Lindahl, T.4    Sedgwick, B.5
  • 80
    • 54849381000 scopus 로고    scopus 로고
    • Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO
    • Jia, G. et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 582, 3313-3319 (2008).
    • (2008) FEBS Lett. , vol.582 , pp. 3313-3319
    • Jia, G.1
  • 81
    • 0028949935 scopus 로고
    • Classical and novel approaches to the detection and localization of the numerous modified nucleotides in eukaryotic ribosomal RNA
    • Maden, B. E., Corbett, M. E., Heeney, P. A., Pugh, K. & Ajuh, P. M. Classical and novel approaches to the detection and localization of the numerous modified nucleotides in eukaryotic ribosomal RNA. Biochimie 77, 22-29 (1995).
    • (1995) Biochimie , vol.77 , pp. 22-29
    • Maden, B.E.1    Corbett, M.E.2    Heeney, P.A.3    Pugh, K.4    Ajuh, P.M.5
  • 82
    • 84877577199 scopus 로고    scopus 로고
    • FTO expression is regulated by availability of essential amino acids
    • Cheung, M. K., Gulati, P., O'Rahilly, S. & Yeo, G. S. FTO expression is regulated by availability of essential amino acids. Int. J. Obes. 37, 744-747 (2012).
    • (2012) Int. J. Obes. , vol.37 , pp. 744-747
    • Cheung, M.K.1    Gulati, P.2    O'Rahilly, S.3    Yeo, G.S.4
  • 83
    • 84877091458 scopus 로고    scopus 로고
    • Fasting induced cytoplasmic Fto expression in some neurons of rat hypothalamus
    • Vujovic, P. et al. Fasting induced cytoplasmic Fto expression in some neurons of rat hypothalamus. PLoS ONE 8, e63694 (2013).
    • (2013) PLoS ONE , vol.8
    • Vujovic, P.1
  • 84
    • 80052461558 scopus 로고    scopus 로고
    • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    • Ito, S. et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333, 1300-1303 (2011).
    • (2011) Science , vol.333 , pp. 1300-1303
    • Ito, S.1
  • 85
    • 84868130511 scopus 로고    scopus 로고
    • 6-methyladenosine RNA demethylase FTO inhibitor
    • 6-methyladenosine RNA demethylase FTO inhibitor. J. Am. Chem. Soc. 134, 17963-17971 (2012).
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 17963-17971
    • Chen, B.1
  • 86
    • 84892372347 scopus 로고    scopus 로고
    • 6-methyladenosine-dependent regulation of messenger RNA stability
    • 6-methyladenosine-dependent regulation of messenger RNA stability. Nature 505, 117-120 (2014).
    • (2014) Nature , vol.505 , pp. 117-120
    • Wang, X.1
  • 87
    • 77952002827 scopus 로고    scopus 로고
    • The YTH domain is a novel RNA binding domain
    • Zhang, Z. et al. The YTH domain is a novel RNA binding domain. J. Biol. Chem. 285, 14701-14710 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 14701-14710
    • Zhang, Z.1
  • 88
    • 84877750692 scopus 로고    scopus 로고
    • 6-formyladenosine in mammalian RNA
    • 6-formyladenosine in mammalian RNA. Nature Commun. 4, 1798 (2013).
    • (2013) Nature Commun. , vol.4 , pp. 1798
    • Fu, Y.1
  • 89
    • 84892937690 scopus 로고    scopus 로고
    • The dataset for protein-RNA binding affinity
    • Yang, X., Li, H., Huang, Y. & Liu, S. The dataset for protein-RNA binding affinity. Protein Sci. 22, 1808-1811 (2013).
    • (2013) Protein Sci. , vol.22 , pp. 1808-1811
    • Yang, X.1    Li, H.2    Huang, Y.3    Liu, S.4
  • 90
    • 79960230895 scopus 로고    scopus 로고
    • Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data
    • Zhang, C. & Darnell, R. B. Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data. Nature Biotech. 29, 607-614 (2011).
    • (2011) Nature Biotech , vol.29 , pp. 607-614
    • Zhang, C.1    Darnell, R.B.2
  • 91
    • 77954387023 scopus 로고    scopus 로고
    • ICLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution
    • Konig, J. et al. iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution. Nature Struct. Mol. Biol. 17, 909-915 (2010).
    • (2010) Nature Struct. Mol. Biol. , vol.17 , pp. 909-915
    • Konig, J.1
  • 92
    • 84936744064 scopus 로고    scopus 로고
    • Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions
    • Sugimoto, Y. et al. Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions. Genome Biol. 13, R67 (2012).
    • (2012) Genome Biol. , vol.13
    • Sugimoto, Y.1
  • 93
    • 33845666681 scopus 로고    scopus 로고
    • Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
    • Botuyan, M. V. et al. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127, 1361-1373 (2006).
    • (2006) Cell , vol.127 , pp. 1361-1373
    • Botuyan, M.V.1
  • 94
    • 36249026356 scopus 로고    scopus 로고
    • Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger
    • Li, H. et al. Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger. Mol. Cell 28, 677-691 (2007).
    • (2007) Mol. Cell , vol.28 , pp. 677-691
    • Li, H.1
  • 96
    • 84871913482 scopus 로고    scopus 로고
    • Stability of miRNA 5′terminal and seed regions is correlated with experimentally observed miRNA-mediated silencing efficacy
    • Hibio, N., Hino, K., Shimizu, E., Nagata, Y. & Ui-Tei, K. Stability of miRNA 5′terminal and seed regions is correlated with experimentally observed miRNA-mediated silencing efficacy. Sci. Rep. 2, 996 (2012).
    • (2012) Sci. Rep. , vol.2 , pp. 996
    • Hibio, N.1    Hino, K.2    Shimizu, E.3    Nagata, Y.4    Ui-Tei, K.5
  • 97
    • 84869846717 scopus 로고    scopus 로고
    • Formation of triple-helical structures by the 3′-end sequences of MALAT1 and MENβ noncoding RNAs
    • Brown, J. A., Valenstein, M. L., Yario, T. A., Tycowski, K. T. & Steitz, J. A. Formation of triple-helical structures by the 3′-end sequences of MALAT1 and MENβ noncoding RNAs. Proc. Natl Acad. Sci. USA 109, 19202-19207 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 19202-19207
    • Brown, J.A.1    Valenstein, M.L.2    Yario, T.A.3    Tycowski, K.T.4    Steitz, J.A.5
  • 98
    • 0030014932 scopus 로고    scopus 로고
    • Internal 6-methyladenine residues increase the in vitro translation efficiency of dihydrofolate reductase messenger RNA
    • Heilman, K. L., Leach, R. A. & Tuck, M. T. Internal 6-methyladenine residues increase the in vitro translation efficiency of dihydrofolate reductase messenger RNA. Int. J. Biochem. Cell Biol. 28, 823-829 (1996).
    • (1996) Int. J. Biochem. Cell Biol. , vol.28 , pp. 823-829
    • Heilman, K.L.1    Leach, R.A.2    Tuck, M.T.3
  • 99
    • 54949112814 scopus 로고    scopus 로고
    • Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability
    • Kariko, K. et al. Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Mol. Ther. 16, 1833-1840 (2008).
    • (2008) Mol. Ther. , vol.16 , pp. 1833-1840
    • Kariko, K.1
  • 100
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis, B. P., Burge, C. B. & Bartel, D. P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120, 15-20 (2005).
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 101
    • 84855944087 scopus 로고    scopus 로고
    • FTO and obesity: A problem for a billion people
    • Yeo, G. S. FTO and obesity: a problem for a billion people. J. Neuroendocrinol. 24, 393-394 (2012).
    • (2012) J. Neuroendocrinol. , vol.24 , pp. 393-394
    • Yeo, G.S.1
  • 102
    • 84875701351 scopus 로고    scopus 로고
    • Genome-wide association studies identify four ER negative-specific breast cancer risk loci
    • Garcia-Closas, M. et al. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nature Genet. 45, 392-398 (2013).
    • (2013) Nature Genet. , vol.45 , pp. 392-398
    • Garcia-Closas, M.1
  • 103
    • 0029866578 scopus 로고    scopus 로고
    • Elevation of internal 6-methyladenine mRNA methyltransferase activity after cellular transformation
    • Tuck, M. T., James, C. B., Kelder, B. & Kopchick, J. J. Elevation of internal 6-methyladenine mRNA methyltransferase activity after cellular transformation. Cancer Lett. 103, 107-113 (1996).
    • (1996) Cancer Lett. , vol.103 , pp. 107-113
    • Tuck, M.T.1    James, C.B.2    Kelder, B.3    Kopchick, J.J.4
  • 105
    • 42249110521 scopus 로고    scopus 로고
    • FTO: The first gene contributing to common forms of human obesity
    • Loos, R. J. & Bouchard, C. FTO: the first gene contributing to common forms of human obesity. Obes Rev. 9, 246-250 (2008).
    • (2008) Obes Rev. , vol.9 , pp. 246-250
    • Loos, R.J.1    Bouchard, C.2
  • 106
    • 67349211789 scopus 로고    scopus 로고
    • Inactivation of the FTO gene protects from obesity
    • Fischer, J. et al. Inactivation of the FTO gene protects from obesity. Nature 458, 894-898 (2009).
    • (2009) Nature , vol.458 , pp. 894-898
    • Fischer, J.1
  • 107
    • 78649459183 scopus 로고    scopus 로고
    • Overexpression of FTO leads to increased food intake and results in obesity
    • Church, C. et al. Overexpression of FTO leads to increased food intake and results in obesity. Nature Genet. 42, 1086-1092 (2010).
    • (2010) Nature Genet. , vol.42 , pp. 1086-1092
    • Church, C.1
  • 108
    • 84875722359 scopus 로고    scopus 로고
    • A variant in FTO shows association with melanoma risk not due to BMI
    • 432e1
    • Iles, M. M. et al. A variant in FTO shows association with melanoma risk not due to BMI. Nature Genet. 45, 428-432, 432e1 (2013).
    • (2013) Nature Genet. , vol.45 , pp. 428-432
    • Iles, M.M.1
  • 109
    • 84887875528 scopus 로고    scopus 로고
    • RNA-methylation-dependent RNA processing controls the speed of the circadian clock
    • Fustin, J.-M. et al. RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell 155, 793-806 (2013).
    • (2013) Cell , vol.155 , pp. 793-806
    • Fustin, J.-M.1
  • 110
    • 84891485596 scopus 로고    scopus 로고
    • Adenosine methylation in Arabidopsis mRNA is associated with the 3′ end and reduced levels cause developmental defects
    • Bodi, Z. et al. Adenosine methylation in Arabidopsis mRNA is associated with the 3′ end and reduced levels cause developmental defects. Front. Plant Sci. 3, 48 (2012).
    • (2012) Front. Plant Sci. , vol.3 , pp. 48
    • Bodi, Z.1
  • 111
    • 13844256557 scopus 로고    scopus 로고
    • Processing the message: Structural insights into capping and decapping mRNA
    • Gu, M. & Lima, C. D. Processing the message: structural insights into capping and decapping mRNA. Curr. Opin. Struct. Biol. 15, 99-106 (2005).
    • (2005) Curr. Opin. Struct. Biol. , vol.15 , pp. 99-106
    • Gu, M.1    Lima, C.D.2
  • 112
    • 0016680603 scopus 로고
    • 5′-terminal 7-methylguanosine in eukaryotic mRNA is required for translation
    • Muthukrishnan, S., Both, G. W., Furuichi, Y. & Shatkin, A. J. 5′-Terminal 7-methylguanosine in eukaryotic mRNA is required for translation. Nature 255, 33-37 (1975).
    • (1975) Nature , vol.255 , pp. 33-37
    • Muthukrishnan, S.1    Both, G.W.2    Furuichi, Y.3    Shatkin, A.J.4
  • 113
    • 0020216820 scopus 로고
    • 5′-terminal caps, cap-binding proteins and eukaryotic mRNA function
    • Shatkin, A. J. et al. 5′-Terminal caps, cap-binding proteins and eukaryotic mRNA function. Biochem. Soc. Symp. 47, 129-143 (1982).
    • (1982) Biochem. Soc. Symp. , vol.47 , pp. 129-143
    • Shatkin, A.J.1
  • 114
    • 0017621466 scopus 로고
    • The 5′-termini of heterogeneous nuclear RNA: A comparison among molecules of different sizes and ages
    • Schibler, U. & Perry, R. P. The 5′-termini of heterogeneous nuclear RNA: a comparison among molecules of different sizes and ages. Nucleic Acids Res. 4, 4133-4149 (1977).
    • (1977) Nucleic Acids Res. , vol.4 , pp. 4133-4149
    • Schibler, U.1    Perry, R.P.2
  • 115
    • 77952496365 scopus 로고    scopus 로고
    • Preparation of eukaryotic mRNA having differently methylated adenosine at the 5′-terminus and the effect of the methyl group in translation
    • Ishikawa, M., Murai, R., Hagiwara, H., Hoshino, T. & Suyama, K. Preparation of eukaryotic mRNA having differently methylated adenosine at the 5′-terminus and the effect of the methyl group in translation. Nucleic Acids Symp. Ser. 129-130 (2009).
    • (2009) Nucleic Acids Symp. Ser. , pp. 129-130
    • Ishikawa, M.1    Murai, R.2    Hagiwara, H.3    Hoshino, T.4    Suyama, K.5
  • 116
    • 0030728936 scopus 로고    scopus 로고
    • Cocrystal structure of the messenger RNA 5′ cap-binding protein (eIF4E) bound to 7-methyl-GDP
    • Marcotrigiano, J., Gingras, A. C., Sonenberg, N. & Burley, S. K. Cocrystal structure of the messenger RNA 5′ cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell 89, 951-961 (1997).
    • (1997) Cell , vol.89 , pp. 951-961
    • Marcotrigiano, J.1    Gingras, A.C.2    Sonenberg, N.3    Burley, S.K.4
  • 117
    • 0034284411 scopus 로고    scopus 로고
    • Functional analysis of putative restriction-modification system genes in the Helicobacter pylori J99 genome
    • Kong, H. et al. Functional analysis of putative restriction-modification system genes in the Helicobacter pylori J99 genome. Nucleic Acids Res. 28, 3216-3223 (2000).
    • (2000) Nucleic Acids Res. , vol.28 , pp. 3216-3223
    • Kong, H.1
  • 118
    • 35549008047 scopus 로고    scopus 로고
    • 6-methyladenosine
    • 6-methyladenosine. Nucleic Acids Res. 35, 6322-6329 (2007).
    • (2007) Nucleic Acids Res. , vol.35 , pp. 6322-6329
    • Dai, Q.1
  • 120
    • 84888423912 scopus 로고    scopus 로고
    • 6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA
    • 6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA. RNA 19, 1848-1856 (2013).
    • (2013) RNA , vol.19 , pp. 1848-1856
    • Liu, N.1
  • 121
    • 0037474152 scopus 로고    scopus 로고
    • Zero-mode waveguides for single-molecule analysis at high concentrations
    • Levene, M. J. et al. Zero-mode waveguides for single-molecule analysis at high concentrations. Science 299, 682-686 (2003).
    • (2003) Science , vol.299 , pp. 682-686
    • Levene, M.J.1
  • 122
    • 84875649230 scopus 로고    scopus 로고
    • Analysis of RNA base modification and structural rearrangement by single-molecule real-time detection of reverse transcription
    • Vilfan, I. D. et al. Analysis of RNA base modification and structural rearrangement by single-molecule real-time detection of reverse transcription. J. Nanobiotechnol. 11, 8 (2013).
    • (2013) J. Nanobiotechnol. , vol.11 , pp. 8
    • Vilfan, I.D.1
  • 123


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.