Crystal structures of the human RNA demethylase alkbh5 reveal basis for substrate recognition

Journal of Biological Chemistry

Volumn 289, Issue 17, 2014, Pages 11571-11583

  Feng, Chong ^a   Liu, Yang ^a   Wang, Guoqiang ^a   Deng, Zengqin ^a   Zhang, Qi ^a   Wu, Wei ^a   Tong, Yufeng ^b,c   Cheng, Changmei ^c   Chen, Zhongzhou ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b TSINGHUA UNIVERSITY   (China)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULES;

COFACTORS; DEMETHYLASE; SELECTIVE INHIBITORS; SMALL MOLECULE INHIBITOR; SMALL MOLECULES; STRUCTURE AND ACTIVITIES; STRUCTURE-BASED DESIGNS; SUBSTRATE RECOGNITION;

RNA;

2 OXOGLUTARIC ACID; ACETIC ACID; CITRIC ACID; CYSTEINE; FAT MASS AND OBESITY ASSOCIATED PROTEIN; HUMAN ALKB HOMOLOG 5; LIGAND; MANGANESE; N OXALYLGLYCINE; OXIDOREDUCTASE; PYRIDINE 2,4 DICARBOXYLATE; SINGLE STRANDED DNA; SINGLE STRANDED RNA; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMISTRY; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DEMETHYLATION; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

ALKB; ALKBH5; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME INHIBITORS; M6A DEMETHYLASE; MRNA; RNA MODIFICATION; SUBSTRATE RECOGNITION;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIOXYGENASES; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84899425559     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.546168     Document Type: Article

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