Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA

Journal of Biological Chemistry

Volumn 283, Issue 36, 2008, Pages 25046-25056

  Westbye, Marianne Pedersen ^a   Feyzi, Emadoldin ^a   Aas, Per Arne ^a   Vågbø, Cathrine Broberg ^a   Talstad, Vivi Anita ^a   Kavli, Bodil ^a   Hagen, Lars ^a   Sundheim, Ottar ^a   Akbari, Mansour ^a   Liabakk, Nina Beate ^a   Slupphaug, Geir ^a   Otterlei, Marit ^a   Krokan, Hans Einar ^a,b  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b NONE   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; DNA; ESCHERICHIA COLI; FLUORESCENCE; GENES; MAINTENANCE; ORGANIC ACIDS; REPAIR; RNA;

ACTIVE SITES; BINDING RESIDUES; DEMETHYLASES; FLUORESCENT TAGS; FUSION PROTEINS; IMMUNOCYTOCHEMISTRY; IN VITRO; MITOCHONDRIAL PROTEINS; OXOGLUTARATE; PRIME SUBSTRATES; WESTERN BLOTS;

NUCLEIC ACIDS;

3 METHYLCYTOSINE; CYTOSINE; MITOCHONDRIAL PROTEIN; PROTEIN HABH1; SINGLE STRANDED DNA; SINGLE STRANDED RNA; UNCLASSIFIED DRUG; 3-METHYLCYTOSINE; ALKB PROTEIN, E COLI; ALKBH2 PROTEIN, HUMAN; ALKBH3 PROTEIN, HUMAN; DIOXYGENASE; DRUG DERIVATIVE; ESCHERICHIA COLI PROTEIN; MITOCHONDRIAL DNA; MIXED FUNCTION OXIDASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RNA; RNA, MITOCHONDRIAL;

ARTICLE; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MASS SPECTROMETRY; MITOCHONDRION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; DNA METHYLATION; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; HELA CELL; METABOLISM; PHYSIOLOGY; RNA PROCESSING; SEQUENCE HOMOLOGY;

ESCHERICHIA COLI;

CYTOSINE; DIOXYGENASES; DNA METHYLATION; DNA REPAIR ENZYMES; DNA, MITOCHONDRIAL; DNA, SINGLE-STRANDED; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HELA CELLS; HUMANS; MITOCHONDRIAL PROTEINS; MIXED FUNCTION OXYGENASES; RNA; RNA PROCESSING, POST-TRANSCRIPTIONAL; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 54049092869     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803776200     Document Type: Article

References (46)

1. Drabløs, F., Feyzi, E., Aas, P. A., Vaagbø, C. B., Kavli, B., Bratlie, M. S., Peña-Diaz, J., Otterlei, M., Slupphaug, G., and Krokan, H. E. (2004) DNA Repair 3, 1389-1407
2. Sedgwick, B. (2004) Nat. Rev. Mol. Cell Biol. 5, 148-157
3. Sedgwick, B., and Lindahl, T. (2002) Oncogene 21, 8886-8894
4. Kataoka, H., Yamamoto, Y., and Sekiguchi, M. (1983) J. Bacteriol. 153, 1301-1307
5. Falnes, P. O., Johansen, R. F., and Seeberg, E. (2002) Nature 419, 178-182
6. Trewick, S. C., Henshaw, T. F., Hausinger, R. P., Lindahl, T., and Sedgwick, B. (2002) Nature 419, 174-178
7. Aravind, L., and Koonin, E. V. (2001) Genome Biol. 2, 0007.1-0007.8
8. Aas, P. A., Otterlei, M., Falnes, P. O., Vaagbø, C. B., Skorpen, F., Akbari, M., Sundheim, O., Bjørås, M., Slupphaug, G., Seeberg, E., and Krokan, H. E. (2003) Nature 421, 859-863
9. Rozenski, J., Crain, P. F., and McCloskey, J. A. (1999) Nucleic Acids Res. 27, 196-197
10. Chang, B., Chen, Y., Zhao, Y., and Bruick, R. K. (2007) Science 318, 444-447
11. Duncan, T., Trewick, S. C., Koivisto, P., Bates, P. A., Lindahl, T., and Sedgwick, B. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 16660-16665
12. Kurowski, M. A., Bhagwat, A. S., Papaj, G., and Bujnicki, J. M. (2003) BMC Genomics 4, 48
13. Ougland, R., Zhang, C. M., Liiv, A., Johansen, R. F., Seeberg, E., Hou, Y. M., Remme, J., and Falnes, P. O. (2004) Mol. Cell 16, 107-116
14. Lee, D. H., Jin, S. G., Cai, S., Chen, Y., Pfeifer, G. P., and O'Connor, T. R. (2005) J. Biol. Chem. 280, 39448-39459
15. Wei, Y. F., Carter, K. C., Wang, R. P., and Shell, B. K. (1996) Nucleic Acids Res. 24, 931-937
16. Pan, Z., Sikandar, S., Witherspoon, M., Dizon, D., Nguyen, T., Benirschke, K., Wiley, C., Vrana, P., and Lipkin, S. M. (2008) Dev. Dyn. 237, 316-327
17. Yang, Y., Liang, Y., Qu, L., Chen, Z., Yi, M., Li, K., and Lemon, S. M. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 7253-7258
18. Akbari, M., Otterlei, M., Peña-Diaz, J., Aas, P. A., Kavli, B., Liabakk, N. B., Hagen, L., Imai, K., Durandy, A., Slupphaug, G., and Krokan, H. E. (2004) Nucleic Acids Res. 32, 5486-5498
19. Akbari, M., Otterlei, M., Peña-Diaz, J., and Krokan, H. E. (2007) Neuroscience 145, 1201-1212
20. Sabourin, P. J., and Bieber, L. L. (1982) J. Biol. Chem. 257, 7468-7471
21. Ringvoll, J., Nordstrand, L. M., Vaagbø, C. B., Talstad, V., Reite, K., Aas, P. A., Lauritzen, K. H., Liabakk, N. B., Bjørk, A., Doughty, R. W., Falnes, P. O., Krokan, H. E., and Klungland, A. (2006) EMBO J. 25, 2189-2198
22. Nilsen, H., Otterlei, M., Haug, T., Solum, K., Nagelhus, T. A., Skorpen, F., and Krokan, H. E. (1997) Nucleic Acids Res. 25, 750-755
23. Bratlie, M. S., and Drabløs, F. (2005) BMC Genomics 6, 1
24. Yu, B., Edström, W. C., Benach, J., Hamuro, Y., Weber, P. C., Gibney, B. R., and Hunt, J. F. (2006) Nature 439, 879-884
25. Sundheim, O., Vaagbø, C. B., Bjørås, M., Sousa, M. M., Talstad, V., Aas, P. A., Drabløs, F., Krokan, H. E., Tainer, J. A., and Slupphaug, G. (2006) EMBO J. 25, 3389-3397
26. Hausinger, R. P. (2004) Crit. Rev. Biochem. Mol. Biol. 39, 21-68
27. Henshaw, T. F., Feig, M., and Hausinger, R. P. (2004) J. Inorg. Biochem. 98, 856-861
28. Welford, R. W., Schlemminger, I., McNeill, L. A., Hewitson, K. S., and Schofield, C. J. (2003) J. Biol. Chem. 278, 10157-10161
29. Mishina, Y., Chen, L. X., and He, C. (2004) J. Am. Chem. Soc. 126, 16930-16936
30. Sawyer, D. E., and Van Houten, B. (1999) Mutat. Res. 434, 161-176
31. Bannister, A. J., and Kouzarides, T. (2005) Nature 436, 1103-1106
32. Nilsen, H., Steinsbekk, K. S., Otterlei, M., Slupphaug, G., Aas, P. A., and Krokan, H. E. (2000) Nucleic Acids Res. 28, 2277-2285
33. Hatchell, E. C., Colley, S. M., Beveridge, D. J., Epis, M. R., Stuart, L. M., Giles, K. M., Redfern, A. D., Miles, L. E., Barker, A., MacDonald, L. M., Arthur, P. G., Lui, J. C., Golding, J. L., McCulloch, R. K., Metcalf, C. B., Wilce, J. A., Wilce, M. C., Lanz, R. B., O'Malley, B. W., and Leedman, P. J. (2006) Mol. Cell 22, 657-668
34. Tsujikawa, K., Koike, K., Kitae, K., Shinkawa, A., Arima, H., Suzuki, T., Tsuchiya, M., Makino, Y., Furukawa, T., Konishi, N., and Yamamoto, H. (2007) J. Cell Mol. Med. 11, 1105-1116
35. Wilson, D. M., 3rd, and Bohr, V. A. (2007) DNA Repair 6, 544-559
36. Lambert, A. J., and Brand, M. D. (2007) Aging Cell 6, 417-420
37. LeDoux, S. P., Wilson, G. L., Beecham, E. J., Stevnsner, T., Wassermann, K., and Bohr, V. A. (1992) Carcinogenesis 13, 1967-1973
38. Harrison, J. F., Rinne, M. L., Kelley, M. R., Druzhyna, N. M., Wilson, G. L., and Ledoux, S. P. (2007) Glia 55, 1416-1425
39. LeDoux, S. P., Druzhyna, N. M., Hollensworth, S. B., Harrison, J. F., and Wilson, G. L. (2007) Neuroscience 145, 1249-1259
40. Singer, B., and Grunberger, D. (1983) Molecular Biology of Mutagens and Carcinogens: Reactions of Directly Acting Agents with Nucleic Acids, Plenum Press, New York
41. Delaney, J. C., and Essigmann, J. M. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 14051-14056
42. Gerken, T., Girard, C. A., Tung, Y. C., Webby, C. J., Saudek, V., Hewitson, K. S., Yeo, G. S., McDonough, M. A., Cunliffe, S., McNeill, L. A., Galvanovskis, J., Rorsman, P., Robins, P., Prieur, X., Coll, A. P., Ma, M., Jovanovic, Z., Farooqi, I. S., Sedgwick, B., Barroso, I., Lindahl, T., Ponting, C. P., Ashcroft, F. M., O'Rahilly, S., and Schofield, C. J. (2007) Science 318, 1469-1472
43. Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F., and Higgins, D. G. (1997) Nucleic Acids Res. 25, 4876-4882
44. Cuff, J. A., and Barton, G. J. (2000) Proteins 40, 502-511
45. Clamp, M., Cuff, J., Searle, S. M., and Barton, G. J. (2004) Bioinformatics 20, 426-427
46. Schwede, T., Kopp, J., Guex, N., and Peitsch, M. C. (2003) Nucleic Acids Res. 31, 3381-3385