Apparent recovery of C18 polyunsaturated fatty acids from feed in cow milk: A meta-analysis of the importance of dietary fatty acids and feeding regimens in diets without fat supplementation

Journal of Dairy Science

Volumn 98, Issue 9, 2015, Pages 6399-6414

  Khiaosa ard, R ^a,b   Kreuzer, M ^a   Leiber, F ^a,c  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^c RESEARCH INSTITUTE OF ORGANIC AGRICULTURE FIBL   (Switzerland)

Author keywords

Conjugated linoleic acid; Diet type; Fatty acid transfer; Feed fatty acids; Milk fat

Indexed keywords

9,11-LINOLEIC ACID; CONJUGATED LINOLEIC ACID; FAT INTAKE; LINOLEIC ACID; LINOLENIC ACID; UNSATURATED FATTY ACID;

ADMINISTRATION AND DOSAGE; ANALYSIS; ANIMAL; ANIMAL FOOD; BOVINE; CHEMISTRY; DIET; FAT INTAKE; META ANALYSIS; MILK; STATISTICAL MODEL; VETERINARY;

ALPHA-LINOLENIC ACID; ANIMAL FEED; ANIMALS; CATTLE; DIET; DIETARY FATS; FATTY ACIDS, UNSATURATED; LINEAR MODELS; LINOLEIC ACID; LINOLEIC ACIDS, CONJUGATED; MILK;

EID: 84939269410     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2015-9459     Document Type: Article

References (130)

1. Adler S.A., Jensen S.K., Thuen E., Gustavsson A.-M., Harstad O.M., Steinshamn H. Effect of silage botanical composition on ruminal biohydrogenation and transfer of fatty acids to milk in dairy cows. J. Dairy Sci. 2013, 96:1135-1147.
2. Akbaridoust G., Plozza T., Trenerry V.C., Wales W.J., Auldist M.J., Dunshea F.R., Ajlouni S. Influence of different systems for feeding supplements to grazing dairy cows on milk fatty acid composition. J. Dairy Res. 2014, 81:156-163.
3. Akraim F., Nicot M.C., Juaneda P., Enjalbert F. Conjugated linolenic acid (CLnA), conjugated linoleic acid (CLA) and other biohydrogenation intermediates in plasma and milk fat of cows fed raw or extruded linseed. Animal 2007, 1:835-843.
4. Allen M.S. Effects of diet on short-term regulation of feed intake by lactating dairy cattle. J. Dairy Sci. 2000, 83:1598-1624.
5. AlZahal O., Or-Rashid M.M., Greenwood S.L., Douglas M.S., McBride B.W. The effect of dietary fiber level on milk fat concentration and fatty acid profile of cows fed diets containing low levels of polyunsaturated fatty acids. J. Dairy Sci. 2009, 92:1108-1116.
6. Aprianita A., Donkor O.N., Moate P.J., Williams S.R.O., Auldist M.J., Greenwood J.S., Hannah M.C., Wales W.J., Vasiljevic T. Effects of dietary cottonseed oil and tannin supplements on protein and fatty acid composition of bovine milk. J. Dairy Res. 2014, 81:183-192.
7. Arvidsson K., Gustavsson A.-M., Fievez V., Martinsson K. The effect of N-fertilisation rate or inclusion of red clover to timothy leys on fatty acid composition in milk of dairy cows fed a commercial silage: concentrate ratio. Animal 2012, 6:1178-1186.
8. Avila C.D., DePeters E.J., Perez-Monti H., Taylor S.J., Zinn R.A. Influences of saturation ratio of supplemental dietary fat on digestion and milk yield in dairy cows. J. Dairy Sci. 2000, 83:1505-1519.
9. Barceló-Coblijn G., Murphy E.J. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: Benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Prog. Lipid Res. 2009, 48:355-374.
10. Bargo F., Delahoy J.E., Schroeder G.F., Baumgard L.H., Muller L.D. Supplementing total mixed rations with pasture increase the content of conjugated linoleic acid in milk. Anim. Feed Sci. Technol. 2006, 131:226-240. a.
11. Bargo F., Delahoy J.E., Schroeder G.F., Muller L.D. Milk fatty acid composition of dairy cows grazing at two pasture allowances and supplemented with different levels and sources of concentrate. Anim. Feed Sci. Technol. 2006, 125:17-31. b.
12. Bartl K., Gomez C.A., García M., Aufdermauer T., Kreuzer M., Hess H.D., Wettstein H.-R. Milk fatty acid profile of Peruvian Criollo and Brown Swiss cows in response to different diet qualities fed at low and high altitude. Arch. Anim. Nutr. 2008, 62:468-484.
13. Beam T.M., Jenkins T.C., Moate P.J., Kohn R.A., Palmquist D.L. Effect of amount and source of fat on the rates of lipolysis and biohydrogenation of fatty acids in ruminal contents. J. Dairy Sci. 2000, 83:2564-2573.
14. Benchaar C., Lettat A., Hassanat F., Yang W.Z., Forster R.J., Petit H.V., Chouinard P.Y. Eugenol for dairy cows fed low or high concentrate diets: Effects on digestion, ruminal fermentation characteristics, rumen microbial populations and milk fatty acid profile. Anim. Feed Sci. Technol. 2012, 178:139-150.
15. Bickerstaffe R., Noakes D.E., Annison E.F. Quantitative aspects of fatty acid biohydrogenation, absorption and transfer into milk fat in the lactating goat, with special reference to the cis- and trans-isomers of octadecenoate and linoleate. Biochem. J. 1972, 130:607-617.
16. Binder, D. A., M. S. Kovacevic, and G. Roberts. 2005. How important is the informativeness of the sampling design? In Proc. Statistical Society of Canada (SSC) Annual Meeting, Accessed Sep. 14, 2014. http://http://www.ssc.ca/survey/documents/SSC2005_D_Binder.pdf.
17. Boivin M., Gervais R., Chouinard P.Y. Effect of grain and forage fractions of corn silage on milk production and composition in dairy cows. Animal 2013, 7:245-254.
18. Bu D.P., Wang J.Q., Dhiman T.R., Liu S.J. Effectiveness of oils rich in linoleic and linolenic acids to enhance conjugated linoleic acid in milk from dairy cows. J. Dairy Sci. 2007, 90:998-1007.
19. Burdge G. Linolenic acid metabolism in men and women: nutritional and biological implications. Curr. Opin. Clin. Nutr. Metab. Care 2004, 7:137-144.
20. Cabiddu A., Salis L., Tweed J.K.S., Molle G., Decandia M., Lee M.R.F. The influence of plant polyphenols on lipolysis and biohydrogenation in dried forages at different phenological stages: In vitro study. J. Sci. Food Agric. 2010, 90:829-835.
21. Cabrita A.R.J., Bessa R.J.B., Alves S.P., Dewhurst R.J., Fonseca A.J.M. Effects of dietary protein and starch on intake, milk production, and milk fatty acid profiles of dairy cows fed corn silage-based diets. J. Dairy Sci. 2007, 90:1429-1439.
22. Cabrita A.R.J., Vale J.M.P., Bessa R.J.B., Dewhurst R.J., Fonseca A.J.M. Effects of dietary starch source and buffers on milk responses and rumen fatty acid biohydrogenation in dairy cows fed maize silage-based diets. Anim. Feed Sci. Technol. 2009, 152:267-277.
23. Caroprese M., Marzano A., Marino R., Gliatta G., Muscio A., Sevi A. Flaxseed supplementation improves fatty acid profile of cow milk. J. Dairy Sci. 2010, 93:2580-2588.
24. Chen P., Ji P., Li S.L. Effects of feeding extruded soybean, ground canola seed and whole cottonseed on ruminal fermentation, performance and milk fatty acid profile in early lactation dairy cows. Asian-Australas. J. Anim. Sci. 2008, 21:204-213.
25. Chichlowski M.W., Schroeder J.W., Park C.S., Keller W.L., Schimek D.E. Altering the fatty acids in milk fat by including canola seed in dairy cattle diets. J. Dairy Sci. 2005, 88:3084-3094.
26. Chilliard Y., Ferlay A., Rosemary M., Doreau M. Ruminant milk fat plasticity: Nutritional control of saturated, polyunsaturated, trans and conjugated fatty acids. Ann. Zootech. 2000, 49:181-205.
27. Chilliard Y., Glasser F., Ferlay A., Bernard L., Rouel J., Doreau M. Diet, rumen biohydrogenation and nutritional quality of cow and goat milk fat. Eur. J. Lipid Sci. Technol. 2007, 109:828-855.
28. Chilliard Y., Martin C., Rouel J., Doreau M. Milk fatty acids in dairy cows fed whole crude linseed, extruded linseed, or linseed oil, and their relationship with methane output. J. Dairy Sci. 2009, 92:5199-5211.
29. Coppa M., Chassaing C., Ferlay A., Agabriel C., Laurent C., Borreani G., Barcarolo R., Baars T., Kusche D., Harstad O.M., Verbič J., Golecký J., Delevaud C., Chilliard Y., Martin B. Potential of milk fatty acid composition to predict diet composition and authenticate feeding systems and altitude origin of European bulk milk. J. Dairy Sci. 2015, 98:1539-1551.
30. Coppa M., Ferlay A., Chassaing C., Agabriel C., Glasser F., Chilliard Y., Borreani G., Barcarolo R., Baars T., Kusche D., Harstad O.M., Verbič J., Golecký J., Martin B. Prediction of bulk milk fatty acid composition based on farming practices collected through on-farm surveys. J. Dairy Sci. 2013, 96:4197-4211.
31. Dai X.J., Wang C., Zhu Q. Milk performance of dairy cows supplemented with rapeseed oil, peanut oil and sunflower seed oil. Czech J. Anim. Sci. 2011, 56:181-191.
32. Dewhurst R.J., Fisher W.J., Tweed J.K.S., Wilkins R.J. Comparison of grass and legume silages for milk production. 1. Production responses with different levels of concentrate. J. Dairy Sci. 2003, 86:2598-2611.
33. Dewhurst R.J., Shingfield K.J., Lee M.R.F., Scollan N.D. Increasing the concentrations of beneficial polyunsaturated fatty acids in milk produced by dairy cows in high-forage systems. Anim. Feed Sci. Technol. 2006, 131:168-206.
34. Dhiman T.R., Satter L.D., Pariza M.W., Galli M.P., Albright K., Tolosa M.X. Conjugated linoleic acid (CLA) content in milk from cows offered diets rich in linoleic and linolenic acid. J. Dairy Sci. 2000, 83:1016-1027.
35. Doreau M., Ferlay A. Digestion and utilization of fatty acids by ruminants. Anim. Feed Sci. Technol. 1994, 45:379-396.
36. Douglas G.N., Rehage J., Beaulieu A.D., Bahaa A.O., Drackley J.K. Prepartum nutrition alters fatty acid composition in plasma, adipose tissue, and liver lipids of periparturient dairy cows. J. Dairy Sci. 2007, 90:2941-2959.
37. Elgersma A., Ellen G., van der Horst H., Boer H., Dekker P.R., Tamminga S. Quick changes in milk fat composition from cows after transition from fresh grass to a silage diet. Anim. Feed Sci. Technol. 2004, 117:13-27.
38. Falchero L., Lombardi G., Gorlier A., Lonati M., Odoardi M., Cavallero A. Variation in fatty acid composition of milk and cheese from cows grazed on two alpine pastures. Dairy Sci. Technol. 2010, 90:657-672.
39. Ferlay A., Martin B., Lerch S., Gobert M., Pradel P., Chilliard Y. Effects of supplementation of maize silage diets with extruded linseed, vitamin E and plant extracts rich in polyphenols, and morning v. evening milking on milk fatty acid profiles in Holstein and Montbéliarde cows. Animal 2010, 4:627-640.
40. Ferlay A., Martin B., Pradel Ph., Coulon J.P., Chilliard Y. Influence of grass-based diets on milk fatty acid composition and milk lipolytic system in Tarentaise and Montbéliarde cow breeds. J. Dairy Sci. 2006, 89:4026-4041.
41. Fievez V., Vlaeminck B., Jenkins T., Enjalbert F., Doreau M. Assessing rumen biohydrogenation and its manipulation in vivo, in vitro and in situ. Eur. J. Lipid Technol. 2007, 109:740-756.
42. Fuentes M.C., Calsamiglia S., Fievez V., Blanch M., Mercadal D. Effect of pH on ruminal fermentation and biohydrogenation of diets rich in omega-3 or omega-6 fatty acids in continuous culture of ruminal fluid. Anim. Feed Sci. Technol. 2011, 169:35-45.
43. Glasser F., Doreau M., Ferlay A., Chilliard Y. Estimation of milk fatty acid yield from milk fat data. J. Dairy Sci. 2007, 90:2302-2304. a.
44. Glasser F., Doreau M., Ferlay A., Loor J.J., Chilliard Y. Milk fatty acids: Mammary synthesis could limit transfer from duodenum in cows. Eur. J. Lipid Sci. Technol. 2007, 109:817-827. b.
45. Glasser F., Ferlay A., Chilliard Y. Oilseed lipid supplements and fatty acid composition of cow milk: A meta-analysis. J. Dairy Sci. 2008, 91:4687-4703. a.
46. Glasser F., Ferlay A., Doreau M., Schmidely P., Sauvant D., Chilliard Y. Long-chain fatty acid metabolism in dairy cows: a meta-analysis of milk fatty acid yield in relation to duodenal flows and de novo synthesis. J. Dairy Sci. 2008, 91:2771-2785. b.
47. Gross J., van Dorland H.A., Bruckmaier R.M., Schwarz F.J. Milk fatty acid profile related to energy balance in dairy cows. J. Dairy Res. 2011, 78:479-488.
48. Grummer R.R. Effect of feed on the composition of milk fat. J. Dairy Sci. 1991, 74:3244-3257.
49. Halmemies-Beauchet-Filleau A., Kairenius P., Ahvenjärvi S., Crosle L.K., Muetzel S., Huhtanen P., Vanhatalo A., Toivonen V., Wallace R.J., Shingfield K.J. Effect of forage conservation method on ruminal lipid metabolism and microbial ecology in lactating cows fed diets containing a 60:40 forage-to-concentrate ratio. J. Dairy Sci. 2013, 96:2428-2447. a.
50. Halmemies-Beauchet-Filleau A., Kairenius P., Ahvenjärvi S., Toivonen V., Huhtanen P., Vanhatalo A., Givens D.I., Shingfield K.J. Effect of forage conservation method on plasma lipids, mammary lipogenesis, and milk fatty acid composition in lactating cows fed diets containing a 60:40 forage-to-concentrate ratio. J. Dairy Sci. 2013, 96:5267-5289. b.
51. Han R., Zheng N., Zhang Y., Zhao X., Bu D., An P., Xu X., Liu S., Wang J. Milk fatty acid profiles in Holstein dairy cows fed diets based on corn stover or mixed forage. Arch. Anim. Nutr. 2014, 68:63-71.
52. Harvatine K.J., Boisclair Y.R., Bauman D.E. Recent advances in the regulation of milk fat synthesis. Animal 2009, 3:40-54.
53. He M.L., Mir P.S., Beauchemin K.A., Ivan M., Mir Z. Effects of dietary sunflower seeds on lactation performance and conjugated linoleic acid content of milk. Can. J. Anim. Sci. 2005, 85:75-83.
54. Höjer A., Adler S., Martinsson K., Jensen S.K., Steinshamn H., Thuen E., Gustavsson A.-M. Effect of legume-grass silages and α-tocopherol supplementation on fatty acid composition and α-tocopherol, β-carotene and retinol concentrations in organically produced bovine milk. Livest. Sci. 2012, 148:268-281.
55. Huang Y., Schoonmaker J.P., Bradford B.J., Beitz D.C. Response of milk fatty acid composition to dietary supplementation of soy oil, conjugated linoleic acid, or both. J. Dairy Sci. 2008, 91:260-270.
56. Jacobs A.A.A., van Baal J., Smits M.A., Taweel H.Z.H., Hendriks W.H., van Vuuren A.M., Dijkstra J. Effects of feeding rapeseed oil, soybean oil, or linseed oil on stearoyl-CoA desaturase expression in the mammary gland of dairy cows. J. Dairy Sci. 2011, 94:874-887.
57. Jayanegara A., Kreuzer M., Wina E., Leiber F. Significance of phenolic compounds in tropical forages for the ruminal bypass of polyunsaturated fatty acids and the appearance of biohydrogenation intermediates as examined in vitro. Anim. Prod. Sci. 2011, 51:1127-1136. a.
58. Jayanegara A., Leiber F., Kreuzer M. Meta-analysis of the relationship between dietary tannin level and methane formation in ruminants from in vivo and in vitro experiments. J. Anim. Physiol. Anim. Nutr. (Berl.) 2012, 96:365-375.
59. Jayanegara A., Marquardt S., Kreuzer M., Leiber F. Nutrient and energy content, in vitro ruminal fermentation characteristics and methanogenic potential of alpine forage plant species during early summer. J. Sci. Food Agric. 2011, 91:1863-1870. b.
60. Jouany J.-P., Lassalas B., Doreau M., Glasser F. Dynamic features of the rumen metabolism of linoleic acid, linolenic acid and linseed oil measured in vitro. Lipids 2007, 42:351-360.
61. Kälber T., Kreuzer M., Leiber F. Effect of feeding buckwheat and chicory silages on fatty acid profile and cheese-making properties of milk from dairy cows. J. Dairy Res. 2013, 80:81-88.
62. Kälber T., Kreuzer M., Leiber F. Milk fatty acid composition of dairy cows fed green whole-plant buckwheat, phacelia or chicory in their vegetative and reproductive stage. Anim. Feed Sci. Technol. 2014, 193:71-83.
63. Kälber T., Meier J.S., Kreuzer M., Leiber F. Flowering catch crops used as forage plants for dairy cows: Influence on fatty acids and tocopherols in milk. J. Dairy Sci. 2011, 94:1477-1489.
64. 13C bicarbonate dilution technique using an automatic blood sampling system. J. Dairy Sci. 2011, 94:1989-2000.
65. Kay J.K., Mackle T.R., Auldist M.J., Thomson N.A., Bauman D.E. Endogenous synthesis of cis-9,trans-11 conjugated linoleic acid in dairy cows fed fresh pasture. J. Dairy Sci. 2004, 87:369-378.
66. Kay J.K., Roche J.R., Kolver E.S., Thomson N.A., Baumgard L.H. A comparison between feeding systems (pasture and TMR) and the effect of vitamin E supplementation on plasma and milk fatty acid profiles in dairy cows. J. Dairy Res. 2005, 72:322-332.
67. Khan N.A., Tewoldebrhan T.A., Zom R.L.G., Cone J.W., Hendriks W.H. Effect of corn silage harvest maturity and concentrate type on milk fatty acid composition of dairy cows. J. Dairy Sci. 2012, 95:1472-1483.
68. Khiaosa-ard R., Bryner S.F., Scheeder M.R.L., Wettstein H.-R., Leiber F., Kreuzer M., Soliva C.R. Evidence for the inhibition of the terminal step of ruminal α-linolenic acid biohydrogenation by condensed tannins. J. Dairy Sci. 2009, 92:177-188.
69. Khiaosa-ard R., Klevenhusen F., Soliva C.R., Kreuzer M., Leiber F. Transfer of linoleic and linolenic acid from feed to milk in cows fed isoenergetic diets differing in proportion and origin of concentrates and roughages. J. Dairy Res. 2010, 77:331-336.
70. Khiaosa-ard R., Soliva C.R., Kreuzer M., Leiber F. Influence of alpine forage either employed as donor cow's feed or as incubation substrate on in vitro ruminal fatty acid biohydrogenation. Livest. Sci. 2011, 140:80-87.
71. Kliem K.E., Morgan R., Humphries D.J., Shingfield K.J., Givens D.I. Effect of replacing grass silage with maize silage in the diet on bovine milk fatty acid composition. Animal 2008, 2:1850-1858.
72. Kraft J., Collomb M., Möckel P., Sieber R., Jahreis G. Differences in CLA isomer distribution of cow's milk lipids. Lipids 2003, 38:657-664.
73. Larsen M.K., Fretté X.C., Kristensen T., Eriksen J., Søegaard K., Nielsen J.H. Fatty acid, tocopherol and carotenoid content in herbage and milk affected by sward composition and season of grazing. J. Sci. Food Agric. 2012, 92:2891-2898.
74. Lee M.R.F., Theobald V.J., Tweed J.K.S., Winters A.L., Scollan N.D. Effect of feeding fresh or conditioned red clover on milk fatty acids and nitrogen utilization in lactating dairy cows. J. Dairy Sci. 2009, 92:1136-1147.
75. Leiber F., Dorn K., Probst J.K., Isensee A., Ackermann N., Kuhn A., Spengler Neff A. Concentrate reduction and sequential roughage offer to dairy cows: effects on milk protein yield, protein efficiency and milk quality. J. Dairy Res. 2015, http://dx.doi.org/10.1017/S0022029915000205 In press.
76. Leiber F., Hochstrasser R., Wettstein H.-R., Kreuzer M. Feeding transition cows with oilseeds: Effects on fatty acid composition of adipose tissue, colostrum and milk. Livest. Sci. 2011, 138:1-12.
77. Leiber F., Kreuzer M., Nigg D., Wettstein H.-R., Scheeder M.R.L. A study on the causes for the elevated n-3 fatty acids in cow's milk of alpine origin. Lipids 2005, 40:191-202.
78. Leiber F., Scheeder M.R.L., Wettstein H.-R., Kreuzer M. Milk fatty acid profile of cows under the influence of alpine hypoxia and high mountainous forage quality. J. Anim. Feed Sci. 2004, 13:693-696.
79. Lock A.L., Bauman D.E. Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health. Lipids 2004, 39:1197-1206.
80. Loor J.J., Ferlay A., Ollier A., Doreau M., Chilliard Y. Relationship among trans and conjugated fatty acids and bovine milk fat yield due to dietary concentrate and linseed oil. J. Dairy Sci. 2005, 88:726-740.
81. Loor J.J., Herbein J.J. Dietary canola or soybean oil with two levels of conjugated linoleic acids (CLA) alter profiles of 18:1 and 18:2 isomers in blood plasma and milk fat from dairy cows. Anim. Feed Sci. Technol. 2003, 103:63-83.
82. Lourenço M., Van Ranst G., De Smet S., Raes K., Fievez V. Effects of grazing pastures with different botanical composition by lambs on rumen fatty acid metabolism and fatty acid pattern of longissimus muscle and subcutaneous fat. Animal 2007, 1:537-545.
83. Lourenço M., Vlaeminck B., Bruinenberg M., Demeyer D., Fievez V. Milk fatty acid composition and associated rumen lipolysis and fatty acid hydrogenation when feeding forages from intensively managed or semi-natural grasslands. Anim. Res. 2005, 54:471-484.
84. Marchesini G., Andrighetto I., Stefani A.-L., Berzaghi P., Tenti S., Segato S. Effect of unsaturated fatty acid supplementation on performance and milk fatty acid profile in dairy cows fed a high fibre diet. Ital. J. Anim. Sci. 2009, 8:391-403.
85. McNamara J.P. Regulation of bovine adipose tissue metabolism during lactation. 5. Relationships of lipid synthesis and lipolysis with energy intake and utilization. J. Dairy Sci. 1989, 72:407-418.
86. Mohammed R., Kennelly J.J., Kramer J.K.G., Beauchemin K.A., Stanton C.S., Murphy J.J. Effect of grain type and processing method on rumen fermentation and milk rumenic acid production. Animal 2010, 4:1425-1444.
87. Mohammed R., Stanton C.S., Kennelly J.J., Kramer J.K.G., Mee J.F., Glimm D.R., O'Donovan M., Murphy J.J. Grazing cows are more efficient than zero-grazed and grass silage-fed cows in milk rumenic acid production. J. Dairy Sci. 2009, 92:3874-3893.
88. Moorby J.M., Lee M.R.F., Davies D.R., Kim E.J., Nute G.R., Ellis N.M., Scollan N.D. Assessment of dietary ratios of red clover and grass silages on milk production and milk quality in dairy cows. J. Dairy Sci. 2009, 92:1148-1160.
89. Morales-Almaráz E., Soldado A., González A., Martínez-Fernández A., Domínguez-Vara I., de la Roza-Delgado B., Vicente F. Improving the fatty acid profile of dairy cow milk by combining grazing with feeding of total mixed ration. J. Dairy Res. 2010, 77:225-230.
90. Nakamura M.T., Nara T.Y. Essential fatty acid synthesis and its regulation in mammals. Prostaglandins Leukot. Essent. Fatty Acids 2003, 68:145-150.
91. Neveu C., Baurhoo B., Mustafa A. Effect of feeding extruded flaxseed with different grains on the performance of dairy cows and milk fatty acid profile. J. Dairy Sci. 2014, 97:1543-1551.
92. Nielsen T.S., Straarup E.M., Vestergaard M., Sejrsen K. Effect of silage type and concentrate level on conjugated linoleic acids, trans-C18:1 isomers and fat content in milk from dairy cows. Reprod. Nutr. Dev. 2006, 46:699-712.
93. Palmquist D.L., Jenkins T.C. Challenges with fats and fatty acid methods. J. Anim. Sci. 2003, 81:3250-3254.
94. Patel M., Wredle E., Bertilsson J. Effect of dietary proportion of grass silage on milk fat with emphasis on odd- and branched-chain fatty acids in dairy cows. J. Dairy Sci. 2013, 96:390-397.
95. Petersen M.B., Jensen S.K. Biohydrogenation of fatty acids is dependent on plant species and feeding regimen of dairy cows. J. Agric. Food Chem. 2014, 62:3570-3576.
96. Petersen M.B., Søegaard K., Jensen S.K. Herb feeding increases n-3 and n-6 fatty acids in cow milk. Livest. Sci. 2011, 141:90-94.
97. Petit H.V., Gagnon N., Mir P.S., Cao R., Cui S. Milk concentration of the mammalian lignan enterolactone, milk production, milk fatty acid profile, and digestibility in dairy cows fed diets containing whole flaxseed or flaxseed meal. J. Dairy Res. 2009, 76:257-264.
98. Petit H.V., Germiquet C., Lebel D. Effect of feeding whole, unprocessed sunflower seeds and flaxseed on milk production, milk composition, and prostaglandin secretion in dairy cows. J. Dairy Sci. 2004, 87:3889-3898.
99. Ranathunga S.D., Kalscheur K.F., Hippen A.R., Schingoethe D.J. Replacement of starch from corn with nonforage fiber from distillers grains and soyhulls in diets of lactating dairy cows. J. Dairy Sci. 2010, 93:1086-1097.
100. Rego O.A., Portugal P.V., Sousa M.B., Rosa H.J.D., Vouzela C.M., Borba A.E.S., Bessa R.J.B. Effect of diet on the fatty acid pattern in milk from dairy cows. Anim. Res. 2004, 53:213-220.
101. Rego O.A., Regalo S.M.M., Rosa H.J.D., Alves S.P., Borba A.E.S., Bessa R.J.B., Cabrita A.R.J., Fonseca A.J.M. Effects of grass silage and soybean meal supplementation on milk production and milk fatty acid profiles of grazing dairy cows. J. Dairy Sci. 2008, 91:2736-2743.
102. Richter E.K., Spangenberg J.E., Klevenhusen F., Soliva C.R., Kreuzer M., Leiber F. Stable carbon isotope composition of c9,t11-conjugated linoleic acid in cow's milk as related to dietary fatty acids. Lipids 2012, 47:161-169.
103. Robbins K.R., Saxton A.M., Southern L.L. Estimation of nutrient requirements using broken-line regression analysis. J. Anim. Sci. 2006, 84:E155-E165.
104. 18:1 fatty acids and isomers of conjugated linoleic acid. Anim. Sci. 2006, 82:479-492.
105. Salawu M.B., Adesogan A.T., Dewhurst R.J. Forage intake, meal patterns, and milk production of lactating dairy cows fed grass silage or pea-wheat bi-crop silages. J. Dairy Sci. 2002, 85:3035-3044.
106. Saliba L., Gervais R., Lebeuf Y., Chouinard P.Y. Effect of feeding linseed oil in diets differing in forage to concentrate ratio: 1. Production performance and milk fat content of biohydrogenation intermediates of α-linolenic acid. J. Dairy Res. 2014, 81:82-90.
107. Sauvant D., Schmidely P., Daudin J.J., St-Pierre N.R. Meta-analyses of experimental data in animal nutrition. Animal 2008, 2:1203-1214.
108. Shingfield K.J., Salo-Väänänen P., Pahkala E., Toivonen V., Jaakkola S., Piironen V., Huhtanen P. Effect of forage conservation method, concentrate level and propylene glycol on the fatty acid composition and vitamin content of cows' milk. J. Dairy Res. 2005, 72:349-361.
109. Solomon R., Chase L.E., Ben-Ghedalia D., Bauman D.E. The effect of nonstructural carbohydrate and addition of full fat extruded soybeans on the concentration of conjugated linoleic acid in the milk fat of dairy cows. J. Dairy Sci. 2000, 83:1322-1329.
110. Soppela P., Nieminen M. Effect of moderate wintertime undernutrition on fatty acid composition of adipose tissue of reindeer (Rangifer tarandustarandus L.). Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2002, 132:403-409.
111. St-Pierre N.R. Integrating quantitative findings from multiple studies using mixed model methodology. J. Dairy Sci. 2001, 84:741-755.
112. Staerfl S.M., Zeitz J.O., Amelchanka S.L., Kälber T., Kreuzer M., Leiber F. Comparison of the milk fatty acid composition from dairy cows fed high-sugar ryegrass, low-sugar ryegrass, or maize. Dairy Sci. Technol. 2013, 93:201-210.
113. Steinshamn H., Thuen E. White or red clover-grass silage in organic dairy milk production: Grassland productivity and milk production responses with different levels of concentrate. Livest. Sci. 2008, 19:202-215.
114. Stergiadis S., Leifert C., Seal C.J., Eyre M.D., Steinshamn H., Butler G. Improving the fatty acid profile of winter milk from housed cows with contrasting feeding regimes by oilseed supplementation. Food Chem. 2014, 164:293-300.
115. Sterk A., Johansson B.E.O., Taweel H.Z.H., Murphy M., van Vuuren A.M., Hendriks W.H., Dijkstra J. Effects of forage type, forage to concentrate ratio, and crushed linseed supplementation on milk fatty acid profile in lactating dairy cows. J. Dairy Sci. 2011, 94:6078-6091.
116. van Dorland H.A., Kreuzer M., Leuenberger H., Wettstein H.R. Comparative potential of white and red clover to modify the milk fatty acid profile of cows fed ryegrass-based diets from zero-grazing and silage systems. J. Sci. Food Agric. 2008, 88:77-85.
117. van Wijlen R.P.J., Colombani P.C. Grass-based ruminant production methods and human bioconversion of vaccenic acid with estimations of maximal dietary intake of conjugated linoleic acids. Int. Dairy J. 2010, 20:433-448.
118. Vanhatalo A., Kuoppala K., Toivonen V., Shingfield K.J. Effects of forage species and stage of maturity on bovine milk fatty acid composition. Eur. J. Lipid Sci. Technol. 2007, 109:856-867.
119. Vasta V., Makkar H.P.S., Mele M., Priolo A. Ruminal biohydrogenation as affected by tannins in vitro. Br. J. Nutr. 2009, 102:82-92.
120. Villalba J.J., Provenza F.D., Han G. Experience influences diet mixing by herbivores: Implications for plant biochemical diversity. Oikos 2004, 107:100-109.
121. Wales W.J., Kolver E.S., Egan A.R., Roche J.R. Effects of strain of Holstein-Friesian and concentrate supplementation on the fatty acid composition of milk fat of dairy cows grazing pasture in early lactation. J. Dairy Sci. 2009, 92:247-255.
122. Ward A.T., Wittenberg K.M., Froebe H.M., Przybylski R., Malcolmson L. Fresh forage and solin supplementation on conjugated linoleic acid levels in plasma and milk. J. Dairy Sci. 2003, 86:1742-1750.
123. Whiting C.M., Mutsvangwa T., Walton J.P., Cant J.P., McBride B.W. Effects of feeding either fresh alfalfa or alfalfa silage on milk fatty acid content in Holstein dairy cows. Anim. Feed Sci. Technol. 2004, 113:27-37.
124. Whitlock L.A., Schingoethe D.J., Hippen A.R., Kalscheur K.F., AbuGhazaleh A.A. Milk production and composition from cows fed high oil or conventional corn at two forage concentrations. J. Dairy Sci. 2003, 86:2428-2437.
125. Willems H., Kreuzer M., Leiber F. Alpha-linolenic and linoleic acid in meat and adipose tissue of grazing lambs differ among alpine pasture types with contrasting plant species and phenolic compound composition. Small Rumin. Res. 2014, 116:153-164.
126. Woods V.B., Fearon E.A. Dietary sources of unsaturated fatty acids for animals and their transfer into meat, milk and eggs: A review. Livest. Sci. 2009, 126:1-20.
127. Yan R., Han J.-G., Zhang X., Li Z. Effects of different corn silage: alfalfa silage ratios and full fat extruded soybeans on milk composition, conjugated linoleic acids content in milk fat and performance of dairy cows. Afr. J. Biotechnol. 2010, 9:5465-5674.
128. Ye J.A., Wang C., Wang H.F., Ye H.W., Wang B.X., Liu H.Y., Wang Y.M., Yang Z.Q., Liu J.X. Milk production and fatty acid profile of dairy cows supplemented with flaxseed oil, soybean oil, or extruded soybeans. Acta Agric. Scand. A-Anim. Sci. 2009, 59:121-129.
129. Zachut M., Arieli A., Lehrer H., Livshitz L., Yakoby S., Moallem U. Effects of increased supplementation of n-3 fatty acids to transition dairy cows on performance and fatty acid profile in plasma, adipose tissue, and milk fat. J. Dairy Sci. 2010, 93:5877-5889.
130. Zunong M., Tuerhongd T., Okamotob M., Hongob A., Hanada M. Effects of a potato pulp silage supplement on the composition of milk fatty acids when fed to grazing dairy cows. Anim. Feed Sci. Technol. 2009, 152:81-91.