Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

Journal of Clinical Investigation

Volumn 125, Issue 8, 2015, Pages 2952-2964

  Tsai, Shihyin ^a   Sitzmann, Joanna M ^a   Dastidar, Somasish G ^b   Rodriguez, Ariana A ^a   Vu, Stephanie L ^a   McDonald, Circe E ^a   Academia, Emmeline C ^a   O'Leary, Monique N ^a   Ashe, Travis D ^b   La Spada, Albert R ^b,c   Kennedy, Brian K ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID BINDING PROTEIN 4; FIBROBLAST GROWTH FACTOR 21; GLUCOSE; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; INITIATION FACTOR 4G; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; CARRIER PROTEIN; EIF4EBP1 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; MUSCLE PROTEIN; PHOSPHOPROTEIN; PPARGC1A PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

ADULT; AEROBIC METABOLISM; AGING; ANIMAL TISSUE; ARTICLE; BODY FAT DISTRIBUTION; BROWN ADIPOSE TISSUE; CELL PROTECTION; CONTROLLED STUDY; ENERGY EXPENDITURE; FATTY LIVER; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HUMAN; INSULIN RESISTANCE; INSULIN RESPONSE; INSULIN SENSITIVITY; MALE; METABOLIC PARAMETERS; METABOLIC RATE; MOUSE; MUSCLE LEVEL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; REGULATORY MECHANISM; RESPIRATORY FUNCTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TISSUE METABOLISM; TISSUE PRESERVATION; TRANSGENIC ANIMAL; ANIMAL; ANTIBODY SPECIFICITY; GENETICS; KNOCKOUT MOUSE; METABOLISM; OXYGEN CONSUMPTION; PATHOLOGY;

AGING; ANIMALS; CARRIER PROTEINS; DIABETES MELLITUS, TYPE 2; FIBROBLAST GROWTH FACTORS; MICE; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; MUSCLE PROTEINS; MUSCLE, SKELETAL; OBESITY; ORGAN SPECIFICITY; OXYGEN CONSUMPTION; PHOSPHOPROTEINS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 84939247637     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI77361     Document Type: Article

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