MTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome

Science

Volumn 342, Issue 6165, 2013, Pages 1524-1528

  Johnson, Simon C ^a   Yanos, Melana E ^a   Kayser, Ernst Bernhard ^b   Quintana, Albert ^c   Sangesland, Maya ^a   Castanza, Anthony ^a   Uhde, Lauren ^a   Hui, Jessica ^a   Wall, Valerie Z ^a   Gagnidze, Arni ^a   Oh, Kelly ^a   Wasko, Brian M ^a   Ramos, Fresnida J ^a   Palmiter, Richard D ^c   Rabinovitch, Peter S ^a   Morgan, Philip G ^b   Sedensky, Margaret M ^b   Kaeberlein, Matt ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SEATTLE CHILDREN S HOSPITAL   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON SULFUR PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; RAPAMYCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; TACROLIMUS;

CHILD HEALTH; DISEASE INCIDENCE; HEALTH CARE; METABOLISM; MITOCHONDRION; NEUROLOGY; RESPIRATION; SIGNALING; SYMPTOM;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CATABOLISM; CHILDHOOD DISEASE; CONTROLLED STUDY; DISEASE COURSE; DISEASE MODEL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSAGE SCHEDULE COMPARISON; DRUG TARGETING; ENZYME DEFICIENCY; ENZYME SUBUNIT; FEMALE; GLYCOLYSIS; KNOCKOUT MOUSE; LEIGH DISEASE; LIFESPAN; MALE; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; ONSET AGE; PRIORITY JOURNAL; RESPIRATORY CHAIN; SURVIVAL RATE; TREATMENT OUTCOME;

MUS;

EID: 84890850876     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1244360     Document Type: Article

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