The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells

EMBO Journal

Volumn 33, Issue 24, 2014, Pages 2922-2936

  Jurkin, Jennifer ^a   Henkel, Theresa ^a   Nielsen, Anne Færch ^b   Minnich, Martina ^c   Popow, Johannes ^d   Kaufmann, Therese ^a   Heindl, Katrin ^e   Hoffmann, Thomas ^c   Busslinger, Meinrad ^c   Martinez, Javier ^a  

^a INSTITUTE OF MOLECULAR BIOTECHNOLOGY   (Austria)

^b European Molecular Biology Organization   (Germany)

^c RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^e WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

antibody secretion; archease; plasma cells; RTCB; XBP1 mRNA splicing

Indexed keywords

ARCHEASE; CD23 ANTIGEN; CRE RECOMBINASE; MESSENGER RNA; PROTEIN; RTCB PROTEIN; TRANSFER RNA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; AMINO ACID TRANSFER RNA LIGASE; ANTIBODY; ARCHEASE PROTEIN, HUMAN; DNA BINDING PROTEIN; FAAP PROTEIN, MOUSE; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY SECRETING CELL; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DIFFERENTIATION; ENDOPLASMIC RETICULUM; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGLOBULIN PRODUCTION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMA CELL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA SPLICING; UNFOLDED PROTEIN RESPONSE; ANIMAL; GENETICS; HELA CELL LINE; METABOLISM; PHYSIOLOGY;

MAMMALIA; MUS;

AMINO ACYL-TRNA SYNTHETASES; ANIMALS; ANTIBODIES; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; MICE; PLASMA CELLS; PROTEINS; RNA SPLICING; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 84918823958     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201490332     Document Type: Article

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