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Volumn 72, Issue 11, 2015, Pages 2061-2074

Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule

Author keywords

Apoptosis; Cell survival; Chronic kidney disease; Ion transport; Na+ H+ exchange; Tubular atrophy

Indexed keywords

CATION TRANSPORT PROTEIN; MEMBRANE PROTEIN; PROTEIN BINDING; SLC9A1 PROTEIN, HUMAN; SODIUM PROTON EXCHANGE PROTEIN;

EID: 84938053891     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-1848-8     Document Type: Review
Times cited : (32)

References (172)
  • 1
    • 0013942130 scopus 로고
    • Chemiosmotic coupling in oxidative and photosynthetic phosphorylation
    • 1:CAS:528:DyaF28XltVWnsro%3D 5329743
    • Mitchell P (1966) Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. Biol Rev Camb Philos Soc 41:445-502
    • (1966) Biol Rev Camb Philos Soc , vol.41 , pp. 445-502
    • Mitchell, P.1
  • 2
    • 0015475455 scopus 로고
    • Cation transport and electrogenesis by Streptococcus faecalis. II. Proton and sodium extrusion
    • 1:CAS:528:DyaE38XhsFSrsr4%3D 4263675
    • Harold FM, Papineau D (1972) Cation transport and electrogenesis by Streptococcus faecalis. II. Proton and sodium extrusion. J Membr Biol 8:45-62
    • (1972) J Membr Biol , vol.8 , pp. 45-62
    • Harold, F.M.1    Papineau, D.2
  • 3
    • 0016261824 scopus 로고
    • Proton/sodium ion antiport in Escherichia coli
    • 1168467 1:CAS:528:DyaE2MXpsFWgtg%3D%3D 4618479
    • West IC, Mitchell P (1974) Proton/sodium ion antiport in Escherichia coli. Biochem J 144:87-90
    • (1974) Biochem J , vol.144 , pp. 87-90
    • West, I.C.1    Mitchell, P.2
  • 4
    • 0017235019 scopus 로고
    • Sodium/proton antiport in brush-border-membrane vesicles isolated from rat small intestine and kidney
    • 1172760 1:CAS:528:DyaE28XktFGnt7g%3D 942389
    • Murer H, Hopfer U, Kinne R (1976) Sodium/proton antiport in brush-border-membrane vesicles isolated from rat small intestine and kidney. Biochem J 154:597-604
    • (1976) Biochem J , vol.154 , pp. 597-604
    • Murer, H.1    Hopfer, U.2    Kinne, R.3
  • 6
    • 84891882891 scopus 로고    scopus 로고
    • Traditional and emerging roles for the SLC9 Na+/H+ exchangers
    • 1:CAS:528:DC%2BC3sXhvFajtrjM 24337822
    • Fuster DG, Alexander RT (2014) Traditional and emerging roles for the SLC9 Na+/H+ exchangers. Pflugers Arch 466:61-76
    • (2014) Pflugers Arch , vol.466 , pp. 61-76
    • Fuster, D.G.1    Alexander, R.T.2
  • 7
    • 84875204528 scopus 로고    scopus 로고
    • SLC9/NHE gene family, a plasma membrane and organellar family of Na(+)/H(+) exchangers
    • 3724465 1:CAS:528:DC%2BC3sXksVyqtro%3D 23506868
    • Donowitz M, Ming TC, Fuster D (2013) SLC9/NHE gene family, a plasma membrane and organellar family of Na(+)/H(+) exchangers. Mol Aspects Med 34:236-251
    • (2013) Mol Aspects Med , vol.34 , pp. 236-251
    • Donowitz, M.1    Ming, T.C.2    Fuster, D.3
  • 11
    • 0033548269 scopus 로고    scopus 로고
    • Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain
    • 1:CAS:528:DyaK1MXhslagsLs%3D 9933641
    • Baird NR, Orlowski J, Szabo EZ, Zaun HC, Schultheis PJ, Menon AG, Shull GE (1999) Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain. J Biol Chem 274:4377-4382
    • (1999) J Biol Chem , vol.274 , pp. 4377-4382
    • Baird, N.R.1    Orlowski, J.2    Szabo, E.Z.3    Zaun, H.C.4    Schultheis, P.J.5    Menon, A.G.6    Shull, G.E.7
  • 14
    • 59149095664 scopus 로고    scopus 로고
    • NhaA crystal structure: Functional-structural insights
    • 1:CAS:528:DC%2BD1MXptVeju78%3D 19448069
    • Padan E, Kozachkov L, Herz K, Rimon A (2009) NhaA crystal structure: functional-structural insights. J Exp Biol 212:1593-1603
    • (2009) J Exp Biol , vol.212 , pp. 1593-1603
    • Padan, E.1    Kozachkov, L.2    Herz, K.3    Rimon, A.4
  • 15
    • 12144271044 scopus 로고    scopus 로고
    • Evolutionary origins of eukaryotic sodium/proton exchangers
    • 1:CAS:528:DC%2BD2MXhsVCks70%3D 15643048
    • Brett CL, Donowitz M, Rao R (2005) Evolutionary origins of eukaryotic sodium/proton exchangers. Am J Physiol Cell Physiol 288:C223-C239
    • (2005) Am J Physiol Cell Physiol , vol.288 , pp. 223-C239
    • Brett, C.L.1    Donowitz, M.2    Rao, R.3
  • 16
    • 33746174597 scopus 로고    scopus 로고
    • Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testis
    • 1:CAS:528:DC%2BD28XntVCqt78%3D 16850186
    • Ye G, Chen C, Han D, Xiong X, Kong Y, Wan B, Yu L (2006) Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testis. Mol Biol Rep 33:175-180
    • (2006) Mol Biol Rep , vol.33 , pp. 175-180
    • Ye, G.1    Chen, C.2    Han, D.3    Xiong, X.4    Kong, Y.5    Wan, B.6    Yu, L.7
  • 17
    • 49649123600 scopus 로고    scopus 로고
    • Characterization of the sodium/hydrogen exchanger NHA2
    • 2488271 1:CAS:528:DC%2BD1cXhtVWltr3E 18508966
    • Fuster DG, Zhang J, Shi M, Bobulescu IA, Andersson S, Moe OW (2008) Characterization of the sodium/hydrogen exchanger NHA2. JASN 19:1547-1556
    • (2008) JASN , vol.19 , pp. 1547-1556
    • Fuster, D.G.1    Zhang, J.2    Shi, M.3    Bobulescu, I.A.4    Andersson, S.5    Moe, O.W.6
  • 18
    • 40949103035 scopus 로고    scopus 로고
    • NHE10, an osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival [corrected]
    • 1:CAS:528:DC%2BD1cXjs12gtrk%3D 18269914
    • Lee SH, Kim T, Park ES, Yang S, Jeong D, Choi Y, Rho J (2008) NHE10, an osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival [corrected]. Biochem Biophys Res Commun 369:320-326
    • (2008) Biochem Biophys Res Commun , vol.369 , pp. 320-326
    • Lee, S.H.1    Kim, T.2    Park, E.S.3    Yang, S.4    Jeong, D.5    Choi, Y.6    Rho, J.7
  • 19
    • 34547231222 scopus 로고    scopus 로고
    • A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC)
    • 1890493 1:CAS:528:DC%2BD2sXmtlehsrg%3D 17517652
    • Wang D, Hu J, Bobulescu IA, Quill TA, McLeroy P, Moe OW, Garbers DL (2007) A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC). Proc Natl Acad Sci USA 104:9325-9330
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 9325-9330
    • Wang, D.1    Hu, J.2    Bobulescu, I.A.3    Quill, T.A.4    McLeroy, P.5    Moe, O.W.6    Garbers, D.L.7
  • 20
    • 0026055340 scopus 로고
    • Mechanisms of receptor-mediated regulation of Na-H exchange
    • 1:CAS:528:DyaK38XpvFeluw%3D%3D 1662062
    • Barber DL (1991) Mechanisms of receptor-mediated regulation of Na-H exchange. Cell Signal 3:387-397
    • (1991) Cell Signal , vol.3 , pp. 387-397
    • Barber, D.L.1
  • 23
    • 0027381360 scopus 로고
    • Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells
    • 1:CAS:528:DyaK3sXmt1anurs%3D 8244989
    • Yu FH, Shull GE, Orlowski J (1993) Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells. J Biol Chem 268:25536-25541
    • (1993) J Biol Chem , vol.268 , pp. 25536-25541
    • Yu, F.H.1    Shull, G.E.2    Orlowski, J.3
  • 25
    • 0028953550 scopus 로고
    • Expression of the human sodium/proton exchanger NHE-1 in Xenopus laevis oocytes enhances sodium/proton exchange activity and establishes sodium/lithium countertransport
    • 1:CAS:528:DyaK2MXltlOjsLg%3D 7603840
    • Busch S, Burckhardt BC, Siffert W (1995) Expression of the human sodium/proton exchanger NHE-1 in Xenopus laevis oocytes enhances sodium/proton exchange activity and establishes sodium/lithium countertransport. Pflugers Arch 429:859-869
    • (1995) Pflugers Arch , vol.429 , pp. 859-869
    • Busch, S.1    Burckhardt, B.C.2    Siffert, W.3
  • 26
    • 0037983655 scopus 로고    scopus 로고
    • Alternative splicing of NHE-1 mediates Na-Li countertransport and associates with activity rate
    • 1:CAS:528:DC%2BD3sXmt1Sjs70%3D 12765964
    • Zerbini G, Maestroni A, Breviario D, Mangili R, Casari G (2003) Alternative splicing of NHE-1 mediates Na-Li countertransport and associates with activity rate. Diabetes 52:1511-1518
    • (2003) Diabetes , vol.52 , pp. 1511-1518
    • Zerbini, G.1    Maestroni, A.2    Breviario, D.3    Mangili, R.4    Casari, G.5
  • 28
    • 45149118301 scopus 로고    scopus 로고
    • Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity
    • 2442331 1:CAS:528:DC%2BD1cXltlGrsrg%3D 18319254
    • Parker MD, Musa-Aziz R, Rojas JD, Choi I, Daly CM, Boron WF (2008) Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity. J Biol Chem 283:12777-12788
    • (2008) J Biol Chem , vol.283 , pp. 12777-12788
    • Parker, M.D.1    Musa-Aziz, R.2    Rojas, J.D.3    Choi, I.4    Daly, C.M.5    Boron, W.F.6
  • 29
    • 0027282066 scopus 로고
    • Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger
    • 1:CAS:528:DyaK3sXlslKiu7g%3D 8393860
    • Orlowski J (1993) Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger. J Biol Chem 268:16369-16377
    • (1993) J Biol Chem , vol.268 , pp. 16369-16377
    • Orlowski, J.1
  • 30
    • 0027298692 scopus 로고
    • Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2)
    • 1:CAS:528:DyaK3sXltlalt70%3D 7685025
    • Tse CM, Levine SA, Yun CH, Montrose MH, Little PJ, Pouyssegur J, Donowitz M (1993) Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2). J Biol Chem 268:11917-11924
    • (1993) J Biol Chem , vol.268 , pp. 11917-11924
    • Tse, C.M.1    Levine, S.A.2    Yun, C.H.3    Montrose, M.H.4    Little, P.J.5    Pouyssegur, J.6    Donowitz, M.7
  • 31
    • 0029805369 scopus 로고    scopus 로고
    • Characterization of the rat Na+/H+ exchanger isoform NHE4 and localization in rat hippocampus
    • 1:CAS:528:DyaK28XntFymu7o%3D 8944646
    • Bookstein C, Musch MW, DePaoli A, Xie Y, Rabenau K, Villereal M, Rao MC, Chang EB (1996) Characterization of the rat Na+/H+ exchanger isoform NHE4 and localization in rat hippocampus. Am J Physiol 271:C1629-C1638
    • (1996) Am J Physiol , vol.271 , pp. 1629-C1638
    • Bookstein, C.1    Musch, M.W.2    Depaoli, A.3    Xie, Y.4    Rabenau, K.5    Villereal, M.6    Rao, M.C.7    Chang, E.B.8
  • 32
    • 0034052723 scopus 로고    scopus 로고
    • Kinetic and pharmacological properties of human brain Na(+)/H(+) exchanger isoform 5 stably expressed in Chinese hamster ovary cells
    • 1:CAS:528:DC%2BD3cXhslWrtro%3D 10692428
    • Szabo EZ, Numata M, Shull GE, Orlowski J (2000) Kinetic and pharmacological properties of human brain Na(+)/H(+) exchanger isoform 5 stably expressed in Chinese hamster ovary cells. J Biol Chem 275:6302-6307
    • (2000) J Biol Chem , vol.275 , pp. 6302-6307
    • Szabo, E.Z.1    Numata, M.2    Shull, G.E.3    Orlowski, J.4
  • 33
    • 0033548079 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain
    • 1:CAS:528:DyaK1MXhslagsLg%3D 9933642
    • Attaphitaya S, Park K, Melvin JE (1999) Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain. J Biol Chem 274:4383-4388
    • (1999) J Biol Chem , vol.274 , pp. 4383-4388
    • Attaphitaya, S.1    Park, K.2    Melvin, J.E.3
  • 34
    • 34547115979 scopus 로고    scopus 로고
    • NHE1 inhibition by amiloride- and benzoyl guanidine-type compounds: Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity
    • 1:CAS:528:DC%2BD2sXntFWrtLs%3D 17493937
    • Pedersen SF, King SA, Nygaard EB, Rigor RR, Cala PM (2007) NHE1 inhibition by amiloride- and benzoyl guanidine-type compounds: inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. J Biol Chem 282:19716-19727
    • (2007) J Biol Chem , vol.282 , pp. 19716-19727
    • Pedersen, S.F.1    King, S.A.2    Nygaard, E.B.3    Rigor, R.R.4    Cala, P.M.5
  • 35
    • 0035942328 scopus 로고    scopus 로고
    • Second-site revertants of a low-sodium-affinity mutant of the Na+/H+ exchanger reveal the participation of TM4 into a highly constrained sodium-binding site
    • 1:CAS:528:DC%2BD3MXit1Cksrk%3D 11305927
    • Touret N, Poujeol P, Counillon L (2001) Second-site revertants of a low-sodium-affinity mutant of the Na+/H+ exchanger reveal the participation of TM4 into a highly constrained sodium-binding site. Biochemistry 40:5095-5101
    • (2001) Biochemistry , vol.40 , pp. 5095-5101
    • Touret, N.1    Poujeol, P.2    Counillon, L.3
  • 36
    • 0027245907 scopus 로고
    • + exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis
    • 46541 1:CAS:528:DyaK3sXksVamtr0%3D 8389452
    • + exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis. Proc Natl Acad Sci USA 90:4508-4512
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4508-4512
    • Counillon, L.1    Franchi, A.2    Pouyssegur, J.3
  • 37
    • 1842290349 scopus 로고    scopus 로고
    • Random mutagenesis reveals a novel site involved in inhibitor interaction within the fourth transmembrane segment of the Na+/H+ exchanger-1
    • 1:CAS:528:DyaK2sXhslCqu7g%3D 9062125
    • Counillon L, Noel J, Reithmeier RA, Pouyssegur J (1997) Random mutagenesis reveals a novel site involved in inhibitor interaction within the fourth transmembrane segment of the Na+/H+ exchanger-1. Biochemistry 36:2951-2959
    • (1997) Biochemistry , vol.36 , pp. 2951-2959
    • Counillon, L.1    Noel, J.2    Reithmeier, R.A.3    Pouyssegur, J.4
  • 38
    • 0346963148 scopus 로고    scopus 로고
    • + and the interaction with amiloride derivatives
    • 14690446
    • + and the interaction with amiloride derivatives. Biochemistry 42:15361-15368
    • (2003) Biochemistry , vol.42 , pp. 15361-15368
    • Noël, J.1    Germain, D.2    Vadnais, J.3
  • 39
    • 0035941272 scopus 로고    scopus 로고
    • Identification of sites in the second exomembrane loop and ninth transmembrane helix of the mammalian Na+/H+ exchanger important for drug recognition and cation translocation
    • 1:STN:280:DC%2BD3MnmslKhtQ%3D%3D 11564737
    • Khadilkar A, Iannuzzi P, Orlowski J (2001) Identification of sites in the second exomembrane loop and ninth transmembrane helix of the mammalian Na+/H+ exchanger important for drug recognition and cation translocation. J Biol Chem 276:43792-43800
    • (2001) J Biol Chem , vol.276 , pp. 43792-43800
    • Khadilkar, A.1    Iannuzzi, P.2    Orlowski, J.3
  • 40
    • 38049188238 scopus 로고    scopus 로고
    • + exchanger 1 (NHE1): Functional and clinical implications
    • 1:CAS:528:DC%2BD2sXhsVGjt7rL 17981808
    • + exchanger 1 (NHE1): functional and clinical implications. J Biol Chem 282:37854-37863
    • (2007) J Biol Chem , vol.282 , pp. 37854-37863
    • Landau, M.1    Herz, K.2    Padan, E.3    Ben-Tal, N.4
  • 41
    • 0028101308 scopus 로고
    • + exchanger isoforms NHE1 and NHE3 exist as stable dimers in membranes with a high degree of specificity for homodimers
    • 1:CAS:528:DyaK2cXhsFOjt70%3D 8300588
    • + exchanger isoforms NHE1 and NHE3 exist as stable dimers in membranes with a high degree of specificity for homodimers. J Biol Chem 269:2589-2596
    • (1994) J Biol Chem , vol.269 , pp. 2589-2596
    • Fafournoux, P.1    Noel, J.2    Pouyssegur, J.3
  • 42
    • 4644271441 scopus 로고    scopus 로고
    • Dimeric interaction between the cytoplasmic domains of the Na+/H+ exchanger NHE1 revealed by symmetrical intermolecular cross-linking and selective co-immunoprecipitation
    • 1:CAS:528:DC%2BD2cXmt1GmsLY%3D 15323573
    • Hisamitsu T, Pang T, Shigekawa M, Wakabayashi S (2004) Dimeric interaction between the cytoplasmic domains of the Na+/H+ exchanger NHE1 revealed by symmetrical intermolecular cross-linking and selective co-immunoprecipitation. Biochemistry 43:11135-11143
    • (2004) Biochemistry , vol.43 , pp. 11135-11143
    • Hisamitsu, T.1    Pang, T.2    Shigekawa, M.3    Wakabayashi, S.4
  • 43
    • 42949152545 scopus 로고    scopus 로고
    • Dimeric structure of human Na+/H+ exchanger isoform 1 over-produced in saccharomyces cerevisiae
    • 18077454
    • Moncoq K, Kemp G, Li X, Fliegel L, Young HS (2007) Dimeric structure of human Na+/H+ exchanger isoform 1 over-produced in saccharomyces cerevisiae. J Biol Chem 283:4145-4154
    • (2007) J Biol Chem , vol.283 , pp. 4145-4154
    • Moncoq, K.1    Kemp, G.2    Li, X.3    Fliegel, L.4    Young, H.S.5
  • 45
    • 53549110255 scopus 로고    scopus 로고
    • Steady-state function of the ubiquitous mammalian Na/H exchanger (NHE1) in relation to dimer coupling models with 2Na/2H stoichiometry
    • 2553392 1:CAS:528:DC%2BD1cXht1Omsr%2FO 18824592
    • Fuster D, Moe OW, Hilgemann DW (2008) Steady-state function of the ubiquitous mammalian Na/H exchanger (NHE1) in relation to dimer coupling models with 2Na/2H stoichiometry. J Gen Physiol 132:465-480
    • (2008) J Gen Physiol , vol.132 , pp. 465-480
    • Fuster, D.1    Moe, O.W.2    Hilgemann, D.W.3
  • 50
    • 18144418959 scopus 로고    scopus 로고
    • Functional linkage of H+/peptide transporter PEPT2 and Na+/H+ exchanger in primary cultures of astrocytes from mouse cerebral cortex
    • 1:CAS:528:DC%2BD2MXjvVOiu7Y%3D 15862787
    • Wada M, Miyakawa S, Shimada A, Okada N, Yamamoto A, Fujita T (2005) Functional linkage of H+/peptide transporter PEPT2 and Na+/H+ exchanger in primary cultures of astrocytes from mouse cerebral cortex. Brain Res 1044:33-41
    • (2005) Brain Res , vol.1044 , pp. 33-41
    • Wada, M.1    Miyakawa, S.2    Shimada, A.3    Okada, N.4    Yamamoto, A.5    Fujita, T.6
  • 51
    • 45249111182 scopus 로고    scopus 로고
    • Na(+)/H(+) exchanger inhibition modifies dopamine neurotransmission during normal and metabolic stress conditions
    • 4099054 1:CAS:528:DC%2BD1cXot1Ogs7c%3D 18363831
    • Rocha MA, Crockett DP, Wong LY, Richardson JR, Sonsalla PK (2008) Na(+)/H(+) exchanger inhibition modifies dopamine neurotransmission during normal and metabolic stress conditions. J Neurochem 106:231-243
    • (2008) J Neurochem , vol.106 , pp. 231-243
    • Rocha, M.A.1    Crockett, D.P.2    Wong, L.Y.3    Richardson, J.R.4    Sonsalla, P.K.5
  • 52
    • 47349123481 scopus 로고    scopus 로고
    • Late expression of Na(+)/H(+) exchanger 1 (NHE1) and neuroprotective effects of NHE inhibitor in the gerbil hippocampal CA1 region induced by transient ischemia
    • 1:CAS:528:DC%2BD1cXptVCjtrg%3D 18511042
    • Hwang IK, Yoo KY, An SJ, Li H, Lee CH, Choi JH, Lee JY, Lee BH, Kim YM, Kwon YG, Won MH (2008) Late expression of Na(+)/H(+) exchanger 1 (NHE1) and neuroprotective effects of NHE inhibitor in the gerbil hippocampal CA1 region induced by transient ischemia. Exp Neurol 212:314-323
    • (2008) Exp Neurol , vol.212 , pp. 314-323
    • Hwang, I.K.1    Yoo, K.Y.2    An, S.J.3    Li, H.4    Lee, C.H.5    Choi, J.H.6    Lee, J.Y.7    Lee, B.H.8    Kim, Y.M.9    Kwon, Y.G.10    Won, M.H.11
  • 53
    • 0011113594 scopus 로고
    • Functional expression of a human Na+/H+ antiporter gene transfected into antiporter-deficient mouse L cells
    • 387143 1:CAS:528:DyaL2sXnvFKhuw%3D%3D 3025840
    • Franchi A, Perucca-Lostanlen D, Pouyssegur J (1986) Functional expression of a human Na+/H+ antiporter gene transfected into antiporter-deficient mouse L cells. Proc Natl Acad Sci USA 83:9388-9392
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 9388-9392
    • Franchi, A.1    Perucca-Lostanlen, D.2    Pouyssegur, J.3
  • 54
    • 0026495612 scopus 로고
    • Immunocytochemical characterization of Na+ - H+ exchanger isoform NHE-1 in rabbit kidney
    • 1:CAS:528:DyaK3sXls1yhug%3D%3D 1279986
    • Biemesderfer D, Reilly RF, Exner M, Igarashi P, Aronson PS (1992) Immunocytochemical characterization of Na+ - H+ exchanger isoform NHE-1 in rabbit kidney. Am J Physiol 263:F833-F840
    • (1992) Am J Physiol , vol.263 , pp. 833-F840
    • Biemesderfer, D.1    Reilly, R.F.2    Exner, M.3    Igarashi, P.4    Aronson, P.S.5
  • 56
    • 0029099062 scopus 로고
    • Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb
    • 1:CAS:528:DyaK2MXpsVSisbw%3D 8569082
    • Amemiya M, Loffing J, Lotscher M, Kaissling B, Alpern RJ, Moe OW (1995) Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb. Kidney Int 48:1206-1215
    • (1995) Kidney Int , vol.48 , pp. 1206-1215
    • Amemiya, M.1    Loffing, J.2    Lotscher, M.3    Kaissling, B.4    Alpern, R.J.5    Moe, O.W.6
  • 62
    • 78649673808 scopus 로고    scopus 로고
    • Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H+ exchanger 1 ubiquitylation, endocytosis, and function
    • 2992263 1:CAS:528:DC%2BC3cXhsVOku73I 20855896
    • Simonin A, Fuster D (2010) Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H+ exchanger 1 ubiquitylation, endocytosis, and function. J Biol Chem 285:38293-38303
    • (2010) J Biol Chem , vol.285 , pp. 38293-38303
    • Simonin, A.1    Fuster, D.2
  • 63
    • 66749133994 scopus 로고    scopus 로고
    • Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice
    • 2692415 1:CAS:528:DC%2BD1MXnsVClsb8%3D 19369449
    • Damkier HH, Prasad V, Hubner CA, Praetorius J (2009) Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice. Am J Physiol Cell Physiol 296:C1291-C1300
    • (2009) Am J Physiol Cell Physiol , vol.296 , pp. 1291-C1300
    • Damkier, H.H.1    Prasad, V.2    Hubner, C.A.3    Praetorius, J.4
  • 64
    • 0029988554 scopus 로고    scopus 로고
    • Characterization of Na+/H+ exchange activity in cultured rat hippocampal astrocytes
    • 1:CAS:528:DyaK28Xis1Cjs7o%3D 8723228
    • Pizzonia JH, Ransom BR, Pappas CA (1996) Characterization of Na+/H+ exchange activity in cultured rat hippocampal astrocytes. J Neurosci Res 44:191-198
    • (1996) J Neurosci Res , vol.44 , pp. 191-198
    • Pizzonia, J.H.1    Ransom, B.R.2    Pappas, C.A.3
  • 65
    • 0031453418 scopus 로고    scopus 로고
    • Expression of Na+ - H+ exchanger isoforms NHE1 and NHE3 in kidney and blood cells of rabbit and rat
    • 1:CAS:528:DyaK1cXovFCh 9438178
    • Rutherford PA, Pizzonia JH, Biemesderfer D, Abu-Alfa A, Reilly R, Aronson PS (1997) Expression of Na+ - H+ exchanger isoforms NHE1 and NHE3 in kidney and blood cells of rabbit and rat. Exp Nephrol 5:490-497
    • (1997) Exp Nephrol , vol.5 , pp. 490-497
    • Rutherford, P.A.1    Pizzonia, J.H.2    Biemesderfer, D.3    Abu-Alfa, A.4    Reilly, R.5    Aronson, P.S.6
  • 66
    • 0027452494 scopus 로고
    • Cloning and analysis of the human myocardial Na+/H+ exchanger
    • 1:CAS:528:DyaK2cXhsFKqs74%3D 8283968
    • Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS (1993) Cloning and analysis of the human myocardial Na+/H+ exchanger. Mol Cell Biochem 125:137-143
    • (1993) Mol Cell Biochem , vol.125 , pp. 137-143
    • Fliegel, L.1    Dyck, J.R.2    Wang, H.3    Fong, C.4    Haworth, R.S.5
  • 67
    • 0036015195 scopus 로고    scopus 로고
    • Roles of the Na, K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility
    • 1:CAS:528:DC%2BD38XktlWku7g%3D 12112599
    • Woo AL, James PF, Lingrel JB (2002) Roles of the Na, K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility. Mol Reprod Dev 62:348-356
    • (2002) Mol Reprod Dev , vol.62 , pp. 348-356
    • Woo, A.L.1    James, P.F.2    Lingrel, J.B.3
  • 68
    • 79953753731 scopus 로고    scopus 로고
    • Structural analysis of the Na+/H+ exchanger isoform 1 (NHE1) using the divide and conquer approach
    • 1:CAS:528:DC%2BC3MXisFentr0%3D 21455270
    • Lee BL, Sykes BD, Fliegel L (2011) Structural analysis of the Na+/H+ exchanger isoform 1 (NHE1) using the divide and conquer approach. Biochem Cell Biol 89:189-199
    • (2011) Biochem Cell Biol , vol.89 , pp. 189-199
    • Lee, B.L.1    Sykes, B.D.2    Fliegel, L.3
  • 69
    • 79956327700 scopus 로고    scopus 로고
    • Two conflicting NHE1 model structures: Compatibility with experimental data and implications for the transport mechanism
    • Schushan M, Landau M, Padan E, Ben-Tal N (2011) Two conflicting NHE1 model structures: compatibility with experimental data and implications for the transport mechanism. J Biol Chem 286:le9
    • (2011) J Biol Chem , vol.286 , pp. le9
    • Schushan, M.1    Landau, M.2    Padan, E.3    Ben-Tal, N.4
  • 70
    • 0027931588 scopus 로고
    • The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain
    • 1:CAS:528:DyaK2cXlt1OqurY%3D 8068684
    • Counillon L, Pouyssegur J, Reithmeier RA (1994) The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain. Biochemistry 33:10463-10469
    • (1994) Biochemistry , vol.33 , pp. 10463-10469
    • Counillon, L.1    Pouyssegur, J.2    Reithmeier, R.A.3
  • 77
    • 84890703276 scopus 로고    scopus 로고
    • Na+/H+ exchanger 1 is regulated via its lipid-interacting domain, which functions as a molecular switch: A pharmacological approach using indolocarbazole compounds
    • 24136992
    • Shimada-Shimizu N, Hisamitsu T, Nakamura TY, Hirayama N, Wakabayashi S (2014) Na+/H+ exchanger 1 is regulated via its lipid-interacting domain, which functions as a molecular switch: a pharmacological approach using indolocarbazole compounds. Mol Pharmacol 85:18-28
    • (2014) Mol Pharmacol , vol.85 , pp. 18-28
    • Shimada-Shimizu, N.1    Hisamitsu, T.2    Nakamura, T.Y.3    Hirayama, N.4    Wakabayashi, S.5
  • 78
    • 3142777645 scopus 로고    scopus 로고
    • Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methods
    • 478595 1:CAS:528:DC%2BD2cXmtVyrsLc%3D 15240890
    • Fuster D, Moe OW, Hilgemann DW (2004) Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methods. Proc Natl Acad Sci USA 101:10482-10487
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10482-10487
    • Fuster, D.1    Moe, O.W.2    Hilgemann, D.W.3
  • 80
    • 3042692979 scopus 로고    scopus 로고
    • CD44 interaction with Na+ - H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion
    • 1:CAS:528:DC%2BD2cXkvFGnsrY%3D 15090545
    • Bourguignon LYW, Singleton PA, Diedrich F, Stern R, Gilad E (2004) CD44 interaction with Na+ - H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. J Biol Chem 279:26991-27007
    • (2004) J Biol Chem , vol.279 , pp. 26991-27007
    • Bourguignon, L.Y.W.1    Singleton, P.A.2    Diedrich, F.3    Stern, R.4    Gilad, E.5
  • 81
    • 67249137553 scopus 로고    scopus 로고
    • A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique
    • 2695096 1:CAS:528:DC%2BD1MXot1CgtLo%3D 19470488
    • Fujita A, Cheng J, Tauchi-Sato K, Takenawa T, Fujimoto T (2009) A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique. Proc Natl Acad Sci USA 106:9256-9261
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9256-9261
    • Fujita, A.1    Cheng, J.2    Tauchi-Sato, K.3    Takenawa, T.4    Fujimoto, T.5
  • 84
    • 34249034647 scopus 로고    scopus 로고
    • + exchanger regulates cell survival by activating and targeting ezrin to specific plasma membrane domains
    • 1:CAS:528:DC%2BD2sXksVSktrY%3D 17535745
    • + exchanger regulates cell survival by activating and targeting ezrin to specific plasma membrane domains. Cell Mol Biol 52:115-121
    • (2006) Cell Mol Biol , vol.52 , pp. 115-121
    • Khan, S.1    Wu, K.L.2    Sedor, J.R.3    Abu Jawdeh, B.G.4    Schelling, J.R.5
  • 86
    • 84865588105 scopus 로고    scopus 로고
    • Characterization of cytoskeletal protein 4.1R interaction with NHE1 (Na(+)/H(+) exchanger isoform 1)
    • 4338608 1:CAS:528:DC%2BC38Xht1Kmsb%2FM 22731252
    • Nunomura W, Denker SP, Barber DL, Takakuwa Y, Gascard P (2012) Characterization of cytoskeletal protein 4.1R interaction with NHE1 (Na(+)/H(+) exchanger isoform 1). Biochem J 446:427-435
    • (2012) Biochem J , vol.446 , pp. 427-435
    • Nunomura, W.1    Denker, S.P.2    Barber, D.L.3    Takakuwa, Y.4    Gascard, P.5
  • 87
    • 0029981094 scopus 로고    scopus 로고
    • A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange
    • 38044 1:CAS:528:DyaK28Xms1Gltr8%3D 8901634
    • Lin X, Barber DL (1996) A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. Proc Natl Acad Sci USA 93:12631-12636
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 12631-12636
    • Lin, X.1    Barber, D.L.2
  • 90
    • 0028242352 scopus 로고
    • The Na+/H+ exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites
    • 1:CAS:528:DyaK2cXksFanurk%3D 8175806
    • Bertrand B, Wakabayashi S, Ikeda T, Pouyssegur J, Shigekawa M (1994) The Na+/H+ exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites. J Biol Chem 269:13703-13709
    • (1994) J Biol Chem , vol.269 , pp. 13703-13709
    • Bertrand, B.1    Wakabayashi, S.2    Ikeda, T.3    Pouyssegur, J.4    Shigekawa, M.5
  • 91
    • 0028277779 scopus 로고
    • Mutation of calmodulin-binding site renders the Na+/H+ exchanger (NHE1) highly H(+)-sensitive and Ca2+ regulation-defective
    • 1:CAS:528:DyaK2cXksl2iurg%3D 8175807
    • Wakabayashi S, Bertrand B, Ikeda T, Pouyssegur J, Shigekawa M (1994) Mutation of calmodulin-binding site renders the Na+/H+ exchanger (NHE1) highly H(+)-sensitive and Ca2+ regulation-defective. J Biol Chem 269:13710-13715
    • (1994) J Biol Chem , vol.269 , pp. 13710-13715
    • Wakabayashi, S.1    Bertrand, B.2    Ikeda, T.3    Pouyssegur, J.4    Shigekawa, M.5
  • 96
    • 0025993390 scopus 로고
    • + exchanger, NHE-1, by phosphorylating a set of common sites
    • 1:CAS:528:DyaK3MXlsFGltbY%3D 1655777
    • + exchanger, NHE-1, by phosphorylating a set of common sites. J Biol Chem 266:19166-19171
    • (1991) J Biol Chem , vol.266 , pp. 19166-19171
    • Sardet, C.1    Fafournoux, P.2    Pouyssegur, J.3
  • 98
    • 0031027106 scopus 로고    scopus 로고
    • + exchanger (NHE1 isoform) in response to growth factors
    • 1:CAS:528:DyaK2sXjsVOrsw%3D%3D 8995258
    • + exchanger (NHE1 isoform) in response to growth factors. J Biol Chem 272:271-279
    • (1997) J Biol Chem , vol.272 , pp. 271-279
    • Bianchini, L.1    L'Allemain, G.2    Pouyssegur, J.3
  • 99
    • 0030872559 scopus 로고    scopus 로고
    • Phosphorylation and regulation of the Na+/H+ exchanger through mitogen-activated protein kinase
    • 1:CAS:528:DyaK2sXktleltbw%3D 9230047
    • Wang H, Silva NL, Lucchesi PA, Haworth R, Wang K, Michalak M, Pelech S, Fliegel L (1997) Phosphorylation and regulation of the Na+/H+ exchanger through mitogen-activated protein kinase. Biochemistry 36:9151-9158
    • (1997) Biochemistry , vol.36 , pp. 9151-9158
    • Wang, H.1    Silva, N.L.2    Lucchesi, P.A.3    Haworth, R.4    Wang, K.5    Michalak, M.6    Pelech, S.7    Fliegel, L.8
  • 100
    • 34249783892 scopus 로고    scopus 로고
    • Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na(+)/H(+) exchanger, NHE1
    • 17321481
    • Pedersen SF, Darborg BV, Rentsch ML, Rasmussen M (2006) Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na(+)/H(+) exchanger, NHE1. Arch Biochem Biophys 462:195-201
    • (2006) Arch Biochem Biophys , vol.462 , pp. 195-201
    • Pedersen, S.F.1    Darborg, B.V.2    Rentsch, M.L.3    Rasmussen, M.4
  • 102
    • 0035903087 scopus 로고    scopus 로고
    • The Nck-interacting kinase (NIK) phosphorylates the Na+ - H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor
    • 1:CAS:528:DC%2BD3MXmsVejsbw%3D 11369779
    • Yan WH, Nehrke K, Choi J, Barber DL (2001) The Nck-interacting kinase (NIK) phosphorylates the Na+ - H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor. J Biol Chem 276:31349-31356
    • (2001) J Biol Chem , vol.276 , pp. 31349-31356
    • Yan, W.H.1    Nehrke, K.2    Choi, J.3    Barber, D.L.4
  • 103
    • 0032541338 scopus 로고    scopus 로고
    • P160ROCK mediates RhoA activation of Na-H exchange
    • 1170800 1:CAS:528:DyaK1cXlslOht74%3D 9707430
    • Tominaga T, Ishizaki T, Narumiya S, Barber DL (1998) p160ROCK mediates RhoA activation of Na-H exchange. EMBO J 17:4712-4722
    • (1998) EMBO J , vol.17 , pp. 4712-4722
    • Tominaga, T.1    Ishizaki, T.2    Narumiya, S.3    Barber, D.L.4
  • 105
    • 70350389830 scopus 로고    scopus 로고
    • The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors
    • 2785354 1:CAS:528:DC%2BD1MXhtFCgs7vK 19622752
    • Meima ME, Webb BA, Witkowska HE, Barber DL (2009) The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors. J Biol Chem 284:26666-26675
    • (2009) J Biol Chem , vol.284 , pp. 26666-26675
    • Meima, M.E.1    Webb, B.A.2    Witkowska, H.E.3    Barber, D.L.4
  • 107
    • 0020528946 scopus 로고
    • + exchange and cytoplasmic pH in the action of growth factors in human fibroblasts
    • 1:CAS:528:DyaL3sXltFKrt7c%3D 6410286
    • + exchange and cytoplasmic pH in the action of growth factors in human fibroblasts. Nature 304:645-648
    • (1983) Nature , vol.304 , pp. 645-648
    • Moolenaar, W.H.1    Tsien, R.Y.2    Van Der Saag, P.T.3    De Laat, S.W.4
  • 108
    • 0031969315 scopus 로고    scopus 로고
    • + exchanger gene expression: Mitogenic stimulation increases NHE1 promoter activity
    • 1:CAS:528:DyaK1cXitVCrtL8%3D 9530116
    • + exchanger gene expression: mitogenic stimulation increases NHE1 promoter activity. Am J Physiol 274:C831-C839
    • (1998) Am J Physiol , vol.274 , pp. 831-C839
    • Besson, P.1    Fernandez-Rachubinski, F.2    Yang, W.3    Fliegel, L.4
  • 109
    • 0242582266 scopus 로고    scopus 로고
    • Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition
    • 1:CAS:528:DC%2BD3sXoslWls78%3D 12947095
    • Putney LK, Barber DL (2003) Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition. J Biol Chem 278:44645-44649
    • (2003) J Biol Chem , vol.278 , pp. 44645-44649
    • Putney, L.K.1    Barber, D.L.2
  • 110
    • 0026577846 scopus 로고
    • + antiporter gene expression increases during retinoic acid-induced granulocytic differentiation of HL60 cells
    • 1:CAS:528:DyaK38XisFartbc%3D 1315322
    • + antiporter gene expression increases during retinoic acid-induced granulocytic differentiation of HL60 cells. J Cell Physiol 151:361-366
    • (1992) J Cell Physiol , vol.151 , pp. 361-366
    • Rao, G.N.1    Sardet, C.2    Pouyssegur, J.3    Berk, B.C.4
  • 111
    • 0030716489 scopus 로고    scopus 로고
    • + antiporter potentiates growth and retinoic acid-induced differentiation of P19 embryonal carcinoma cells
    • 1:CAS:528:DyaK2sXmvV2isbY%3D 9334233
    • + antiporter potentiates growth and retinoic acid-induced differentiation of P19 embryonal carcinoma cells. J Biol Chem 272:26545-26549
    • (1997) J Biol Chem , vol.272 , pp. 26545-26549
    • Wang, H.1    Singh, D.2    Fliegel, L.3
  • 112
    • 0031878095 scopus 로고    scopus 로고
    • Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading
    • 25483 1:CAS:528:DyaK1cXlsVSqtbY%3D 9693382
    • Tominaga T, Barber DL (1998) Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading. Mol Biol Cell 9:2287-2303
    • (1998) Mol Biol Cell , vol.9 , pp. 2287-2303
    • Tominaga, T.1    Barber, D.L.2
  • 113
    • 0037164808 scopus 로고    scopus 로고
    • Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1
    • 2173980 1:CAS:528:DC%2BD3sXjt1em 12486114
    • Denker SP, Barber DL (2002) Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J Cell Biol 159:1087-1096
    • (2002) J Cell Biol , vol.159 , pp. 1087-1096
    • Denker, S.P.1    Barber, D.L.2
  • 114
    • 0025745212 scopus 로고
    • Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin α5β1, independent of cell shape
    • 52401 1:CAS:528:DyaK3MXlsFGqtLY%3D 1652767
    • Schwartz MA, Lechene C, Ingber DE (1991) Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin α5β1, independent of cell shape. Proc Natl Acad Sci USA 88:7849-7853
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7849-7853
    • Schwartz, M.A.1    Lechene, C.2    Ingber, D.E.3
  • 115
    • 0027054949 scopus 로고
    • + antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism
    • 1:CAS:528:DyaK38XmtV2luro%3D 1331102
    • + antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism. J Biol Chem 267:23823-23828
    • (1992) J Biol Chem , vol.267 , pp. 23823-23828
    • Grinstein, S.1    Woodside, M.2    Sardet, C.3    Pouyssegur, J.4    Rotin, D.5
  • 116
    • 0029665771 scopus 로고    scopus 로고
    • + antiporter NHE1 via mitogen and hypertonic stimulation
    • 1:CAS:528:DyaK28XjvVSqu7s%3D 8647925
    • + antiporter NHE1 via mitogen and hypertonic stimulation. J Cell Physiol 168:8-17
    • (1996) J Cell Physiol , vol.168 , pp. 8-17
    • McSwine, R.L.1    Li, J.2    Villereal, M.L.3
  • 117
    • 4544280986 scopus 로고    scopus 로고
    • + exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes
    • 1:CAS:528:DC%2BD2cXptVyisb4%3D 15355855
    • + exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes. Am J Physiol Cell Physiol 287:C844-C850
    • (2004) Am J Physiol Cell Physiol , vol.287 , pp. 844-C850
    • Baumgartner, M.1    Patel, H.2    Barber, D.L.3
  • 118
    • 84915768155 scopus 로고    scopus 로고
    • The Na(+)/H(+) exchanger and pH regulation in the heart
    • 1:CAS:528:DC%2BC2cXhvFantLbI 25354428
    • Odunewu-Aderibigbe A, Fliegel L (2014) The Na(+)/H(+) exchanger and pH regulation in the heart. IUBMB Life 66:679-685
    • (2014) IUBMB Life , vol.66 , pp. 679-685
    • Odunewu-Aderibigbe, A.1    Fliegel, L.2
  • 119
    • 0030048987 scopus 로고    scopus 로고
    • Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification
    • 40107 1:CAS:528:DyaK28XnslOmsQ%3D%3D 8570610
    • Gottlieb RA, Nordberg J, Skowronski E, Babior BM (1996) Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. Proc Natl Acad Sci USA 93:654-658
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 654-658
    • Gottlieb, R.A.1    Nordberg, J.2    Skowronski, E.3    Babior, B.M.4
  • 120
    • 0033776271 scopus 로고    scopus 로고
    • Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis
    • 1:CAS:528:DC%2BD3cXlt1Sls70%3D 10854321
    • Matsuyama S, Llopis J, Deveraux QL, Tsien RY, Reed JC (2000) Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol 2:318-325
    • (2000) Nat Cell Biol , vol.2 , pp. 318-325
    • Matsuyama, S.1    Llopis, J.2    Deveraux, Q.L.3    Tsien, R.Y.4    Reed, J.C.5
  • 121
    • 0034796446 scopus 로고    scopus 로고
    • Effect of pH, ionic charge, and osmolality on cytochrome c-mediated caspase-3 activity
    • 1:CAS:528:DC%2BD3MXnsFSltLc%3D
    • Segal MS, Beem E (2001) Effect of pH, ionic charge, and osmolality on cytochrome c-mediated caspase-3 activity. Am J Physiol 281:C1196-C1204
    • (2001) Am J Physiol , vol.281 , pp. 1196-C1204
    • Segal, M.S.1    Beem, E.2
  • 122
    • 33845334495 scopus 로고    scopus 로고
    • Acid DNases and their interest among apoptotic endonucleases
    • 1:CAS:528:DC%2BD28Xhtlarur%2FM 16989934
    • Counis MF, Torriglia A (2006) Acid DNases and their interest among apoptotic endonucleases. Biochimie 88:1851-1858
    • (2006) Biochimie , vol.88 , pp. 1851-1858
    • Counis, M.F.1    Torriglia, A.2
  • 123
    • 84895464538 scopus 로고    scopus 로고
    • Intracellular pH regulation by acid-base transporters in mammalian neurons
    • 3923155 24592239
    • Ruffin VA, Salameh AI, Boron WF, Parker MD (2014) Intracellular pH regulation by acid-base transporters in mammalian neurons. Front Physiol 5:43
    • (2014) Front Physiol , vol.5 , pp. 43
    • Ruffin, V.A.1    Salameh, A.I.2    Boron, W.F.3    Parker, M.D.4
  • 124
    • 84873583928 scopus 로고    scopus 로고
    • The role of Na(+)/H(+) exchanger isoform 1 in inflammatory responses: Maintaining H(+) homeostasis of immune cells
    • 1:CAS:528:DC%2BC3sXhslyhs73K 23224899
    • Shi Y, Kim D, Caldwell M, Sun D (2013) The role of Na(+)/H(+) exchanger isoform 1 in inflammatory responses: maintaining H(+) homeostasis of immune cells. Adv Exp Med Biol 961:411-418
    • (2013) Adv Exp Med Biol , vol.961 , pp. 411-418
    • Shi, Y.1    Kim, D.2    Caldwell, M.3    Sun, D.4
  • 125
    • 0028817908 scopus 로고
    • Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex
    • 301292 1:CAS:528:DyaK2MXoslWrtLo%3D 8573791
    • Plopper GE, McNamee HP, Dike LE, Bojanowski K, Ingber DE (1995) Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol Biol Cell 6:1349-1365
    • (1995) Mol Biol Cell , vol.6 , pp. 1349-1365
    • Plopper, G.E.1    McNamee, H.P.2    Dike, L.E.3    Bojanowski, K.4    Ingber, D.E.5
  • 126
    • 84874210262 scopus 로고    scopus 로고
    • The Na(+)/H(+)-exchanger (NHE1) generates pH nanodomains at focal adhesions
    • 1:CAS:528:DC%2BC3sXivFOlsb0%3D 23184727
    • Ludwig FT, Schwab A, Stock C (2013) The Na(+)/H(+)-exchanger (NHE1) generates pH nanodomains at focal adhesions. J Cell Physiol 228:1351-1358
    • (2013) J Cell Physiol , vol.228 , pp. 1351-1358
    • Ludwig, F.T.1    Schwab, A.2    Stock, C.3
  • 129
    • 23844449323 scopus 로고    scopus 로고
    • Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange
    • 1474168 1:CAS:528:DC%2BD2MXps1Omsbg%3D 15946960
    • Stock C, Gassner B, Hauck CR, Arnold H, Mally S, Eble JA, Dieterich P, Schwab A (2005) Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange. J Physiol 567:225-238
    • (2005) J Physiol , vol.567 , pp. 225-238
    • Stock, C.1    Gassner, B.2    Hauck, C.R.3    Arnold, H.4    Mally, S.5    Eble, J.A.6    Dieterich, P.7    Schwab, A.8
  • 130
    • 84892426231 scopus 로고    scopus 로고
    • Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe
    • 1:CAS:528:DC%2BC2cXpsFeguro%3D 24337203
    • Greco MR, Antelmi E, Busco G, Guerra L, Rubino R, Casavola V, Reshkin SJ, Cardone RA (2014) Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe. Oncol Rep 31:940-946
    • (2014) Oncol Rep , vol.31 , pp. 940-946
    • Greco, M.R.1    Antelmi, E.2    Busco, G.3    Guerra, L.4    Rubino, R.5    Casavola, V.6    Reshkin, S.J.7    Cardone, R.A.8
  • 131
    • 84855310010 scopus 로고    scopus 로고
    • NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1-MMP
    • 1:CAS:528:DC%2BC38XnvVCl 21997166
    • Lin Y, Wang J, Jin W, Wang L, Li H, Ma L, Li Q, Pang T (2012) NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1-MMP. Cell Biochem Funct 30:41-46
    • (2012) Cell Biochem Funct , vol.30 , pp. 41-46
    • Lin, Y.1    Wang, J.2    Jin, W.3    Wang, L.4    Li, H.5    Ma, L.6    Li, Q.7    Pang, T.8
  • 132
    • 0022536201 scopus 로고
    • Na+ -H+ exchange in luminal-membrane vesicles from rabbit proximal convoluted and straight tubules in response to metabolic acidosis
    • 1147295 1:CAS:528:DyaL28XlslSjtb8%3D 3814082
    • Jacobsen C, Kragh-Hansen U, Sheikh MI (1986) Na+ -H+ exchange in luminal-membrane vesicles from rabbit proximal convoluted and straight tubules in response to metabolic acidosis. Biochem J 239:411-416
    • (1986) Biochem J , vol.239 , pp. 411-416
    • Jacobsen, C.1    Kragh-Hansen, U.2    Sheikh, M.I.3
  • 133
    • 0024555939 scopus 로고
    • - Transport
    • 1:STN:280:DyaL1M7jt1Oqsg%3D%3D 2537027
    • - transport. Am J Physiol 256:F335-F341
    • (1989) Am J Physiol , vol.256 , pp. 335-F341
    • Baum, M.1
  • 134
    • 0010217910 scopus 로고    scopus 로고
    • Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule
    • 300838 1:CAS:528:DC%2BD3cXisFOlurk%3D 10772659
    • Choi JY, Shah M, Lee MG, Schultheis PJ, Shull GE, Muallem S, Baum M (2000) Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule. J Clin Invest 105:1141-1146
    • (2000) J Clin Invest , vol.105 , pp. 1141-1146
    • Choi, J.Y.1    Shah, M.2    Lee, M.G.3    Schultheis, P.J.4    Shull, G.E.5    Muallem, S.6    Baum, M.7
  • 135
    • 84875151624 scopus 로고    scopus 로고
    • Phosphate transporters of the SLC20 and SLC34 families
    • 1:CAS:528:DC%2BC3sXksVyqtrY%3D 23506879
    • Forster IC, Hernando N, Biber J, Murer H (2013) Phosphate transporters of the SLC20 and SLC34 families. Mol Aspects Med 34:386-395
    • (2013) Mol Aspects Med , vol.34 , pp. 386-395
    • Forster, I.C.1    Hernando, N.2    Biber, J.3    Murer, H.4
  • 136
    • 0017701092 scopus 로고
    • Kinetics of Na+ transport in Necturus proximal tubule
    • 2228468 1:CAS:528:DyaE2sXltlSqtbc%3D 894258
    • Spring KR, Giebisch G (1977) Kinetics of Na+ transport in Necturus proximal tubule. J Gen Physiol 70:307-328
    • (1977) J Gen Physiol , vol.70 , pp. 307-328
    • Spring, K.R.1    Giebisch, G.2
  • 139
    • 84876988668 scopus 로고    scopus 로고
    • 3- co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes
    • 3650695 1:CAS:528:DC%2BC3sXos1Kguro%3D 23420656
    • 3- co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes. J Physiol 591:2287-2306
    • (2013) J Physiol , vol.591 , pp. 2287-2306
    • Garciarena, C.D.1    Ma, Y.L.2    Swietach, P.3    Huc, L.4    Vaughan-Jones, R.D.5
  • 140
    • 27644530863 scopus 로고    scopus 로고
    • Functional role of Na+ -HCO3- cotransport in migration of transformed renal epithelial cells
    • 1474735 1:CAS:528:DC%2BD2MXhtFyhsbzP 16037087
    • Schwab A, Rossmann H, Klein M, Dieterich P, Gassner B, Neff C, Stock C, Seidler U (2005) Functional role of Na+ -HCO3- cotransport in migration of transformed renal epithelial cells. J Physiol 568:445-458
    • (2005) J Physiol , vol.568 , pp. 445-458
    • Schwab, A.1    Rossmann, H.2    Klein, M.3    Dieterich, P.4    Gassner, B.5    Neff, C.6    Stock, C.7    Seidler, U.8
  • 141
    • 33744810075 scopus 로고    scopus 로고
    • Na/H exchangers and the regulation of volume
    • 1:CAS:528:DC%2BD28XlvVCguro%3D
    • Alexander RT, Grinstein S (2006) Na/H exchangers and the regulation of volume. Acta Physiol (Oxf) 187:159-167
    • (2006) Acta Physiol (Oxf) , vol.187 , pp. 159-167
    • Alexander, R.T.1    Grinstein, S.2
  • 142
    • 0033968208 scopus 로고    scopus 로고
    • Sodium-potassium-chloride cotransport
    • 1:CAS:528:DC%2BD3cXmtl2jug%3D%3D 10617769
    • Russell JM (2000) Sodium-potassium-chloride cotransport. Physiol Rev 80:211-276
    • (2000) Physiol Rev , vol.80 , pp. 211-276
    • Russell, J.M.1
  • 143
    • 0035310427 scopus 로고    scopus 로고
    • Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD)
    • 2278524 1:CAS:528:DC%2BD3MXjs1OqsL4%3D 11283221
    • Okada Y, Maeno E, Shimizu T, Dezaki K, Wang J, Morishima S (2001) Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD). J Physiol 532:3-16
    • (2001) J Physiol , vol.532 , pp. 3-16
    • Okada, Y.1    Maeno, E.2    Shimizu, T.3    Dezaki, K.4    Wang, J.5    Morishima, S.6
  • 144
    • 0030071370 scopus 로고    scopus 로고
    • Apical localization of the Na-K-Cl cotransporter, rBSC1, on rat thick ascending limbs
    • 1:CAS:528:DyaK28Xht1amtr8%3D 8770947
    • Kaplan MR, Plotkin MD, Lee WS, Xu ZC, Lytton J, Hebert SC (1996) Apical localization of the Na-K-Cl cotransporter, rBSC1, on rat thick ascending limbs. Kidney Int 49:40-47
    • (1996) Kidney Int , vol.49 , pp. 40-47
    • Kaplan, M.R.1    Plotkin, M.D.2    Lee, W.S.3    Xu, Z.C.4    Lytton, J.5    Hebert, S.C.6
  • 145
    • 0031779780 scopus 로고    scopus 로고
    • Immunolocalization and tissue-specific splicing of AE2 anion exchanger in mouse kidney
    • 1:CAS:528:DyaK1cXjvFWis7s%3D 9621277
    • Stuart-Tilley AK, Shmukler BE, Brown D, Alper SL (1998) Immunolocalization and tissue-specific splicing of AE2 anion exchanger in mouse kidney. JASN 9:946-959
    • (1998) JASN , vol.9 , pp. 946-959
    • Stuart-Tilley, A.K.1    Shmukler, B.E.2    Brown, D.3    Alper, S.L.4
  • 146
    • 0028100685 scopus 로고
    • Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation
    • 1:CAS:528:DyaK2cXmtVWktbs%3D 8089122
    • Kapus A, Grinstein S, Wasan S, Kandasamy R, Orlowski J (1994) Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation. J Biol Chem 269:23544-23552
    • (1994) J Biol Chem , vol.269 , pp. 23544-23552
    • Kapus, A.1    Grinstein, S.2    Wasan, S.3    Kandasamy, R.4    Orlowski, J.5
  • 147
    • 0031907623 scopus 로고    scopus 로고
    • Effect of long-term hyperosmolality on the Na+/H+ exchanger isoform NHE-3 in LLC-PK1 cells
    • 1:CAS:528:DyaK1cXhtVGhsLg%3D 9461102
    • Soleimani M, Watts BA III, Singh G, Good DW (1998) Effect of long-term hyperosmolality on the Na+/H+ exchanger isoform NHE-3 in LLC-PK1 cells. Kidney Int 53:423-431
    • (1998) Kidney Int , vol.53 , pp. 423-431
    • Soleimani, M.1    Watts, B.A.2    Singh, G.3    Good, D.W.4
  • 148
    • 0030747226 scopus 로고    scopus 로고
    • Induction of tyrosine phosphorylation and Na+/H+ exchanger activation during shrinkage of human neutrophils
    • 1:CAS:528:DyaK2sXksFOnu7o%3D 9211867
    • Krump E, Nikitas K, Grinstein S (1997) Induction of tyrosine phosphorylation and Na+/H+ exchanger activation during shrinkage of human neutrophils. J Biol Chem 272:17303-17311
    • (1997) J Biol Chem , vol.272 , pp. 17303-17311
    • Krump, E.1    Nikitas, K.2    Grinstein, S.3
  • 150
    • 0021013862 scopus 로고
    • + exchange in lymphocytes by osmotically induced volume changes and by cytoplasmic acidification
    • 1:CAS:528:DyaL2cXitV2lug%3D%3D 6644271
    • + exchange in lymphocytes by osmotically induced volume changes and by cytoplasmic acidification. J Gen Physiol 82:619-638
    • (1983) J Gen Physiol , vol.82 , pp. 619-638
    • Grinstein, S.1    Clarke, C.A.2    Rothstein, A.3
  • 151
    • 0029864909 scopus 로고    scopus 로고
    • Na+/H+ exchange activity during phagocytosis in human neutrophils: Role of Fcgamma receptors and tyrosine kinases
    • 1:CAS:528:DyaK28XhvVSmu70%3D 8601583
    • Fukushima T, Waddell TK, Grinstein S, Goss GG, Orlowski J, Downey GP (1996) Na+/H+ exchange activity during phagocytosis in human neutrophils: role of Fcgamma receptors and tyrosine kinases. J Cell Biol 132:1037-1052
    • (1996) J Cell Biol , vol.132 , pp. 1037-1052
    • Fukushima, T.1    Waddell, T.K.2    Grinstein, S.3    Goss, G.G.4    Orlowski, J.5    Downey, G.P.6
  • 158
    • 84911004350 scopus 로고    scopus 로고
    • Huntingtin regulates Ca chemotaxis and K-facilitated cAMP chemotaxis, in conjuction with the monovalent cation/H exchanger Nhe1, in a model developmental system: Insights into its possible role in Huntingtons disease
    • 1:CAS:528:DC%2BC2cXhsVakt7vI 25149514
    • Wessels D, Lusche DF, Scherer A, Kuhl S, Myre MA, Soll DR (2014) Huntingtin regulates Ca chemotaxis and K-facilitated cAMP chemotaxis, in conjuction with the monovalent cation/H exchanger Nhe1, in a model developmental system: insights into its possible role in Huntingtons disease. Dev Biol 394:24-38
    • (2014) Dev Biol , vol.394 , pp. 24-38
    • Wessels, D.1    Lusche, D.F.2    Scherer, A.3    Kuhl, S.4    Myre, M.A.5    Soll, D.R.6
  • 159
    • 0014421532 scopus 로고
    • Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis
    • 1:STN:280:DyaF1czis1eksw%3D%3D 4173786
    • Risdon RA, Sloper JC, De Wardener HE (1968) Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis. Lancet 2:363-366
    • (1968) Lancet , vol.2 , pp. 363-366
    • Risdon, R.A.1    Sloper, J.C.2    De Wardener, H.E.3
  • 160
    • 0014885804 scopus 로고
    • Structural-functional correlations in renal disease
    • 1:STN:280:DyaE38%2FjtFKksQ%3D%3D 5521736
    • Schainuck LI, Striker GE, Cutler RE, Benditt EP (1970) Structural-functional correlations in renal disease. Hum Pathol 1:631-641
    • (1970) Hum Pathol , vol.1 , pp. 631-641
    • Schainuck, L.I.1    Striker, G.E.2    Cutler, R.E.3    Benditt, E.P.4
  • 161
    • 0023583181 scopus 로고
    • Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney: A morphometric contribution
    • 1:STN:280:DyaL1c7kvVSisw%3D%3D 3439552
    • Bohle A, Mackensen-Haen S, von Gise H (1987) Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney: a morphometric contribution. Am J Nephrol 7:421-433
    • (1987) Am J Nephrol , vol.7 , pp. 421-433
    • Bohle, A.1    Mackensen-Haen, S.2    Von Gise, H.3
  • 162
    • 0031850058 scopus 로고    scopus 로고
    • Fas-dependent fratricidal apoptosis is a mechanism of tubular epithelial cell deletion in chronic renal failure
    • 1:CAS:528:DyaK1cXltlequrs%3D 9690559
    • Schelling JR, Nkemere N, Kopp JB, Cleveland RP (1998) Fas-dependent fratricidal apoptosis is a mechanism of tubular epithelial cell deletion in chronic renal failure. Lab Invest 78:813-824
    • (1998) Lab Invest , vol.78 , pp. 813-824
    • Schelling, J.R.1    Nkemere, N.2    Kopp, J.B.3    Cleveland, R.P.4
  • 163
    • 34249944402 scopus 로고    scopus 로고
    • Apoptosis induction is associated with decreased NHE1 expression in neonatal unilateral ureteric obstruction
    • Manucha W, Carrizo L, Ruete C, Valles PG (2007) Apoptosis induction is associated with decreased NHE1 expression in neonatal unilateral ureteric obstruction. BJU Int 100:191-198
    • (2007) BJU Int , vol.100 , pp. 191-198
    • Manucha, W.1    Carrizo, L.2    Ruete, C.3    Valles, P.G.4
  • 164
    • 84907495270 scopus 로고    scopus 로고
    • RhoA and MAPKinase signal transduction pathways regulate NHE1 Na+/H+ exchanger-dependent proximal tubule cell apoptosis following mechanical stretch
    • 1:CAS:528:DC%2BC2cXhvFWqs7vP 25080524
    • Bocanegra V, Gil Lorenzo AF, Cacciamani V, Benardon ME, Costantino VV, Valles PG (2014) RhoA and MAPKinase signal transduction pathways regulate NHE1 Na+/H+ exchanger-dependent proximal tubule cell apoptosis following mechanical stretch. Am J Physiol Renal Physiol 307:F881-F889
    • (2014) Am J Physiol Renal Physiol , vol.307 , pp. 881-F889
    • Bocanegra, V.1    Gil Lorenzo, A.F.2    Cacciamani, V.3    Benardon, M.E.4    Costantino, V.V.5    Valles, P.G.6
  • 166
    • 0034616942 scopus 로고    scopus 로고
    • Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    • 1:CAS:528:DC%2BD3cXkvFCrtr4%3D 10929712
    • Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL (2000) Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102:43-53
    • (2000) Cell , vol.102 , pp. 43-53
    • Verhagen, A.M.1    Ekert, P.G.2    Pakusch, M.3    Silke, J.4    Connolly, L.M.5    Reid, G.E.6    Moritz, R.L.7    Simpson, R.J.8    Vaux, D.L.9
  • 167
    • 84897413007 scopus 로고    scopus 로고
    • Na/H exchanger-1 reduces podocyte injury caused by endoplasmic reticulum stress via autophagy activation
    • 1:CAS:528:DC%2BC2cXivFanurY%3D 24566932
    • Feng Z, Tang L, Wu L, Cui S, Hong Q, Cai G, Wu D, Fu B, Wei R, Chen X (2014) Na/H exchanger-1 reduces podocyte injury caused by endoplasmic reticulum stress via autophagy activation. Lab Invest 94:439-454
    • (2014) Lab Invest , vol.94 , pp. 439-454
    • Feng, Z.1    Tang, L.2    Wu, L.3    Cui, S.4    Hong, Q.5    Cai, G.6    Wu, D.7    Fu, B.8    Wei, R.9    Chen, X.10
  • 169
    • 4344625264 scopus 로고    scopus 로고
    • Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: Prevention by chronic therapy with a peroxynitrite scavenger ebselen
    • 1:CAS:528:DC%2BD2cXntVeht74%3D 15339988
    • Chander PN, Gealekman O, Brodsky SV, Elitok S, Tojo A, Crabtree M, Gross SS, Goligorsky MS (2004) Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen. J Am Soc Nephrol 15:2391-2403
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2391-2403
    • Chander, P.N.1    Gealekman, O.2    Brodsky, S.V.3    Elitok, S.4    Tojo, A.5    Crabtree, M.6    Gross, S.S.7    Goligorsky, M.S.8
  • 170
    • 23644438916 scopus 로고    scopus 로고
    • Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes
    • 1:CAS:528:DC%2BD2MXnt1yntr4%3D 16046298
    • Wang Z, Jiang T, Li J, Proctor G, McManaman JL, Lucia S, Chua S, Levi M (2005) Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Diabetes 54:2328-2335
    • (2005) Diabetes , vol.54 , pp. 2328-2335
    • Wang, Z.1    Jiang, T.2    Li, J.3    Proctor, G.4    McManaman, J.L.5    Lucia, S.6    Chua, S.7    Levi, M.8
  • 172
    • 84876413711 scopus 로고    scopus 로고
    • NHE1 inhibition improves tissue perfusion and resuscitation outcome after severe hemorrhage
    • 1:CAS:528:DC%2BC38XhtFGrsbzF 22878146
    • Wu D, Russano K, Kouz I, Abraham WM (2013) NHE1 inhibition improves tissue perfusion and resuscitation outcome after severe hemorrhage. J Surg Res 181:e75-e81
    • (2013) J Surg Res , vol.181 , pp. 75-e81
    • Wu, D.1    Russano, K.2    Kouz, I.3    Abraham, W.M.4


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