Random mutagenesis reveals a novel site involved in inhibitor interaction within the fourth transmembrane segment of the Na+/H+ exchanger-1

Biochemistry

Volumn 36, Issue 10, 1997, Pages 2951-2959

  Counillon, Laurent ^a   Noël, Josette ^a,b   Reithmeier, Reinhart A F ^a,c   Pouysségur, Jacques ^a  

^a UNIVERSITÉ CÔTE D'AZUR   (France)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

(3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE; ALANINE; AMILORIDE; AMILORIDE DERIVATIVE; AMINO ACID; ASPARTIC ACID; CARBONYL DERIVATIVE; GLYCINE; LEUCINE; PHENYLALANINE; PROTON; SODIUM ION;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHINESE HAMSTER; CONTROLLED STUDY; FIBROBLAST; HUMAN; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; SITE DIRECTED MUTAGENESIS;

AMILORIDE; BINDING SITES; CLONE CELLS; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DRUG RESISTANCE; FIBROBLASTS; GUANIDINES; HUMANS; MEMBRANE PROTEINS; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN STRUCTURE, SECONDARY; SODIUM; SODIUM-HYDROGEN ANTIPORTER; SULFONES;

EID: 1842290349     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9615405     Document Type: Article

References (29)

1. Arguello, J. M., & Lingrel, J. B. (1995) J. Biol. Chem. 270, 22764-22771.
2. Aronson, P. S. (1985) Annu. Rev. Physiol. 47, 545-560.
3. Boron, W., & De Veer, P. (1976) J. Gen. Physiol. 67, 91-112.
4. Counillon, L., & Pouysségur, J. (1993) Curr. Opin. Nephrol. Hypertens. 2, 708-714.
5. Counillon, L. , Scholz, W. , Lang, H. J., & Pouysségur J. (1993a) Mol. Pharmacol. 44, 1041-1045.
6. Counillon, L., Franchi, A., & Pouysségur, J. (1993b) Proc. Natl. Acad. Sci. U.S.A. 90, 4508-4512.
7. Counillon, L., Pouysségur, J., & Reithmeier, R. A. F. (1994) Biochemistry 33, 10463-10469.
8. Deber, C. M., & Li, S. C. (1995) Biopolymers 37, 295-318.
9. Diaz, J. J., Rhoads, D. D., & Roufa, R. J. (1991) BioTechniques 11, 204-211.
10. Fafournoux, P., Ghysdael, J., Sardet, C., & Pouysségur, J. (1991) Biochemistry 30, 9510-9515.
11. Franchi, A., Cragoe, E. J., & Pouysségur, J. (1986) J. Biol. Chem. 261, 14614-14620.
12. Kleyman, T. R., & Cragoe, E. J. (1988) J. Membr. Biol. 105, 1-21.
13. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 488-492.
14. Lazdunski, M., Frelin, C., & Vigne, P. (1985) J. Mol. Cell. Cardiol. 17, 1029-1042.
15. Orlowski, J., & Kandasamy, R. A. (1996) J. Biol. Chem. 271, 19922-19927.
16. Orlowski, J., Kandasamy, R. A., & Shull, G. E. (1992) J. Biol. Chem. 267, 9331-9339.
17. Pouysségur, J. (1985) Trends Biochem. Sci. 10, 453-455.
18. Pouysségur J., Sardet, C., Franchi, A., L'Allemain, G., & Paris, S. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 4833-4837.
19. Sanger, F., Nicklen, S., & Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 5463-5467.
20. Sardet, C., Franchi, A., & Pouysségur, J. (1989) Cell 56, 271-280.
21. Sardet, C., Counillon, L., Franchi, A., & Pouysségur, J. (1990) Science 247, 723-726.
22. Scholz, W., Albus, U., Counillon, L., Gogelein, H., Lang, H. J., Linz, W., Werchert, A., & Scholkens, B. A. (1995) Cardiovasc. Res. 29, 260-268.
23. Tse, C., M., Brant, S. R., Walker, S., Pouysségur, J., & Donowitz, M. (1992) J. Biol. Chem. 267, 9340-9346.
24. Tse, C. M., Levine, S. A., Yun, C., Montrose, M. H., Little, P. J., Pouysségur, J., & Donowitz, M. (1993a) J. Biol. Chem. 268, 11917-11924.
25. Tse, C. M., Levine, S., Yun, C., Brant, S., Counillon, L., Pouysségur, J., & Donowitz, M. (1993b) J. Membr. Biol. 135, 93-108.
26. Von Heijne, G. (1991) J. Mol. Biol. 218, 499-503.
27. Wigler, M., Sweet, R., Sim, G. K., Wold, B., Pellicer, A., Lacy, E., Maniatis, T., Silverstein, S., & Axel, R. (1979) Cell 16, 777-785.
28. Williams, K. A., & Deber, C. M. (1991) Biochemistry 30, 8920-8923.
29. Yun, C. H., Little, P. J., Nath, S. K., Levine, S. A., Pouysségur, J., Tse, C. M., & Donowitz, M. (1993) Biochem. Biophys. Res. Commun. 193, 132-139.