Effect of pH, ionic charge, and osmolality on cytochrome c-mediated caspase-3 activity

American Journal of Physiology - Cell Physiology

Volumn 281, Issue 4 50-4, 2001, Pages

  Segal, Mark S ^a,b   Beem, Elaine ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

Apoptosis; Cell death; Potassium

Indexed keywords

ANION; CASPASE 3; CYTOCHROME C; ION;

ACIDIFICATION; APOPTOSIS; ARTICLE; CELL DEATH; CELL FREE SYSTEM; CONCENTRATION RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME RELEASE; HUMAN; HUMAN CELL; IONIC STRENGTH; OSMOLALITY; PH; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034796446     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2001.281.4.c1196     Document Type: Article

References (37)

1. Rapid spectrophotometric method for quantitation of cytochrome c release from isolated mitochondria or permeabilized cells revisited
2. + channels
3. Taurine transport in rat astrocytes adapted to hyperosmotic conditions
4. Characterization of cell volume loss in CEM-C7A cells during dexamethasone-induced apoptosis
5. +, cell shrinkage, and mitochondrial membrane potential during lymphocyte apoptosis
6. Apoptosis. Mitochondria - The death signal integrators
7. Biochemical pathways of caspase activation during apoptosis
8. Mitochondrial control of apoptosis: The role of cytochrome c
9. Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes
10. Caspases: The executioners of apoptosis
11. Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1
12. Endostatin induces endothelial cell apoptosis
13. Apoptosis by a cytosolic extract from Fas-activated cells
14. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
15. Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells
16. Mitochondria and apoptosis
17. The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles
18. + suppresses the activation of apoptosis in lymphocytes
19. Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo
20. The mitochondrial death/life regulator in apoptosis and necrosis
21. Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3
22. Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis
23. Induction of apoptotic program in cell-free extracts: Rquirement for dATP and cytochrome c
24. Protein measurement with the Folin phenol reagent
25. From the cover: Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis
26. An algorithm for least squares estimation of nonlinear parameters
27. Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis
28. Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90
29. Morphological aspects of glucocorticoid-induced cell death in human lymphoblastoid cells
30. Biochemical characteristics of caspases-3, -6, -7, and -8
31. Volume regulation during recovery from chronic hypertonicity in brain glial cells
32. Role of astrocytes in ionic and volume homeostasis in spinal cord during development and injury
33. Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release
34. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
35. Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: A structural basis for specific adaptor/caspase interaction
36. An APAF1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9