Glutamate 346 of Human Na+-H+ Exchanger NHE1 Is Crucial for Modulating both the Affinity for Na+ and the Interaction with Amiloride Derivatives

Biochemistry

Volumn 42, Issue 51, 2003, Pages 15361-15368

  Noël, Josette ^a   Germain, David ^a   Vadnais, Julie ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOLOGICAL MEMBRANES; DERIVATIVES; PROTEINS; SODIUM;

MUTATIONS;

BIOCHEMISTRY;

(3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE; 5 (N ETHYL N ISOPROPYL)AMILORIDE; AMILORIDE DERIVATIVE; AMINO ACID; ASPARTIC ACID; GLUTAMIC ACID; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN 1;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL LINE; DRUG PROTEIN BINDING; DRUG SENSITIVITY; HUMAN; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ANALYSIS;

AMILORIDE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CELL LINE; CRICETINAE; DRUG RESISTANCE; GLUTAMIC ACID; GUANIDINES; HUMANS; MUTAGENESIS, SITE-DIRECTED; POTASSIUM; PROTONS; RNA, MESSENGER; SODIUM; SODIUM-HYDROGEN ANTIPORTER; SULFONES; VARIATION (GENETICS);

ANIMALIA;

EID: 0346963148     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035296a     Document Type: Article

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