APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor

Cell Reports

Volumn 7, Issue 4, 2014, Pages 1227-1238

  Ryu, Jiyoon ^a   Galan, Amanda K ^a   Xin, Xiaoban ^a   Dong, Feng ^b   Abdul Ghani, Muhammad A ^b   Zhou, Lijun ^a   Wang, Changhua ^a   Li, Cuiling ^c   Holmes, Bekke M ^b   Sloane, Lauren B ^a   Austad, Steven N ^a,b   Guo, Shaodong ^d   Musi, Nicolas ^b   DeFronzo, Ralph A ^b   Deng, Chuxia ^c   White, Morris F ^e   Liu, Feng ^a,b   Dong, Lily Q ^a,b  

^a University of Texas Health Science Center at San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ADIPONECTIN; APPL1 PROTEIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; UNCLASSIFIED DRUG; PROTEIN APPL1; APPL1 PROTEIN, HUMAN; APPL1 PROTEIN, MOUSE; INSULIN RECEPTOR SUBSTRATE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN SIGNALING; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; GENE DELETION; GENE INACTIVATION; HORMONAL REGULATION; PROTEIN FUNCTION; RECEPTOR BINDING; SYSTEMIC DISEASE; TARGET ORGAN; ANIMAL; C57BL MOUSE; CELL LINE; DEFICIENCY; EMBRYONIC STEM CELL; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION;

MUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADIPONECTIN; ANIMALS; CELL LINE; EMBRYONIC STEM CELLS; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHORYLATION; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 84901248649     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.04.006     Document Type: Article

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