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Volumn 125, Issue 17, 2012, Pages 4090-4102

APPL1 regulates basal NF-kB activity by stabilizing NIK

Author keywords

APPL1; NF kB pathway; NIK; TRAF2

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN PLECKSTRIN PHOSPHOTYROSINE LEUCINE ZIPPER MOTIF 1; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NF KAPPA B INDUCING KINASE; PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UNCLASSIFIED DRUG;

EID: 84869099031     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.105171     Document Type: Article
Times cited : (27)

References (59)
  • 1
    • 17844396206 scopus 로고    scopus 로고
    • Adiponectin inhibits LPS-induced NFkappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes
    • Ajuwon, K. M. and Spurlock, M. E. (2005). Adiponectin inhibits LPS-induced NFkappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R1220-R1225.
    • (2005) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.288
    • Ajuwon, K.M.1    Spurlock, M.E.2
  • 2
    • 84934436838 scopus 로고    scopus 로고
    • Physiological roles and mechanisms of signaling by TRAF2 and TRAF5
    • Au, P. Y. and Yeh, W. C. (2007). Physiological roles and mechanisms of signaling by TRAF2 and TRAF5. Adv. Exp. Med. Biol. 597, 32-47.
    • (2007) Adv. Exp. Med. Biol. , vol.597 , pp. 32-47
    • Au, P.Y.1    Yeh, W.C.2
  • 3
    • 70350088552 scopus 로고    scopus 로고
    • Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex
    • Banach-Orlowska, M., Pilecka, I., Torun, A., Pyrzynska, B. and Miaczynska, M. (2009). Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex. Biochem. J. 423, 389-400.
    • (2009) Biochem. J. , vol.423 , pp. 389-400
    • Banach-Orlowska, M.1    Pilecka, I.2    Torun, A.3    Pyrzynska, B.4    Miaczynska, M.5
  • 4
    • 68549111215 scopus 로고    scopus 로고
    • Nuclear trafficking and functions of endocytic proteins implicated in oncogenesis
    • Borlido, J., Zecchini, V. and Mills, I. G. (2009). Nuclear trafficking and functions of endocytic proteins implicated in oncogenesis. Traffic 10, 1209-1220.
    • (2009) Traffic , vol.10 , pp. 1209-1220
    • Borlido, J.1    Zecchini, V.2    Mills, I.G.3
  • 7
    • 54049138456 scopus 로고    scopus 로고
    • Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression
    • Chandrasekar, B., Boylston, W. H., Venkatachalam, K., Webster, N. J., Prabhu, S. D. and Valente, A. J. (2008). Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression. J. Biol. Chem. 283, 24889-24898.
    • (2008) J. Biol. Chem. , vol.283 , pp. 24889-24898
    • Chandrasekar, B.1    Boylston, W.H.2    Venkatachalam, K.3    Webster, N.J.4    Prabhu, S.D.5    Valente, A.J.6
  • 8
    • 65449161015 scopus 로고    scopus 로고
    • APPL1 potentiates insulinmediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice
    • Cheng, K. K., Iglesias, M. A., Lam, K. S., Wang, Y., Sweeney, G., Zhu, W., Vanhoutte, P. M., Kraegen, E. W. and Xu, A. (2009). APPL1 potentiates insulinmediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice. Cell Metab. 9, 417-427.
    • (2009) Cell Metab , vol.9 , pp. 417-427
    • Cheng, K.K.1    Iglesias, M.A.2    Lam, K.S.3    Wang, Y.4    Sweeney, G.5    Zhu, W.6    Vanhoutte, P.M.7    Kraegen, E.W.8    Xu, A.9
  • 9
    • 84934439306 scopus 로고    scopus 로고
    • Structural revelations of TRAF2 function in TNF receptor signaling pathway
    • Chung, J. Y., Lu, M., Yin, Q. and Wu, H. (2007). Structural revelations of TRAF2 function in TNF receptor signaling pathway. Adv. Exp. Med. Biol. 597, 93-113.
    • (2007) Adv. Exp. Med. Biol. , vol.597 , pp. 93-113
    • Chung, J.Y.1    Lu, M.2    Yin, Q.3    Wu, H.4
  • 12
    • 2342510314 scopus 로고    scopus 로고
    • Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways
    • Gao, H., Sun, Y., Wu, Y., Luan, B., Wang, Y., Qu, B. and Pei, G. (2004). Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways. Mol. Cell 14, 303-317.
    • (2004) Mol. Cell , vol.14 , pp. 303-317
    • Gao, H.1    Sun, Y.2    Wu, Y.3    Luan, B.4    Wang, Y.5    Qu, B.6    Pei, G.7
  • 13
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Ghosh, S. and Karin, M. (2002). Missing pieces in the NF-kappaB puzzle. Cell 109 Suppl., S81-S96.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Ghosh, S.1    Karin, M.2
  • 14
    • 8444220390 scopus 로고    scopus 로고
    • TRAF2 differentially regulates the canonical and noncanonical pathways of NFkappaB activation in mature B cells
    • Grech, A. P., Amesbury, M., Chan, T., Gardam, S., Basten, A. and Brink, R. (2004). TRAF2 differentially regulates the canonical and noncanonical pathways of NFkappaB activation in mature B cells. Immunity 21, 629-642.
    • (2004) Immunity , vol.21 , pp. 629-642
    • Grech, A.P.1    Amesbury, M.2    Chan, T.3    Gardam, S.4    Basten, A.5    Brink, R.6
  • 15
    • 1542380581 scopus 로고    scopus 로고
    • Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB
    • Habelhah, H., Takahashi, S., Cho, S. G., Kadoya, T., Watanabe, T. and Ronai, Z. (2004). Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB. EMBO J. 23, 322-332.
    • (2004) EMBO J , vol.23 , pp. 322-332
    • Habelhah, H.1    Takahashi, S.2    Cho, S.G.3    Kadoya, T.4    Watanabe, T.5    Ronai, Z.6
  • 16
    • 33847381993 scopus 로고    scopus 로고
    • Globular adiponectin activates nuclear factor-kappaB and activating protein-1 and enhances angiotensin II-induced proliferation in cardiac fibroblasts
    • Hattori, Y., Hattori, S., Akimoto, K., Nishikimi, T., Suzuki, K., Matsuoka, H. and Kasai, K. (2007). Globular adiponectin activates nuclear factor-kappaB and activating protein-1 and enhances angiotensin II-induced proliferation in cardiac fibroblasts. Diabetes 56, 804-808.
    • (2007) Diabetes , vol.56 , pp. 804-808
    • Hattori, Y.1    Hattori, S.2    Akimoto, K.3    Nishikimi, T.4    Suzuki, K.5    Matsuoka, H.6    Kasai, K.7
  • 17
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • Hayden, M. S. and Ghosh, S. (2004). Signaling to NF-kappaB. Genes Dev. 18, 2195-2224.
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 18
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • Hayden, M. S. and Ghosh, S. (2008). Shared principles in NF-kappaB signaling. Cell 132, 344-362.
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 19
    • 47149096915 scopus 로고    scopus 로고
    • Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity
    • Heilbronn, L. K. and Campbell, L. V. (2008). Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr. Pharm. Des. 14, 1225-1230.
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 1225-1230
    • Heilbronn, L.K.1    Campbell, L.V.2
  • 20
    • 33645312379 scopus 로고    scopus 로고
    • Circuitry of nuclear factor kappaB signaling
    • Hoffmann, A. and Baltimore, D. (2006). Circuitry of nuclear factor kappaB signaling. Immunol. Rev. 210, 171-186.
    • (2006) Immunol. Rev. , vol.210 , pp. 171-186
    • Hoffmann, A.1    Baltimore, D.2
  • 21
    • 27144506049 scopus 로고    scopus 로고
    • Production of endoribonuclease-prepared short interfering RNAs for gene silencing in mammalian cells
    • Kittler, R., Heninger, A. K., Franke, K., Habermann, B. and Buchholz, F. (2005). Production of endoribonuclease-prepared short interfering RNAs for gene silencing in mammalian cells. Nat. Methods 2, 779-784.
    • (2005) Nat. Methods , vol.2 , pp. 779-784
    • Kittler, R.1    Heninger, A.K.2    Franke, K.3    Habermann, B.4    Buchholz, F.5
  • 22
    • 2942731516 scopus 로고    scopus 로고
    • Regulation of the NFkappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation
    • Liao, G., Zhang, M., Harhaj, E. W. and Sun, S. C. (2004). Regulation of the NFkappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J. Biol. Chem. 279, 26243-26250.
    • (2004) J. Biol. Chem. , vol.279 , pp. 26243-26250
    • Liao, G.1    Zhang, M.2    Harhaj, E.W.3    Sun, S.C.4
  • 23
    • 48149114957 scopus 로고    scopus 로고
    • Lymphotoxinalpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells
    • Madge, L. A., Kluger, M. S., Orange, J. S. and May, M. J. (2008). Lymphotoxinalpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells. J. Immunol. 180, 3467-3477.
    • (2008) J. Immunol. , vol.180 , pp. 3467-3477
    • Madge, L.A.1    Kluger, M.S.2    Orange, J.S.3    May, M.J.4
  • 28
    • 0033517348 scopus 로고    scopus 로고
    • Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2
    • Mitsuuchi, Y., Johnson, S. W., Sonoda, G., Tanno, S., Golemis, E. A. and Testa, J. R. (1999). Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene 18, 4891-4898.
    • (1999) Oncogene , vol.18 , pp. 4891-4898
    • Mitsuuchi, Y.1    Johnson, S.W.2    Sonoda, G.3    Tanno, S.4    Golemis, E.A.5    Testa, J.R.6
  • 29
    • 79952509253 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor cross-talk
    • Naudé, P. J., den Boer, J. A., Luiten, P. G. and Eisel, U. L. (2011). Tumor necrosis factor receptor cross-talk. FEBS J. 278, 888-898.
    • (2011) FEBS J , vol.278 , pp. 888-898
    • Naudé, P.J.1    den Boer, J.A.2    Luiten, P.G.3    Eisel, U.L.4
  • 30
    • 0034641647 scopus 로고    scopus 로고
    • Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway
    • Ouchi, N., Kihara, S., Arita, Y., Okamoto, Y., Maeda, K., Kuriyama, H., Hotta, K., Nishida, M., Takahashi, M., Muraguchi, M. et al. (2000). Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 102, 1296-1301.
    • (2000) Circulation , vol.102 , pp. 1296-1301
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3    Okamoto, Y.4    Maeda, K.5    Kuriyama, H.6    Hotta, K.7    Nishida, M.8    Takahashi, M.9    Muraguchi, M.10
  • 31
    • 0033517189 scopus 로고    scopus 로고
    • NF-kappaB activation by tumour necrosis factor requires the Akt serinethreonine kinase
    • Ozes, O. N., Mayo, L. D., Gustin, J. A., Pfeffer, S. R., Pfeffer, L. M. and Donner, D. B. (1999). NF-kappaB activation by tumour necrosis factor requires the Akt serinethreonine kinase. Nature 401, 82-85.
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 32
    • 0036771765 scopus 로고    scopus 로고
    • Two pathways to NF-kappaB
    • Pomerantz, J. L. and Baltimore, D. (2002). Two pathways to NF-kappaB. Mol. Cell 10, 693-695.
    • (2002) Mol. Cell , vol.10 , pp. 693-695
    • Pomerantz, J.L.1    Baltimore, D.2
  • 33
    • 67949106368 scopus 로고    scopus 로고
    • Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis
    • Pyrzynska, B., Pilecka, I. and Miaczynska, M. (2009). Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis. Mol. Oncol. 3, 321-338.
    • (2009) Mol. Oncol. , vol.3 , pp. 321-338
    • Pyrzynska, B.1    Pilecka, I.2    Miaczynska, M.3
  • 34
    • 28844498364 scopus 로고    scopus 로고
    • Stabilization of basally translated NF-kappaBinducing kinase (NIK) protein functions as a molecular switch of processing of NFkappaB2 p100
    • Qing, G., Qu, Z. and Xiao, G. (2005). Stabilization of basally translated NF-kappaBinducing kinase (NIK) protein functions as a molecular switch of processing of NFkappaB2 p100. J. Biol. Chem. 280, 40578-40582.
    • (2005) J. Biol. Chem. , vol.280 , pp. 40578-40582
    • Qing, G.1    Qu, Z.2    Xiao, G.3
  • 35
    • 67650540827 scopus 로고    scopus 로고
    • Endosomal adaptor proteins APPL1 and APPL2 are novel activators of betacatenin/ TCF-mediated transcription
    • Rashid, S., Pilecka, I., Torun, A., Olchowik, M., Bielinska, B. and Miaczynska, M. (2009). Endosomal adaptor proteins APPL1 and APPL2 are novel activators of betacatenin/ TCF-mediated transcription. J. Biol. Chem. 284, 18115-18128.
    • (2009) J. Biol. Chem. , vol.284 , pp. 18115-18128
    • Rashid, S.1    Pilecka, I.2    Torun, A.3    Olchowik, M.4    Bielinska, B.5    Miaczynska, M.6
  • 37
    • 0042867242 scopus 로고    scopus 로고
    • Troglitazone antagonizes tumor necrosis factor-alpha-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kappaB
    • Ruan, H., Pownall, H. J. and Lodish, H. F. (2003). Troglitazone antagonizes tumor necrosis factor-alpha-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kappaB. J. Biol. Chem. 278, 28181-28192.
    • (2003) J. Biol. Chem. , vol.278 , pp. 28181-28192
    • Ruan, H.1    Pownall, H.J.2    Lodish, H.F.3
  • 38
    • 36148932174 scopus 로고    scopus 로고
    • The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
    • Saito, T., Jones, C. C., Huang, S., Czech, M. P. and Pilch, P. F. (2007). The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. J. Biol. Chem. 282, 32280-32287.
    • (2007) J. Biol. Chem. , vol.282 , pp. 32280-32287
    • Saito, T.1    Jones, C.C.2    Huang, S.3    Czech, M.P.4    Pilch, P.F.5
  • 39
    • 33750443289 scopus 로고    scopus 로고
    • IkappaB kinase complexes: gateways to NF-kappaB activation and transcription
    • Scheidereit, C. (2006). IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene 25, 6685-6705.
    • (2006) Oncogene , vol.25 , pp. 6685-6705
    • Scheidereit, C.1
  • 40
    • 42949092018 scopus 로고    scopus 로고
    • The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development
    • Schenck, A., Goto-Silva, L., Collinet, C., Rhinn, M., Giner, A., Habermann, B., Brand, M. and Zerial, M. (2008). The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell 133, 486-497.
    • (2008) Cell , vol.133 , pp. 486-497
    • Schenck, A.1    Goto-Silva, L.2    Collinet, C.3    Rhinn, M.4    Giner, A.5    Habermann, B.6    Brand, M.7    Zerial, M.8
  • 42
    • 78650907445 scopus 로고    scopus 로고
    • A single NFkB system for both canonical and non-canonical signaling
    • Shih, V. F., Tsui, R., Caldwell, A. and Hoffmann, A. (2011). A single NFkB system for both canonical and non-canonical signaling. Cell Res. 21, 86-102.
    • (2011) Cell Res , vol.21 , pp. 86-102
    • Shih, V.F.1    Tsui, R.2    Caldwell, A.3    Hoffmann, A.4
  • 44
    • 78650920066 scopus 로고    scopus 로고
    • Non-canonical NF-kB signaling pathway
    • Sun, S. C. (2011). Non-canonical NF-κB signaling pathway. Cell Res. 21, 71-85.
    • (2011) Cell Res , vol.21 , pp. 71-85
    • Sun, S.C.1
  • 45
    • 52049095036 scopus 로고    scopus 로고
    • New insights into NF-kappaB regulation and function
    • Sun, S. C. and Ley, S. C. (2008). New insights into NF-kappaB regulation and function. Trends Immunol. 29, 469-478.
    • (2008) Trends Immunol , vol.29 , pp. 469-478
    • Sun, S.C.1    Ley, S.C.2
  • 46
    • 0029786304 scopus 로고    scopus 로고
    • Anatomy of TRAF2, Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins
    • Takeuchi, M., Rothe, M., and Goeddel, D. V. (1996). Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. J. Biol. Chem. 271, 19935-19942.
    • (1996) J. Biol. Chem. , vol.271 , pp. 19935-19942
    • Takeuchi, M.1    Rothe, M.2    Goeddel, D.V.3
  • 47
    • 77949900267 scopus 로고    scopus 로고
    • Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts
    • Tan, Y., You, H., Wu, C., Altomare, D. A. and Testa, J. R. (2010). Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts. J. Biol. Chem. 285, 6377-6389.
    • (2010) J. Biol. Chem. , vol.285 , pp. 6377-6389
    • Tan, Y.1    You, H.2    Wu, C.3    Altomare, D.A.4    Testa, J.R.5
  • 48
    • 38449089987 scopus 로고    scopus 로고
    • Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway
    • Tang, C. H., Chiu, Y. C., Tan, T. W., Yang, R. S. and Fu, W. M. (2007). Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway. J. Immunol. 179, 5483-5492.
    • (2007) J. Immunol. , vol.179 , pp. 5483-5492
    • Tang, C.H.1    Chiu, Y.C.2    Tan, T.W.3    Yang, R.S.4    Fu, W.M.5
  • 49
    • 77956407149 scopus 로고    scopus 로고
    • NF-kB inducing kinase: a key regulator in the immune system and in cancer
    • Thu, Y. M. and Richmond, A. (2010). NF-kB inducing kinase: a key regulator in the immune system and in cancer. Cytokine Growth Factor Rev. 21, 213-226.
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 213-226
    • Thu, Y.M.1    Richmond, A.2
  • 50
    • 80051664762 scopus 로고    scopus 로고
    • Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment
    • Urbanska, A., Sadowski, L., Kalaidzidis, Y. and Miaczynska, M. (2011). Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment. Traffic 12, 1227-1241.
    • (2011) Traffic , vol.12 , pp. 1227-1241
    • Urbanska, A.1    Sadowski, L.2    Kalaidzidis, Y.3    Miaczynska, M.4
  • 51
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • Vallabhapurapu, S. and Karin, M. (2009). Regulation and function of NF-kappaB transcription factors in the immune system. Annu. Rev. Immunol. 27, 693-733.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 53
    • 79952498248 scopus 로고    scopus 로고
    • TNFR1-induced activation of the classical NFkB pathway
    • Wajant, H. and Scheurich, P. (2011). TNFR1-induced activation of the classical NFkB pathway. FEBS J. 278, 862-876.
    • (2011) FEBS J , vol.278 , pp. 862-876
    • Wajant, H.1    Scheurich, P.2
  • 54
    • 15744361975 scopus 로고    scopus 로고
    • Tom1 (target of Myb 1) is a novel negative regulator of interleukin-1- and tumor necrosis factor-induced signaling pathways
    • Yamakami, M. and Yokosawa, H. (2004). Tom1 (target of Myb 1) is a novel negative regulator of interleukin-1- and tumor necrosis factor-induced signaling pathways. Biol. Pharm. Bull. 27, 564-566.
    • (2004) Biol. Pharm. Bull. , vol.27 , pp. 564-566
    • Yamakami, M.1    Yokosawa, H.2
  • 55
    • 42149110830 scopus 로고    scopus 로고
    • Control of canonical NF-kappaB activation through the NIK-IKK complex pathway
    • Zarnegar, B., Yamazaki, S., He, J. Q. and Cheng, G. (2008a). Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. Proc. Natl. Acad. Sci. USA 105, 3503-3508.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 3503-3508
    • Zarnegar, B.1    Yamazaki, S.2    He, J.Q.3    Cheng, G.4
  • 56
    • 56349164239 scopus 로고    scopus 로고
    • Noncanonical NFkappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
    • Zarnegar, B. J., Wang, Y., Mahoney, D. J., Dempsey, P. W., Cheung, H. H., He, J., Shiba, T., Yang, X., Yeh, W. C., Mak, T. W. et al. (2008b). Noncanonical NFkappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat. Immunol. 9, 1371-1378.
    • (2008) Nat. Immunol. , vol.9 , pp. 1371-1378
    • Zarnegar, B.J.1    Wang, Y.2    Mahoney, D.J.3    Dempsey, P.W.4    Cheung, H.H.5    He, J.6    Shiba, T.7    Yang, X.8    Yeh, W.C.9    Mak, T.W.10
  • 57
    • 69249147344 scopus 로고    scopus 로고
    • Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/ Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways
    • Zhou, L., Deepa, S. S., Etzler, J. C., Ryu, J., Mao, X., Fang, Q., Liu, D. D., Torres, J. M., Jia, W., Lechleiter, J. D. et al. (2009). Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/ Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways. J. Biol. Chem. 284, 22426-22435.
    • (2009) J. Biol. Chem. , vol.284 , pp. 22426-22435
    • Zhou, L.1    Deepa, S.S.2    Etzler, J.C.3    Ryu, J.4    Mao, X.5    Fang, Q.6    Liu, D.D.7    Torres, J.M.8    Jia, W.9    Lechleiter, J.D.10
  • 58
    • 34547198755 scopus 로고    scopus 로고
    • Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5
    • Zhu, G., Chen, J., Liu, J., Brunzelle, J. S., Huang, B., Wakeham, N., Terzyan, S., Li, X., Rao, Z., Li, G. et al. (2007). Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. EMBO J. 26, 3484-3493.
    • (2007) EMBO J , vol.26 , pp. 3484-3493
    • Zhu, G.1    Chen, J.2    Liu, J.3    Brunzelle, J.S.4    Huang, B.5    Wakeham, N.6    Terzyan, S.7    Li, X.8    Rao, Z.9    Li, G.10
  • 59
    • 62549151303 scopus 로고    scopus 로고
    • A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes
    • Zoncu, R., Perera, R. M., Balkin, D. M., Pirruccello, M., Toomre, D. and De Camilli, P. (2009). A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. Cell 136, 1110-1121.
    • (2009) Cell , vol.136 , pp. 1110-1121
    • Zoncu, R.1    Perera, R.M.2    Balkin, D.M.3    Pirruccello, M.4    Toomre, D.5    De Camilli, P.6


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