Expression of apoptosis related proteins: RAIDD, ZIP kinase, Bim/BOD, p21, Bax, Bcl-2 and NF-κB in brains of patients with Down syndrome

Journal of Neural Transmission, Supplement

Volumn , Issue 61, 2001, Pages 181-192

  Engidawork, E ^a   Gulesserian, T ^a   Seidl, R ^a   Cairns, N ^b   Lubec, G ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE; PROTEIN P21; RAIDD PROTEIN; SYNAPTOTAGMIN; UNCLASSIFIED DRUG; ZIPPER INTERACTING PROTEIN KINASE; BCL 2 BINDING PROTEIN, BIM; BCL-2-BINDING PROTEIN, BIM; CARRIER PROTEIN; CIP1 PROTEIN; CYCLINE; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASES; PROTO ONCOGENE PROTEINS; PROTO ONCOGENE PROTEINS C BCL 2; ZIP KINASE;

ADULT; ARTICLE; CELL LOSS; CEREBELLUM; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN SYNDROME; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; MALE; NERVE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; WESTERN BLOTTING; AGED; APOPTOSIS; BIOSYNTHESIS; BRAIN; METABOLISM; PATHOLOGY;

AGED; APOPTOSIS; BLOTTING, WESTERN; BRAIN; CARRIER PROTEINS; CYCLINS; DOWN SYNDROME; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; MIDDLE AGE; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SUPPORT, NON-U.S. GOV'T;

EID: 0035226623     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6262-0_14     Document Type: Article

References (47)

1. Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES (1997) CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FASL/tumor necrosis factor receptor interacting protein, RIP. Cancer Res 57: 615-619
2. Anderson AJ, Stoltzner S, Lai Florence Su J, Nixon RA (2000) Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer's disease, and effect of postmortem tissue archival on TUNEL. Neurobiol Aging 21: 511-524
3. Andersson P (1997) Kinase cascades regulating entry into apoptosis. Microbiol Mol Biol Rev 66: 33-46
4. Aravind L, Dixit VM, Koonin EV (1999) The domains of death: evolution of the apoptosis machinery. TIBS 24: 47-53
5. Asada M, Yamada T, Ichijo H, Delia D, Miyazono K, Fukumoro K, Mizutani S (1999) Apoptosis inhibitory activity of cytoplasmic p21 (Cip1/WaF1) in monocyte differentiation. EMBO J 18: 1223-1234
6. Castagne V, Gautschi M, Lefevre K, Posada A, Clarke PGH (1999) Relationships between neuronal death and the cellular redox status. Focus on the developing nervous system. Prog Neurobiol 59: 397-423
7. Chang BD, Watanabe K, Broude EV, Fang J, Poole JC, Kalinichenko TV, Roninson IB (2000) Effects of p21 (WAF-1, Cip-1, Sdi-1) on cellular gene expression: implication for carcinogenesis, senescence and age related disease. Proc Natl Acad Sci USA 94: 11357-11362
8. Chen J, Jackson PK, Kirschner MW, Duzta A (1995) Separate domains of p21 involved in the inhibition of CDK kinase and PCNA. Nature 374: 386-388
9. de Hann JB, Cristiano F, Iannello RC, Kola I (1995) Cu/Zn-superoxide dismutase and gluthatione peroxidase during aging. Biochem Mol Biol Int 35: 1281-1297
10. de la Monte SM, Sohn YK, Ganju YK, Wands JR (1998) p53 and CD95 associated apoptosis in neurodegenerative diseases. Lab Invest 78: 401-411
11. Deng G, Su JH, Ivins KJ, Van Houten B, Cotman CW (1999) Bcl-2 facilitates recovery from DANN damage after oxidative stress. Exp Neurol 159: 309-318
12. Duan H, Dixit VM (1997) RAIDD is a new death adaptor molecule. Nature 385: 86-89
13. El-Diery WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackmann J, Pietenpol JA (1994) WAF1/CIP1 is induced in p53 mediated G1 arrest and apoptosis. Cancer Res 54: 1169-1174
14. Engidawork E, Gulesserian T, Seidl R, Cairns N, Lubec G (2001) Expression of apoptosis related proteins in brains of patients with Alzheimer's disease. Neurosci Lett 303: 79-82
15. Franzoso G, Biswas P, Poli G, Carlson LM, Brown KD, Tomita-Yamaguchi M, Fauci AS, Siebelist UK (1994) A family of serine proteases expressed exclusively in myleomonocytic cells specifically process the NF-κB subunit p65 in vitro and may impair HIV replication in these cells. J Exp Med 180: 1445-1456
16. Grilli M, Memo M (1999) Nuclear factor-kappa B/Rel proteins: a point of convergence of signaling pathways relevant in neuronal function and dysfunction. Biochem Pharmacol 57: 1-7
17. Gulesserian T, Engidawork E, Yoo BC, Cairns N, Lubec G (2001) Comparable apoptotic pathways in frontal cortex and cerebellum of patients with Down syndrome (this volume)
18. Hofmann K, Bucher P, Tschopp J (1997) The CARD domain: a new apoptotic signaling motif. Trends Biochem Sci 22: 155
19. Hsu SY, Lin P, Hsueh AJ BOD (Bcl-2 related ovarian death gene) is an ovarian BH3 domain containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol Endocrinol 12: 1432-1440
20. Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C (1997) Transcription factor NF-κB is activated in primary neurons by amyloid β peptides in neurons surrounding early plaques from patients with Alzheimer's disease. Proc Natl Acad Sci USA 94: 2642-2647
21. Kaltschmidt B, Uherek M, Volk B, Wellmann H, Kaltschmidt C (1999) Inhibition of NF-κB potentiates amyloid β peptide mediated neuronal apoptosis. Proc Natl Acad Sci USA 96: 9409-9414
22. Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (1998) ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol Cell Biol 18: 1642-1651
23. Kogel D, Bierbaum H, Preuss U, Scheidtmann KH (1999) C-terminal truncation of Dlk/ZIP kinase leads to abrogation of nuclear transport and high apoptotic activity. Oncogene 18: 7212-7218
24. Krosmeyer SJ (1995) Regulators of cell death. Trends Genet 11: 101-105
25. Lowry OH, Rosebrough NJ, Farr AL, Randal RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275
26. Mann DMA (1988) The pathological association between Down Syndrome and Alzheimer's disease. Mech Aging Dev 43: 99-136
27. Mattson MP, Culmsee C, Yu Z, Camandola S (2000) Roles of nuclear factor kappa B in neuronal survival and plasticity. J Neurochem 74: 443-456
28. Mattson MP, Duan W, Chan SL, Camandola S (1999) Par-4: an emerging pivotal player in neuronal apoptosis and neurodegenerative disorders. J Mol Neurosci 13: 17-30
29. Moore PA, Ruben SM, Rosen CA (1993) Conservation of transcriptional activation functions of the NF-κB p50 and p65 subunits in mammalian cells and Sacchromyces cerevisiae. Mol Cell Biol 13: 1666-1674
30. Nagy ZS, Esiri MM (1997) Apoptosis related protein expression in the hippocampus in Alzheimer's disease. Neurobiol Aging 18: 565-571
31. O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC (1998) Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J 17: 384-395
32. Oltvazi ZN, Milliman CL, Krosmeyer SJ (1993) Bcl-2 hetrodimerizes in vivo with a conserved homolog Bax that accelerates programmed cell death. Cell 74: 609-619
33. Page G, Kogel D, Rangnekar V, Scheidtmann KH (1999) Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis. Oncogene 18: 7265-7273
34. Polyak K, Waldman T, He TC, Kinzler KW, Vogelstein B (1996) Genetic determinants of p53 induced apoptosis and growth arrest. Genes Dev 10: 1945-1952
35. Satou T, Cummings BJ, Cotman CW (1995) Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity. Brain Res 697: 35-43
36. Sawa A, Oyama F, Cairns NJ, Amano N, Matsushita M (1997) Aberrant expression of Bcl-2 gene family in Down syndrome brains. Mol Brain Res 48: 53-59
37. Seidl R, Fang-Kircher S, Bidmon B, Cairns N, Lubec G (1999) Apoptosis associated protein p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome. Neurosci Lett 260: 9-12
38. Sherr CJ, Roberts JM (1995) Inhibitors of mammalian G1 cyclin dependent kinases. Genes Dev 9: 1149-1163
39. Shim J, Lee H, Park J, Kim H, Choi EJ (1996) A nonenzymatic p21 protein inhibitor of stress activated protein kinases. Nature 381: 804-806
40. Simeonidis S, Liang S, Chen G, Thanos D (1997) Cloning and functional characterization of mouse IκB epsilon. Proc Natl Acad Sci USA 94: 14372-14377
41. Steinman RA, Hoffman B, Iro A, Guillouf C, Liebermann DA, el-Houseini ME (1994) Induction of p21 (Waf-1/CIP1) during differentiation. Oncogene 9: 3389-3396
42. Tsujimoto Y, Cossman J, Jette E, Croce CM (1985) Involvement of the Bcl-2 gene in human follicular lymphoma. Science 228: 1440-1443
43. Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z, Kolesnick RN (1996) Requirement for ceramide initiated SAPK/JNK signaling in stress induced apoptosis. Nature 380: 75-79
44. Villunger A, Huang DCS, Holler N, Tschopp J, Strasser A (2000) Fas ligand induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP or RAIDD. J Immunol 165: 1337-1343
45. Wolf BB, Green DR (1999) Suicidal tendencies: apoptotic cell death by caspase family proteinases. J Biol Chem 274: 20049-20052
46. Wu H, Wade M, Krall L, Grisham J, Xiong Y, Van Dyke T (1996) Targeted in vivo expression of the cyclin dependent kinase inhibitor p21 halts hepatocytes cell cycle progression, postnatal liver development and regeneration. Genes Dev 10: 245-260
47. Yoshioka K, Yamamoto S, Moriguchi N, Miyata H, Tsukiyama K, Isokawa S, Horiuchi F, Takemura T (2000) Overexpression of Bcl-2 in transient abnormal myleopoiesis associated with Down syndrome. Ann Hematol 79: 319-321