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Volumn 7, Issue JUN, 2015, Pages

Menopause, obesity and inflammation: Interactive risk factors for Alzheimer's disease

Author keywords

Adiposity; Aging; Alzheimer's disease; Estrogen; Hormone therapy; Inflammation; Obesity

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; APOLIPOPROTEIN E4; BETA SECRETASE 1; BRAIN DERIVED NEUROTROPHIC FACTOR; CLUSTERIN; ESTRADIOL; ESTROGEN; INSULIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; PLACEBO; PROGESTERONE; PROSTAGLANDIN E2; SOMATOMEDIN; TAU PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 84936092088     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2015.00130     Document Type: Article
Times cited : (77)

References (216)
  • 1
    • 77955979357 scopus 로고    scopus 로고
    • Pathways linking Abeta and tau pathologies
    • F.M. LaFerla (2010) Pathways linking Abeta and tau pathologies. Biochem Soc Trans 38 993-5. doi: 10.1042/BST0380993
    • (2010) Biochem Soc Trans , vol.38 , pp. 993-995
    • LaFerla, F.M.1
  • 2
    • 84922479199 scopus 로고    scopus 로고
    • Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease
    • G.P. Morris, I.A. Clark, and B. Vissel (2014) Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease. Acta Neuropathol Commun 2 135. doi: 10.1186/s40478-014-0135-5
    • (2014) Acta Neuropathol Commun , vol.2 , pp. 135
    • Morris, G.P.1    Clark, I.A.2    Vissel, B.3
  • 3
    • 84880759156 scopus 로고    scopus 로고
    • Neurotoxicity of amyloid beta-protein: synaptic and network dysfunction
    • L. Mucke, and D.J. Selkoe (2012) Neurotoxicity of amyloid beta-protein: synaptic and network dysfunction. Cold Spring Harb Perspect Med 2 a006338. doi: 10.1101/cshperspect.a006338
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. a006338
    • Mucke, L.1    Selkoe, D.J.2
  • 4
  • 5
    • 0026597063 scopus 로고
    • Alzheimer's disease: the amyloid cascade hypothesis
    • J.A. Hardy, and G.A. Higgins (1992) Alzheimer's disease: the amyloid cascade hypothesis. Science 256 184-5.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 6
    • 84880187014 scopus 로고    scopus 로고
    • Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal
    • J. Hardy (2006) Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal. J Alzheimers Dis 9 151-3.
    • (2006) J Alzheimers Dis , vol.9 , pp. 151-153
    • Hardy, J.1
  • 8
    • 84919466585 scopus 로고    scopus 로고
    • Lost after translation: missorting of Tau protein and consequences for Alzheimer disease
    • H. Zempel, and E. Mandelkow (2014) Lost after translation: missorting of Tau protein and consequences for Alzheimer disease. Trends Neurosci 37 721-32. doi: 10.1016/j.tins.2014.08.004
    • (2014) Trends Neurosci , vol.37 , pp. 721-732
    • Zempel, H.1    Mandelkow, E.2
  • 9
    • 84899019792 scopus 로고    scopus 로고
    • Amyloid-beta and tau: the trigger and bullet in Alzheimer disease pathogenesis
    • G.S. Bloom (2014) Amyloid-beta and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol 71 505-8. doi: 10.1001/jamaneurol.2013.5847
    • (2014) JAMA Neurol , vol.71 , pp. 505-508
    • Bloom, G.S.1
  • 10
    • 57649187117 scopus 로고    scopus 로고
    • Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease
    • L. Mosconi, A. Pupi, and M.J. De Leon (2008) Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease. Ann N Y Acad Sci 1147 180-95. doi: 10.1196/annals.1427.007
    • (2008) Ann N Y Acad Sci , vol.1147 , pp. 180-195
    • Mosconi, L.1    Pupi, A.2    De Leon, M.J.3
  • 11
    • 81855164838 scopus 로고    scopus 로고
    • Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions
    • J. Yao, J.R. Rettberg, L.P. Klosinski, E. Cadenas, and R.D. Brinton ( 2011) Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions. Mol Aspects Med 32 247-57. doi: 10.1016/j.mam.2011.10.005
    • (2011) Mol Aspects Med , vol.32 , pp. 247-257
    • Yao, J.1    Rettberg, J.R.2    Klosinski, L.P.3    Cadenas, E.4    Brinton, R.D.5
  • 12
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • B.V. Zlokovic (2011) Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 12 723-38. doi: 10.1038/nrn3114
    • (2011) Nat Rev Neurosci , vol.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 13
    • 11444256801 scopus 로고    scopus 로고
    • Glia and their cytokines in progression of neurodegeneration
    • R.E. Mrak, and W.S. Griffin (2005) Glia and their cytokines in progression of neurodegeneration. Neurobiol Aging 26 349-54. doi: 10.1016/j.neurobiolaging.2004.05.010
    • (2005) Neurobiol Aging , vol.26 , pp. 349-354
    • Mrak, R.E.1    Griffin, W.S.2
  • 14
  • 15
    • 84896690513 scopus 로고    scopus 로고
    • Prevalence of childhood and adult obesity in the United States, 2011-2012
    • C.L. Ogden, M.D. Carroll, B.K. Kit, and K.M. Flegal (2014) Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 311 806-14. doi: 10.1001/jama.2014.732
    • (2014) JAMA , vol.311 , pp. 806-814
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3    Flegal, K.M.4
  • 16
    • 84988814458 scopus 로고    scopus 로고
    • Past and future corollaries of theories on causes of metabolic syndrome and obesity related co-morbidities part 2: a composite unifying theory review of human specific co-adaptations to brain energy consumption
    • A.T. McGill (2014) Past and future corollaries of theories on causes of metabolic syndrome and obesity related co-morbidities part 2: a composite unifying theory review of human specific co-adaptations to brain energy consumption. Arch Public Health 72 31. doi: 10.1186/2049-3258-72-31
    • (2014) Arch Public Health , vol.72 , pp. 31
    • McGill, A.T.1
  • 17
    • 84904468550 scopus 로고    scopus 로고
    • Obesity-associated hypertension: recent progress in deciphering the pathogenesis
    • K. Rahmouni (2014) Obesity-associated hypertension: recent progress in deciphering the pathogenesis. Hypertension 64 215-21. doi: 10.1161/HYPERTENSIONAHA.114.00920
    • (2014) Hypertension , vol.64 , pp. 215-221
    • Rahmouni, K.1
  • 18
    • 69249205739 scopus 로고    scopus 로고
    • Obesity, inflammation, and atherosclerosis
    • V.Z. Rocha, and P. Libby (2009) Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol 6 399-409. doi: 10.1038/nrcardio.2009.55
    • (2009) Nat Rev Cardiol , vol.6 , pp. 399-409
    • Rocha, V.Z.1    Libby, P.2
  • 19
    • 84897109680 scopus 로고    scopus 로고
    • Alzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactions
    • A. Jayaraman, and C.J. Pike (2014) Alzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactions. Curr Diab Rep 14 476. doi: 10.1007/s11892-014-0476-2
    • (2014) Curr Diab Rep , vol.14 , pp. 476
    • Jayaraman, A.1    Pike, C.J.2
  • 20
    • 84921682801 scopus 로고    scopus 로고
    • Longitudinal inflammation, cognitive decline, and Alzheimer's disease: a mini-review
    • B.M. Bettcher, and J.H. Kramer (2014) Longitudinal inflammation, cognitive decline, and Alzheimer's disease: a mini-review. Clin Pharmacol Ther 96 464-9. doi: 10.1038/clpt.2014.147
    • (2014) Clin Pharmacol Ther , vol.96 , pp. 464-469
    • Bettcher, B.M.1    Kramer, J.H.2
  • 22
    • 84875655895 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature
    • T. Wyss-Coray, and J. Rogers (2012) Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med 2 a006346. doi: 10.1101/cshperspect.a006346
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. a006346
    • Coray-Wyss, T.1    Rogers, J.2
  • 23
    • 84899917388 scopus 로고    scopus 로고
    • Sex modifies the APOE-related risk of developing Alzheimer disease
    • A. Altmann, L. Tian, V.W. Henderson, M.D. Greicius, and I. Alzheimer's Disease Neuroimaging Initiative (2014) Sex modifies the APOE-related risk of developing Alzheimer disease. Ann Neurol 75 563-73. doi: 10.1002/ana.24135
    • (2014) Ann Neurol , vol.75 , pp. 563-573
    • Altmann, A.1    Tian, L.2    Henderson, V.W.3    Greicius, M.D.4
  • 24
    • 84934272438 scopus 로고    scopus 로고
    • Metabolic syndrome, aging and involvement of oxidative stress
    • F. Bonomini, L.F. Rodella, and R. Rezzani (2015) Metabolic syndrome, aging and involvement of oxidative stress. Aging Dis 6 109-20. doi: 10.14336/AD.2014.0305
    • (2015) Aging Dis , vol.6 , pp. 109-120
    • Bonomini, F.1    Rodella, L.F.2    Rezzani, R.3
  • 25
    • 84989332872 scopus 로고    scopus 로고
    • Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome
    • B. Kim, and E.L. Feldman (2015) Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome. Exp Mol Med 47 e149. doi: 10.1038/emm.2015.3
    • (2015) Exp Mol Med , vol.47 , pp. e149
    • Kim, B.1    Feldman, E.L.2
  • 26
    • 76849101075 scopus 로고    scopus 로고
    • Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders
    • L.A. Profenno, A.P. Porsteinsson, and S.V. Faraone (2010) Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders. Biol Psychiatry 67 505-12. doi: 10.1016/j.biopsych.2009.02.013
    • (2010) Biol Psychiatry , vol.67 , pp. 505-512
    • Profenno, L.A.1    Porsteinsson, A.P.2    Faraone, S.V.3
  • 27
  • 28
    • 4043104808 scopus 로고    scopus 로고
    • Comorbid type 2 diabetes mellitus and hypertension exacerbates cognitive decline: evidence from a longitudinal study
    • L.B. Hassing, S.M. Hofer, S.E. Nilsson, S. Berg, N.L. Pedersen, G. McClearn, and B. Johansson (2004) Comorbid type 2 diabetes mellitus and hypertension exacerbates cognitive decline: evidence from a longitudinal study. Age Ageing 33 355-61. doi: 10.1093/ageing/afh100
    • (2004) Age Ageing , vol.33 , pp. 355-361
    • Hassing, L.B.1    Hofer, S.M.2    Nilsson, S.E.3    Berg, S.4    Pedersen, N.L.5    McClearn, G.6    Johansson, B.7
  • 29
    • 85027917954 scopus 로고    scopus 로고
    • Geriatric conditions develop in middle-aged adults with diabetes
    • C.T. Cigolle, P.G. Lee, K.M. Langa, Y.Y. Lee, Z. Tian, and C.S. Blaum (2011) Geriatric conditions develop in middle-aged adults with diabetes. J Gen Intern Med 26 272-9. doi: 10.1007/s11606-010-1510-y
    • (2011) J Gen Intern Med , vol.26 , pp. 272-279
    • Cigolle, C.T.1    Lee, P.G.2    Langa, K.M.3    Lee, Y.Y.4    Tian, Z.5    Blaum, C.S.6
  • 30
    • 33644553117 scopus 로고    scopus 로고
    • Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus
    • G.J. Biessels, F.E. De Leeuw, J. Lindeboom, F. Barkhof, and P. Scheltens (2006) Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus. J Neurol Neurosurg Psychiatry 77 304-7. doi: 10.1136/jnnp.2005.069583
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , pp. 304-307
    • Biessels, G.J.1    De Leeuw, F.E.2    Lindeboom, J.3    Barkhof, F.4    Scheltens, P.5
  • 31
    • 5344256250 scopus 로고    scopus 로고
    • Hyperinsulinemia and risk of Alzheimer disease
    • J.A. Luchsinger, M.X. Tang, S. Shea, and R. Mayeux (2004) Hyperinsulinemia and risk of Alzheimer disease. Neurology 63 1187-92.
    • (2004) Neurology , vol.63 , pp. 1187-1192
    • Luchsinger, J.A.1    Tang, M.X.2    Shea, S.3    Mayeux, R.4
  • 34
    • 79955600723 scopus 로고    scopus 로고
    • Midlife overweight and obesity increase late-life dementia risk: a population-based twin study
    • W.L. Xu, A.R. Atti, M. Gatz, N.L. Pedersen, B. Johansson, and L. Fratiglioni (2011) Midlife overweight and obesity increase late-life dementia risk: a population-based twin study. Neurology 76 1568-74. doi: 10.1212/WNL.0b013e3182190d09
    • (2011) Neurology , vol.76 , pp. 1568-1574
    • Xu, W.L.1    Atti, A.R.2    Gatz, M.3    Pedersen, N.L.4    Johansson, B.5    Fratiglioni, L.6
  • 37
    • 47949111598 scopus 로고    scopus 로고
    • Central obesity and increased risk of dementia more than three decades later
    • R.A. Whitmer, D.R. Gustafson, E. Barrett-Connor, M.N. Haan, E.P. Gunderson, and K. Yaffe (2008) Central obesity and increased risk of dementia more than three decades later. Neurology 71 1057-64. doi: 10.1212/01.wnl.0000306313.89165.ef
    • (2008) Neurology , vol.71 , pp. 1057-1064
    • Whitmer, R.A.1    Gustafson, D.R.2    Barrett-Connor, E.3    Haan, M.N.4    Gunderson, E.P.5    Yaffe, K.6
  • 38
    • 84861460193 scopus 로고    scopus 로고
    • Central obesity in the elderly is related to late-onset Alzheimer disease
    • J.A. Luchsinger, D. Cheng, M.X. Tang, N. Schupf, and R. Mayeux (2012) Central obesity in the elderly is related to late-onset Alzheimer disease. Alzheimer Dis Assoc Disord 26 101-5. doi: 10.1097/WAD.0b013e318222f0d4
    • (2012) Alzheimer Dis Assoc Disord , vol.26 , pp. 101-105
    • Luchsinger, J.A.1    Cheng, D.2    Tang, M.X.3    Schupf, N.4    Mayeux, R.5
  • 40
    • 84864692285 scopus 로고    scopus 로고
    • Relation between body mass index, waist circumference, and cardiovascular outcomes in 19,579 diabetic patients with established vascular disease: the REACH Registry
    • J. Dallongeville, D.L. Bhatt, P.H. Steg, P. Ravaud, P.W. Wilson, K.A. Eagle, S. Goto, J.L. Mas, G. Montalescot, and R.R. Investigators (2012) Relation between body mass index, waist circumference, and cardiovascular outcomes in 19,579 diabetic patients with established vascular disease: the REACH Registry. Eur J Prev Cardiol 19 241-9. doi: 10.1177/1741826710394305
    • (2012) Eur J Prev Cardiol , vol.19 , pp. 241-249
    • Dallongeville, J.1    Bhatt, D.L.2    Steg, P.H.3    Ravaud, P.4    Wilson, P.W.5    Eagle, K.A.6    Goto, S.7    Mas, J.L.8    Montalescot, G.9    Investigators, R.R.10
  • 42
    • 84873617421 scopus 로고    scopus 로고
    • beta-alanyl-L-histidine rescues cognitive deficits caused by feeding a high fat diet in a transgenic mouse model of Alzheimer's disease
    • B. Herculano, M. Tamura, A. Ohba, M. Shimatani, N. Kutsuna, and T. Hisatsune (2013) beta-alanyl-L-histidine rescues cognitive deficits caused by feeding a high fat diet in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis 33 983-97. doi: 10.3233/JAD-2012-121324
    • (2013) J Alzheimers Dis , vol.33 , pp. 983-997
    • Herculano, B.1    Tamura, M.2    Ohba, A.3    Shimatani, M.4    Kutsuna, N.5    Hisatsune, T.6
  • 43
    • 77954955083 scopus 로고    scopus 로고
    • High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
    • C. Julien, C. Tremblay, A. Phivilay, L. Berthiaume, V. Emond, P. Julien, and F. Calon (2010) High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model. Neurobiol Aging 31 1516-31. doi: 10.1016/j.neurobiolaging.2008.08.022
    • (2010) Neurobiol Aging , vol.31 , pp. 1516-1531
    • Julien, C.1    Tremblay, C.2    Phivilay, A.3    Berthiaume, L.4    Emond, V.5    Julien, P.6    Calon, F.7
  • 45
    • 84903362402 scopus 로고    scopus 로고
    • Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology
    • M.E. Orr, A. Salinas, R. Buffenstein, and S. Oddo (2014) Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging 35 1233-42. doi: 10.1016/j.neurobiolaging.2013.12.006
    • (2014) Neurobiol Aging , vol.35 , pp. 1233-1242
    • Orr, M.E.1    Salinas, A.2    Buffenstein, R.3    Oddo, S.4
  • 46
    • 84886611064 scopus 로고    scopus 로고
    • Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease
    • A.M. Barron, E.R. Rosario, R. Elteriefi, and C.J. Pike (2013) Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease. PLoS One 8 e78554. doi: 10.1371/journal.pone.0078554
    • (2013) PLoS One , vol.8 , pp. e78554
    • Barron, A.M.1    Rosario, E.R.2    Elteriefi, R.3    Pike, C.J.4
  • 47
    • 47849114072 scopus 로고    scopus 로고
    • Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat
    • A.C. Granholm, H.A. Bimonte-Nelson, A.B. Moore, M.E. Nelson, L.R. Freeman, and K. Sambamurti (2008) Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat. J Alzheimers Dis 14 133-45.
    • (2008) J Alzheimers Dis , vol.14 , pp. 133-145
    • Granholm, A.C.1    Bimonte-Nelson, H.A.2    Moore, A.B.3    Nelson, M.E.4    Freeman, L.R.5    Sambamurti, K.6
  • 49
    • 0037135258 scopus 로고    scopus 로고
    • A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning
    • R. Molteni, R.J. Barnard, Z. Ying, C.K. Roberts, and F. Gomez-Pinilla (2002) A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 112 803-14.
    • (2002) Neuroscience , vol.112 , pp. 803-814
    • Molteni, R.1    Barnard, R.J.2    Ying, Z.3    Roberts, C.K.4    Gomez-Pinilla, F.5
  • 51
    • 72749106820 scopus 로고    scopus 로고
    • Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding
    • A.J. Murray, N.S. Knight, L.E. Cochlin, S. McAleese, R.M. Deacon, J.N. Rawlins, and K. Clarke (2009) Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding. FASEB J 23 4353-60. doi: 10.1096/fj.09-139691
    • (2009) FASEB J , vol.23 , pp. 4353-4360
    • Murray, A.J.1    Knight, N.S.2    Cochlin, L.E.3    McAleese, S.4    Deacon, R.M.5    Rawlins, J.N.6    Clarke, K.7
  • 52
    • 37549035051 scopus 로고    scopus 로고
    • Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease
    • D. Cao, H. Lu, T.L. Lewis, and L. Li (2007) Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease. J Biol Chem 282 36275-82. doi: 10.1074/jbc.M703561200
    • (2007) J Biol Chem , vol.282 , pp. 36275-36282
    • Cao, D.1    Lu, H.2    Lewis, T.L.3    Li, L.4
  • 53
    • 84921320404 scopus 로고    scopus 로고
    • Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats
    • T.M. Hsu, V.R. Konanur, L. Taing, R. Usui, B.D. Kayser, M.I. Goran, and S.E. Kanoski (2015) Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats. Hippocampus 25 227-39. doi: 10.1002/hipo.22368
    • (2015) Hippocampus , vol.25 , pp. 227-239
    • Hsu, T.M.1    Konanur, V.R.2    Taing, L.3    Usui, R.4    Kayser, B.D.5    Goran, M.I.6    Kanoski, S.E.7
  • 54
    • 84907920449 scopus 로고    scopus 로고
    • Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function
    • A. Jayaraman, D. Lent-Schochet, and C.J. Pike (2014) Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function. J Neuroinflammation 11 162. doi: 10.1186/s12974-014-0162-y
    • (2014) J Neuroinflammation , vol.11 , pp. 162
    • Jayaraman, A.1    Lent-Schochet, D.2    Pike, C.J.3
  • 55
    • 84922693194 scopus 로고    scopus 로고
    • Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease
    • E. Blazquez, E. Velazquez, V. Hurtado-Carneiro, and J.M. Ruiz-Albusac (2014) Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease. Front Endocrinol 5 161. doi: 10.3389/fendo.2014.00161
    • (2014) Front Endocrinol , vol.5 , pp. 161
    • Blazquez, E.1    Velazquez, E.2    Hurtado-Carneiro, V.3    Ruiz-Albusac, J.M.4
  • 56
    • 84897954482 scopus 로고    scopus 로고
    • Brain metabolic dysfunction at the core of Alzheimer's disease
    • S.M. de la Monte, and M. Tong (2014) Brain metabolic dysfunction at the core of Alzheimer's disease. Biochem Pharmacol 88 548-59. doi: 10.1016/j.bcp.2013.12.012
    • (2014) Biochem Pharmacol , vol.88 , pp. 548-559
    • de la Monte, S.M.1    Tong, M.2
  • 57
    • 17844364259 scopus 로고    scopus 로고
    • Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease
    • L. Mosconi (2005) Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD. Eur J Nucl Med Mol Imaging 32 486-510. doi: 10.1007/s00259-005-1762-7
    • (2005) FDG-PET studies in MCI and AD. Eur J Nucl Med Mol Imaging , vol.32 , pp. 486-510
    • Mosconi, L.1
  • 58
    • 34147173277 scopus 로고    scopus 로고
    • Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment
    • S. Craft (2007) Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res 4 147-52.
    • (2007) Curr Alzheimer Res , vol.4 , pp. 147-152
    • Craft, S.1
  • 59
    • 33845541048 scopus 로고    scopus 로고
    • Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance: the cerebral basis for impaired control of food intake in metabolic syndrome?
    • K. Anthony, L.J. Reed, J.T. Dunn, E. Bingham, D. Hopkins, P.K. Marsden, and S.A. Amiel (2006) Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance: the cerebral basis for impaired control of food intake in metabolic syndrome? Diabetes 55 2986-92. doi: 10.2337/db06-0376
    • (2006) Diabetes , vol.55 , pp. 2986-2992
    • Anthony, K.1    Reed, L.J.2    Dunn, J.T.3    Bingham, E.4    Hopkins, D.5    Marsden, P.K.6    Amiel, S.A.7
  • 61
    • 84922666525 scopus 로고    scopus 로고
    • Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia
    • A. Claxton, L.D. Baker, A. Hanson, E.H. Trittschuh, B. Cholerton, A. Morgan, M. Callaghan, M. Arbuckle, C. Behl, and S. Craft (2015) Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia. J Alzheimers Dis 44 897-906. doi: 10.3233/JAD-141791
    • (2015) J Alzheimers Dis , vol.44 , pp. 897-906
    • Claxton, A.1    Baker, L.D.2    Hanson, A.3    Trittschuh, E.H.4    Cholerton, B.5    Morgan, A.6    Callaghan, M.7    Arbuckle, M.8    Behl, C.9    Craft, S.10
  • 62
    • 77956013253 scopus 로고    scopus 로고
    • Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up
    • J.P. Thaler, and M.W. Schwartz (2010) Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology 151 4109-15. doi: 10.1210/en.2010-0336
    • (2010) Endocrinology , vol.151 , pp. 4109-4115
    • Thaler, J.P.1    Schwartz, M.W.2
  • 66
    • 79960880118 scopus 로고    scopus 로고
    • Assessing the contribution of inflammation in models of Alzheimer's disease
    • H. Johnston, H. Boutin, and S.M. Allan (2011) Assessing the contribution of inflammation in models of Alzheimer's disease. Biochem Soc Trans 39 886-90. doi: 10.1042/BST0390886
    • (2011) Biochem Soc Trans , vol.39 , pp. 886-890
    • Johnston, H.1    Boutin, H.2    Allan, S.M.3
  • 67
    • 84908376800 scopus 로고    scopus 로고
    • Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease
    • Z. Tucsek, P. Toth, D. Sosnowska, T. Gautam, M. Mitschelen, A. Koller, G. Szalai, W.E. Sonntag, Z. Ungvari, and A. Csiszar (2014) Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease. J Gerontol A Biol Sci Med Sci 69 1212-26. doi: 10.1093/gerona/glt177
    • (2014) J Gerontol A Biol Sci Med Sci , vol.69 , pp. 1212-1226
    • Tucsek, Z.1    Toth, P.2    Sosnowska, D.3    Gautam, T.4    Mitschelen, M.5    Koller, A.6    Szalai, G.7    Sonntag, W.E.8    Ungvari, Z.9    Csiszar, A.10
  • 68
    • 84866773764 scopus 로고    scopus 로고
    • Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease
    • D. Yu, B. Corbett, Y. Yan, G.X. Zhang, P. Reinhart, S.J. Cho, and J. Chin (2012) Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease. Neurobiol Aging 33 2942-7. doi: 10.1016/j.neurobiolaging.2012.02.023
    • (2012) Neurobiol Aging , vol.33 , pp. 2942-2947
    • Yu, D.1    Corbett, B.2    Yan, Y.3    Zhang, G.X.4    Reinhart, P.5    Cho, S.J.6    Chin, J.7
  • 69
    • 84877586983 scopus 로고    scopus 로고
    • Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model
    • S. Takeda, N. Sato, K. Ikimura, H. Nishino, H. Rakugi, and R. Morishita (2013) Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model. Neurobiol Aging 34 2064-70. doi: 10.1016/j.neurobiolaging.2013.02.010
    • (2013) Neurobiol Aging , vol.34 , pp. 2064-2070
    • Takeda, S.1    Sato, N.2    Ikimura, K.3    Nishino, H.4    Rakugi, H.5    Morishita, R.6
  • 75
    • 84936078795 scopus 로고    scopus 로고
    • Neuroimmunology: TREM2 in Alzheimer disease
    • O. Leavy (2015) Neuroimmunology: TREM2 in Alzheimer disease. Nat Rev Immunol 15 201. doi: 10.1038/nri3842
    • (2015) Nat Rev Immunol , vol.15 , pp. 201
    • Leavy, O.1
  • 78
    • 84956768867 scopus 로고    scopus 로고
    • Microglia and neuroprotection
    • Z. Chen, and B.D. Trapp (2015) Microglia and neuroprotection. J Neurochem. doi: 10.1111/jnc.13062
    • (2015) J Neurochem
    • Chen, Z.1    Trapp, B.D.2
  • 80
    • 84874776157 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators
    • H.S. Suh, M.L. Zhao, L. Derico, N. Choi, and S.C. Lee (2013) Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators. J Neuroinflammation 10 37. doi: 10.1186/1742-2094-10-37
    • (2013) J Neuroinflammation , vol.10 , pp. 37
    • Suh, H.S.1    Zhao, M.L.2    Derico, L.3    Choi, N.4    Lee, S.C.5
  • 81
    • 70449526190 scopus 로고    scopus 로고
    • Heterogeneity of microglial activation in the innate immune response in the brain
    • C.A. Colton (2009) Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol 4 399-418. doi: 10.1007/s11481-009-9164-4
    • (2009) J Neuroimmune Pharmacol , vol.4 , pp. 399-418
    • Colton, C.A.1
  • 82
    • 59349100950 scopus 로고    scopus 로고
    • Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: underlying mechanisms
    • J.L. Teeling, and V.H. Perry (2009) Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: underlying mechanisms. Neuroscience 158 1062-73. doi: 10.1016/j.neuroscience.2008.07.031
    • (2009) Neuroscience , vol.158 , pp. 1062-1073
    • Teeling, J.L.1    Perry, V.H.2
  • 84
    • 80052266213 scopus 로고    scopus 로고
    • The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
    • E. Karran, M. Mercken, and B. De Strooper (2011) The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov 10 698-712. doi: 10.1038/nrd3505
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 698-712
    • Karran, E.1    Mercken, M.2    De Strooper, B.3
  • 85
    • 24744467358 scopus 로고    scopus 로고
    • Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines
    • J. Koenigsknecht-Talboo, and G.E. Landreth (2005) Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines. J Neurosci 25 8240-9. doi: 10.1523/JNEUROSCI.1808-05.2005
    • (2005) J Neurosci , vol.25 , pp. 8240-8249
    • Talboo-Koenigsknecht, J.1    Landreth, G.E.2
  • 86
    • 58149216131 scopus 로고    scopus 로고
    • Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age dependent switch in the microglial phenotype from alternative to classic
    • S. Jimenez, D. Baglietto-Vargas, C. Caballero, I. Moreno-Gonzalez, M. Torres, R. Sanchez-Varo, D. Ruano, M. Vizuete, A. Gutierrez, and J. Vitorica (2008) Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age dependent switch in the microglial phenotype from alternative to classic. J Neurosci 28 11650-61. doi: 10.1523/JNEUROSCI.3024-08.2008
    • (2008) J Neurosci , vol.28 , pp. 11650-11661
    • Jimenez, S.1    Baglietto-Vargas, D.2    Caballero, C.3    Moreno-Gonzalez, I.4    Torres, M.5    Sanchez-Varo, R.6    Ruano, D.7    Vizuete, M.8    Gutierrez, A.9    Vitorica, J.10
  • 87
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • G.S. Hotamisligil, N.S. Shargill, and B.M. Spiegelman (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 88
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • G.S. Hotamisligil (2006) Inflammation and metabolic disorders. Nature 444 860-7. doi: 10.1038/nature05485
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 90
    • 0037219294 scopus 로고    scopus 로고
    • The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat
    • D.J. Nieves, M. Cnop, B. Retzlaff, C.E. Walden, J.D. Brunzell, R.H . Knopp, and S.E. Kahn (2003) The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat. Diabetes 52 172-9.
    • (2003) Diabetes , vol.52 , pp. 172-179
    • Nieves, D.J.1    Cnop, M.2    Retzlaff, B.3    Walden, C.E.4    Brunzell, J.D.5    Knopp, R.H.6    Kahn, S.E.7
  • 91
    • 52749092267 scopus 로고    scopus 로고
    • Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
    • D. Patsouris, P.P. Li, D. Thapar, J. Chapman, J.M. Olefsky, and J.G. Neels (2008) Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 8 301-9. doi: 10.1016/j.cmet.2008.08.015
    • (2008) Cell Metab , vol.8 , pp. 301-309
    • Patsouris, D.1    Li, P.P.2    Thapar, D.3    Chapman, J.4    Olefsky, J.M.5    Neels, J.G.6
  • 92
    • 84891719310 scopus 로고    scopus 로고
    • Hypothalamic inflammation: marker or mechanism of obesity pathogenesis?
    • J.P. Thaler, S.J. Guyenet, M.D. Dorfman, B.E. Wisse, and M.W. Schwartz (2013) Hypothalamic inflammation: marker or mechanism of obesity pathogenesis? Diabetes 62 2629-34. doi: 10.2337/db12-1605
    • (2013) Diabetes , vol.62 , pp. 2629-2634
    • Thaler, J.P.1    Guyenet, S.J.2    Dorfman, M.D.3    Wisse, B.E.4    Schwartz, M.W.5
  • 93
    • 24944438230 scopus 로고    scopus 로고
    • Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    • C.T. De Souza, E.P. Araujo, S. Bordin, R. Ashimine, R.L. Zollner, A.C. Boschero, M.J. Saad, and L.A. Velloso (2005) Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146 4192-9. doi: 10.1210/en.2004-1520
    • (2005) Endocrinology , vol.146 , pp. 4192-4199
    • De Souza, C.T.1    Araujo, E.P.2    Bordin, S.3    Ashimine, R.4    Zollner, R.L.5    Boschero, A.C.6    Saad, M.J.7    Velloso, L.A.8
  • 97
    • 85028251189 scopus 로고    scopus 로고
    • Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism
    • H.K. Park, and R.S. Ahima (2015) Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism 64 24-34. doi: 10.1016/j.metabol.2014.08.004
    • (2015) Metabolism , vol.64 , pp. 24-34
    • Park, H.K.1    Ahima, R.S.2
  • 99
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    • G.M. Lord, G. Matarese, J.K. Howard, R.J. Baker, S.R. Bloom, and R.I. Lechler (1998) Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394 897-901. doi: 10.1038/29795
    • (1998) Nature , vol.394 , pp. 897-901
    • Lord, G.M.1    Matarese, G.2    Howard, J.K.3    Baker, R.J.4    Bloom, S.R.5    Lechler, R.I.6
  • 100
    • 0034628016 scopus 로고    scopus 로고
    • Human leptin enhances activation and proliferation of human circulating T lymphocytes
    • C. Martin-Romero, J. Santos-Alvarez, R. Goberna, and V. Sanchez-Margalet (2000) Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 199 15-24. doi: 10.1006/cimm.1999.1594
    • (2000) Cell Immunol , vol.199 , pp. 15-24
    • Romero-Martin, C.1    Santos-Alvarez, J.2    Goberna, R.3    Sanchez-Margalet, V.4
  • 101
    • 0033602850 scopus 로고    scopus 로고
    • Human leptin stimulates proliferation and activation of human circulating monocytes
    • J. Santos-Alvarez, R. Goberna, and V. Sanchez-Margalet (1999) Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol 194 6-11. doi: 10.1006/cimm.1999.1490
    • (1999) Cell Immunol , vol.194 , pp. 6-11
    • Alvarez-Santos, J.1    Goberna, R.2    Sanchez-Margalet, V.3
  • 102
    • 0036854487 scopus 로고    scopus 로고
    • Leptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclo947 oxygenase-2 in murine macrophage J774A.1
    • G.M. Raso, M. Pacilio, E. Esposito, A. Coppola, R. Di Carlo, and R. Meli (2002) Leptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclo947 oxygenase-2 in murine macrophage J774A.1. Br J Pharmacol 137 799-804. doi: 10.1038/sj.bjp.0704903
    • (2002) Br J Pharmacol , vol.137 , pp. 799-804
    • Raso, G.M.1    Pacilio, M.2    Esposito, E.3    Coppola, A.4    Di Carlo, R.5    Meli, R.6
  • 103
    • 84866764462 scopus 로고    scopus 로고
    • Leptin, a neuroendocrine mediator of immune responses, inflammation, and sickness behaviors
    • E.D. Carlton, G.E. Demas, and S.S. French (2012) Leptin, a neuroendocrine mediator of immune responses, inflammation, and sickness behaviors. Horm Behav 62 272-9. doi: 10.1016/j.yhbeh.2012.04.010
    • (2012) Horm Behav , vol.62 , pp. 272-279
    • Carlton, E.D.1    Demas, G.E.2    French, S.S.3
  • 111
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • G.S. Hotamisligil, P. Arner, J.F. Caro, R.L. Atkinson, and B.M. Spiegelman (1995) Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95 2409-15. doi: 10.1172/JCI117936
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 112
    • 0032743517 scopus 로고    scopus 로고
    • Circulating tumor necrosis factor alpha concentrations are higher in abdominal versus peripheral obesity
    • C. Tsigos, I. Kyrou, E. Chala, P. Tsapogas, J.C. Stavridis, S.A. Raptis, and N. Katsilambros (1999) Circulating tumor necrosis factor alpha concentrations are higher in abdominal versus peripheral obesity. Metabolism 48 1332-5.
    • (1999) Metabolism , vol.48 , pp. 1332-1335
    • Tsigos, C.1    Kyrou, I.2    Chala, E.3    Tsapogas, P.4    Stavridis, J.C.5    Raptis, S.A.6    Katsilambros, N.7
  • 113
    • 0037334295 scopus 로고    scopus 로고
    • Regulation of chemokine receptor expression in human microglia and astrocytes
    • G. Flynn, S. Maru, J. Loughlin, I.A. Romero, and D. Male (2003) Regulation of chemokine receptor expression in human microglia and astrocytes. J Neuroimmunol 136 84-93.
    • (2003) J Neuroimmunol , vol.136 , pp. 84-93
    • Flynn, G.1    Maru, S.2    Loughlin, J.3    Romero, I.A.4    Male, D.5
  • 115
    • 56149092503 scopus 로고    scopus 로고
    • Cell death after spinal cord injury is exacerbated by rapid TNF alpha-induced trafficking of GluR2-lacking AMPARs to the plasma membrane
    • A.R. Ferguson, R.N. Christensen, J.C. Gensel, B.A. Miller, F. Sun, E.C. Beattie, J.C. Bresnahan, and M.S. Beattie (2008) Cell death after spinal cord injury is exacerbated by rapid TNF alpha-induced trafficking of GluR2-lacking AMPARs to the plasma membrane. J Neurosci 28 11391-400. doi: 10.1523/JNEUROSCI.3708-08.2008
    • (2008) J Neurosci , vol.28 , pp. 11391-11400
    • Ferguson, A.R.1    Christensen, R.N.2    Gensel, J.C.3    Miller, B.A.4    Sun, F.5    Beattie, E.C.6    Bresnahan, J.C.7    Beattie, M.S.8
  • 116
    • 33947512432 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice
    • M. Yamamoto, T. Kiyota, M. Horiba, J.L. Buescher, S.M. Walsh, H.E. Gendelman, and T. Ikezu (2007) Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol 170 680-92. doi: 10.2353/ajpath.2007.060378
    • (2007) Am J Pathol , vol.170 , pp. 680-692
    • Yamamoto, M.1    Kiyota, T.2    Horiba, M.3    Buescher, J.L.4    Walsh, S.M.5    Gendelman, H.E.6    Ikezu, T.7
  • 117
    • 51749118278 scopus 로고    scopus 로고
    • Distinctive postprandial modulation of beta cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids
    • S. Lopez, B. Bermudez, Y.M. Pacheco, J. Villar, R. Abia, and F.J. Muriana (2008) Distinctive postprandial modulation of beta cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids. Am J Clin Nutr 88 638-44.
    • (2008) Am J Clin Nutr , vol.88 , pp. 638-644
    • Lopez, S.1    Bermudez, B.2    Pacheco, Y.M.3    Villar, J.4    Abia, R.5    Muriana, F.J.6
  • 118
    • 0034678024 scopus 로고    scopus 로고
    • Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)- dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB inducing kinase-dependent signaling mechanism
    • K.T. Akama, and L.J. Van Eldik (2000) Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB inducing kinase-dependent signaling mechanism. J Biol Chem 275 7918-24.
    • (2000) J Biol Chem , vol.275 , pp. 7918-7924
    • Akama, K.T.1    Van Eldik, L.J.2
  • 120
    • 77049093949 scopus 로고    scopus 로고
    • Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer's disease and non-demented patients
    • X. Cheng, L. Yang, P. He, R. Li, and Y. Shen (2010) Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer's disease and non-demented patients. J Alzheimers Dis 19 621-30. doi: 10.3233/JAD-2010-1253
    • (2010) J Alzheimers Dis , vol.19 , pp. 621-630
    • Cheng, X.1    Yang, L.2    He, P.3    Li, R.4    Shen, Y.5
  • 121
    • 2942741013 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease
    • R. Li, R. Strohmeyer, Z. Liang, L.F. Lue, and J. Rogers (2004) CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease. Neurobiol Aging 25 991-9. doi: 10.1016/j.neurobiolaging.2003.10.016
    • (2004) Neurobiol Aging , vol.25 , pp. 991-999
    • Li, R.1    Strohmeyer, R.2    Liang, Z.3    Lue, L.F.4    Rogers, J.5
  • 122
    • 0036584232 scopus 로고    scopus 로고
    • Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia
    • 20026340
    • Z. Xie, M. Wei, T.E. Morgan, P. Fabrizio, D. Han, C.E. Finch, and V.D. Longo (2002) Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. J Neurosci 22 3484-92. doi: 20026340
    • (2002) J Neurosci , vol.22 , pp. 3484-3492
    • Xie, Z.1    Wei, M.2    Morgan, T.E.3    Fabrizio, P.4    Han, D.5    Finch, C.E.6    Longo, V.D.7
  • 123
    • 34548316575 scopus 로고    scopus 로고
    • Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice
    • P. He, Z. Zhong, K. Lindholm, L. Berning, W. Lee, C. Lemere, M. Staufenbiel, R. Li, and Y. Shen (2007) Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice. J Cell Biol 178 829-41. doi: 10.1083/jcb.200705042
    • (2007) J Cell Biol , vol.178 , pp. 829-841
    • He, P.1    Zhong, Z.2    Lindholm, K.3    Berning, L.4    Lee, W.5    Lemere, C.6    Staufenbiel, M.7    Li, R.8    Shen, Y.9
  • 124
    • 0033678516 scopus 로고    scopus 로고
    • Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
    • J.P. Bastard, C. Jardel, E. Bruckert, P. Blondy, J. Capeau, M. Laville, H. Vidal, and B. Hainque (2000) Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 85 3338-42. doi: 10.1210/jcem.85.9.6839
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3338-3342
    • Bastard, J.P.1    Jardel, C.2    Bruckert, E.3    Blondy, P.4    Capeau, J.5    Laville, M.6    Vidal, H.7    Hainque, B.8
  • 125
    • 0035023128 scopus 로고    scopus 로고
    • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    • P.A. Kern, S. Ranganathan, C. Li, L. Wood, and G. Ranganathan (2001) Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280 E745-51.
    • (2001) Am J Physiol Endocrinol Metab , vol.280 , pp. E745-E751
    • Kern, P.A.1    Ranganathan, S.2    Li, C.3    Wood, L.4    Ranganathan, G.5
  • 126
    • 0035908632 scopus 로고    scopus 로고
    • C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
    • A.D. Pradhan, J.E. Manson, N. Rifai, J.E. Buring, and P.M. Ridker (2001) C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286 327-34.
    • (2001) JAMA , vol.286 , pp. 327-334
    • Pradhan, A.D.1    Manson, J.E.2    Rifai, N.3    Buring, J.E.4    Ridker, P.M.5
  • 127
    • 0035909217 scopus 로고    scopus 로고
    • Inflammatory pathways in atherosclerosis and acute coronary syndromes
    • J. Plutzky (2001) Inflammatory pathways in atherosclerosis and acute coronary syndromes. Am J Cardiol 88 10K-15K.
    • (2001) Am J Cardiol , vol.88 , pp. 10K-15K
    • Plutzky, J.1
  • 128
    • 34047155003 scopus 로고    scopus 로고
    • Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
    • L. Fontana, J.C. Eagon, M.E. Trujillo, P.E. Scherer, and S. Klein (2007) Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56 1010-3. doi: 10.2337/db06-1656
    • (2007) Diabetes , vol.56 , pp. 1010-1013
    • Fontana, L.1    Eagon, J.C.2    Trujillo, M.E.3    Scherer, P.E.4    Klein, S.5
  • 130
    • 0036894360 scopus 로고    scopus 로고
    • Interleukin-6 induces cellular insulin resistance in hepatocytes
    • J.J. Senn, P.J. Klover, I.A. Nowak, and R.A. Mooney (2002) Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 51 3391-9.
    • (2002) Diabetes , vol.51 , pp. 3391-3399
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Mooney, R.A.4
  • 131
    • 84905821144 scopus 로고    scopus 로고
    • Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife
    • A. Singh-Manoux, A. Dugravot, E. Brunner, M. Kumari, M. Shipley, A. Elbaz, and M. Kivimaki (2014) Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife. Neurology 83 486-93. doi: 10.1212/WNL.0000000000000665
    • (2014) Neurology , vol.83 , pp. 486-493
    • Manoux-Singh, A.1    Dugravot, A.2    Brunner, E.3    Kumari, M.4    Shipley, M.5    Elbaz, A.6    Kivimaki, M.7
  • 132
    • 84856069957 scopus 로고    scopus 로고
    • Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease
    • S.Y. Chen, T.F. Chen, L.C. Lai, J.H. Chen, Y. Sun, L.L. Wen, P.K. Yip, Y.M. Chu, and Y.C. Chen (2012) Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease. J Neuroinflammation 9 21. doi: 10.1186/1742-2094-9-21
    • (2012) J Neuroinflammation , vol.9 , pp. 21
    • Chen, S.Y.1    Chen, T.F.2    Lai, L.C.3    Chen, J.H.4    Sun, Y.5    Wen, L.L.6    Yip, P.K.7    Chu, Y.M.8    Chen, Y.C.9
  • 133
    • 0032914896 scopus 로고    scopus 로고
    • A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease
    • A. Papassotiropoulos, M. Bagli, F. Jessen, T.A. Bayer, W. Maier, M.L. Rao, and R. Heun (1999) A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease. Ann Neurol 45 666-8.
    • (1999) Ann Neurol , vol.45 , pp. 666-668
    • Papassotiropoulos, A.1    Bagli, M.2    Jessen, F.3    Bayer, T.A.4    Maier, W.5    Rao, M.L.6    Heun, R.7
  • 136
    • 0029417080 scopus 로고
    • Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
    • D. Blum-Degen, T. Muller, W. Kuhn, M. Gerlach, H. Przuntek, and P. Riederer (1995) Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci Lett 202 17-20.
    • (1995) Neurosci Lett , vol.202 , pp. 17-20
    • Degen-Blum, D.1    Muller, T.2    Kuhn, W.3    Gerlach, M.4    Przuntek, H.5    Riederer, P.6
  • 137
    • 84869857934 scopus 로고    scopus 로고
    • Interleukin-6, a major cytokine in the central nervous system
    • M. Erta, A. Quintana, and J. Hidalgo (2012) Interleukin-6, a major cytokine in the central nervous system. Int J Biol Sci 8 1254-66. doi: 10.7150/ijbs.4679
    • (2012) Int J Biol Sci , vol.8 , pp. 1254-1266
    • Erta, M.1    Quintana, A.2    Hidalgo, J.3
  • 138
    • 1642420308 scopus 로고    scopus 로고
    • Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway
    • R.A. Quintanilla, D.I. Orellana, C. Gonzalez-Billault, and R.B. Maccioni (2004) Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway. Exp Cell Res 295 245-57. doi: 10.1016/j.yexcr.2004.01.002
    • (2004) Exp Cell Res , vol.295 , pp. 245-257
    • Quintanilla, R.A.1    Orellana, D.I.2    Gonzalez-Billault, C.3    Maccioni, R.B.4
  • 139
    • 0029052462 scopus 로고
    • Reproductive factors and family history of breast cancer in relation to plasma estrogen and prolactin levels in postmenopausal women in the Nurses' Health Study (United States)
    • S.E. Hankinson, G.A. Colditz, D.J. Hunter, J.E. Manson, W.C. Willett, M.J. Stampfer, C. Longcope, and F.E. Speizer (1995) Reproductive factors and family history of breast cancer in relation to plasma estrogen and prolactin levels in postmenopausal women in the Nurses' Health Study (United States). Cancer Causes Control 6 217-24.
    • (1995) Cancer Causes Control , vol.6 , pp. 217-224
    • Hankinson, S.E.1    Colditz, G.A.2    Hunter, D.J.3    Manson, J.E.4    Willett, W.C.5    Stampfer, M.J.6    Longcope, C.7    Speizer, F.E.8
  • 141
    • 0036775703 scopus 로고    scopus 로고
    • Fertility and number of children in patients with Alzheimer's disease
    • U. Ptok, K. Barkow, and R. Heun (2002) Fertility and number of children in patients with Alzheimer's disease. Arch Womens Ment Health 5 83-6. doi: 10.1007/s00737-002-0142-6
    • (2002) Arch Womens Ment Health , vol.5 , pp. 83-86
    • Ptok, U.1    Barkow, K.2    Heun, R.3
  • 144
    • 0037368254 scopus 로고    scopus 로고
    • Nulliparity and late menopause are associated with decreased cognitive decline
    • R.N. McLay, P.M. Maki, and C.G. Lyketsos (2003) Nulliparity and late menopause are associated with decreased cognitive decline. J Neuropsychiatry Clin Neurosci 15 161-7.
    • (2003) J Neuropsychiatry Clin Neurosci , vol.15 , pp. 161-167
    • McLay, R.N.1    Maki, P.M.2    Lyketsos, C.G.3
  • 145
    • 84895768182 scopus 로고    scopus 로고
    • Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women
    • R. Bove, E. Secor, L.B. Chibnik, L.L. Barnes, J.A. Schneider, D.A. Bennett, and P.L. De Jager (2014) Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women. Neurology 82 222-9. doi: 10.1212/WNL.0000000000000033
    • (2014) Neurology , vol.82 , pp. 222-229
    • Bove, R.1    Secor, E.2    Chibnik, L.B.3    Barnes, L.L.4    Schneider, J.A.5    Bennett, D.A.6    De Jager, P.L.7
  • 146
    • 34948829010 scopus 로고    scopus 로고
    • Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause
    • W.A. Rocca, J.H. Bower, D.M. Maraganore, J.E. Ahlskog, B.R. Grossardt, M. de Andrade, and L.J. Melton, 3rd (2007) Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause. Neurology 69 1074-83. doi: 10.1212/01.wnl.0000276984.19542.e6
    • (2007) Neurology , vol.69 , pp. 1074-1083
    • Rocca, W.A.1    Bower, J.H.2    Maraganore, D.M.3    Ahlskog, J.E.4    Grossardt, B.R.5    de Andrade, M.6    Melton, L.J.7
  • 147
    • 79952311053 scopus 로고    scopus 로고
    • Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity
    • W.A. Rocca, B.R. Grossardt, and L.T. Shuster (2011) Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity. Brain Res 1379 188-98. doi: 10.1016/j.brainres.2010.10.031
    • (2011) Brain Res , vol.1379 , pp. 188-198
    • Rocca, W.A.1    Grossardt, B.R.2    Shuster, L.T.3
  • 150
    • 79953116520 scopus 로고    scopus 로고
    • Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease
    • E.R. Rosario, L. Chang, E.H. Head, F.Z. Stanczyk, and C.J. Pike (2011) Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease. Neurobiol Aging 32 604-13. doi: 10.1016/j.neurobiolaging.2009.04.008
    • (2011) Neurobiol Aging , vol.32 , pp. 604-613
    • Rosario, E.R.1    Chang, L.2    Head, E.H.3    Stanczyk, F.Z.4    Pike, C.J.5
  • 154
    • 0030152121 scopus 로고    scopus 로고
    • Cognitive skills associated with estrogen replacement in women with Alzheimer's disease
    • V.W. Henderson, L. Watt, and J.G. Buckwalter (1996) Cognitive skills associated with estrogen replacement in women with Alzheimer's disease. Psychoneuroendocrinology 21 421-30.
    • (1996) Psychoneuroendocrinology , vol.21 , pp. 421-430
    • Henderson, V.W.1    Watt, L.2    Buckwalter, J.G.3
  • 155
    • 0037032401 scopus 로고    scopus 로고
    • Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study
    • P.P. Zandi, M.C. Carlson, B.L. Plassman, K.A. Welsh-Bohmer, L.S. Mayer, D.C. Steffens, J.C. Breitner, and I. Cache County Memory Study (2002) Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study. JAMA 288 2123-9.
    • (2002) JAMA , vol.288 , pp. 2123-2129
    • Zandi, P.P.1    Carlson, M.C.2    Plassman, B.L.3    Welsh-Bohmer, K.A.4    Mayer, L.S.5    Steffens, D.C.6    Breitner, J.C.7
  • 156
    • 0030748719 scopus 로고    scopus 로고
    • A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging
    • C. Kawas, S. Resnick, A. Morrison, R. Brookmeyer, M. Corrada, A. Zonderman, C. Bacal, D.D. Lingle, and E. Metter (1997) A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology 48 1517-21.
    • (1997) Neurology , vol.48 , pp. 1517-1521
    • Kawas, C.1    Resnick, S.2    Morrison, A.3    Brookmeyer, R.4    Corrada, M.5    Zonderman, A.6    Bacal, C.7    Lingle, D.D.8    Metter, E.9
  • 157
    • 0030591669 scopus 로고    scopus 로고
    • Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease
    • M.X. Tang, D. Jacobs, Y. Stern, K. Marder, P. Schofield, B. Gurland, H. Andrews, and R. Mayeux (1996) Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 348 429-32. doi: 10.1016/S0140-6736(96)03356-9
    • (1996) Lancet , vol.348 , pp. 429-432
    • Tang, M.X.1    Jacobs, D.2    Stern, Y.3    Marder, K.4    Schofield, P.5    Gurland, B.6    Andrews, H.7    Mayeux, R.8
  • 158
    • 36849045250 scopus 로고    scopus 로고
    • Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice
    • J.C. Carroll, E.R. Rosario, L. Chang, F.Z. Stanczyk, S. Oddo, F.M. LaFerla, and C.J. Pike (2007) Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci 27 13357-65. doi: 10.1523/JNEUROSCI.2718-07.2007
    • (2007) J Neurosci , vol.27 , pp. 13357-13365
    • Carroll, J.C.1    Rosario, E.R.2    Chang, L.3    Stanczyk, F.Z.4    Oddo, S.5    LaFerla, F.M.6    Pike, C.J.7
  • 160
    • 80052640194 scopus 로고    scopus 로고
    • 17beta-Estradiol regulates insulin-degrading enzyme expression via an ERbeta/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention
    • L. Zhao, J. Yao, Z. Mao, S. Chen, Y. Wang, and R.D. Brinton (2011) 17beta-Estradiol regulates insulin-degrading enzyme expression via an ERbeta/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention. Neurobiol Aging 32 1949-63. doi: 10.1016/j.neurobiolaging.2009.12.010
    • (2011) Neurobiol Aging , vol.32 , pp. 1949-1963
    • Zhao, L.1    Yao, J.2    Mao, Z.3    Chen, S.4    Wang, Y.5    Brinton, R.D.6
  • 162
    • 2942755831 scopus 로고    scopus 로고
    • Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study
    • S.A. Shumaker, C. Legault, L. Kuller, S.R. Rapp, L. Thal, D.S. Lane, H. Fillit, M.L. Stefanick, S.L. Hendrix, C.E. Lewis, K. Masaki, L.H. Coker, and S. Women's Health Initiative Memory (2004) Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study. JAMA 291 2947-58. doi: 10.1001/jama.291.24.2947
    • (2004) JAMA , vol.291 , pp. 2947-2958
    • Shumaker, S.A.1    Legault, C.2    Kuller, L.3    Rapp, S.R.4    Thal, L.5    Lane, D.S.6    Fillit, H.7    Stefanick, M.L.8    Hendrix, S.L.9    Lewis, C.E.10    Masaki, K.11    Coker, L.H.12
  • 163
    • 33646005802 scopus 로고    scopus 로고
    • Potential importance of early initiation of hormone therapy for cognitive benefit
    • P.M. Maki (2006) Potential importance of early initiation of hormone therapy for cognitive benefit. Menopause 13 6-7. doi: 10.1097/01.gme.0000194822.76774.30
    • (2006) Menopause , vol.13 , pp. 6-7
    • Maki, P.M.1
  • 166
    • 79551493889 scopus 로고    scopus 로고
    • Timing of hormone therapy and dementia: the critical window theory revisited
    • R.A. Whitmer, C.P. Quesenberry, J. Zhou, and K. Yaffe (2011) Timing of hormone therapy and dementia: the critical window theory revisited. Ann Neurol 69 163-9. doi: 10.1002/ana.22239
    • (2011) Ann Neurol , vol.69 , pp. 163-169
    • Whitmer, R.A.1    Quesenberry, C.P.2    Zhou, J.3    Yaffe, K.4
  • 170
    • 53649097589 scopus 로고    scopus 로고
    • The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol
    • C.M. Brown, E. Choi, Q. Xu, M.P. Vitek, and C.A. Colton (2008) The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol. Neurobiol Aging 29 1783-94. doi: 10.1016/j.neurobiolaging.2007.04.018
    • (2008) Neurobiol Aging , vol.29 , pp. 1783-1794
    • Brown, C.M.1    Choi, E.2    Xu, Q.3    Vitek, M.P.4    Colton, C.A.5
  • 171
    • 0034705091 scopus 로고    scopus 로고
    • Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction
    • K. Yaffe, M. Haan, A. Byers, C. Tangen, and L. Kuller (2000) Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction. Neurology 54 1949-54.
    • (2000) Neurology , vol.54 , pp. 1949-1954
    • Yaffe, K.1    Haan, M.2    Byers, A.3    Tangen, C.4    Kuller, L.5
  • 175
    • 84866172856 scopus 로고    scopus 로고
    • Do changes in sex steroid hormones precede or follow increases in body weight during the menopause transition? Results from the Study of Women's Health Across the Nation
    • R.P. Wildman, P.G. Tepper, S. Crawford, J.S. Finkelstein, K. Sutton-Tyrrell, R.C. Thurston, N. Santoro, B. Sternfeld, and G.A. Greendale (2012) Do changes in sex steroid hormones precede or follow increases in body weight during the menopause transition? Results from the Study of Women's Health Across the Nation. J Clin Endocrinol Metab 97 E1695-704. doi: 10.1210/jc.2012-1614
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. E1695-E1704
    • Wildman, R.P.1    Tepper, P.G.2    Crawford, S.3    Finkelstein, J.S.4    Sutton-Tyrrell, K.5    Thurston, R.C.6    Santoro, N.7    Sternfeld, B.8    Greendale, G.A.9
  • 176
    • 0032717904 scopus 로고    scopus 로고
    • Weight gain and the menopause: a 5-year prospective study
    • J.R. Guthrie, L. Dennerstein, and E.C. Dudley (1999) Weight gain and the menopause: a 5-year prospective study. Climacteric 2 205-11.
    • (1999) Climacteric , vol.2 , pp. 205-211
    • Guthrie, J.R.1    Dennerstein, L.2    Dudley, E.C.3
  • 177
    • 7244253095 scopus 로고    scopus 로고
    • Physical activity and changes in weight and waist circumference in midlife women: findings from the Study of Women's Health Across the Nation
    • B. Sternfeld, H. Wang, C.P. Quesenberry, Jr., B. Abrams, S.A. Everson-Rose, G.A. Greendale, K.A. Matthews, J.I. Torrens, and M. Sowers (2004) Physical activity and changes in weight and waist circumference in midlife women: findings from the Study of Women's Health Across the Nation. Am J Epidemiol 160 912-22. doi: 10.1093/aje/kwh299
    • (2004) Am J Epidemiol , vol.160 , pp. 912-922
    • Sternfeld, B.1    Wang, H.2    Quesenberry, C.P.3    Abrams, B.4    Everson-Rose, S.A.5    Greendale, G.A.6    Matthews, K.A.7    Torrens, J.I.8    Sowers, M.9
  • 178
    • 77955466621 scopus 로고    scopus 로고
    • Menopausal transition and changes of body composition: a prospective study in Chinese perimenopausal women
    • S.C. Ho, S. Wu, S.G. Chan, and A. Sham (2010) Menopausal transition and changes of body composition: a prospective study in Chinese perimenopausal women. Int J Obes (Lond) 34 1265-74. doi: 10.1038/ijo.2010.33
    • (2010) Int J Obes (Lond) , vol.34 , pp. 1265-1274
    • Ho, S.C.1    Wu, S.2    Chan, S.G.3    Sham, A.4
  • 180
    • 0028882708 scopus 로고
    • Changes in energy balance and body composition at menopause: a controlled longitudinal study
    • E.T. Poehlman, M.J. Toth, and A.W. Gardner (1995) Changes in energy balance and body composition at menopause: a controlled longitudinal study. Ann Intern Med 123 673-5.
    • (1995) Ann Intern Med , vol.123 , pp. 673-675
    • Poehlman, E.T.1    Toth, M.J.2    Gardner, A.W.3
  • 181
    • 72449127495 scopus 로고    scopus 로고
    • Ovarian function and obesity--interrelationship, impact on women's reproductive lifespan and treatment options
    • D. Rachon, and H. Teede (2010) Ovarian function and obesity--interrelationship, impact on women's reproductive lifespan and treatment options. Mol Cell Endocrinol 316 172-9. doi: 10.1016/j.mce.2009.09.026
    • (2010) Mol Cell Endocrinol , vol.316 , pp. 172-179
    • Rachon, D.1    Teede, H.2
  • 182
    • 0038645816 scopus 로고    scopus 로고
    • The emergence of the metabolic syndrome with menopause
    • M.C. Carr (2003) The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab 88 2404-11. doi: 10.1210/jc.2003-030242
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2404-2411
    • Carr, M.C.1
  • 183
    • 43249124233 scopus 로고    scopus 로고
    • Postmenopausal status according to years since menopause as an independent risk factor for the metabolic syndrome
    • G.J. Cho, J.H. Lee, H.T. Park, J.H. Shin, S.C. Hong, T. Kim, J.Y. Hur, K.W. Lee, Y.K. Park, and S.H. Kim (2008) Postmenopausal status according to years since menopause as an independent risk factor for the metabolic syndrome. Menopause 15 524-9. doi: 10.1097/gme.0b013e3181559860
    • (2008) Menopause , vol.15 , pp. 524-529
    • Cho, G.J.1    Lee, J.H.2    Park, H.T.3    Shin, J.H.4    Hong, S.C.5    Kim, T.6    Hur, J.Y.7    Lee, K.W.8    Park, Y.K.9    Kim, S.H.10
  • 184
    • 0034504237 scopus 로고    scopus 로고
    • Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
    • B.L. Wajchenberg (2000) Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21 697-738. doi: 10.1210/edrv.21.6.0415
    • (2000) Endocr Rev , vol.21 , pp. 697-738
    • Wajchenberg, B.L.1
  • 185
    • 49449119100 scopus 로고    scopus 로고
    • Menopause and the metabolic syndrome: the Study of Women's Health Across the Nation
    • I. Janssen, L.H. Powell, S. Crawford, B. Lasley, and K. Sutton-Tyrrell (2008) Menopause and the metabolic syndrome: the Study of Women's Health Across the Nation. Arch Intern Med 168 1568-75. doi: 10.1001/archinte.168.14.1568
    • (2008) Arch Intern Med , vol.168 , pp. 1568-1575
    • Janssen, I.1    Powell, L.H.2    Crawford, S.3    Lasley, B.4    Sutton-Tyrrell, K.5
  • 188
    • 0031739555 scopus 로고    scopus 로고
    • Menopause, central body fatness, and insulin resistance: effects of hormone-replacement therapy
    • A. Tchernof, J. Calles-Escandon, C.K. Sites, and E.T. Poehlman (1998) Menopause, central body fatness, and insulin resistance: effects of hormone-replacement therapy. Coron Artery Dis 9 503-11.
    • (1998) Coron Artery Dis , vol.9 , pp. 503-511
    • Tchernof, A.1    Calles-Escandon, J.2    Sites, C.K.3    Poehlman, E.T.4
  • 189
    • 84870255429 scopus 로고    scopus 로고
    • Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance
    • R.E. Stubbins, V.B. Holcomb, J. Hong, and N.P. Nunez (2012) Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance. Eur J Nutr 51 861-70. doi: 10.1007/s00394-011-0266-4
    • (2012) Eur J Nutr , vol.51 , pp. 861-870
    • Stubbins, R.E.1    Holcomb, V.B.2    Hong, J.3    Nunez, N.P.4
  • 190
    • 66449086930 scopus 로고    scopus 로고
    • Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity
    • N.H. Rogers, J.W. Perfield, 2nd, K.J. Strissel, M.S. Obin, and A.S. Greenberg (2009) Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity. Endocrinology 150 2161-8. doi: 10.1210/en.2008-1405
    • (2009) Endocrinology , vol.150 , pp. 2161-2168
    • Rogers, N.H.1    Perfield, J.W.2    Strissel, K.J.3    Obin, M.S.4    Greenberg, A.S.5
  • 191
    • 33746862148 scopus 로고    scopus 로고
    • Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syndrome in postmenopausal women
    • S.R. Salpeter, J.M. Walsh, T.M. Ormiston, E. Greyber, N.S. Buckley, and E.E. Salpeter (2006) Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syndrome in postmenopausal women. Diabetes Obes Metab 8 538-54. doi: 10.1111/j.1463-1326.2005.00545.x
    • (2006) Diabetes Obes Metab , vol.8 , pp. 538-554
    • Salpeter, S.R.1    Walsh, J.M.2    Ormiston, T.M.3    Greyber, E.4    Buckley, N.S.5    Salpeter, E.E.6
  • 192
    • 0026347185 scopus 로고
    • Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause
    • J. Haarbo, U. Marslew, A. Gotfredsen, and C. Christiansen (1991) Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause. Metabolism 40 1323-6.
    • (1991) Metabolism , vol.40 , pp. 1323-1326
    • Haarbo, J.1    Marslew, U.2    Gotfredsen, A.3    Christiansen, C.4
  • 193
    • 84871241078 scopus 로고    scopus 로고
    • Hormone therapy is associated with better body composition and adipokine/glucose profiles: a study with monozygotic co-twin control design
    • M. Ahtiainen, M. Alen, E. Pollanen, S. Pulkkinen, P.H. Ronkainen, U.M. Kujala, J. Kaprio, S. Sipila, and V. Kovanen (2012) Hormone therapy is associated with better body composition and adipokine/glucose profiles: a study with monozygotic co-twin control design. Menopause 19 1329-35. doi: 10.1097/gme.0b013e31825a3344
    • (2012) Menopause , vol.19 , pp. 1329-1335
    • Ahtiainen, M.1    Alen, M.2    Pollanen, E.3    Pulkkinen, S.4    Ronkainen, P.H.5    Kujala, U.M.6    Kaprio, J.7    Sipila, S.8    Kovanen, V.9
  • 194
    • 0032887033 scopus 로고    scopus 로고
    • Hormone replacement therapy affects body composition and leptin differently in obese and non-obese postmenopausal women
    • K. Kristensen, S.B. Pedersen, P. Vestergaard, L. Mosekilde, and B. Richelsen (1999) Hormone replacement therapy affects body composition and leptin differently in obese and non-obese postmenopausal women. J Endocrinol 163 55-62.
    • (1999) J Endocrinol , vol.163 , pp. 55-62
    • Kristensen, K.1    Pedersen, S.B.2    Vestergaard, P.3    Mosekilde, L.4    Richelsen, B.5
  • 195
    • 84883203393 scopus 로고    scopus 로고
    • The association of elective hormone therapy with changes in lipids among glucose intolerant postmenopausal women in the diabetes prevention program
    • S.H. Golden, C. Kim, E. Barrett-Connor, B. Nan, S. Kong, R. Goldberg, and G. Diabetes Prevention Program Research (2013) The association of elective hormone therapy with changes in lipids among glucose intolerant postmenopausal women in the diabetes prevention program. Metabolism 62 1313-22. doi: 10.1016/j.metabol.2013.04.005
    • (2013) Metabolism , vol.62 , pp. 1313-1322
    • Golden, S.H.1    Kim, C.2    Barrett-Connor, E.3    Nan, B.4    Kong, S.5    Goldberg, R.6
  • 196
    • 0023759831 scopus 로고
    • Role of gestational hormones in the induction of insulin resistance
    • E.A. Ryan, and L. Enns (1988) Role of gestational hormones in the induction of insulin resistance. J Clin Endocrinol Metab 67 341-7. doi: 10.1210/jcem-67-2-341
    • (1988) J Clin Endocrinol Metab , vol.67 , pp. 341-347
    • Ryan, E.A.1    Enns, L.2
  • 197
    • 80051668223 scopus 로고    scopus 로고
    • Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors
    • M.R. Meyer, D.J. Clegg, E.R. Prossnitz, and M. Barton (2011) Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors. Acta Physiol (Oxf) 203 259-69. doi: 10.1111/j.1748-1716.2010.02237.x
    • (2011) Acta Physiol (Oxf) , vol.203 , pp. 259-269
    • Meyer, M.R.1    Clegg, D.J.2    Prossnitz, E.R.3    Barton, M.4
  • 199
    • 0033749264 scopus 로고    scopus 로고
    • Increased adipose tissue in male and female estrogen receptor-alpha knockout mice
    • P.A. Heine, J.A. Taylor, G.A. Iwamoto, D.B. Lubahn, and P.S. Cooke (2000) Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci U S A 97 12729-34. doi: 10.1073/pnas.97.23.12729
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 12729-12734
    • Heine, P.A.1    Taylor, J.A.2    Iwamoto, G.A.3    Lubahn, D.B.4    Cooke, P.S.5
  • 202
    • 0036188807 scopus 로고    scopus 로고
    • Changes in proinflammatory cytokine activity after menopause
    • J. Pfeilschifter, R. Koditz, M. Pfohl, and H. Schatz (2002) Changes in proinflammatory cytokine activity after menopause. Endocr Rev 23 90-119. doi: 10.1210/edrv.23.1.0456
    • (2002) Endocr Rev , vol.23 , pp. 90-119
    • Pfeilschifter, J.1    Koditz, R.2    Pfohl, M.3    Schatz, H.4
  • 203
    • 34547792318 scopus 로고    scopus 로고
    • The complex role of estrogens in inflammation
    • R.H. Straub (2007) The complex role of estrogens in inflammation. Endocr Rev 28 521-74. doi: 10.1210/er.2007-0001
    • (2007) Endocr Rev , vol.28 , pp. 521-574
    • Straub, R.H.1
  • 204
    • 77952955740 scopus 로고    scopus 로고
    • Sex steroids as inflammatory regulators
    • S.C. Gilliver (2010) Sex steroids as inflammatory regulators. J Steroid Biochem Mol Biol 120 105-15. doi: 10.1016/j.jsbmb.2009.12.015
    • (2010) J Steroid Biochem Mol Biol , vol.120 , pp. 105-115
    • Gilliver, S.C.1
  • 206
    • 84861347494 scopus 로고    scopus 로고
    • Estrogen and the cardiovascular system
    • A.A. Knowlton, and A.R. Lee (2012) Estrogen and the cardiovascular system. Pharmacol Ther 135 54-70. doi: 10.1016/j.pharmthera.2012.03.007
    • (2012) Pharmacol Ther , vol.135 , pp. 54-70
    • Knowlton, A.A.1    Lee, A.R.2
  • 207
    • 84880326927 scopus 로고    scopus 로고
    • Estrogens, osteoarthritis and inflammation
    • M. Martin-Millan, and S. Castaneda (2013) Estrogens, osteoarthritis and inflammation. Joint Bone Spine 80 368-73. doi: 10.1016/j.jbspin.2012.11.008
    • (2013) Joint Bone Spine , vol.80 , pp. 368-373
    • Millan-Martin, M.1    Castaneda, S.2
  • 210
    • 84873475157 scopus 로고    scopus 로고
    • Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes
    • M. Sarvari, E. Hrabovszky, I. Kallo, N. Solymosi, I. Liko, N. Berchtold, C. Cotman, and Z. Liposits (2012) Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. J Neuroinflammation 9 264. doi: 10.1186/1742-2094-9-264
    • (2012) J Neuroinflammation , vol.9 , pp. 264
    • Sarvari, M.1    Hrabovszky, E.2    Kallo, I.3    Solymosi, N.4    Liko, I.5    Berchtold, N.6    Cotman, C.7    Liposits, Z.8
  • 211
  • 212
    • 84861312425 scopus 로고    scopus 로고
    • A lack of ovarian function increases neuroinflammation in aged mice
    • V. Benedusi, C. Meda, S. Della Torre, G. Monteleone, E. Vegeto, and A. Maggi (2012) A lack of ovarian function increases neuroinflammation in aged mice. Endocrinology 153 2777-88. doi: 10.1210/en.2011-1925
    • (2012) Endocrinology , vol.153 , pp. 2777-2788
    • Benedusi, V.1    Meda, C.2    Della Torre, S.3    Monteleone, G.4    Vegeto, E.5    Maggi, A.6
  • 213
    • 77953543310 scopus 로고    scopus 로고
    • A high cholesterol diet elevates hippocampal cytokine expression in an age and estrogen-dependent manner in female rats
    • D.K. Lewis, S. Bake, K. Thomas, M.K. Jezierski, and F. Sohrabji (2010) A high cholesterol diet elevates hippocampal cytokine expression in an age and estrogen-dependent manner in female rats. J Neuroimmunol 223 31-8. doi: 10.1016/j.jneuroim.2010.03.024
    • (2010) J Neuroimmunol , vol.223 , pp. 31-38
    • Lewis, D.K.1    Bake, S.2    Thomas, K.3    Jezierski, M.K.4    Sohrabji, F.5
  • 214
    • 0042886042 scopus 로고    scopus 로고
    • Differential effects of estrogen in the injured forebrain of young adult and reproductive senescent animals
    • V.L. Nordell, M.M. Scarborough, A.K. Buchanan, and F. Sohrabji (2003) Differential effects of estrogen in the injured forebrain of young adult and reproductive senescent animals. Neurobiol Aging 24 733-43.
    • (2003) Neurobiol Aging , vol.24 , pp. 733-743
    • Nordell, V.L.1    Scarborough, M.M.2    Buchanan, A.K.3    Sohrabji, F.4
  • 215
    • 67449141652 scopus 로고    scopus 로고
    • Protective actions of sex steroid hormones in Alzheimer's disease
    • C.J. Pike, J.C. Carroll, E.R. Rosario, and A.M. Barron (2009) Protective actions of sex steroid hormones in Alzheimer's disease. Front Neuroendocrinol 30 239-58. doi: 10.1016/j.yfrne.2009.04.015
    • (2009) Front Neuroendocrinol , vol.30 , pp. 239-258
    • Pike, C.J.1    Carroll, J.C.2    Rosario, E.R.3    Barron, A.M.4


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