Longitudinal Inflammation, Cognitive Decline, and Alzheimer's Disease: A Mini-Review

Clinical Pharmacology and Therapeutics

Volumn 96, Issue 4, 2014, Pages 464-469

  Bettcher, B M ^a   Kramer, J H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ALZHEIMER DISEASE; COGNITIVE DEFECT; HUMAN; IMMUNOLOGY; INFLAMMATION; METABOLISM; MILD COGNITIVE IMPAIRMENT; PSYCHOLOGY; RISK FACTOR; TIME;

AGING; ALZHEIMER DISEASE; COGNITION DISORDERS; HUMANS; INFLAMMATION; MILD COGNITIVE IMPAIRMENT; RISK FACTORS; TIME FACTORS;

EID: 84921682801     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2014.147     Document Type: Review

References (39)

1. Franceschi, C. et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N. Y. Acad. Sci. 908, 244-254 (2000
2. Eikelenboom, P., Hoozemans, J.J., Veerhuis, R., Van Exel, E., Rozemuller, A.J. & Van Gool, W.A. Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease. Alzheimers. Res. Ther. 4, 15 (2012
3. Kravitz, B.A., Corrada, M.M. & Kawas, C.H. Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old. Alzheimers. Dement. 5, 318-323 (2009
4. Bettcher, B.M. et al. C-reactive protein is related to memory and medial temporal brain volume in older adults. Brain Behav Immun 26, 103-108 (2012
5. Anan, F. et al. High-sensitivity C-reactive protein is associated with hippocampus volume in nondementia patients with type 2 diabetes mellitus. Metabolism 60, 460-466 (2011
6. Zhang, H. et al. Role of TNF-alpha in vascular dysfunction. Clin. Sci. 116, 219-230 (2009
7. Wersching, H. et al. Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology 74, 1022-1029 (2010
8. Arvanitakis, Z. et al. Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology. Neurology 70, 2219-2225 (2008
9. Lyketsos, C.G. et al. Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial. Neurology 68,1800-1808 (2007
10. Metti, A.L. & Cauley, J.A. How predictive of dementia are peripheral inflammatory markers in the elderly? Neurodegener. Dis. Manag. 2, 609-622 (2012
11. Wyss-Coray, T. Inflammation in Alzheimer disease: Driving force, bystander or beneficial response? Nat. Med. 12, 1005-1015 (2006
12. Yaffe, K. et al. The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA 292, 2237-2242 (2004
13. Yaffe, K., Haan, M., Blackwell, T., Cherkasova, E., Whitmer, R.A. & West, N. Metabolic syndrome and cognitive decline in elderly Latinos: Findings from the Sacramento Area Latino Study of Aging study. J. Am. Geriatr. Soc. 55, 758-762 (2007
14. Engelhart, M.J. et al. Inflammatory proteins in plasma and the risk of dementia: The Rotterdam study. Arch. Neurol. 61, 668-672 (2004
15. Weaver, J.D., Huang, M.H., Albert, M., Harris, T., Rowe, J.W. & Seeman, T.E. Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging. Neurology 59, 371-378 (2002
16. T arkowski, E., Andreasen, N., Tarkowski, A. & Blennow, K. Intrathecal inflammation precedes development of Alzheimer's disease. J. Neurol. Neurosurg. Psychiatr. 74, 1200-1205 (2003
17. Schmidt, R., Schmidt, H., Curb, J.D., Masaki, K., White, L.R. & Launer, L.J. Early inflammation and dementia: A 25-year follow-up of the Honolulu-Asia Aging Study. Ann. Neurol. 52, 168-174 (2002
18. T an, Z.S. et al. Inflammatory markers and the risk of Alzheimer disease: The Framingham Study. Neurology 68, 1902-1908 (2007
19. Buchhave, P., Zetterberg, H., Blennow, K., Minthon, L., Janciauskiene, S. & Hansson, O. Soluble TNF receptors are associated with Aß metabolism and conversion to dementia in subjects with mild cognitive impairment. Neurobiol. Aging 31, 1877-1884 (2010
20. Holmes, C. et al. Systemic inflammation and disease progression in Alzheimer disease. Neurology 73, 768-774 (2009
21. Cunningham, C. Systemic inflammation and delirium: Important co-factors in the progression of dementia. Biochem. Soc. Trans. 39, 945-953 (2011
22. Dik, M.G., Jonker, C., Hack, C.E., Smit, J.H., Comijs, H.C. & Eikelenboom, P. Serum inflammatory proteins and cognitive decline in older persons. Neurology 64, 1371-1377 (2005
23. Ravaglia, G. et al. Blood inflammatory markers and risk of dementia: The Conselice Study of Brain Aging. Neurobiol. Aging 28, 1810-1820 (2007
24. Eriksson, U.K. et al. Associations of gene sequence variation and serum levels of C-reactive protein and interleukin-6 with Alzheimer's disease and dementia. J. Alzheimers Dis. 23, 361-369 (2011
25. Gallacher, J. et al. Is sticky blood bad for the brain?: Hemostatic and inflammatory systems and dementia in the Caerphilly Prospective Study. Arterioscler. Thromb. Vasc. Biol. 30, 599-604 (2010
26. Lima, T.A., Adler, A.L., Minett, T., Matthews, F.E., Brayne, C. & Marioni, R.E.; Medical Research Council Cognitive Function and Ageing Study. C-reactive protein, APOE genotype and longitudinal cognitive change in an older population. Age Ageing 43, 289-292 (2014
27. Van Den Berg, E., Biessels, G.J., De Craen, A.J., Gussekloo, J. & Westendorp, R.G. The metabolic syndrome is associated with decelerated cognitive decline in the oldest old. Neurology 69, 979-985 (2007
28. Weverling-Rijnsburger, A.W., Blauw, G.J., Lagaay, A.M., Knook, D.L., Meinders, A.E. & Westendorp, R.G. Total cholesterol and risk of mortality in the oldest old. Lancet 350, 1119-1123 (1997
29. Van Den Kommer, T.N., Dik, M.G., Comijs, H.C., Jonker, C. & Deeg, D.J. Homocysteine and inflammation: Predictors of cognitive decline in older persons? Neurobiol. Aging 31, 1700-1709 (2010
30. Van Den Kommer, T.N., Dik, M.G., Comijs, H.C., Jonker, C. & Deeg, D.J. Role of lipoproteins and inflammation in cognitive decline: Do they interact? Neurobiol. Aging 33, 196.e1-196.12 (2012
31. Jenny, N.S. et al. Long-term assessment of inflammation and healthy aging in late life: The Cardiovascular Health Study All Stars. J. Gerontol. A Biol. Sci. Med. Sci. 67, 970-976 (2012
32. Sundelöf, J. et al. Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: A prospective population-based study. J. Alzheimers Dis. 18, 71-78 (2009
33. T eunissen, C.E. et al. Inflammation markers in relation to cognition in a healthy aging population. J. Neuroimmunol. 134, 142-150 (2003
34. Metti, A.L. et al. Change in inflammatory markers and cognitive status in the oldest-old women from the Study of Osteoporotic Fractures. J. Am. Geriatr. Soc. 62, 662-666 (2014
35. Lanzrein, A.S., Johnston, C.M., Perry, V.H., Jobst, K.A., King, E.M. & Smith, A.D. Longitudinal study of inflammatory factors in serum, cerebrospinal fluid, and brain tissue in Alzheimer disease: Interleukin-1beta, interleukin-6, interleukin-1 receptor antagonist, tumor necrosis factor-alpha, the soluble tumor necrosis factor receptors I and II, and alpha1-antichymotrypsin. Alzheimer Dis. Assoc. Disord. 12, 215-227 (1998
36. Leung, R. et al. Inflammatory proteins in plasma are associated with severity of Alzheimer's disease. PLoS ONE 8, e64971 (2013
37. Galimberti, D. et al. Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer's disease. Neurobiol. Aging 27, 1763-1768 (2006
38. T hompson, D.K., Huffman, K.M., Kraus, W.E. & Kraus, V.B. Critical appraisal of four IL-6 immunoassays. PLoS ONE 7, e30659 (2012
39. Rosenberg-Hasson, Y., Hansmann, L., Liedtke, M., Herschmann, I. & Maecker, H.T. Effects of serum and plasma matrices on multiplex immunoassays. Immunol. Res. 58, 224-233 (2014).