Leptin potentiates IFN-γ-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1

British Journal of Pharmacology

Volumn 137, Issue 6, 2002, Pages 799-804

  Raso, Giuseppina Mattace ^a   Pacilio, Maria ^a   Esposito, Emanuela ^a   Coppola, Anna ^a   Di Carlo, Raffaele ^a   Meli, Rosaria ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Cyclo oxygenase 2; Inducible nitric oxide synthase; Interferon ; Leptin; Leptin receptor; Macrophage

Indexed keywords

CYCLOOXYGENASE 2; LEPTIN RECEPTOR; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; RECOMBINANT GAMMA INTERFERON; RECOMBINANT LEPTIN;

ANIMAL CELL; ARTICLE; CELL VIABILITY; DRUG POTENCY; DRUG POTENTIATION; GENE EXPRESSION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BLOTTING, WESTERN; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTERFERON TYPE II; LEPTIN; MACROPHAGES; MICE; NITRATES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0036854487     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704903     Document Type: Article

References (36)

1. Akarasereenont, P., Mitchell, J.A., Thiemermann, C. & Vane, J.R. (1994). Involvement of tyrosine kinase in the induction of cyclooxygenase and nitric oxide synthase by endotoxin in cultured cells. Br. J. Pharmacol., 113, 1522-1528.
2. Bado, A., Levasseur, S., Attoub, S., Kermorgant, S., Laigneau, J.P., Bortoluzzi, M.N., Moizo, L., Lehy, T., Guerre-Millo, M., Le Marchand-Brustel, Y. & Lewin, M.J. (1998). The stomach is a source of leptin. Nature, 394, 790-793.
3. Banks, A.S., Davis, S.M., Bates, S.H. & Myers, M.G. (2000). Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem., 275, 14563-14572.
4. Bauman, H., Morella, K.K., White, D.W., Dembski, M., Bailon, P.S., Kim, H., Lai, C. & Tartaglia, L.A. (1996). The full-length leptin receptor has signalling capabilities of interleukin 6-type cytokine receptors. Proc. Natl. Acad. Sci. USA, 93, 8374-8378.
5. Bennet, B., Solar, G., Yuan, J., Mathias, J., Thomas, G. & Matthews, W. (1996). A role for leptin and its cognate receptor in hematopoiesis. Curr. Biol., 6, 1170-1180.
6. Bouloumie, A., Drexler, H.C.A., Lafontan, M. & Busse, R. (1998). Leptin, the product of Ob gene, promotes angiogenesis. Circ. Res., 83, 1059-1066.
7. Brenner, C.A., Tam, A.W., Nelson, P.A., Engelman, E.G., Susuki, N., Fry, K.E. & Larrick, J.W. (1989). Message amplification phenotyping: A technique to simultaneously measure multiple mRNAs from small numbers of cells. Biotechniques., 7, 1096-1103.
8. Caprio, M., Isidori, A.M., Carta, A.R., Moretti, C., Dufau, M.L. & Fabbri, A. (1999). Expression of functional leptin receptor in rodent Leydig cells. Endocrinology, 140, 4939-4947.
9. Chomczynski, P. & Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
10. Di Rosa, M., Ialenti, A., Ianaro, A. & Sautebin, L. (1996). Interaction between nitric oxide and cyclooxygenase pathways. Prostaglandins Leukot. Essent. Fatty Acids, 54, 229-238.
11. Fantuzzi, G. & Faggioni, R. (2000). Leptin in the regulation of immunity, inflammation, and hematopoiesis. J. Leukoc. Biol., 68, 437-446.
12. Gainsford, T., Willson, T.A., Metcalf, D., Handman, E., McFarlane, C., Ng, A., Nicola, N.A., Alexander, W.S. & Hilton, D.J. (1996). Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc. Natl. Acad. Sci. USA, 93, 14564-14568.
13. Grunfeld, C., Zhao, C., Fuller, J., Pollack, A., Moser, A., Friedman, J. & Feingold, K.R. (1996). Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J. Clin. Invest., 97, 2152-2157.
14. Gualillo, O., Eiras, S., Lago, F., Dieguez, C. & Casaneuva, F.F. (2000). Elevated serum leptin concentrations induced by experimental acute inflammation. Life Sci., 67, 2433-2441.
15. Hoggard, N., Hunter, L., Dunkan, J.S., William, L.M., Trayhurn, P. & Mercer, J.G. (1997). Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proc. Natl. Acad, Sci. USA, 94, 11073-11078.
16. Janik, J.E., Curtis, B.D, Considine, R.V., Rager, H.C., Powers, G.C., Alvord, W.G., Smith, J.W., Gause, B.L. & Kopp, W.C. (1997). Interleukin 1 alpha increases serum leptin concentrations in humans. J. Clin. Endocrinol. Metab., 82, 3084-3086.
17. Kim, Y., Uotani, S., Pierroz, D.D., Flier, J.S. & Kahn, B.B. (2000). In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues overlapping but distinct pathways from insulin. Endocrinology, 141, 2328-2339.
18. Lee, S.H., Soyoola, E., Chanmugam, P., Hart, S., Sun, W., Zhong, H., Liou, S., Simmons, D. & Hwang, D. (1992). Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J. Biol. Chem., 267, 25934-24938.
19. Loffreda, S., Yang, S.Q., Lin, H.Z., Karp, C.L., Brengman, M.L., Wang, D.J., Klein, A.S., Bulkley, G.B., Bao, C., Noble, P.W., Lane, M.D. & Diehl, A.M. (1998). Leptin regulates proinflammatory immune responses. FASEB J., 12, 57-65.
20. Lord, G.M., Matarese, G., Howard, J.K., Baker, R.J., Bloom, S.R. & Lechler, R.I. (1998). Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature, 294, 897-901.
21. Maier, J.A., Hla, T. & Maciag, T. (1990). Cyclooxygenase in an immediate-early gene induced by interleukin-1 in human endothelial cells. J. Biol. Chem., 265, 12231-12234.
22. Masuzaki, H., Ogawa, Y., Sagawa, N., Hosoda, K., Matsumoti, T., Mise, H., Nishimura, H., Yoshimasa, Y., Tanaka, I., Mori, T. & Nakao, K. (1997). Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans. Nature Med., 3, 1029-1033.
23. Mitchell, J.A., Larkin, S. & Williams, T.J. (1991). Cyclooxygenase-2: Regulation and relevance in inflammation. Biochem. Pharmacol., 50, 1535-1542.
24. Moncada, S., Palmer, R.M.J. & Higgs, E.A. (1991). Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-141.
25. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63.
26. Murakami, T., Yamashita, T., Iida, M., Kuwajima, M. & Shima, K. (1997). A short form of leptin receptor performs signal transduction. Biochem. Biophys. Res. Comm., 231, 26-29.
27. Nussler, A.K. & Billiar, T.R. (1993). Inflammation, immunoregulation, and inducible nitric oxide synthase. J. Leuk. Biol., 54, 171-178.
28. O'Rourke, L, Yeaman, S.J. & Shepherd, P.R. (2001). Insulin and leptin acutely regulate cholesterol ester metabolism macrophages by novel signaling pathways. Diabetes, 50, 955-961.
29. Salvemini, D., Misko, T.P., Masferrer, J.L., Seibert, K., Currie, M.G. & Needleman, P. (1993). Nitric oxide activates cyclooxygenasse enzymes. Proc. Natl. Acad. Sci. USA, 90, 7240-7244.
30. Santos-Alvarez, J., Goberna, R. & Sanchez-Margalet, B. (1999). Human leptin stimulates proliferation and activation of human circulating monocytes. Cell. Immunol., 194, 6-11.
31. Sarraf, P., Frederich, R.C., Turner, E.M., Ma, G., Jaskowiak, N.T., Rivet III, D.J., Filier, J.S., Lowell, B.B., Fraker, D.L. & Alexande, H.R. (1997). Multiple cytokines and acute inflammation raise mouse leptin levels. Potential role in inflammatory anorexia. J. Exp. Med., 185, 171-175.
32. Schwartz, M.W. & Seeley, R. (1997). Neuroendocrine responses to starvation and weight loss. N. Engl. J. Med., 336, 1802-1811.
33. Swierkosz, T.A., Mitchell, J.A., Warner, T.D., Botting, R.M. & Vane, J.R. (1995). Co-induction of nitric oxide synthase and cyclo-oxygenase: Interactions between nitric oxide and prostaglandins. Br. J. Pharmacol., 114, 1335-1342.
34. Tartaglia, L.A. (1997). The leptin receptor. J. Biol. Chem., 272, 6093-6096.
35. Tartaglia, L.A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G.J., Campfield, L.A., Clark, F.T. & Deeds, J. (1995). Identification and expression cloning of a leptin receptor, OB-R. Cell, 83, 1263-1271.
36. Thomsen, L.L., Ching, L.M., Zuang, L, Gavin, J.B. & Baguley, B.C. (1991). Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice. Cancer Res., 51, 71-81.