Obesity, adipokines and neuroinflammation

Neuropharmacology

Volumn 96, Issue PA, 2015, Pages 124-134

  Aguilar Valles, Argel ^a   Inoue, Wataru ^b   Rummel, Christoph ^c   Luheshi, Giamal N ^d  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b WESTERN UNIVERSITY   (Canada)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

Author keywords

Adiponectin; Cytokines; Inflammation; Leptin; Neuroimmune interactions; Neutrophil granulocytes; Psychiatric disorders

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; APELIN; COMPLEMENT COMPONENT C1Q; COMPLEMENT FACTOR D; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 6; LEPTIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OMENTIN 1; RESISTIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; COMORBIDITY; DIABETES MELLITUS; DISEASE ASSOCIATION; HUMAN; IMMUNOMODULATION; INFLAMMATION; MENTAL DISEASE; NERVOUS SYSTEM INFLAMMATION; NEUROIMMUNOLOGY; NEUROPATHOLOGY; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; RISK FACTOR; WHITE ADIPOSE TISSUE; ANIMAL; BLOOD; COMPLICATION; ENCEPHALITIS; IMMUNOLOGY; PHYSIOLOGY;

ADIPOKINES; ADIPONECTIN; ANIMALS; ENCEPHALITIS; HUMANS; INFLAMMATION; LEPTIN; OBESITY;

EID: 84930927234     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.12.023     Document Type: Review

References (227)

1. A. Aguilar-Valles, S. Jung, S. Poole, C. Flores, and G.N. Luheshi Leptin and interleukin-6 alter the function of mesolimbic dopamine neurons in a rodent model of prenatal inflammation Psychoneuroendocrinology 37 2012 956 969
2. A. Aguliar-Valles, J. Kim, S. Jung, B. Woodside, and G.N. Luheshi Role of brain transmigrating neutrophils in depression-like behavior during systemic infection Mol. Psychiatry 19 2014 599 606
3. B. Antuna-Puente, B. Feve, S. Fellahi, and J.P. Bastard Adipokines: the missing link between insulin resistance and obesity Diabetes Metab. 34 2008 2 11
4. I.A. Arnoldussen, A.J. Kiliaan, and D.R. Gustafson Obesity and dementia: adipokines interact with the brain Eur. Neuropsychopharmacol. 12 2014 1982 1999
5. W.A. Banks, A.J. Kastin, and E.G. Gutierrez Penetration of interleukin-6 across the murine blood-brain barrier Neurosci. Lett. 179 1994 53 56
6. W.A. Banks, A.J. Kastin, W. Huang, J.B. Jaspan, and L.M. Maness Leptin enters the brain by a saturable system independent of insulin Peptides 17 1996 305 311
7. T.J. Bartness, Y. Liu, Y.B. Shrestha, and V. Ryu Neural innervation of white adipose tissue and the control of lipolysis Front. Neuroendocrinol. 35 2014 473 493
8. S. Basu, M. Haghiac, P. Surace, J.C. Challier, M. Guerre-Millo, K. Singh, T. Waters, J. Minium, L. Presley, P.M. Catalano, and S. Hauguel-de Mouzon Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation Obesity (Silver Spring) 19 2011 476 482
9. D.E. Berkowitz, D. Brown, K.M. Lee, C. Emala, D. Palmer, Y. An, and M. Breslow Endotoxin-induced alteration in the expression of leptin and beta3-adrenergic receptor in adipose tissue Am. J. Physiol. 274 1998 E992 E997
10. R.I. Berkowitz, and A.N. Fabricatore Obesity, psychiatric status, and psychiatric medications Psychiatr. Clin. North Am. 34 2011 747 764
11. C. Berlato, M.A. Cassatella, I. Kinjyo, L. Gatto, A. Yoshimura, and F. Bazzoni Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation J. Immunol. 168 2002 6404 6411
12. M. Bluher Adipokines - removing road blocks to obesity and diabetes therapy Mol. Metab. 3 2014 230 240
13. M. Bokarewa, I. Nagaev, L. Dahlberg, U. Smith, and A. Tarkowski Resistin, an adipokine with potent proinflammatory properties J. Immunol. 174 2005 5789 5795
14. M. Bougoulia, A. Triantos, and G. Koliakos Effect of weight loss with or without orlistat treatment on adipocytokines, inflammation, and oxidative markers in obese women Hormones (Athens) 5 2006 259 269
15. M. Bougoulia, A. Triantos, and G. Koliakos Plasma interleukin-6 levels, glutathione peroxidase and isoprostane in obese women before and after weight loss. Association with cardiovascular risk factors Hormones (Athens) 5 2006 192 199
16. P. Brun, I. Castagliuolo, V. Di Leo, A. Buda, M. Pinzani, G. Palu, and D. Martines Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis Am. J. Physiol. Gastrointest. Liver Physiol. 292 2007 G518 G525
17. L. Brunetti, C. Di Nisio, L. Recinella, A. Chiavaroli, S. Leone, C. Ferrante, G. Orlando, and M. Vacca Effects of vaspin, chemerin and omentin-1 on feeding behavior and hypothalamic peptide gene expression in the rat Peptides 32 2011 1866 1871
18. L. Brunetti, G. Orlando, C. Ferrante, L. Recinella, S. Leone, A. Chiavaroli, C. Di Nisio, R. Shohreh, F. Manippa, A. Ricciuti, and M. Vacca Orexigenic effects of omentin-1 related to decreased CART and CRH gene expression and increased norepinephrine synthesis and release in the hypothalamus Peptides 44 2013 66 74
19. L. Brunetti, L. Recinella, C. Di Nisio, A. Chiavaroli, S. Leone, C. Ferrante, G. Orlando, and M. Vacca Effects of visfatin/PBEF/NAMPT on feeding behaviour and hypothalamic neuromodulators in the rat J. Biol. Regul. Homeost. Agents 26 2012 295 302
20. A. Bruno, S. Conus, I. Schmid, and H.U. Simon Apoptotic pathways are inhibited by leptin receptor activation in neutrophils J. Immunol. 174 2005 8090 8096
21. L. Brydon Adiposity, leptin and stress reactivity in humans Biol. Psychol. 86 2011 114 120
22. R. Burcelin Regulation of metabolism: a cross talk between gut microbiota and its human host Physiology (Bethesda) 27 2012 300 307
23. M. Buyse, M.L. Ovesjo, H. Goiot, S. Guilmeau, G. Peranzi, L. Moizo, F. Walker, M.J. Lewin, B. Meister, and A. Bado Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve Eur. J. Neurosci. 14 2001 64 72
24. M.P. Canale, S. Manca di Villahermosa, G. Martino, V. Rovella, A. Noce, A. De Lorenzo, and N. Di Daniele Obesity-related metabolic syndrome: mechanisms of sympathetic overactivity Int. J. Endocrinol. 2013 2013 865965
25. P.D. Cani, J. Amar, M.A. Iglesias, M. Poggi, C. Knauf, D. Bastelica, A.M. Neyrinck, F. Fava, K.M. Tuohy, C. Chabo, A. Waget, E. Delmee, B. Cousin, T. Sulpice, B. Chamontin, J. Ferrieres, J.F. Tanti, G.R. Gibson, L. Casteilla, N.M. Delzenne, M.C. Alessi, and R. Burcelin Metabolic endotoxemia initiates obesity and insulin resistance Diabetes 56 2007 1761 1772
26. P.D. Cani, R. Bibiloni, C. Knauf, A. Waget, A.M. Neyrinck, N.M. Delzenne, and R. Burcelin Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice Diabetes 57 2008 1470 1481
27. H. Cao Adipocytokines in obesity and metabolic disease J. Endocrinol. 220 2014 T47 T59
28. L. Capuron, and A.H. Miller Immune system to brain signaling: neuropsychopharmacological implications Pharmacol. Ther. 130 2011 226 238
29. L. Capuron, C. Poitou, D. Machaux-Tholliez, V. Frochot, J.L. Bouillot, A. Basdevant, S. Laye, and K. Clement Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation Psychol. Med. 41 2011 1517 1528
30. F. Carbone, C. La Rocca, and G. Matarese Immunological functions of leptin and adiponectin Biochimie 94 2012 2082 2088
31. B. Carpiniello, F. Pinna, F. Velluzzi, and A. Loviselli Mental disorders in patients with metabolic syndrome. The key role of central obesity Eat Weight Disord. 17 2012 e259 266
32. A.F. Carvalho, D.Q. Rocha, R.S. McIntyre, L.M. Mesquita, C.A. Kohler, T.N. Hyphantis, P.M. Sales, R. Machado-Vieira, and M. Berk Adipokines as emerging depression biomarkers: a systematic review and meta-analysis J. Psychiatr. Res. 59 2014 28 37
33. B. Chen, W.Q. Liao, N. Xu, H. Xu, J.Y. Wen, C.A. Yu, X.Y. Liu, C.L. Li, S.M. Zhao, and W. Campbell Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action Brain Res. 1273 2009 129 137
34. K. Cianflone, Z. Xia, and L.Y. Chen Critical review of acylation-stimulating protein physiology in humans and rodents Biochim. Biophys. Acta 1609 2003 127 143
35. G. Cizza, V.T. Nguyen, F. Eskandari, Z. Duan, E.C. Wright, J.C. Reynolds, R.S. Ahima, and M.R. Blackman Low 24-hour adiponectin and high nocturnal leptin concentrations in a case-control study of community-dwelling premenopausal women with major depressive disorder: the Premenopausal, Osteopenia/Osteoporosis, Women, Alendronate, Depression (POWER) study J. Clin. Psychiatry 71 2010 1079 1087
36. M.A. Cline, W. Nandar, B.C. Prall, C.N. Bowden, and D.M. Denbow Central visfatin causes orexigenic effects in chicks Behav. Brain Res. 186 2008 293 297
37. J. Contreras, and D.S. Rao MicroRNAs in inflammation and immune responses Leukemia 26 2012 404 413
38. K.S. Cook, H.Y. Min, D. Johnson, R.J. Chaplinsky, J.S. Flier, C.R. Hunt, and B.M. Spiegelman Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve Science 237 1987 402 405
39. S.J. Creely, P.G. McTernan, C.M. Kusminski, M. Fisher, N.F. Da Silva, M. Khanolkar, M. Evans, A.L. Harte, and S. Kumar Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes Am. J. Physiol. Endocrinol. Metab. 292 2007 E740 E747
40. L. Dai, P.M. Smith, M. Kuksis, and A.V. Ferguson Apelin acts in the subfornical organ to influence neuronal excitability and cardiovascular function J. Physiol. 591 2013 3421 3432
41. R.T. Day, R.C. Cavaglieri, and D. Feliers Apelin retards the progression of diabetic nephropathy Am. J. Physiol. Renal Physiol. 304 2013 F788 F800
42. C.M. de Souza Batista, R.Z. Yang, M.J. Lee, N.M. Glynn, D.Z. Yu, J. Pray, K. Ndubuizu, S. Patil, A. Schwartz, M. Kligman, S.K. Fried, D.W. Gong, A.R. Shuldiner, T.I. Pollin, and J.C. McLenithan Omentin plasma levels and gene expression are decreased in obesity Diabetes 56 2007 1655 1661
43. A. Denes, S. Ferenczi, and K.J. Kovacs Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood-brain barrier damage and brain oedema independently of infarct size J. Neuroinflammation 8 2011 164
44. A. Denes, N. Humphreys, T.E. Lane, R. Grencis, and N. Rothwell Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice J. Neurosci. 30 2010 10086 10095
45. R. Dent, A. Blackmore, J. Peterson, R. Habib, G.P. Kay, A. Gervais, V. Taylor, and G. Wells Changes in body weight and psychotropic drugs: a systematic synthesis of the literature PLoS One 7 2012 e36889
46. G.B. Di Gregorio, L. Hensley, T. Lu, G. Ranganathan, and P.A. Kern Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity Am. J. Physiol. Endocrinol. Metab. 287 2004 E182 E187
47. L.H. Dib, M.T. Ortega, S.D. Fleming, S.K. Chapes, and T. Melgarejo Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice Endocrinology 155 2014 40 46
48. C.A. Dinarello Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist Int. Rev. Immunol. 16 1998 457 499
49. C.A. Dinarello, A. Simon, and J.W. van der Meer Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases Nat. Rev. Drug Discov. 11 2012 633 652
50. B.S. Diniz, A.L. Teixeira, A.C. Campos, A.S. Miranda, N.P. Rocha, L.L. Talib, W.F. Gattaz, and O.V. Forlenza Reduced serum levels of adiponectin in elderly patients with major depression J. Psychiatr. Res. 46 2012 1081 1085
51. T. Eller, V. Vasar, J. Shlik, and E. Maron Pro-inflammatory cytokines and treatment response to escitalopram in major depressive disorder Prog. Neuropsychopharmacol. Biol. Psychiatry 32 2008 445 450
52. J.K. Elmquist, R.S. Ahima, E. Maratos-Flier, J.S. Flier, and C.B. Saper Leptin activates neurons in ventrobasal hypothalamus and brainstem Endocrinology 138 1997 839 842
53. E. Esel, S. Ozsoy, A. Tutus, S. Sofuoglu, S. Kartalci, F. Bayram, Z. Kokbudak, and M. Kula Effects of antidepressant treatment and of gender on serum leptin levels in patients with major depression Prog. Neuropsychopharmacol. Biol. Psychiatry 29 2005 565 570
54. A. Eskilsson, E. Mirrasekhian, S. Dufour, M. Schwaninger, D. Engblom, and A. Blomqvist Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to STAT3-dependent induction of brain endothelial prostaglandin synthesis J. Neurosci. 34 2014 15957 15961
55. K. Esposito, A. Pontillo, F. Giugliano, G. Giugliano, R. Marfella, G. Nicoletti, and D. Giugliano Association of low interleukin-10 levels with the metabolic syndrome in obese women J. Clin. Endocrinol. Metab. 88 2003 1055 1058
56. A.N. Fabricatore, T.A. Wadden, A.J. Higginbotham, L.F. Faulconbridge, A.M. Nguyen, S.B. Heymsfield, and M.S. Faith Intentional weight loss and changes in symptoms of depression: a systematic review and meta-analysis Int. J. Obes. (Lond.) 35 2011 1363 1376
57. R. Faggioni, G. Fantuzzi, J. Fuller, C.A. Dinarello, K.R. Feingold, and C. Grunfeld IL-1 beta mediates leptin induction during inflammation Am. J. Physiol. 274 1998 R204 R208
58. R. Faggioni, G. Fantuzzi, C. Gabay, A. Moser, C.A. Dinarello, K.R. Feingold, and C. Grunfeld Leptin deficiency enhances sensitivity to endotoxin-induced lethality Am. J. Physiol. 276 1999 R136 R142
59. R. Faggioni, J. Fuller, A. Moser, K.R. Feingold, and C. Grunfeld LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice Am. J. Physiol. 273 1997 R181 R186
60. J.N. Fain, A.K. Madan, M.L. Hiler, P. Cheema, and S.W. Bahouth Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans Endocrinology 145 2004 2273 2282
61. G. Fantuzzi Adipose tissue, adipokines, and inflammation J. Allergy Clin. Immunol. 115 2005 911 919 Quiz 920
62. G. Fantuzzi, and R. Faggioni Leptin in the regulation of immunity, inflammation, and hematopoiesis J. Leukoc. Biol. 68 2000 437 446
63. A. Festa, R. D'Agostino Jr., K. Williams, A.J. Karter, E.J. Mayer-Davis, R.P. Tracy, and S.M. Haffner The relation of body fat mass and distribution to markers of chronic inflammation Int. J. Obes. Relat. Metab. Disord. 25 2001 1407 1415
64. B.N. Finck, K.W. Kelley, R. Dantzer, and R.W. Johnson In vivo and in vitro evidence for the involvement of tumor necrosis factor-alpha in the induction of leptin by lipopolysaccharide Endocrinology 139 1998 2278 2283
65. J. Francis, P.S. MohanKumar, S.M. MohanKumar, and S.K. Quadri Systemic administration of lipopolysaccharide increases plasma leptin levels: blockade by soluble interleukin-1 receptor Endocrine 10 1999 291 295
66. S.K. Fried, D.A. Bunkin, and A.S. Greenberg Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid J. Clin. Endocrinol. Metab. 83 1998 847 850
67. G. Frisullo, M. Mirabella, F. Angelucci, M. Caggiula, R. Morosetti, C. Sancricca, A.K. Patanella, V. Nociti, R. Iorio, A. Bianco, V. Tomassini, C. Pozzilli, P.A. Tonali, G. Matarese, and A.P. Batocchi The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis J. Neuroimmunol. 192 2007 174 183
68. A. Fukuhara, M. Matsuda, M. Nishizawa, K. Segawa, M. Tanaka, K. Kishimoto, Y. Matsuki, M. Murakami, T. Ichisaka, H. Murakami, E. Watanabe, T. Takagi, M. Akiyoshi, T. Ohtsubo, S. Kihara, S. Yamashita, M. Makishima, T. Funahashi, S. Yamanaka, R. Hiramatsu, Y. Matsuzawa, and I. Shimomura Visfatin: a protein secreted by visceral fat that mimics the effects of insulin Science 307 2005 426 430
69. S. Gaige, A. Abysique, and M. Bouvier Effects of leptin on cat intestinal vagal mechanoreceptors J. Physiol. 543 2002 679 689
70. S. Gautam, and P.S. Meena Drug-emergent metabolic syndrome in patients with schizophrenia receiving atypical (second-generation) antipsychotics Indian J. Psychiatry 53 2011 128 133
71. L. Gautron, R. Mingam, A. Moranis, C. Combe, and S. Laye Influence of feeding status on neuronal activity in the hypothalamus during lipopolysaccharide-induced anorexia in rats Neuroscience 134 2005 933 946
72. R.R. Gerner, V. Wieser, A.R. Moschen, and H. Tilg Metabolic inflammation: role of cytokines in the crosstalk between adipose tissue and liver Can. J. Physiol. Pharmacol. 91 2013 867 872
73. B.I. Goldstein, S.M. Liu, N. Zivkovic, A. Schaffer, L.C. Chien, and C. Blanco The burden of obesity among adults with bipolar disorder in the United States Bipolar Disord. 13 2011 387 395
74. C. Grunfeld, C. Zhao, J. Fuller, A. Pollack, A. Moser, J. Friedman, and K.R. Feingold Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters J. Clin. Investig. 97 1996 2152 2157
75. L.M. Harden, I. du Plessis, S. Poole, and H.P. Laburn Interleukin-6 and leptin mediate lipopolysaccharide-induced fever and sickness behavior Physiol. Behav. 89 2006 146 155
76. E. Haroon, C.L. Raison, and A.H. Miller Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior Neuropsychopharmacology 37 2012 137 162
77. T. Hatzelmann, L.M. Harden, J. Roth, and R. Gerstberger Antipyretic effect of central [Pyr1]apelin13 on LPS-induced fever in the rat Regul. Pept. 184 2013 6 13
78. L.K. Heilbronn, and L.V. Campbell Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity Curr. Pharm. Des. 14 2008 1225 1230
79. T.A. Hopkins, N. Ouchi, R. Shibata, and K. Walsh Adiponectin actions in the cardiovascular system Cardiovasc. Res. 74 2007 11 18
80. T. Hosoi, Y. Okuma, and Y. Nomura Electrical stimulation of afferent vagus nerve induces IL-1beta expression in the brain and activates HPA axis Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 2000 R141 R147
81. T. Hosoi, Y. Okuma, and Y. Nomura Leptin regulates interleukin-1beta expression in the brain via the STAT3-independent mechanisms Brain Res. 949 2002 139 146
82. G.S. Hotamisligil, N.S. Shargill, and B.M. Spiegelman Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance Science 259 1993 87 91
83. J.K. Howard, G.M. Lord, G. Matarese, S. Vendetti, M.A. Ghatei, M.A. Ritter, R.I. Lechler, and S.R. Bloom Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice J. Clin. Investig. 104 1999 1051 1059
84. Q. Huang, R. Rivest, and D. Richard Effects of leptin on corticotropin-releasing factor (CRF) synthesis and CRF neuron activation in the paraventricular hypothalamic nucleus of obese (ob/ob) mice Endocrinology 139 1998 1524 1532
85. T. Hubschle, E. Thom, A. Watson, J. Roth, S. Klaus, and W. Meyerhof Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation J. Neurosci. 21 2001 2413 2424
86. F. Illan-Gomez, M. Gonzalvez-Ortega, I. Orea-Soler, M.S. Alcaraz-Tafalla, A. Aragon-Alonso, M. Pascual-Diaz, M. Perez-Paredes, and M.L. Lozano-Almela Obesity and inflammation: change in adiponectin, C-reactive protein, tumour necrosis factor-alpha and interleukin-6 after bariatric surgery Obes. Surg. 22 2012 950 955
87. W. Inoue, S. Poole, A.F. Bristow, and G.N. Luheshi Leptin induces cyclooxygenase-2 via an interaction with interleukin-1beta in the rat brain Eur. J. Neurosci. 24 2006 2233 2245
88. W. Inoue, G. Somay, S. Poole, and G.N. Luheshi Immune-to-brain signaling and central prostaglandin E2 synthesis in fasted rats with altered lipopolysaccharide-induced fever Am. J. Physiol. Regul. Integr. Comp. Physiol. 295 2008 133 143
89. G.M. Jow, T.T. Yang, and C.L. Chen Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia J. Affect Disord. 90 2006 21 27
90. C.E. Juge-Aubry, E. Somm, V. Giusti, A. Pernin, R. Chicheportiche, C. Verdumo, F. Rohner-Jeanrenaud, D. Burger, J.M. Dayer, and C.A. Meier Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammation Diabetes 52 2003 1104 1110
91. A. Khan, K.A. Schwartz, R.L. Kolts, and W.A. Brown BMI, sex, and antidepressant response J. Affect Disord. 99 2007 101 106
92. D. Kim, J. Kim, J.H. Yoon, J. Ghim, K. Yea, P. Song, S. Park, A. Lee, C.P. Hong, M.S. Jang, Y. Kwon, S. Park, M.H. Jang, P.O. Berggren, P.G. Suh, and S.H. Ryu CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice Diabetologia 57 2014 1456 1465
93. M.J. Kim, W. Lee, E.J. Park, and S.Y. Park C1qTNF-related protein-6 increases the expression of interleukin-10 in macrophages Mol. Cells 30 2010 59 64
94. S. Kloiber, M. Ising, S. Reppermund, S. Horstmann, T. Dose, M. Majer, J. Zihl, H. Pfister, P.G. Unschuld, F. Holsboer, and S. Lucae Overweight and obesity affect treatment response in major depression Biol. Psychiatry 62 2007 321 326
95. S. Koenig, G. Luheshi, T. Wenz, R. Gerstberger, J. Roth, and C. Rummel Leptin is involved in age-dependent changes in response to systemic inflammation in the rat Brain Behav. Immun. 36 2014 128 138
96. H.P. Kopp, C.W. Kopp, A. Festa, K. Krzyzanowska, S. Kriwanek, E. Minar, R. Roka, and G. Schernthaner Impact of weight loss on inflammatory proteins and their association with the insulin resistance syndrome in morbidly obese patients Arterioscler. Thromb. Vasc. Biol. 23 2003 1042 1047
97. Z. Kotan, E. Sarandol, E. Kirhan, G. Ozkaya, and S. Kirli Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features Ther. Adv. Psychopharmacol. 2 2012 65 74
98. T. Kraus, M. Haack, A. Schuld, D. Hinze-Selch, D. Koethe, and T. Pollmacher Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine Pharmacopsychiatry 35 2002 220 225
99. T. Kraus, M. Haack, A. Schuld, D. Hinze-Selch, and T. Pollmacher Low leptin levels but normal body mass indices in patients with depression or schizophrenia Neuroendocrinology 73 2001 243 247
100. J. Krist, K. Wieder, N. Kloting, A. Oberbach, S. Kralisch, T. Wiesner, M.R. Schon, D. Gartner, A. Dietrich, E. Shang, T. Lohmann, M. Dressler, M. Fasshauer, M. Stumvoll, and M. Bluher Effects of weight loss and exercise on apelin serum concentrations and adipose tissue expression in human obesity Obes. Facts 6 2013 57 69
101. H. Kwon, and J.E. Pessin Adipokines mediate inflammation and insulin resistance Front. Endocrinol. (Lausanne) 4 2013 71
102. A. La Cava, and G. Matarese The weight of leptin in immunity Nat. Rev. Immunol. 4 2004 371 379
103. Q.L. Lam, and L. Lu Role of leptin in immunity Cell. Mol. Immunol. 4 2007 1 13
104. R.E. Landman, J.J. Puder, E. Xiao, P.U. Freda, M. Ferin, and S.L. Wardlaw Endotoxin stimulates leptin in the human and nonhuman primate J. Clin. Endocrinol. Metab. 88 2003 1285 1291
105. E.B. Lee, G. Warmann, R. Dhir, and R.S. Ahima Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity J. Neurosci. 31 2011 14361 14366
106. S. Lehr, S. Hartwig, D. Lamers, S. Famulla, S. Muller, F.G. Hanisch, C. Cuvelier, J. Ruige, K. Eckardt, D.M. Ouwens, H. Sell, and J. Eckel Identification and validation of novel adipokines released from primary human adipocytes Mol. Cell. Proteomics 11 2012 M111 010504
107. S. Lehr, S. Hartwig, and H. Sell Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders Proteomics Clin. Appl. 6 2012 91 101
108. S. Li, H.J. Shin, E.L. Ding, and R.M. van Dam Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis JAMA 302 2009 179 188
109. Z. Li, S. Yang, H. Lin, J. Huang, P.A. Watkins, A.B. Moser, C. Desimone, X.Y. Song, and A.M. Diehl Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease Hepatology 37 2003 343 350
110. H. Liang, B. Yin, H. Zhang, S. Zhang, Q. Zeng, J. Wang, X. Jiang, L. Yuan, C.Y. Wang, and Z. Li Blockade of tumor necrosis factor (TNF) receptor type 1-mediated TNF-alpha signaling protected Wistar rats from diet-induced obesity and insulin resistance Endocrinology 149 2008 2943 2951
111. A.S. Lihn, J.M. Bruun, G. He, S.B. Pedersen, P.F. Jensen, and B. Richelsen Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects Mol. Cell. Endocrinol. 219 2004 9 15
112. J. Liu, J.C. Garza, J. Bronner, C.S. Kim, W. Zhang, and X.Y. Lu Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine Psychopharmacology (Berl) 207 2010 535 545
113. J. Liu, M. Guo, D. Zhang, S.Y. Cheng, M. Liu, J. Ding, P.E. Scherer, F. Liu, and X.Y. Lu Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity Proc. Natl. Acad. Sci. U. S. A. 109 2012 12248 12253
114. J.C. Lo, S. Ljubicic, B. Leibiger, M. Kern, I.B. Leibiger, T. Moede, M.E. Kelly, D. Chatterjee Bhowmick, I. Murano, P. Cohen, A.S. Banks, M.J. Khandekar, A. Dietrich, J.S. Flier, S. Cinti, M. Bluher, N.N. Danial, P.O. Berggren, and B.M. Spiegelman Adipsin is an adipokine that improves beta cell function in diabetes Cell 158 2014 41 53
115. S. Loffreda, S.Q. Yang, H.Z. Lin, C.L. Karp, M.L. Brengman, D.J. Wang, A.S. Klein, G.B. Bulkley, C. Bao, P.W. Noble, M.D. Lane, and A.M. Diehl Leptin regulates proinflammatory immune responses FASEB J. 12 1998 57 65
116. A.L. Lopresti, and P.D. Drummond Obesity and psychiatric disorders: commonalities in dysregulated biological pathways and their implications for treatment Prog. Neuropsychopharmacol. Biol. Psychiatry 45 2013 92 99
117. G.M. Lord, G. Matarese, J.K. Howard, R.J. Baker, S.R. Bloom, and R.I. Lechler Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression Nature 394 1998 897 901
118. X.Y. Lu, C.S. Kim, A. Frazer, and W. Zhang Leptin: a potential novel antidepressant Proc. Natl. Acad. Sci. U. S. A. 103 2006 1593 1598
119. G.N. Luheshi, J.D. Gardner, D.A. Rushforth, A.S. Loudon, and N.J. Rothwell Leptin actions on food intake and body temperature are mediated by IL-1 Proc. Natl. Acad. Sci. U. S. A. 96 1999 7047 7052
120. G.N. Luheshi, and C. Rummel Is programming of weight regulation immune to neonatal inflammation? Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 2007 R578 R580
121. F.S. Luppino, L.M. de Wit, P.F. Bouvy, T. Stijnen, P. Cuijpers, B.W. Penninx, and F.G. Zitman Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies Arch. Gen. Psychiatry 67 2010 220 229
122. G. Maina, V. Salvi, A. Vitalucci, V. D'Ambrosio, and F. Bogetto Prevalence and correlates of overweight in drug-naive patients with bipolar disorder J. Affect Disord. 110 2008 149 155
123. C.A. Mastronardi, W.H. Yu, V.K. Srivastava, W.L. Dees, and S.M. McCann Lipopolysaccharide-induced leptin release is neurally controlled Proc. Natl. Acad. Sci. U. S. A. 98 2001 14720 14725
124. G. Matarese, A. Di Giacomo, V. Sanna, G.M. Lord, J.K. Howard, A. Di Tuoro, S.R. Bloom, R.I. Lechler, S. Zappacosta, and S. Fontana Requirement for leptin in the induction and progression of autoimmune encephalomyelitis J. Immunol. 166 2001 5909 5916
125. B.W. McColl, N.J. Rothwell, and S.M. Allan Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms J. Neurosci. 27 2007 4403 4412
126. C.A. Meier, E. Bobbioni, C. Gabay, F. Assimacopoulos-Jeannet, A. Golay, and J.M. Dayer IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin? J. Clin. Endocrinol. Metab. 87 2002 1184 1188
127. Y. Milaneschi, E.M. Simonsick, N. Vogelzangs, E.S. Strotmeyer, K. Yaffe, T.B. Harris, M.I. Tolea, L. Ferrucci, and B.W. Penninx Leptin, abdominal obesity, and onset of depression in older men and women J. Clin. Psychiatry 73 2012 1205 1211
128. A.A. Miller, and S.J. Spencer Obesity and neuroinflammation: a pathway to cognitive impairment Brain Behav. Immun. 42 2014 10 21
129. A.H. Miller, V. Maletic, and C.L. Raison Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression Biol. Psychiatry 65 2009 732 741
130. P.K. Mishra, H. Hsuchou, S. Ouyang, A.J. Kastin, X. Wu, and W. Pan Loss of astrocytic leptin signaling worsens experimental autoimmune encephalomyelitis Brain Behav. Immun. 34 2013 98 107
131. V. Mohamed-Ali, S. Goodrick, A. Rawesh, D.R. Katz, J.M. Miles, J.S. Yudkin, S. Klein, and S.W. Coppack Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo J. Clin. Endocrinol. Metab. 82 1997 4196 4200
132. F. Montecucco, G. Bianchi, P. Gnerre, M. Bertolotto, F. Dallegri, and L. Ottonello Induction of neutrophil chemotaxis by leptin: crucial role for p38 and Src kinases Ann. N. Y. Acad. Sci. 1069 2006 463 471
133. S.I. Moore, G.B. Huffnagle, G.H. Chen, E.S. White, and P. Mancuso Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae Infect. Immun. 71 2003 4182 4185
134. A.R. Moschen, A. Kaser, B. Enrich, B. Mosheimer, M. Theurl, H. Niederegger, and H. Tilg Visfatin, an adipocytokine with proinflammatory and immunomodulating properties J. Immunol. 178 2007 1748 1758
135. A.R. Moschen, C. Molnar, B. Enrich, S. Geiger, C.F. Ebenbichler, and H. Tilg Adipose and liver expression of interleukin (IL)-1 family members in morbid obesity and effects of weight loss Mol. Med. 17 2011 840 845
136. K.T. Murphy, G.J. Schwartz, N.L. Nguyen, J.M. Mendez, V. Ryu, and T.J. Bartness Leptin-sensitive sensory nerves innervate white fat Am. J. Physiol. Endocrinol. Metab. 304 2013 E1338 E1347
137. J. Mütze, J. Roth, R. Gerstberger, K. Matsumura, and T. Hübschle Immunohistochemical evidence of functional leptin receptor expression in neuronal and endothelial cells of the rat brain Neurosci. Lett. 394 2006 105 110
138. J.W. Newcomer Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review CNS Drugs 19 Suppl. 1 2005 1 93
139. B.J. Nicklas, W. Ambrosius, S.P. Messier, G.D. Miller, B.W. Penninx, R.F. Loeser, S. Palla, E. Bleecker, and M. Pahor Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial Am. J. Clin. Nutr. 79 2004 544 551
140. E. Nigro, O. Scudiero, M.L. Monaco, A. Palmieri, G. Mazzarella, C. Costagliola, A. Bianco, and A. Daniele New insight into adiponectin role in obesity and obesity-related diseases Biomed. Res. Int. 2014 2014 658913
141. M. Nishimura, Y. Izumiya, A. Higuchi, R. Shibata, J. Qiu, C. Kudo, H.K. Shin, M.A. Moskowitz, and N. Ouchi Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms Circulation 117 2008 216 223
142. S.M. O'Brien, P. Scully, P. Fitzgerald, L.V. Scott, and T.G. Dinan Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy J. Psychiatr. Res. 41 2007 326 331
143. K. Ohashi, J.L. Parker, N. Ouchi, A. Higuchi, J.A. Vita, N. Gokce, A.A. Pedersen, C. Kalthoff, S. Tullin, A. Sams, R. Summer, and K. Walsh Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype J. Biol. Chem. 285 2010 6153 6160
144. K. Ohashi, R. Shibata, T. Murohara, and N. Ouchi Role of anti-inflammatory adipokines in obesity-related diseases Trends Endocrinol. Metab. 25 2014 348 355
145. N. Ouchi, S. Kihara, Y. Arita, Y. Okamoto, K. Maeda, H. Kuriyama, K. Hotta, M. Nishida, M. Takahashi, M. Muraguchi, Y. Ohmoto, T. Nakamura, S. Yamashita, T. Funahashi, and Y. Matsuzawa Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway Circulation 102 2000 1296 1301
146. N. Ouchi, and K. Walsh Adiponectin as an anti-inflammatory factor Clin. Chim. Acta 380 2007 24 30
147. B. Pakiz, S.W. Flatt, W.A. Bardwell, C.L. Rock, and P.J. Mills Effects of a weight loss intervention on body mass, fitness, and inflammatory biomarkers in overweight or obese breast cancer survivors Int. J. Behav. Med. 18 2011 333 341
148. C. Pang, Z. Gao, J. Yin, J. Zhang, W. Jia, and J. Ye Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity Am. J. Physiol. Endocrinol. Metab. 295 2008 E313 E322
149. G.I. Papakostas, T. Petersen, D.V. Iosifescu, A.M. Burns, A.A. Nierenberg, J.E. Alpert, J.F. Rosenbaum, and M. Fava Obesity among outpatients with major depressive disorder Int. J. Neuropsychopharmacol. 8 2005 59 63
150. B.S. Park, S.H. Jin, J.J. Park, J.W. Park, I.S. Namgoong, Y.I. Kim, B.J. Lee, and J.G. Kim Visfatin induces sickness responses in the brain PLoS One 6 2011 e15981
151. H.K. Park, and R.S. Ahima Resistin in rodents and humans Diabetes Metab. J. 37 2013 404 414
152. H.K. Park, M. Qatanani, E.R. Briggs, R.S. Ahima, and M.A. Lazar Inflammatory induction of human resistin causes insulin resistance in endotoxemic mice Diabetes 60 2011 775 783
153. J.A. Pasco, F.N. Jacka, L.J. Williams, M.J. Henry, G.C. Nicholson, M.A. Kotowicz, and M. Berk Leptin in depressed women: cross-sectional and longitudinal data from an epidemiologic study J. Affect Disord. 107 2008 221 225
154. B.K. Pedersen Muscles and their myokines J. Exp. Biol. 214 2011 337 346
155. B.K. Pedersen, A. Steensberg, C. Fischer, C. Keller, P. Keller, P. Plomgaard, M. Febbraio, and B. Saltin Searching for the exercise factor: is IL-6 a candidate? J. Muscle Res. Cell Motil. 24 2003 113 119
156. V.H. Perry, C. Cunningham, and C. Holmes Systemic infections and inflammation affect chronic neurodegeneration Nat. Rev. Immunol. 7 2007 161 167
157. J.H. Peters, B.M. McKay, S.M. Simasko, and R.C. Ritter Leptin-induced satiation mediated by abdominal vagal afferents Am. J. Physiol. Regul. Integr. Comp. Physiol. 288 2005 R879 R884
158. J.H. Peters, R.C. Ritter, and S.M. Simasko Leptin and CCK selectively activate vagal afferent neurons innervating the stomach and duodenum Am. J. Physiol. Regul. Integr. Comp. Physiol. 290 2006 R1544 R1549
159. N.M. Petry, D. Barry, R.H. Pietrzak, and J.A. Wagner Overweight and obesity are associated with psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions Psychosom. Med. 70 2008 288 297
160. L. Piccio, C. Cantoni, J.G. Henderson, D. Hawiger, M. Ramsbottom, R. Mikesell, J. Ryu, C.S. Hsieh, V. Cremasco, W. Haynes, L.Q. Dong, L. Chan, D. Galimberti, and A.H. Cross Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis Eur. J. Immunol. 43 2013 2089 2100
161. J. Pohl, B. Woodside, and G.N. Luheshi Changes in hypothalamically mediated acute-phase inflammatory responses to lipopolysaccharide in diet-induced obese rats Endocrinology 150 2009 4901 4910
162. J. Pohl, B. Woodside, and G.N. Luheshi Leptin modulates the late fever response to LPS in diet-induced obese animals Brain Behav. Immun. 42 2014 41 47
163. C. Procaccini, V. De Rosa, M. Galgani, F. Carbone, C. La Rocca, L. Formisano, and G. Matarese Role of adipokines signaling in the modulation of T cells function Front. Immunol. 4 2013 332
164. N. Quan In-depth conversation: spectrum and kinetics of neuroimmune afferent pathways Brain Behav. Immun. 40 2014 1 8
165. M.J. Radin, L.C. Sharkey, and B.J. Holycross Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses Vet. Clin. Pathol. 38 2009 136 156
166. S.R. Rao Inflammatory markers and bariatric surgery: a meta-analysis Inflamm. Res. 61 2012 789 807
167. A.C. Rivenes, S.B. Harvey, and A. Mykletun The relationship between abdominal fat, obesity, and common mental disorders: results from the HUNT study J. Psychosom. Res. 66 2009 269 275
168. R.T. Rubin, M.E. Rhodes, and R.K. Czambel Sexual diergism of baseline plasma leptin and leptin suppression by arginine vasopressin in major depressives and matched controls Psychiatry Res. 113 2002 255 268
169. C. Rummel-Kluge, K. Komossa, S. Schwarz, H. Hunger, F. Schmid, C.A. Lobos, W. Kissling, J.M. Davis, and S. Leucht Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis Schizophr. Res. 123 2010 225 233
170. C. Rummel, T. Hübschle, R. Gerstberger, and J. Roth Nuclear translocation of the transcription factor STAT3 in the guinea pig brain during systemic or localized inflammation J. Physiol. 557 2004 671 687
171. C. Rummel, W. Inoue, S. Poole, and G.N. Luheshi Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation Mol. Psychiatry 15 2010 523 534
172. C. Rummel, W. Inoue, C. Sachot, S. Poole, T. Hübschle, and G.N. Luheshi Selective contribution of interleukin-6 and leptin to brain inflammatory signals induced by systemic LPS injection in mice J. Comp. Neurol. 511 2008 373 395
173. C. Rummel, C. Sachot, S. Poole, and G.N. Luheshi Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain Am. J. Physiol. Regul. Integr. Comp. Physiol. 291 2006 R1316 R1326
174. C. Rummel, T. Voss, K. Matsumura, S. Korte, R. Gerstberger, J. Roth, and T. Hübschle Nuclear STAT3 translocation in guinea pig and rat brain endothelium during systemic challenge with lipopolysaccharide and interleukin-6 J. Comp. Neurol. 491 2005 1 14
175. A.S. Ryan, and B.J. Nicklas Reductions in plasma cytokine levels with weight loss improve insulin sensitivity in overweight and obese postmenopausal women Diabetes Care 27 2004 1699 1705
176. G. Sabio, M. Das, A. Mora, Z. Zhang, J.Y. Jun, H.J. Ko, T. Barrett, J.K. Kim, and R.J. Davis A stress signaling pathway in adipose tissue regulates hepatic insulin resistance Science 322 2008 1539 1543
177. C. Sachot, S. Poole, and G.N. Luheshi Circulating leptin mediates lipopolysaccharide-induced anorexia and fever in rats J. Physiol. 561 2004 263 272
178. C. Sachot, C. Rummel, A.F. Bristow, and G.N. Luheshi The role of the vagus nerve in mediating the long-term anorectic effects of leptin J. Neuroendocrinol. 19 2007 250 261
179. B. Samal, Y. Sun, G. Stearns, C. Xie, S. Suggs, and I. McNiece Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor Mol. Cell. Biol. 14 1994 1431 1437
180. K. Sanderson, G.C. Patton, C. McKercher, T. Dwyer, and A.J. Venn Overweight and obesity in childhood and risk of mental disorder: a 20-year cohort study Aust. N. Z. J. Psychiatry 45 2011 384 392
181. V. Sanna, A. Di Giacomo, A. La Cava, R.I. Lechler, S. Fontana, S. Zappacosta, and G. Matarese Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses J. Clin. Investig. 111 2003 241 250
182. P. Sarraf, R.C. Frederich, E.M. Turner, G. Ma, N.T. Jaskowiak, D.J. Rivet 3rd, J.S. Flier, B.B. Lowell, D.L. Fraker, and H.R. Alexander Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia J. Exp. Med. 185 1997 171 175
183. D.C. Saucillo, V.A. Gerriets, J. Sheng, J.C. Rathmell, and N.J. Maciver Leptin metabolically licenses T cells for activation to link nutrition and immunity J. Immunol. 192 2014 136 144
184. C. Schilling, M. Gilles, W.F. Blum, E. Daseking, M. Colla, B. Weber-Hamann, F. Lederbogen, B. Krumm, I. Heuser, S.A. Wudy, D. Kopf, and M. Deuschle Leptin plasma concentrations increase during antidepressant treatment with amitriptyline and mirtazapine, but not paroxetine and venlafaxine: leptin resistance mediated by antihistaminergic activity? J. Clin. Psychopharmacol. 33 2013 99 103
185. A.J. Schottelius, M.W. Mayo, R.B. Sartor, and A.S. Baldwin Jr. Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding J. Biol. Chem. 274 1999 31868 31874
186. A. Serretti, and L. Mandelli Antidepressants and body weight: a comprehensive review and meta-analysis J. Clin. Psychiatry 71 2010 1259 1272
187. R.C. Shelton, and A.H. Miller Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression Prog. Neurobiol. 91 2010 275 299
188. D. Siegl, T. Annecke, B.L. Johnson 3rd, C. Schlag, A. Martignoni, N. Huber, P. Conzen, C.C. Caldwell, and J. Tschop Obesity-induced hyperleptinemia improves survival and immune response in a murine model of sepsis Anesthesiology 121 2014 98 114
189. J. Skalicky, V. Muzakova, R. Kandar, M. Meloun, T. Rousar, and V. Palicka Evaluation of oxidative stress and inflammation in obese adults with metabolic syndrome Clin. Chem. Lab. Med. 46 2008 499 505
190. S.J. Spencer, A. Mouihate, and Q.J. Pittman Peripheral inflammation exacerbates damage after global ischemia independently of temperature and acute brain inflammation Stroke 38 2007 1570 1577
191. N. Stefan, and H.U. Haring The role of hepatokines in metabolism Nat. Rev. Endocrinol. 9 2013 144 152
192. C.M. Steppan, S.T. Bailey, S. Bhat, E.J. Brown, R.R. Banerjee, C.M. Wright, H.R. Patel, R.S. Ahima, and M.A. Lazar The hormone resistin links obesity to diabetes Nature 409 2001 307 312
193. A. Subedi, and P.H. Park Autocrine and paracrine modulation of microRNA-155 expression by globular adiponectin in RAW 264.7 macrophages: involvement of MAPK/NF-kappaB pathway Cytokine 64 2013 638 641
194. A. Tarkowski, J. Bjersing, A. Shestakov, and M.I. Bokarewa Resistin competes with lipopolysaccharide for binding to toll-like receptor 4 J. Cell. Mol. Med. 14 2010 1419 1431
195. J. Thundyil, D. Pavlovski, C.G. Sobey, and T.V. Arumugam Adiponectin receptor signalling in the brain Br. J. Pharmacol. 165 2012 313 327
196. P. Trayhurn, and I.S. Wood Adipokines: inflammation and the pleiotropic role of white adipose tissue Br. J. Nutr. 92 2004 347 355
197. J. Tschöp, R. Nogueiras, S. Haas-Lockie, K.R. Kasten, T.R. Castaneda, N. Huber, K. Guanciale, D. Perez-Tilve, K. Habegger, N. Ottaway, S.C. Woods, B. Oldfield, I. Clarke, S. Chua Jr., I.S. Farooqi, S. O'Rahilly, C.C. Caldwell, and M.H. Tschop CNS leptin action modulates immune response and survival in sepsis J. Neurosci. 30 2010 6036 6047
198. R. Uher, O. Mors, J. Hauser, M. Rietschel, W. Maier, D. Kozel, N. Henigsberg, D. Souery, A. Placentino, N. Perroud, M.Z. Dernovsek, J. Strohmaier, E.R. Larsen, A. Zobel, A. Leszczynska-Rodziewicz, P. Kalember, L. Pedrini, S. Linotte, C. Gunasinghe, K.J. Aitchison, P. McGuffin, and A. Farmer Body weight as a predictor of antidepressant efficacy in the GENDEP project J. Affect Disord. 118 2009 147 154
199. A. Utagawa, J.S. Truettner, W.D. Dietrich, and H.M. Bramlett Systemic inflammation exacerbates behavioral and histopathological consequences of isolated traumatic brain injury in rats Exp. Neurol. 211 2008 283 291
200. A.K. van Reedt Dortland, E.J. Giltay, T. van Veen, F.G. Zitman, and B.W. Penninx Longitudinal relationship of depressive and anxiety symptoms with dyslipidemia and abdominal obesity Psychosom. Med. 75 2013 83 89
201. S. Verma, S.H. Li, C.H. Wang, P.W. Fedak, R.K. Li, R.D. Weisel, and D.A. Mickle Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction Circulation 108 2003 736 740
202. N. Vogelzangs, S.B. Kritchevsky, A.T. Beekman, A.B. Newman, S. Satterfield, E.M. Simonsick, K. Yaffe, T.B. Harris, and B.W. Penninx Depressive symptoms and change in abdominal obesity in older persons Arch. Gen. Psychiatry 65 2008 1386 1393
203. J.J. Wakshlag, A.M. Struble, C.B. Levine, J.J. Bushey, D.P. Laflamme, and G.M. Long The effects of weight loss on adipokines and markers of inflammation in dogs Br. J. Nutr. 106 Suppl. 1 2011 S11 S14
204. K. Wallenius, V. Wallenius, D. Sunter, S.L. Dickson, and J.O. Jansson Intracerebroventricular interleukin-6 treatment decreases body fat in rats Biochem. Biophys. Res. Commun. 293 2002 560 565
205. V. Wallenius, K. Wallenius, B. Ahren, M. Rudling, H. Carlsten, S.L. Dickson, C. Ohlsson, and J.O. Jansson Interleukin-6-deficient mice develop mature-onset obesity Nat. Med. 8 2002 75 79
206. T.C. Wascher, J.H. Lindeman, H. Sourij, T. Kooistra, G. Pacini, and M. Roden Chronic TNF-alpha neutralization does not improve insulin resistance or endothelial function in "healthy" men with metabolic syndrome Mol. Med. 17 2011 189 193
207. B. Weber-Hamann, J. Kratzsch, D. Kopf, F. Lederbogen, M. Gilles, I. Heuser, and M. Deuschle Resistin and adiponectin in major depression: the association with free cortisol and effects of antidepressant treatment J. Psychiatr. Res. 41 2007 344 350
208. J. Weigert, M. Neumeier, A. Schaffler, M. Fleck, J. Scholmerich, C. Schutz, and C. Buechler The adiponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells FEBS Lett. 579 2005 5565 5570
209. B.E. Wisse, K. Ogimoto, G.J. Morton, C.W. Wilkinson, R.S. Frayo, D.E. Cummings, and M.W. Schwartz Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasis Am. J. Physiol. Endocrinol. Metab. 287 2004 E1107 E1113
210. A.M. Wolf, D. Wolf, H. Rumpold, B. Enrich, and H. Tilg Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes Biochem. Biophys. Res. Commun. 323 2004 630 635
211. B. Wolfing, C. Buechler, J. Weigert, M. Neumeier, C. Aslanidis, J. Schoelmerich, and A. Schaffler Effects of the new C1q/TNF-related protein (CTRP-3) "cartonectin" on the adipocytic secretion of adipokines Obesity (Silver Spring) 16 2008 1481 1486
212. I.S. Wood, F.P. de Heredia, B. Wang, and P. Trayhurn Cellular hypoxia and adipose tissue dysfunction in obesity Proc. Nutr. Soc. 68 2009 370 377
213. E. Xiao, L. Xia-Zhang, N.R. Vulliemoz, M. Ferin, and S.L. Wardlaw Leptin modulates inflammatory cytokine and neuroendocrine responses to endotoxin in the primate Endocrinology 144 2003 4350 4353
214. N. Yamada, G. Katsuura, Y. Ochi, K. Ebihara, T. Kusakabe, K. Hosoda, and K. Nakao Impaired CNS leptin action is implicated in depression associated with obesity Endocrinology 152 2011 2634 2643
215. N. Yamaguchi, J.G. Argueta, Y. Masuhiro, M. Kagishita, K. Nonaka, T. Saito, S. Hanazawa, and Y. Yamashita Adiponectin inhibits Toll-like receptor family-induced signaling FEBS Lett. 579 2005 6821 6826
216. R.Z. Yang, M.J. Lee, H. Hu, J. Pray, H.B. Wu, B.C. Hansen, A.R. Shuldiner, S.K. Fried, J.C. McLenithan, and D.W. Gong Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action Am. J. Physiol. Endocrinol. Metab. 290 2006 E1253 E1261
217. J. Ye, Z. Gao, J. Yin, and Q. He Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice Am. J. Physiol. Endocrinol. Metab. 293 2007 E1118 E1128
218. J. Ye, and O.P. McGuinness Inflammation during obesity is not all bad: evidence from animal and human studies Am. J. Physiol. Endocrinol. Metab. 304 2013 E466 E477
219. R. Yoshimura, H. Hori, A. Ikenouchi-Sugita, W. Umene-Nakano, N. Ueda, and J. Nakamura Higher plasma interleukin-6 (IL-6) level is associated with SSRI- or SNRI-refractory depression Prog. Neuropsychopharmacol. Biol. Psychiatry 33 2009 722 726
220. S. Younis, I. Rosner, D. Rimar, N. Boulman, M. Rozenbaum, M. Odeh, and G. Slobodin Weight change during pharmacological blockade of interleukin-6 or tumor necrosis factor-alpha in patients with inflammatory rheumatic disorders: a 16-week comparative study Cytokine 61 2013 353 355
221. J.S. Yudkin, C.D. Stehouwer, J.J. Emeis, and S.W. Coppack C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler. Thromb. Vasc. Biol. 19 1999 972 978
222. M. Zeman, R. Jirak, M. Jachymova, M. Vecka, E. Tvrzicka, and A. Zak Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance in depressive women Neuro Endocrinol. Lett. 30 2009 387 395
223. F. Zhang, M.B. Basinski, J.M. Beals, S.L. Briggs, L.M. Churgay, D.K. Clawson, R.D. DiMarchi, T.C. Furman, J.E. Hale, H.M. Hsiung, B.E. Schoner, D.P. Smith, X.Y. Zhang, J.P. Wery, and R.W. Schevitz Crystal structure of the obese protein leptin-E100 Nature 387 1997 206 209
224. Y. Zhang, M. Matheny, S. Zolotukhin, N. Tumer, and P.J. Scarpace Regulation of adiponectin and leptin gene expression in white and brown adipose tissues: influence of beta3-adrenergic agonists, retinoic acid, leptin and fasting Biochim. Biophys. Acta 1584 2002 115 122
225. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman Positional cloning of the mouse obese gene and its human homologue Nature 372 1994 425 432
226. X. Zhong, X. Li, F. Liu, H. Tan, and D. Shang Omentin inhibits TNF-alpha-induced expression of adhesion molecules in endothelial cells via ERK/NF-kappaB pathway Biochem. Biophys. Res. Commun. 425 2012 401 406
227. M.R. Zielinski, D.L. Dunbrasky, P. Taishi, G. Souza, and J.M. Krueger Vagotomy attenuates brain cytokines and sleep induced by peripherally administered tumor necrosis factor-alpha and lipopolysaccharide in mice Sleep 36 2013 1227 1238 1238A