Modulation of Aβ peptides by estrogen in mouse models

Journal of Neurochemistry

Volumn 80, Issue 1, 2002, Pages 191-196

  Zheng, H ^b   Xu, H ^c   Uljon, S N ^c   Gross, R ^c   Hardy, K ^a   Gaynor, J ^a   Lafrancois, J ^a   Simpkins, J ^d   Refolo, L M ^a   Petanceska, S ^a   Wang, R ^c   Duff, K ^a,e  

^a NEW YORK UNIVERSITY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d UNIVERSITY OF NORTH TEXAS   (United States)

^e NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

Alzheimer's disease; Estrogen; Model; Transgenic mouse

Indexed keywords

AMYLOID BETA PROTEIN; ESTRADIOL; ESTROGEN;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; ESTROGEN ACTIVITY; ESTROGEN DEFICIENCY; ESTROGEN THERAPY; FEMALE; HUMAN; MENOPAUSE; MOUSE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN DETERMINATION; RISK FACTOR; SENILE PLAQUE; TRANSGENIC MOUSE;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ESTRADIOL; HUMANS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; OVARIECTOMY; PEPTIDE FRAGMENTS; PRESENILIN-1;

ANIMALIA; MUS MUSCULUS;

EID: 0036270344     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-3042.2001.00690.x     Document Type: Article

References (21)

1. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
2. Augmented senile plaque load in aged female β-amyloid precursor protein transgenic mice
3. Estrogens influence growth, maturation, and amyloid beta-peptide production in neuroblastoma cells and in a β-APP transfected kidney 293 cell line
4. Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1
5. Alzheimer-type neuropathology in transgenic mice over-expressing V717F β-amyloid precursor protein
6. Effective oral administration of 17β-estradiol to female C57BL/6J mice through the drinking water
7. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
8. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
9. Estrogen regulates metabolism of Alzheimer amyloid β precursor protein
10. Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice
11. Estrogen enhances uptake of amyloid β-protein by microglia derived from the human cortex
12. Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats
13. Estradiol and progesterone regulate neuronal structure and synaptic connectivity in adult as well as developing brain
14. Amyloid phenotype characterization of transgenic mice over-expressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes
15. Ovariectomy and 17β-estradiol modulate the levels of Alzheimer's amyloid β peptides in brain
16. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
17. Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester
18. Effect of oestregen during menopause on risk and age at onset of Alzheimer's disease
19. The profile of soluble amyloid β protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry
20. Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1, and amyloid precursor protein transgenes
21. Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides