The perimenopausal aging transition in the female rat brain: Decline in bioenergetic systems and synaptic plasticity

Neurobiology of Aging

Volumn 36, Issue 7, 2015, Pages 2282-2295

  Yin, Fei ^a   Yao, Jia ^a   Sancheti, Harsh ^a   Feng, Tao ^b   Melcangi, Roberto C ^c   Morgan, Todd E ^a   Finch, Caleb E ^a   Pike, Christian J ^a   Mack, Wendy J ^b   Cadenas, Enrique ^a   Brinton, Roberta D ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Fatty acid metabolism; Female brain aging; Glucose metabolism; Hypometabolism; Long term potentiation; Mitochondria; Perimenopause; Synaptic plasticity

Indexed keywords

AMYLOID BETA PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ESTETROL; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLUORODEOXYGLUCOSE F 18; GLUCOSE TRANSPORTER 3; GLUTAMATE DECARBOXYLASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NUCLEAR RESPIRATORY FACTOR 1; PEROXIREDOXIN 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C BETA3; PROGESTERONE; PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B; PROTEIN KINASE B; SOMATOMEDIN C; FATTY ACID; GLUCOSE; PPARGC1A PROTEIN, RAT; TRANSCRIPTION FACTOR;

ACYCLICITY; ADULT; AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BIOENERGY; BIOINFORMATICS; BRAIN METABOLISM; CHRONOLOGICAL AGING; CLIMACTERIUM; CONTROLLED STUDY; DOWN REGULATION; ENDOCRINE AGING; FATTY ACID METABOLISM; FEMALE; FEMALE BRAIN AGING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOMICS; GLUCOSE METABOLISM; HIPPOCAMPAL CA1 REGION; INFLAMMATION; IRREGULAR CYCLE; LONG TERM POTENTIATION; MENSTRUAL CYCLE; MIDDLE AGED; MITOCHONDRIAL DYNAMICS; NERVE CELL PLASTICITY; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; OVARY CYCLE; OXIDATION REDUCTION STATE; POSITRON EMISSION TOMOGRAPHY; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; REGULAR CYCLE; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; ANIMAL MODEL; BRAIN; ENERGY METABOLISM; GENE EXPRESSION; GENETICS; LIPID METABOLISM; METABOLISM; MITOCHONDRION; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

AGING; ALZHEIMER DISEASE; AMP-ACTIVATED PROTEIN KINASES; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; ENERGY METABOLISM; FATTY ACIDS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCOSE; INSULIN-LIKE GROWTH FACTOR I; LIPID METABOLISM; LONG-TERM POTENTIATION; MITOCHONDRIA; MODELS, ANIMAL; NEURONAL PLASTICITY; PERIMENOPAUSE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTORS;

EID: 84930089697     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2015.03.013     Document Type: Article

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